{"id":"https://openalex.org/W2321051992","doi":"https://doi.org/10.1158/1538-7445.am2013-1256","title":"Abstract 1256: Humoral autoimmune response to a RNA-binding protein HCC1/CAPER in hepatocellular carcinoma (HCC).","display_name":"Abstract 1256: Humoral autoimmune response to a RNA-binding protein HCC1/CAPER in hepatocellular carcinoma (HCC).","publication_year":2013,"publication_date":"2013-04-01","ids":{"openalex":"https://openalex.org/W2321051992","doi":"https://doi.org/10.1158/1538-7445.am2013-1256","mag":"2321051992"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2013-1256","doi":"https://doi.org/10.1158/1538-7445.am2013-1256","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2013-1256","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000885936","display_name":"Liping Dai","orcid":"https://orcid.org/0000-0002-5531-1776","observed_orcids":["https://orcid.org/0000-0002-5531-1776"]},"institutions":[{"id":"https://openalex.org/I164936912","display_name":"The University of Texas at El Paso","ror":"https://ror.org/04d5vba33","country_code":"US","type":"education","lineage":["https://openalex.org/I164936912"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liping Dai","raw_affiliation_strings":["1Department of Biological Sciences, The University of Texas, El Paso, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Biological Sciences, The University of Texas, El Paso, TX;","institution_ids":["https://openalex.org/I164936912"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008889856","display_name":"Pengfei Ren","orcid":"https://orcid.org/0000-0002-2644-3905","observed_orcids":["https://orcid.org/0000-0002-2644-3905"]},"institutions":[{"id":"https://openalex.org/I164936912","display_name":"The University of Texas at El Paso","ror":"https://ror.org/04d5vba33","country_code":"US","type":"education","lineage":["https://openalex.org/I164936912"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pengfei Ren","raw_affiliation_strings":["1Department of Biological Sciences, The University of Texas, El Paso, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Biological Sciences, The University of Texas, El Paso, TX;","institution_ids":["https://openalex.org/I164936912"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100379548","display_name":"Xinxin Liu","orcid":"https://orcid.org/0000-0002-4961-0227","observed_orcids":["https://orcid.org/0000-0002-4961-0227"]},"institutions":[{"id":"https://openalex.org/I164936912","display_name":"The University of Texas at El Paso","ror":"https://ror.org/04d5vba33","country_code":"US","type":"education","lineage":["https://openalex.org/I164936912"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xinxin Liu","raw_affiliation_strings":["1Department of Biological Sciences, The University of Texas, El Paso, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Biological Sciences, The University of Texas, El Paso, TX;","institution_ids":["https://openalex.org/I164936912"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055636960","display_name":"Rosalia Ortega","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I164936912","display_name":"The University of Texas at El Paso","ror":"https://ror.org/04d5vba33","country_code":"US","type":"education","lineage":["https://openalex.org/I164936912"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rosalia Ortega","raw_affiliation_strings":["1Department of Biological Sciences, The University of Texas, El Paso, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Biological Sciences, The University of Texas, El Paso, TX;","institution_ids":["https://openalex.org/I164936912"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wu Yao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I164936912","display_name":"The University of Texas at El Paso","ror":"https://ror.org/04d5vba33","country_code":"US","type":"education","lineage":["https://openalex.org/I164936912"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wu Yao","raw_affiliation_strings":["1Department of Biological Sciences, The University of Texas, El Paso, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Biological Sciences, The University of Texas, El Paso, TX;","institution_ids":["https://openalex.org/I164936912"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038593941","display_name":"Kaijuan Wang","orcid":"https://orcid.org/0000-0002-3300-9453","observed_orcids":["https://orcid.org/0000-0002-3300-9453"]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kaijuan Wang","raw_affiliation_strings":["2Key Laboratory of Tumor Epidemiology, Zhengzhou University School of Medicine, Zhengzhou, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Key Laboratory of Tumor Epidemiology, Zhengzhou University School of