{"id":"https://openalex.org/W2321246652","doi":"https://doi.org/10.1097/cej.0000000000000046","title":"Engrailed-2 protein as a potential urinary prostate cancer biomarker","display_name":"Engrailed-2 protein as a potential urinary prostate cancer biomarker","publication_year":2014,"publication_date":"2014-07-08","ids":{"openalex":"https://openalex.org/W2321246652","doi":"https://doi.org/10.1097/cej.0000000000000046","mag":"2321246652","pmid":"https://pubmed.ncbi.nlm.nih.gov/25003607"},"language":"en","primary_location":{"id":"doi:10.1097/cej.0000000000000046","doi":"https://doi.org/10.1097/cej.0000000000000046","is_oa":false,"landing_page_url":"https://doi.org/10.1097/cej.0000000000000046","pdf_url":null,"source":{"id":"https://openalex.org/S35423025","display_name":"European Journal of Cancer Prevention","issn_l":"0959-8278","issn":["0959-8278","1473-5709"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Cancer Prevention","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://repozytorium.umk.pl/bitstreams/d9dc41bd-b1c7-439a-bf6d-5728c441767e/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017418601","display_name":"Micha\u0142 Piotr Marsza\u0142\u0142","orcid":"https://orcid.org/0000-0001-9948-9456","observed_orcids":["https://orcid.org/0000-0001-9948-9456"]},"institutions":[{"id":"https://openalex.org/I3019271933","display_name":"Nicolaus Copernicus University","ror":"https://ror.org/0102mm775","country_code":"PL","type":"education","lineage":["https://openalex.org/I3019271933"]},{"id":"https://openalex.org/I4210148386","display_name":"Collegium Medicum in Bydgoszcz","ror":"https://ror.org/04c5jwj47","country_code":"PL","type":"education","lineage":["https://openalex.org/I3019271933","https://openalex.org/I4210148386"]},{"id":"https://openalex.org/I4402554138","display_name":"Jan Biziel University Hospital No. 2 in Bydgoszcz","ror":"https://ror.org/05r81yb60","country_code":"PL","type":"healthcare","lineage":["https://openalex.org/I3019271933","https://openalex.org/I4210148386","https://openalex.org/I4402554138"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Micha\u0142 Piotr Marsza\u0142\u0142","raw_affiliation_strings":["Departments of aMedicinal Chemistry bLaboratory Medicine, Collegium Medicum in Bydgoszcz cDepartment of Urology, J. Biziel Hospital, Nicolaus Copernicus University, Bydgoszcz, Poland","Medicinal Chemistry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of aMedicinal Chemistry bLaboratory Medicine, Collegium Medicum in Bydgoszcz cDepartment of Urology, J. Biziel Hospital, Nicolaus Copernicus University, Bydgoszcz, Poland","institution_ids":["https://openalex.org/I3019271933","https://openalex.org/I4210148386","https://openalex.org/I4402554138"]},{"raw_affiliation_string":"Medicinal Chemistry","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052025544","display_name":"Wiktor Dariusz Sroka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Wiktor Sroka","raw_affiliation_strings":["Medicinal Chemistry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal Chemistry","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110012692","display_name":"Marek Adamowski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marek Adamowski","raw_affiliation_strings":["Medicinal Chemistry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal Chemistry","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071624786","display_name":"Piotr S\u0142upski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019271933","display_name":"Nicolaus Copernicus University","ror":"https://ror.org/0102mm775","country_code":"PL","type":"education","lineage":["https://openalex.org/I3019271933"]},{"id":"https://openalex.org/I4402554138","display_name":"Jan Biziel University Hospital No. 2 in Bydgoszcz","ror":"https://ror.org/05r81yb60","country_code":"PL","type":"healthcare","lineage":["https://openalex.org/I3019271933","https://openalex.org/I4210148386","https://openalex.org/I4402554138"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Piotr S\u0142upski","raw_affiliation_strings":["Department of Urology, J. Biziel Hospital, Nicolaus Copernicus University, Bydgoszcz, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, J. Biziel Hospital, Nicolaus Copernicus University, Bydgoszcz, Poland","institution_ids":["https://openalex.org/I3019271933","https://openalex.org/I4402554138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032177837","display_name":"Piotr Jarzemski","orcid":"https://orcid.org/0000-0002-9451-7320","observed_orcids":["https://orcid.org/0000-0002-9451-7320","https://orcid.org/0000-0002-2727-3653"]},"institutions":[{"id":"https://openalex.org/I3019271933","display_name":"Nicolaus Copernicus University","ror":"https://ror.org/0102mm775","country_code":"PL","type":"education","lineage":["https://openalex.org/I3019271933"]},{"id":"https://openalex.org/I4402554138","display_name":"Jan Biziel