{"id":"https://openalex.org/W2321377008","doi":"https://doi.org/10.1056/nejmoa1203166","title":"Peginesatide for Anemia in Patients with Chronic Kidney Disease Not Receiving Dialysis","display_name":"Peginesatide for Anemia in Patients with Chronic Kidney Disease Not Receiving Dialysis","publication_year":2013,"publication_date":"2013-01-23","ids":{"openalex":"https://openalex.org/W2321377008","doi":"https://doi.org/10.1056/nejmoa1203166","mag":"2321377008","pmid":"https://pubmed.ncbi.nlm.nih.gov/23343062"},"language":"en","primary_location":{"id":"doi:10.1056/nejmoa1203166","doi":"https://doi.org/10.1056/nejmoa1203166","is_oa":true,"landing_page_url":"https://doi.org/10.1056/nejmoa1203166","pdf_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMoa1203166?articleTools=true","source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMoa1203166?articleTools=true","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109958119","display_name":"Iain C. Macdougall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153400","display_name":"King's College Hospital","ror":"https://ror.org/044nptt90","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210111135","https://openalex.org/I4210153400"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Iain C. Macdougall","raw_affiliation_strings":["Renal Unit, King's College Hospital, London, United Kingdom. iain.macdougall@nhs.net","Renal Unit, King's College Hospital, London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renal Unit, King's College Hospital, London, United Kingdom. iain.macdougall@nhs.net","institution_ids":["https://openalex.org/I4210153400"]},{"raw_affiliation_string":"Renal Unit, King's College Hospital, London","institution_ids":["https://openalex.org/I4210153400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035767298","display_name":"Robert Provenzano","orcid":"https://orcid.org/0000-0003-0003-7367","observed_orcids":["https://orcid.org/0000-0003-0003-7367"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert Provenzano","raw_affiliation_strings":["St. Clair Specialty Physicians, Detroit"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Clair Specialty Physicians, Detroit","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043774040","display_name":"Amit Kumar Sharma","orcid":"https://orcid.org/0000-0002-2616-0884","observed_orcids":["https://orcid.org/0000-0002-2616-0884"]},"institutions":[{"id":"https://openalex.org/I4210158753","display_name":"Boise Kidney & Hypertension Institute","ror":"https://ror.org/05m9b9906","country_code":"US","type":"education","lineage":["https://openalex.org/I4210158753"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amit Sharma","raw_affiliation_strings":["Boise Kidney and Hypertension Institute, Meridian, ID"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boise Kidney and Hypertension Institute, Meridian, ID","institution_ids":["https://openalex.org/I4210158753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021193745","display_name":"Bruce Spinowitz","orcid":"https://orcid.org/0000-0003-1122-0490","observed_orcids":["https://orcid.org/0000-0003-1122-0490"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bruce S. Spinowitz","raw_affiliation_strings":["Nephrology Associates, Flushing"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nephrology Associates, Flushing","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038452276","display_name":"Rebecca J. Schmidt","orcid":"https://orcid.org/0000-0003-1582-2747","observed_orcids":["https://orcid.org/0000-0003-1582-2747"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rebecca J. Schmidt","raw_affiliation_strings":["Robert C. Byrd Health Sciences Center, Morgantown, WV"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Robert C. Byrd Health Sciences Center, Morgantown, WV","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046497650","display_name":"Pablo E. P\u00e9rgola","orcid":"https://orcid.org/0000-0002-5876-894X","observed_orcids":["https://orcid.org/0000-0002-5876-894X"]},"institutions":[{"id":"https://openalex.org/I4210157924","display_name":"Renal Associates P. A.","ror":"https://ror.org/04wc1v131","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210157924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pablo E. Pergola","raw_affiliation_strings":["Renal Associates, San Antonio, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renal Associates, San Antonio, TX","institution_ids":["https://openalex.org/I4210157924"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080419400","display_name":"Raja Issa Zabaneh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raja I. Zabaneh","raw_affiliation_strings":["Northwest Louisiana Nephrology