Medicine, Zhengzhou, China;","institution_ids":["https://openalex.org/I38877650"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mingan Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingan Wang","raw_affiliation_strings":["2Key Laboratory of Tumor Epidemiology, Zhengzhou University School of Medicine, Zhengzhou, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Key Laboratory of Tumor Epidemiology, Zhengzhou University School of Medicine, Zhengzhou, China;","institution_ids":["https://openalex.org/I38877650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065446697","display_name":"Eng M. Tan","orcid":"https://orcid.org/0000-0002-8711-3248","observed_orcids":["https://orcid.org/0000-0002-8711-3248"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eng M. Tan","raw_affiliation_strings":["3The Scripps Research Institute, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3The Scripps Research Institute, La Jolla, CA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100646259","display_name":"Jianying Zhang","orcid":"https://orcid.org/0000-0003-2938-9526","observed_orcids":["https://orcid.org/0000-0003-2938-9526"]},"institutions":[{"id":"https://openalex.org/I164936912","display_name":"The University of Texas at El Paso","ror":"https://ror.org/04d5vba33","country_code":"US","type":"education","lineage":["https://openalex.org/I164936912"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianying Zhang","raw_affiliation_strings":["1Department of Biological Sciences, The University of Texas, El Paso, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Biological Sciences, The University of Texas, El Paso, TX;","institution_ids":["https://openalex.org/I164936912"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"73","issue":"8_Supplement","first_page":"1256","last_page":"1256"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9067000150680542,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9067000150680542,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.01209999993443489,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.009800000116229057,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9639999866485596},{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.9319999814033508},{"id":"https://openalex.org/keywords/tumor-associated-antigens","display_name":"tumor-associated antigens","score":0.824999988079071},{"id":"https://openalex.org/keywords/serological-markers","display_name":"serological markers","score":0.7480000257492065},{"id":"https://openalex.org/keywords/rna-binding-proteins","display_name":"RNA-binding proteins","score":0.7229999899864197},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.6660000085830688},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.8140000104904175},{"id":"https://openalex.org/keywords/chronic-hepatitis","display_name":"chronic hepatitis","score":0.8790000081062317},{"id":"https://openalex.org/keywords/cancer-immunodiagnosis","display_name":"cancer immunodiagnosis","score":0.7440000176429749},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.44999998807907104}],"concepts":[{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.6866809725761414},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.6725959181785583},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5913886427879333},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.5666275024414062},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5232245326042175},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5022983551025391},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.47895246744155884},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.44409245252609253},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.4265231490135193},{"id":"https://openalex.org/C45189115","wikidata":"https://www.wikidata.org/wiki/Q502159","display_name":"Serology","level":3,"score":0.4259267747402191},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.41922903060913086},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.41419708728790283},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3939427435398102},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36423346400260925},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2244398593902588},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2185783088207245},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13112366199493408},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08295398950576782}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2013-1256","doi":"https://doi.org/10.1158/1538-7445.am2013-1256","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2013-1256","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1608820529","https://openalex.org/W2136902996","https://openalex.org/W63170496","https://openalex.org/W7098896709","https://openalex.org/W2356356202","https://openalex.org/W2170371318","