University Hospital No. 2 in Bydgoszcz","ror":"https://ror.org/05r81yb60","country_code":"PL","type":"healthcare","lineage":["https://openalex.org/I3019271933","https://openalex.org/I4210148386","https://openalex.org/I4402554138"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Piotr Jarzemski","raw_affiliation_strings":["Department of Urology, J. Biziel Hospital, Nicolaus Copernicus University, Bydgoszcz, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, J. Biziel Hospital, Nicolaus Copernicus University, Bydgoszcz, Poland","institution_ids":["https://openalex.org/I3019271933","https://openalex.org/I4402554138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085368146","display_name":"Joanna Si\u00f3dmiak","orcid":"https://orcid.org/0000-0002-7374-9122","observed_orcids":["https://orcid.org/0000-0002-7374-9122"]},"institutions":[{"id":"https://openalex.org/I4210148386","display_name":"Collegium Medicum in Bydgoszcz","ror":"https://ror.org/04c5jwj47","country_code":"PL","type":"education","lineage":["https://openalex.org/I3019271933","https://openalex.org/I4210148386"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Joanna Si\u00f3dmiak","raw_affiliation_strings":["Laboratory Medicine, Collegium Medicum in Bydgoszcz"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory Medicine, Collegium Medicum in Bydgoszcz","institution_ids":["https://openalex.org/I4210148386"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023067753","display_name":"Gra\u017cyna Odrow\u0105\u017c\u2010Sypniewska","orcid":"https://orcid.org/0000-0001-8965-5350","observed_orcids":["https://orcid.org/0000-0001-8965-5350"]},"institutions":[{"id":"https://openalex.org/I4210148386","display_name":"Collegium Medicum in Bydgoszcz","ror":"https://ror.org/04c5jwj47","country_code":"PL","type":"education","lineage":["https://openalex.org/I3019271933","https://openalex.org/I4210148386"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Gra\u017cyna Odrow\u0105\u017c-Sypniewska","raw_affiliation_strings":["Laboratory Medicine, Collegium Medicum in Bydgoszcz"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory Medicine, Collegium Medicum in Bydgoszcz","institution_ids":["https://openalex.org/I4210148386"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5017418601","https://openalex.org/A5052025544"],"corresponding_institution_ids":["https://openalex.org/I3019271933","https://openalex.org/I4210148386","https://openalex.org/I4402554138"],"apc_list":null,"apc_paid":null,"fwci":3.193,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.92154994,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"24","issue":"1","first_page":"51","last_page":"56"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.9458000063896179,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.9458000063896179,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.045899998396635056,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/engrailed-2","display_name":"Engrailed-2","score":0.8659999966621399},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.7580000162124634},{"id":"https://openalex.org/keywords/urinary-biomarkers","display_name":"urinary biomarkers","score":0.8600000143051147},{"id":"https://openalex.org/keywords/prostate-massage","display_name":"prostatic massage","score":0.9570000171661377},{"id":"https://openalex.org/keywords/benign-prostatic-hyperplasia","display_name":"benign prostatic hyperplasia","score":0.9959999918937683},{"id":"https://openalex.org/keywords/gleason-score","display_name":"Gleason score","score":0.9070000052452087},{"id":"https://openalex.org/keywords/tumor-stage","display_name":"tumor stage","score":0.9879999756813049},{"id":"https://openalex.org/keywords/prostate-specific-antigen","display_name":"prostate-specific antigen","score":0.9760000109672546},{"id":"https://openalex.org/keywords/cancer-diagnosis","display_name":"cancer diagnosis","score":0.4950000047683716}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.8547966480255127},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.788799524307251},{"id":"https://openalex.org/C175259745","wikidata":"https://www.wikidata.org/wiki/Q179415","display_name":"Massage","level":3,"score":0.741097092628479},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.6901419758796692},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.6763061881065369},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.6135187745094299},{"id":"https://openalex.org/C2781406297","wikidata":"https://www.wikidata.org/wiki/Q409450","display_name":"Prostate-specific antigen","level":4,"score":0.553112804889679},{"id":"https://openalex.org/C2781217009","wikidata":"https://www.wikidata.org/wiki/Q4086927","display_name":"Prostate