{"id":"https://openalex.org/W2321152572","doi":"https://doi.org/10.2307/3580221","title":"Effects of Radiation on Incidence of Primary Liver Cancer among Atomic Bomb Survivors","display_name":"Effects of Radiation on Incidence of Primary Liver Cancer among Atomic Bomb Survivors","publication_year":1999,"publication_date":"1999-10-01","ids":{"openalex":"https://openalex.org/W2321152572","doi":"https://doi.org/10.2307/3580221","mag":"2321152572","pmid":"https://pubmed.ncbi.nlm.nih.gov/10477913"},"language":"en","primary_location":{"id":"doi:10.2307/3580221","doi":"https://doi.org/10.2307/3580221","is_oa":false,"landing_page_url":"https://doi.org/10.2307/3580221","pdf_url":null,"source":{"id":"https://openalex.org/S152208300","display_name":"Radiation Research","issn_l":"0033-7587","issn":["0033-7587","1938-5404"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315745","host_organization_name":"Radiation Research Society","host_organization_lineage":["https://openalex.org/P4310315745"],"host_organization_lineage_names":["Radiation Research Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiation Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082900334","display_name":"JOHN B. COLOGNE","orcid":"https://orcid.org/0000-0003-1540-6639","observed_orcids":["https://orcid.org/0000-0003-1540-6639"]},"institutions":[{"id":"https://openalex.org/I21578748","display_name":"Radiation Effects Research Foundation","ror":"https://ror.org/01fmtas32","country_code":"JP","type":"facility","lineage":["https://openalex.org/I21578748"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"John B. Cologne","raw_affiliation_strings":["Department of Statistics, Radiation Effects Research Foundation, 5-2 Hijiyama Park, Minami-ku, Hiroshima, Japan 732-0815"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, Radiation Effects Research Foundation, 5-2 Hijiyama Park, Minami-ku, Hiroshima, Japan 732-0815","institution_ids":["https://openalex.org/I21578748"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109361805","display_name":"Shoji Tokuoka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shoji Tokuoka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044794605","display_name":"Gilbert Wheeler Beebe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gilbert W. Beebe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Toshiyuki Fukuhara","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Toshiyuki Fukuhara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5038743598","display_name":"Kiy\u00f3hiko Mabuchi","orcid":"https://orcid.org/0000-0002-8867-8777","observed_orcids":["https://orcid.org/0000-0002-8867-8777"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kiyohiko Mabuchi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.8786,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.90312466,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"152","issue":"4","first_page":"364","last_page":"364"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9067000150680542,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9067000150680542,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10844","display_name":"Radiation Dose and Imaging","score":0.02500000037252903,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.014000000432133675,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atomic-bomb-survivors","display_name":"atomic bomb survivors","score":0.8450000286102295},{"id":"https://openalex.org/keywords/primary-liver-cancer","display_name":"primary liver cancer","score":0.8080000281333923},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9869999885559082},{"id":"https://openalex.org/keywords/cholangiocarcinoma","display_name":"cholangiocarcinoma","score":0.9240000247955322},{"id":"https://openalex.org/keywords/hemangiosarcoma","display_name":"hemangiosarcoma","score":0.9440000057220459},{"id":"https://openalex.org/keywords/whole-body-radiation-exposure","display_name":"whole-body radiation exposure","score":0.8360000252723694},{"id":"https://openalex.org/keywords/excess-relative-risk","display_name":"excess relative risk","score":0.777999997138977},{"id":"https://openalex.org/keywords/sex-differences-in-cancer-risk","display_name":"sex differences in cancer risk","score":0.7310000061988831},{"id":"https://openalex.org/keywords/age-at-exposure","display_name":"age at exposure","score":0.847000002861023},{"id":"https://openalex.org/keywords/liver-dose","display_name":"liver dose","score":0.4869999885559082},{"id":"https://openalex.org/keywords/hiroshima","display_name":"Hiroshima","score":0.6679999828338623},{"id":"https://openalex.org/keywords/nagasaki","display_name":"Nagasaki","score":1.0}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7252516150474548},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.6512062549591064},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.6353828310966492},{"id":"https://openalex.org/C120195587","wikidata":"https://www.wikidata.org/wiki/Q2138790","display_name":"Absolute risk reduction","level":3,"score":0.5625593066215515},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.5470703840255737},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.5354630351066589},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5172998905181885},{"id":"https://openalex.org/C2780353417","wikidata":"https://www.wikidata.org/wiki/Q423827","display_name":"Thorotrast","level":2,"score":0.4472801685333252},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.43910297751426697},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4329472482204437},{"id":"https://openalex.org/C2776231280","wikidata":"https://www.wikidata.org/wiki/Q623031","display_name":"Liver