Research, Shreveport"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwest Louisiana Nephrology Research, Shreveport","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044746344","display_name":"Sandra Tong-Starksen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151439","display_name":"Affymax (United States)","ror":"https://ror.org/0505r1x13","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151439"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandra Tong-Starksen","raw_affiliation_strings":["Affymax, Palo Alto, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affymax, Palo Alto, CA","institution_ids":["https://openalex.org/I4210151439"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108493061","display_name":"Martha R. Mayo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151439","display_name":"Affymax (United States)","ror":"https://ror.org/0505r1x13","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151439"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martha R. Mayo","raw_affiliation_strings":["Affymax, Palo Alto, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affymax, Palo Alto, CA","institution_ids":["https://openalex.org/I4210151439"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011086107","display_name":"Hong Tang","orcid":"https://orcid.org/0000-0003-2410-9177","observed_orcids":["https://orcid.org/0000-0003-2410-9177"]},"institutions":[{"id":"https://openalex.org/I4210151439","display_name":"Affymax (United States)","ror":"https://ror.org/0505r1x13","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151439"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hong Tang","raw_affiliation_strings":["Affymax, Palo Alto, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affymax, Palo Alto, CA","institution_ids":["https://openalex.org/I4210151439"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108403081","display_name":"Krishna R. Polu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151439","display_name":"Affymax (United States)","ror":"https://ror.org/0505r1x13","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151439"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Krishna R. Polu","raw_affiliation_strings":["Affymax, Palo Alto, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affymax, Palo Alto, CA","institution_ids":["https://openalex.org/I4210151439"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027701183","display_name":"Anne\u2010Marie Duli\u00e8ge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151439","display_name":"Affymax (United States)","ror":"https://ror.org/0505r1x13","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151439"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anne-Marie Duliege","raw_affiliation_strings":["Affymax, Palo Alto, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affymax, Palo Alto, CA","institution_ids":["https://openalex.org/I4210151439"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016502106","display_name":"Steven N. Fishbane","orcid":"https://orcid.org/0000-0002-2238-8574","observed_orcids":["https://orcid.org/0000-0002-2238-8574"]},"institutions":[{"id":"https://openalex.org/I139290212","display_name":"Hofstra University","ror":"https://ror.org/03pm18j10","country_code":"US","type":"education","lineage":["https://openalex.org/I139290212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven Fishbane","raw_affiliation_strings":["Hofstra North Shore\u2013LIJ School of Medicine, Great Neck"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hofstra North Shore\u2013LIJ School of Medicine, Great Neck","institution_ids":["https://openalex.org/I139290212"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":11.9254,"has_fulltext":false,"cited_by_count":117,"citation_normalized_percentile":{"value":0.9896148,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"368","issue":"4","first_page":"320","last_page":"332"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11534","display_name":"Erythropoietin and Anemia Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11534","display_name":"Erythropoietin and Anemia Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/peginesatide","display_name":"peginesatide","score":0.9890000224113464},{"id":"https://openalex.org/keywords/darbepoetin-alfa","display_name":"darbepoetin alfa","score":0.9599999785423279},{"id":"https://openalex.org/keywords/anemia-of-chronic-kidney-disease","display_name":"anemia of chronic kidney disease","score":0.8809999823570251},{"id":"https://openalex.org/keywords/non-dialysis-dependent-chronic-kidney-disease","display_name":"non-dialysis chronic kidney disease","score":0.7940000295639038},{"id":"https://openalex.org/keywords/erythropoiesis-stimulating-agents","display_name":"erythropoiesis-stimulating