biopsy","level":4,"score":0.49461671710014343},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.45189666748046875},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4435688853263855},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.4168202877044678},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.37028610706329346},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.34642598032951355},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.23160982131958008},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07087993621826172},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000099266","descriptor_name":"Engrailed 2 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D051517","descriptor_name":"Digital Rectal Examination","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D051517","descriptor_name":"Digital Rectal Examination","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1097/cej.0000000000000046","doi":"https://doi.org/10.1097/cej.0000000000000046","is_oa":false,"landing_page_url":"https://doi.org/10.1097/cej.0000000000000046","pdf_url":null,"source":{"id":"https://openalex.org/S35423025","display_name":"European Journal of Cancer Prevention","issn_l":"0959-8278","issn":["0959-8278","1473-5709"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Cancer Prevention","raw_type":"journal-article"},{"id":"pmid:25003607","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25003607","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)","raw_type":"Comparative Study"},{"id":"pmh:oai:repozytorium.umk.pl:item/2732","doi":null,"is_oa":true,"landing_page_url":"http://repozytorium.umk.pl/handle/item/2732","pdf_url":"https://repozytorium.umk.pl/bitstreams/d9dc41bd-b1c7-439a-bf6d-5728c441767e/download","source":{"id":"https://openalex.org/S4306400983","display_name":"Nicolaus Copernicus University Repository (Nicolaus Copernicus University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I3019271933","host_organization_name":"Nicolaus Copernicus University","host_organization_lineage":["https://openalex.org/I3019271933"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:repozytorium.umk.pl:item/2732","doi":null,"is_oa":true,"landing_page_url":"http://repozytorium.umk.pl/handle/item/2732","pdf_url":"https://repozytorium.umk.pl/bitstreams/d9dc41bd-b1c7-439a-bf6d-5728c441767e/download","source":{"id":"https://openalex.org/S4306400983","display_name":"Nicolaus Copernicus University Repository (Nicolaus Copernicus University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I3019271933","host_organization_name":"Nicolaus Copernicus University","host_organization_lineage":["https://openalex.org/I3019271933"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2321246652.pdf","grobid_xml":"https://content.openalex.org/works/W2321246652.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7073716064","https://openalex.org/W1594862406","https://openalex.org/W2141019253","https://openalex.org/W2522786791","https://openalex.org/W2023655867","https://openalex.org/W2074168444","https://openalex.org/W2758470947","https://openalex.org/W2983647179","https://openalex.org/W2069918579","https://openalex.org/W2100711790"],"abstract_inverted_index":{"This":[0],"study":[1],"was":[2,160],"designed":[3],"to":[4,82,162,165,187],"compare":[5],"and":[6,18,32,39,49,55,73,88,127,169,192],"evaluate":[7],"the":[8,45,71,83,124,131,166,195],"presence":[9],"of":[10,154,178,194],"engrailed-2":[11],"(EN2)":[12],"protein":[13],"in":[14,99,105,116,123,130,137,145],"urine":[15,35,51,106,117],"collected":[16],"before":[17,38,54,118],"after":[19,41,57,107,148],"prostate":[20,27,42,58,66,108,119,149,155,201],"massage":[21,109,120,156],"as":[22,184],"a":[23,176],"diagnostic":[24],"marker":[25,177],"for":[26],"cancer":[28],"(PCa).":[29],"We":[30],"analysed":[31],"compared":[33],"76":[34],"samples":[36,52],"(38":[37],"38":[40],"massage)":[43,59],"from":[44,60,70,113],"benign":[46],"group":[47,126],"(BPH)":[48],"66":[50],"(33":[53],"33":[56],"patients":[61,139,147],"with":[62,75,180],"PCa":[63,72,125,138,179],"confirmed":[64],"by":[65,95],"biopsy.":[67],"EN2":[68,91,103,135,158,172],"levels":[69,92,104,136,159],"men":[74],"BPH":[76],"(age":[77],"range":[78],"50-82)":[79],"were":[80,93,110,140],"related":[81,164,186],"tumour":[84,170,188],"stage,":[85],"Gleason":[86,167],"score":[87,168],"prostate-specific":[89],"antigen.":[90],"determined":[94,115],"enzyme-linked":[96],"immunosorbent":[97],"assay":[98],"urine.":[100],"The":[101,133,151,190],"median":[102],"significantly":[111],"different":[112],"those":[114,144,185],"(1.25":[121],"ng/ml":[122,129],"0.34":[128],"BPH).":[132],"mean":[134],"3.76-fold":[141],"higher":[142],"than":[143],"non-PCa":[146],"massage.":[150,202],"distinct":[152],"influence":[153],"on":[157,200],"found":[161],"be":[163,174],"stage.":[171],"may":[173],"considered":[175],"certain":[181],"limitations,":[182],"such":[183],"staging.":[189],"specificity":[191],"sensitivity":[193],"protocol":[196],"are":[197],"highly":[198],"dependent":[199]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}