{"id":"https://openalex.org/W2321328797","doi":"https://doi.org/10.1158/1538-7445.am2013-2103","title":"Abstract 2103: XB05: a promising small molecule for cancer therapy.","display_name":"Abstract 2103: XB05: a promising small molecule for cancer therapy.","publication_year":2013,"publication_date":"2013-04-01","ids":{"openalex":"https://openalex.org/W2321328797","doi":"https://doi.org/10.1158/1538-7445.am2013-2103","mag":"2321328797"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2013-2103","doi":"https://doi.org/10.1158/1538-7445.am2013-2103","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2013-2103","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108564748","display_name":"Francesca R. \u0160alipur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francesca R. Salipur","raw_affiliation_strings":["1University of Louisville Biochemistry Dept, Louisville, KY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Louisville Biochemistry Dept, Louisville, KY;","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068444084","display_name":"Elsa M. Reyes\u2010Reyes","orcid":"https://orcid.org/0000-0001-5784-2346","observed_orcids":["https://orcid.org/0000-0001-5784-2346"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elsa M. Reyes Reyes","raw_affiliation_strings":["1University of Louisville Biochemistry Dept, Louisville, KY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Louisville Biochemistry Dept, Louisville, KY;","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026013529","display_name":"Bo Xu","orcid":"https://orcid.org/0000-0001-8702-1872","observed_orcids":["https://orcid.org/0000-0001-8702-1872"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bo Xu","raw_affiliation_strings":["2University of Louisville Chemistry Dept, Louisville, KY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of Louisville Chemistry Dept, Louisville, KY;","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009887861","display_name":"Ned B. Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ned Smith","raw_affiliation_strings":["3University of Louisville Pharmacology and Toxicology, Louisville, KY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3University of Louisville Pharmacology and Toxicology, Louisville, KY;","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103224508","display_name":"Jian Cai","orcid":"https://orcid.org/0000-0003-1573-5934","observed_orcids":["https://orcid.org/0000-0003-1573-5934"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jian Cai","raw_affiliation_strings":["3University of Louisville Pharmacology and Toxicology, Louisville, KY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3University of Louisville Pharmacology and Toxicology, Louisville, KY;","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061002470","display_name":"Gerald B. Hammond","orcid":"https://orcid.org/0000-0002-9814-5536","observed_orcids":["https://orcid.org/0000-0002-9814-5536"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerald B. Hammond","raw_affiliation_strings":["2University of Louisville Chemistry Dept, Louisville, KY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of Louisville Chemistry Dept, Louisville, KY;","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063771330","display_name":"Paula J. Bates","orcid":"https://orcid.org/0000-0002-4622-4152","observed_orcids":["https://orcid.org/0000-0002-4622-4152"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paula J. Bates","raw_affiliation_strings":["4University of Louisville Department of Medicine, Louisville, KY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4University of Louisville Department of Medicine, Louisville, KY","institution_ids":["https://openalex.org/I142740786"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I142740786"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"73","issue":"8_Supplement","first_page":"2103","last_page":"2103"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.25440001487731934,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.25440001487731934,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.1404000073671341,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.11079999804496765,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/small-molecule-anticancer-drugs","display_name":"small molecule anticancer agents","score":0.8960000276565552},{"id":"https://openalex.org/keywords/sox9","display_name":"SOX9","score":0.9850000143051147},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.7889999747276306},{"id":"https://openalex.org/keywords/myeloid-leukemia","display_name":"myeloid leukemia","score":0.8960000276565552},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8769999742507935},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.9980000257492065},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6840000152587891},{"id":"https://openalex.org/keywords/necrosis","display_name":"necrosis","score":0.9610000252723694},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.5690000057220459},{"id":"https://openalex.org/keywords/drug-sensitivity-biomarkers","display_name":"drug