agents","score":0.984000027179718},{"id":"https://openalex.org/keywords/hemoglobin-maintenance","display_name":"hemoglobin maintenance","score":0.7390000224113464},{"id":"https://openalex.org/keywords/cardiovascular-safety","display_name":"cardiovascular safety","score":0.7720000147819519},{"id":"https://openalex.org/keywords/non-inferiority","display_name":"non-inferiority","score":0.8989999890327454},{"id":"https://openalex.org/keywords/dose-comparison","display_name":"dose comparison","score":0.5320000052452087},{"id":"https://openalex.org/keywords/iron-supplementation","display_name":"iron supplementation","score":0.328000009059906},{"id":"https://openalex.org/keywords/iron-deficiency-anemia","display_name":"iron deficiency anemia","score":0.414000004529953},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.32100000977516174}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9642361402511597},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.8222041726112366},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.8113861680030823},{"id":"https://openalex.org/C2781404941","wikidata":"https://www.wikidata.org/wiki/Q2178381","display_name":"Darbepoetin alfa","level":3,"score":0.7413427829742432},{"id":"https://openalex.org/C2779703530","wikidata":"https://www.wikidata.org/wiki/Q837174","display_name":"Erythropoiesis","level":3,"score":0.7023041844367981},{"id":"https://openalex.org/C2779978075","wikidata":"https://www.wikidata.org/wiki/Q202301","display_name":"Dialysis","level":2,"score":0.6927878856658936},{"id":"https://openalex.org/C2778534260","wikidata":"https://www.wikidata.org/wiki/Q218706","display_name":"Erythropoietin","level":2,"score":0.5211943984031677},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4855892062187195},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.43140357732772827},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.42922189831733704}],"mesh":[{"descriptor_ui":"D000068256","descriptor_name":"Darbepoetin alfa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000740","descriptor_name":"Anemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000740","descriptor_name":"Anemia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004921","descriptor_name":"Erythropoietin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004921","descriptor_name":"Erythropoietin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D004921","descriptor_name":"Erythropoietin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006397","descriptor_name":"Hematinics","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006397","descriptor_name":"Hematinics","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006454","descriptor_name":"Hemoglobins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1056/nejmoa1203166","doi":"https://doi.org/10.1056/nejmoa1203166","is_oa":true,"landing_page_url":"https://doi.org/10.1056/nejmoa1203166","pdf_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMoa1203166?articleTools=true","source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},{"id":"pmid:23343062","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23343062","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The New England journal of medicine","raw_type":"Clinical Trial, Phase III"},{"id":"pmh:oai:kclpure.kcl.ac.uk:publications/c4b26309-d4e8-4f7c-a203-1eb1e946d698","doi":null,"is_oa":false,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/c4b26309-d4e8-4f7c-a203-1eb1e946d698","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Macdougall, I, Provenzano, R, Sharma, A, Spinowitz, B S, Schmidt, R J, Pergola, P E, Zabaneh, R I, Tong-Starksen, S, Mayo, M R, Tang, H, Polu, K R, Duliege, A-M, Fishbane, S 2013, 'Peginesatide for anemia in patients with chronic kidney disease not receiving dialysis', New England Journal of Medicine, vol. 368, no. 4, pp. 320-32. https://doi.org/10.1056/NEJMoa1203166","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:3176354658","doi":null,"is_oa":false,"landing_page_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMoa1203166","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1056/nejmoa1203166","doi":"https://doi.org/10.1056/nejmoa1203166","is_oa":true,"landing_page_url":"https://doi.org/10.1056/nejmoa1203166","pdf_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMoa1203166?articleTools=true","source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2321377008.pdf"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W71611872","https://openalex.org/W1967041620","https://openalex.org/W1973618050","https://openalex.org/W1985653723","https://openalex.org/W1998943227","https://openalex.org/W2005973637","https://openalex.org/W2025091441","https://openalex.org/W2029