https://openalex.org/W2068831456","https://openalex.org/W2183675001","https://openalex.org/W2251282020","https://openalex.org/W2400986393"],"abstract_inverted_index":{"Abstract":[0],"HCC1":[1,38,72,102,288,327,341],"was":[2,86,103,236,251,257,282,293],"originally":[3],"cloned":[4],"as":[5,88,165,179,222,224],"a":[6,11,25,89,98,104,127,140,315,376],"cell":[7],"nuclear":[8],"autoantigen":[9],"in":[10,36,56,79,146,168,184,211,254,262,290,299,348,380],"patient":[12],"with":[13,92,215,231],"liver":[14,217,301],"cirrhosis":[15,218],"that":[16,49,77,101,124,133,156,261,298,310],"progressed":[17],"to":[18,173,187,196,239,332,375],"HCC.":[19],"The":[20,46,66,246,285,307],"full-length":[21],"sequence":[22],"of":[23,27,42,60,71,106,181,244,248,273,287,326,340,387,392],"HCC1encodes":[24],"protein":[26,69,241,378],"530":[28],"amino":[29],"acids":[30],"and":[31,44,68,109,112,198,207,219,279],"migrating":[32],"at":[33,76],"64":[34],"kDa":[35],"SDS-PAGE.":[37],"has":[39,51,122],"two":[40,338],"isoforms":[41,339],"HCC1.4":[43,199],"HCC1.3.":[45,322],"difference":[47,270],"is":[48,126],"HCC1.3":[50,197],"6-amino":[52],"acid":[53],"deletion":[54],"located":[55],"the":[57,61,182,191,268,334,388,393],"RNP-1-like":[58],"region":[59],"putative":[62],"third":[63],"RNP-CS":[64],"domain.":[65],"nucleotides":[67],"sequences":[70],"were":[73,200],"not":[74,283,321],"found":[75],"time":[78],"searching":[80],"available":[81],"databases":[82],"and,":[83],"therefore,":[84],"it":[85,115],"considered":[87],"novel":[90,128],"gene":[91],"unknown":[93],"function.":[94],"Several":[95],"years":[96],"later,":[97],"group":[99,121],"showed":[100],"co-activator":[105,130],"activating":[107],"protein-1":[108],"estrogen":[110],"receptors":[111],"proposed":[113],"naming":[114],"CAPER.":[116],"Further":[117,323],"study":[118,325],"by":[119,203],"other":[120],"demonstrated":[123,155],"HCC1/CAPER":[125,145,174,379],"transcriptional":[129],"for":[131,144,318,396],"v-Rel":[132],"strongly":[134],"suppresses":[135],"its":[136],"transforming":[137],"activity,":[138],"uncovering":[139],"tumor":[141],"suppressor":[142],"role":[143],"regulating":[147],"Rel's":[148],"oncogenic":[149],"activity.":[150],"Our":[151],"previous":[152],"studies":[153],"have":[154],"autoantibodies":[157,172],"against":[158],"tumor-associated":[159],"antigens":[160],"(TAAs)":[161],"can":[162,175,342],"be":[163,176,188,314],"regarded":[164],"serological":[166],"biomarkers":[167],"cancer":[169],"immunodiagnosis.":[170],"Whether":[171],"also":[177,237,294],"used":[178],"one":[180],"markers":[183],"HCC":[185,232,277,291,349],"remains":[186],"investigated.":[189],"In":[190],"present":[192],"study,":[193],"autoantibody":[194,312],"responses":[195],"firstly":[201],"evaluated":[202],"ELISA,":[204],"western":[205],"blotting":[206],"indirect":[208],"immunofluorescence":[209],"assay":[210],"sera":[212,265],"from":[213,225],"patients":[214,278],"HCC,":[216,255,319],"chronic":[220],"hepatitis,":[221],"well":[223],"normal":[226,263,280,300],"human":[227,264],"individuals.":[228],"Immunohistochemistry":[229],"(IHC)":[230],"tissue":[233],"array":[234],"slides":[235],"performed":[238],"analyze":[240],"expression":[242,289],"profiles":[243],"HCC1.":[245],"prevalence":[247],"anti-HCC1.4":[249,311],"antibodies":[250,275],"13.5%":[252],"(23/171)":[253],"which":[256],"significantly":[258,295],"higher":[259,296],"than":[260,297],"(1.1%).":[266],"Whereas":[267],"significant":[269],"regarding":[271],"frequency":[272,286],"anti-HCC1.3":[274],"between":[276],"individuals":[281],"found.":[284],"tissues":[292,302],"(57.5%":[303],"vs.":[304],"0%;":[305],"P<0.001).":[306],"data":[308],"suggests":[309],"may":[313,328],"potential":[316],"biomarker":[317],"but":[320],"functional":[324],"provide":[329],"more":[330],"evidence":[331],"address":[333],"question":[335],"why":[336],"these":[337],"induce":[343],"different":[344],"humoral":[345],"immune":[346],"response":[347,374],"patients.":[350],"Citation":[351],"Format:":[352],"Liping":[353],"Dai,":[354],"Pengfei":[355],"Ren,":[356],"Xinxin":[357],"Liu,":[358],"Rosalia":[359],"Ortega,":[360],"Wu":[361],"Yao,":[362],"Kaijuan":[363],"Wang,":[364,366],"Mingan":[365],"Eng":[367],"M.":[368],"Tan,":[369],"Jianying":[370],"Zhang.":[371],"Humoral":[372],"autoimmune":[373],"RNA-binding":[377],"hepatocellular":[381],"carcinoma":[382],"(HCC).":[383],"[abstract].":[384],"In:":[385],"Proceedings":[386],"104th":[389],"Annual":[390],"Meeting":[391],"American":[394],"Association":[395],"Cancer":[397,407],"Research;":[398],"2013":[399],"Apr":[400],"6-10;":[401],"Washington,":[402],"DC.":[403],"Philadelphia":[404],"(PA):":[405],"AACR;":[406],"Res":[408],"2013;73(8":[409],"Suppl):Abstract":[410],"nr":[411],"1256.":[412],"doi:10.1158/1538-7445.AM2013-1256":[413]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2016-06-24T00:00:00"}