cancer","level":3,"score":0.4243772625923157},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.40265658497810364},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36389389634132385},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.19007793068885803},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D003644","descriptor_name":"Death Certificates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007564","descriptor_name":"Japan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009381","descriptor_name":"Neoplasms, Radiation-Induced","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D009689","descriptor_name":"Nuclear Warfare","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017741","descriptor_name":"Survivors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2307/3580221","doi":"https://doi.org/10.2307/3580221","is_oa":false,"landing_page_url":"https://doi.org/10.2307/3580221","pdf_url":null,"source":{"id":"https://openalex.org/S152208300","display_name":"Radiation Research","issn_l":"0033-7587","issn":["0033-7587","1938-5404"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315745","host_organization_name":"Radiation Research Society","host_organization_lineage":["https://openalex.org/P4310315745"],"host_organization_lineage_names":["Radiation Research Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiation Research","raw_type":"journal-article"},{"id":"pmid:10477913","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10477913","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiation research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8799999952316284}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G5588419645","display_name":null,"funder_award_id":"NCI-4893-8-001","funder_id":"https://openalex.org/F4320332162","funder_display_name":"Centers for Disease Control and Prevention"}],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320332162","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1552290465","https://openalex.org/W1953801372","https://openalex.org/W1972348155","https://openalex.org/W1989457822","https://openalex.org/W1991120246","https://openalex.org/W2011925039","https://openalex.org/W2018204743","https://openalex.org/W2018462232","https://openalex.org/W2024137940","https://openalex.org/W2041643960","https://openalex.org/W2044575867","https://openalex.org/W2051138868","https://openalex.org/W2078927048","https://openalex.org/W2081084310","https://openalex.org/W2097014874","https://openalex.org/W2098990836","https://openalex.org/W2108048045","https://openalex.org/W2161205058","https://openalex.org/W2243268247","https://openalex.org/W2302381017","https://openalex.org/W2319782924","https://openalex.org/W2320519684","https://openalex.org/W2407010145","https://openalex.org/W2423492680","https://openalex.org/W2493016457","https://openalex.org/W2500584501","https://openalex.org/W2724744060"],"related_works":["https://openalex.org/W2956440671","https://openalex.org/W1991848123","https://openalex.org/W2045331413","https://openalex.org/W2132848234","https://openalex.org/W2460560426","https://openalex.org/W2124435581","https://openalex.org/W2141786774","https://openalex.org/W2132643703","https://openalex.org/W2171653711","https://openalex.org/W1985892592"],"abstract_inverted_index":{"We":[0],"describe":[1],"the":[2,89,108,148,173,183],"radiation":[3,56,167],"risk":[4,52,78,99,116,201],"for":[5,101],"primary":[6,45],"liver":[7,38,63,204],"cancers":[8],"between":[9],"1958":[10],"and":[11,22,73,155],"1987":[12],"in":[13,20,87,96,107,117,134,147],"a":[14,30,82,132],"cohort":[15],"of":[16,34,153,182,202],"atomic":[17,54],"bomb":[18,55],"survivors":[19],"Hiroshima":[21],"Nagasaki,":[23],"Japan.":[24],"The":[25],"analysis":[26],"is":[27,191],"based":[28],"on":[29],"comprehensive":[31],"pathology":[32],"review":[33],"known":[35],"or":[36,123,136],"suspected":[37],"neoplasms":[39],"that":[40,159],"generated":[41],"518":[42],"incident,":[43],"first":[44],"cases,":[46],"mostly":[47],"hepatocellular":[48],"carcinoma.":[49],"Excess":[50,98],"relative":[51,77],"from":[53],"was":[57,93,112,129],"linear:":[58],"0.81":[59],"per":[60],"sievert":[61],"weighted":[62],"dose":[64],"(95%":[65],"CI":[66],"[0.32,":[67],"1.43];":[68],"P":[69],"<":[70],"0.001).":[71],"Males":[72],"females":[74],"had":[75],"similar":[76],"so":[79],"that,":[80],"given":[81],"threefold":[83],"higher":[84,95],"background":[85],"incidence":[86,92],"males,":[88,189],"radiation-related":[90,184,203],"excess":[91,115,185],"substantially":[94],"males.":[97],"peaked":[100],"those":[102,118],"with":[103,165,172],"age":[104,121,125],"at":[105,199],"exposure":[106],"early":[109],"20s;":[110],"there":[111],"essentially":[113],"no":[114],"exposed":[119],"before":[120],"10":[122],"after":[124],"45.":[126],"Whether":[127],"this":[128],"due":[130],"to":[131,193],"difference":[133],"sensitivity":[135],"possible":[137],"confounding":[138],"by":[139],"other":[140],"factors":[141,196],"could":[142],"not":[143,162],"be":[144],"addressed":[145],"retrospectively":[146],"full":[149],"cohort.":[150],"A":[151],"paucity":[152],"cholangiocarcinoma":[154],"hemangiosarcoma":[156],"cases":[157,186],"suggested":[158],"they":[160,170],"are":[161,171],"significantly":[163],"associated":[164],"whole-body":[166],"exposure,":[168],"as":[169],"internal":[174],"alpha-particle-emitting":[175],"radiological":[176],"contrast":[177],"medium":[178],"Thorotrast.":[179],"Because":[180],"most":[181],"occurred":[187],"among":[188],"it":[190],"important":[192],"ascertain":[194],"what":[195],"put":[197],"men":[198],"greater":[200],"cancer.":[205]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":6},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}