738096","https://openalex.org/W2040029744","https://openalex.org/W2040557090","https://openalex.org/W2046224330","https://openalex.org/W2048802503","https://openalex.org/W2079506738","https://openalex.org/W2096931444","https://openalex.org/W2107096899","https://openalex.org/W2109214349","https://openalex.org/W2112557949","https://openalex.org/W2120309176","https://openalex.org/W2123639625","https://openalex.org/W2134487085","https://openalex.org/W2135819931","https://openalex.org/W2145632027","https://openalex.org/W2152183263","https://openalex.org/W2153926185","https://openalex.org/W2278696640","https://openalex.org/W2315613377","https://openalex.org/W2331089096","https://openalex.org/W2604777988","https://openalex.org/W3142248588"],"related_works":["https://openalex.org/W2331089096","https://openalex.org/W2109214349","https://openalex.org/W2049376624","https://openalex.org/W11030815","https://openalex.org/W2071444329","https://openalex.org/W4233288745","https://openalex.org/W1987282825","https://openalex.org/W2022064013","https://openalex.org/W1557578023","https://openalex.org/W2326175559"],"abstract_inverted_index":{"BACKGROUND:":[0],"Peginesatide":[1],"is":[2],"a":[3,60,63,84],"peptide-based":[4],"erythropoiesis-stimulating":[5],"agent":[6],"(ESA)":[7],"that":[8,309],"may":[9],"have":[10],"therapeutic":[11],"potential":[12],"for":[13,111,219,236,270,283],"anemia":[14],"in":[15,36,185,194,204,242,316,331],"patients":[16,39,56,332],"with":[17,32,198,202,288,297,329,333],"advanced":[18],"chronic":[19,334],"kidney":[20,335],"disease.":[21],"We":[22],"evaluated":[23,161],"the":[24,122,126,131,135,142,146,163,195,220,237,271],"safety":[25,159,273],"and":[26,54,100,106,175,187,226,241,256,295,318,325,345,359],"efficacy":[27,118,301],"of":[28,66,74,87,93,145,165,224,291,302,310],"peginesatide,":[29],"as":[30,200],"compared":[31,201],"another":[33],"ESA,":[34],"darbepoetin,":[35,287],"983":[37],"such":[38],"who":[40,337],"were":[41,96,207,246,327,338],"not":[42,339],"undergoing":[43,340],"dialysis.":[44,341],"METHODS:":[45],"In":[46,172],"two":[47],"randomized,":[48],"controlled,":[49],"open-label":[50],"studies":[51,174],"(PEARL":[52],"1":[53,206],"2),":[55],"received":[57],"peginesatide":[58,180,199,225,284,303,330],"once":[59,79],"month,":[61],"at":[62,83,176],"starting":[64,85,178,222,239],"dose":[65,86,223],"0.025":[67],"mg":[68,71],"or":[69,77,114,156],"0.04":[70,233],"per":[72,90,109,154,210,229,249,259],"kilogram":[73],"body":[75],"weight,":[76],"darbepoetin":[78,184,203,311],"every":[80,313],"2":[81,244,314],"weeks,":[82],"0.75":[88],"\u03bcg":[89],"kilogram.":[91],"Doses":[92],"both":[94,173,177],"drugs":[95],"adjusted":[97],"to":[98,130,183,217,234,254,264,281,286,308],"achieve":[99],"maintain":[101],"hemoglobin":[102,128,189,196,320],"levels":[103],"between":[104],"11.0":[105],"12.0":[107],"g":[108,153,209,228,248,258],"deciliter":[110,155,211,230,250,260],"52":[112],"weeks":[113],"more.":[115],"The":[116,191,267,300],"primary":[117],"end":[119,169,274],"point":[120,275],"was":[121,139,151,160,181,276,306],"mean":[123,132,192],"change":[124],"from":[125],"baseline":[127],"level":[129,133,197],"during":[134],"evaluation":[136],"period;":[137],"noninferiority":[138],"established":[140],"if":[141],"lower":[143,221],"limit":[144],"two-sided":[147],"97.5%":[148],"confidence":[149,213],"interval":[150,214],"-1.0":[152],"higher.":[157],"Cardiovascular":[158],"on":[162],"basis":[164],"an":[166],"adjudicated":[167],"composite":[168],"point.":[170],"RESULTS:":[171],"doses,":[179],"noninferior":[182],"increasing":[186,317],"maintaining":[188,319],"levels.":[190,321],"differences":[193],"PEARL":[205,243],"0.03":[208],"(97.5%":[212,231,251,261],"[CI],":[215],"-0.19":[216],"0.26)":[218],"0.26":[227],"CI,":[232,252,262,279],"0.48)":[235],"higher":[238,289],"dose,":[240],"they":[245],"0.14":[247],"-0.09":[253],"0.36)":[255],"0.31":[257],"0.08":[263],"0.54),":[265],"respectively.":[266],"hazard":[268],"ratio":[269],"cardiovascular":[272,323],"1.32":[277],"(95%":[278],"0.97":[280],"1.81)":[282],"relative":[285],"incidences":[290],"death,":[292],"unstable":[293],"angina,":[294],"arrhythmia":[296],"peginesatide.":[298],"CONCLUSIONS:":[299],"(administered":[304,312],"monthly)":[305],"similar":[307],"weeks)":[315],"However,":[322],"events":[324],"mortality":[326],"increased":[328],"disease":[336],"(Funded":[342],"by":[343],"Affymax":[344],"Takeda":[346],"Pharmaceutical;":[347],"ClinicalTrials.gov":[348],"numbers,":[349],"NCT00598273":[350],"[PEARL":[351,354],"1],":[352,358],"NCT00598442":[353],"2],":[355],"NCT00597753":[356],"[EMERALD":[357,361],"NCT00597584":[360],"2].).":[362]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":21}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