sensitivity biomarkers","score":0.734000027179718},{"id":"https://openalex.org/keywords/sirna-knockdown","display_name":"siRNA knockdown","score":0.9269999861717224}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6231901049613953},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.5999287962913513},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5799499750137329},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.563060998916626},{"id":"https://openalex.org/C117262875","wikidata":"https://www.wikidata.org/wiki/Q5135057","display_name":"Clonogenic assay","level":3,"score":0.5418534874916077},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.47121280431747437},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.45915451645851135},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41442757844924927},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39860737323760986},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.26618829369544983},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17800253629684448},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12887787818908691}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2013-2103","doi":"https://doi.org/10.1158/1538-7445.am2013-2103","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2013-2103","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2017779684","https://openalex.org/W7160273911","https://openalex.org/W2739844752","https://openalex.org/W2887773812","https://openalex.org/W2884859060","https://openalex.org/W2012999558","https://openalex.org/W4391520515","https://openalex.org/W2586147930","https://openalex.org/W4394760647","https://openalex.org/W2326493884"],"abstract_inverted_index":{"Abstract":[0],"XB05":[1,15,37,66,96,168,177],"is":[2,108],"synthetic":[3],"small":[4,229],"molecule":[5,230],"which":[6],"was":[7],"serendipitously":[8],"discovered":[9],"to":[10,61,95,140],"have":[11],"potent":[12,174],"anticancer":[13],"properties.":[14],"displays":[16],"selectivity":[17],"for":[18,63,192,197,231,246],"malignant":[19],"cells":[20,27,33,139,181],"over":[21],"non-malignant":[22],"cells.":[23],"Human":[24],"myeloid":[25],"leukemia":[26],"(U937)":[28],"and":[29,46,50,68,97,122,157,188,199],"human":[30,115,179],"lung":[31,116,137],"cancer":[32,117,138,180,232],"(A549)":[34],"treated":[35],"with":[36,133,203],"show":[38,144],"an":[39],"increase":[40],"in":[41,93],"oxidative":[42],"stress,":[43],"DNA":[44],"damage":[45],"a":[47,58,88,112,183,189,195,227],"mixed":[48],"apoptotic":[49],"necrotic":[51],"mechanism":[52,185],"of":[53,76,99,114,136,148,153,176,186,201,237,242],"cell":[54,82,91,118,124,155],"death.":[55],"We":[56,104],"conducted":[57],"COMPARE":[59],"analysis":[60,86],"search":[62],"correlations":[64],"between":[65,90],"response":[67,94],"gene":[69],"expression":[70,98,130],"using":[71],"publicly":[72],"available":[73],"microarray":[74],"studies":[75],"the":[77,100,134,151,164,238,243],"National":[78],"Cancer":[79,247,257],"Institute":[80],"60":[81],"line":[83],"panel.":[84],"This":[85],"uncovered":[87],"correlation":[89],"death":[92],"transcription":[101],"factor,":[102],"SOX9.":[103],"find":[105],"that":[106,128,145,158],"SOX9":[107,129,149,159,193],"differentially":[109],"expressed":[110],"across":[111],"panel":[113],"lines.":[119],"MTT":[120],"proliferation":[121],"clonogenic":[123],"survival":[125],"assays":[126],"suggest":[127],"positively":[131],"correlates":[132],"sensitivity":[135],"XB05.":[141,204],"Furthermore,":[142],"we":[143],"siRNA":[146],"knockdown":[147],"recapitulates":[150],"phenotype":[152],"XB05-induced":[154],"death,":[156],"may":[160],"be":[161],"downregulated":[162],"at":[163],"protein":[165],"level":[166],"by":[167],"treatment.":[169],"Overall,":[170],"these":[171],"data":[172],"demonstrate":[173],"activity":[175],"against":[178],"via":[182],"novel":[184],"action,":[187],"potential":[190],"role":[191],"as":[194],"biomarker":[196],"selection":[198],"monitoring":[200],"therapy":[202],"Citation":[205],"Format:":[206],"Francesca":[207],"R.":[208],"Salipur,":[209],"Elsa":[210],"M.":[211],"Reyes":[212],"Reyes,":[213],"Bo":[214],"Xu,":[215],"Ned":[216],"Smith,":[217],"Jian":[218],"Cai,":[219],"Gerald":[220],"B.":[221],"Hammond,":[222],"Paula":[223],"J.":[224],"Bates.":[225],"XB05:":[226],"promising":[228],"therapy.":[233],"[abstract].":[234],"In:":[235],"Proceedings":[236],"104th":[239],"Annual":[240],"Meeting":[241],"American":[244],"Association":[245],"Research;":[248],"2013":[249],"Apr":[250],"6-10;":[251],"Washington,":[252],"DC.":[253],"Philadelphia":[254],"(PA):":[255],"AACR;":[256],"Res":[258],"2013;73(8":[259],"Suppl):Abstract":[260],"nr":[261],"2103.":[262],"doi:10.1158/1538-7445.AM2013-2103":[263]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}
