{"id":"https://openalex.org/W2320914947","doi":null,"title":"[Serum leptin and adiponectin concentrations in patients infected with human immunodeficiency virus type 1 (HIV-1) on antiretroviral therapy].","display_name":"[Serum leptin and adiponectin concentrations in patients infected with human immunodeficiency virus type 1 (HIV-1) on antiretroviral therapy].","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W2320914947","mag":"2320914947","pmid":"https://pubmed.ncbi.nlm.nih.gov/16335669"},"language":"pl","primary_location":{"id":"pmid:16335669","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16335669","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endokrynologia Polska","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://journals.viamedica.pl/endokrynologia_polska/article/view/25902","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019868771","display_name":"Magdalena Leszczyszyn\u2010Pynka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79833322","display_name":"Pomeranian Medical University","ror":"https://ror.org/01v1rak05","country_code":"PL","type":"education","lineage":["https://openalex.org/I79833322"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Magdalena Leszczyszyn-Pynka","raw_affiliation_strings":["Department of Infections Diseases, Pomeranian Medical University, Szczecin","Klinika Chor\u00f3b Zaka\u017anych PAM, Szczecin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infections Diseases, Pomeranian Medical University, Szczecin","institution_ids":["https://openalex.org/I79833322"]},{"raw_affiliation_string":"Klinika Chor\u00f3b Zaka\u017anych PAM, Szczecin","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069930293","display_name":"S\u0142awomir Pynka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S\u0142awomir Pynka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082140105","display_name":"Anna Boro\u0144\u2010Kaczmarska","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anna Boro\u0144-Kaczmarska","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5085789380","display_name":"Krystyna Pilarska","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Krystyna Pilarska","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2155,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.56038434,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"56","issue":"1","first_page":"19","last_page":"24"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11655","display_name":"HIV-related health complications and treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11655","display_name":"HIV-related health complications and treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":0.8840000033378601},{"id":"https://openalex.org/keywords/adiponectin","display_name":"adiponectin","score":1.0},{"id":"https://openalex.org/keywords/hiv-1-infection","display_name":"HIV-1 infection","score":0.8619999885559082},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.9760000109672546},{"id":"https://openalex.org/keywords/lipodystrophy","display_name":"lipodystrophy","score":0.8820000290870667},{"id":"https://openalex.org/keywords/dyslipidemia","display_name":"dyslipidemia","score":0.8730000257492065},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9760000109672546},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.9490000009536743},{"id":"https://openalex.org/keywords/serum-lipids","display_name":"serum lipids","score":0.7329999804496765},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.8569999933242798},{"id":"https://openalex.org/keywords/total-cholesterol","display_name":"total cholesterol","score":0.7720000147819519},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.8009999990463257},{"id":"https://openalex.org/keywords/atherosclerosis-risk","display_name":"atherosclerosis risk","score":0.9350000023841858}],"concepts":[{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.9227467775344849},{"id":"https://openalex.org/C2776782570","wikidata":"https://www.wikidata.org/wiki/Q357439","display_name":"Adiponectin","level":4,"score":0.8993881344795227},{"id":"https://openalex.org/C2780941825","wikidata":"https://www.wikidata.org/wiki/Q1538213","display_name":"Lipodystrophy","level":5,"score":0.8198943138122559},{"id":"https://openalex.org/C2777275308","wikidata":"https://www.wikidata.org/wiki/Q234668","display_name":"Cart","level":2,"score":0.7379453182220459},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7349672913551331},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7097088694572449},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.568409264087677},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.4896133542060852},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.4335158169269562},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.3804253339767456},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.35214653611183167},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.2779351472854614},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.25434058904647827},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.20361366868019104},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1318567395210266},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008076","descriptor_name":"Cholesterol, HDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008078","descriptor_name":"Cholesterol, LDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D023241","descriptor_name":"Antiretroviral Therapy, Highly Active","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D039682","descriptor_name":"HIV-Associated Lipodystrophy Syndrome","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D052242","descriptor_name":"Adiponectin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:16335669","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16335669","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endokrynologia Polska","raw_type":"English Abstract"},{"id":"pmh:oai:czasopisma.viamedica.pl:article/25902","doi":null,"is_oa":true,"landing_page_url":"https://journals.viamedica.pl/endokrynologia_polska/article/view/25902","pdf_url":"https://journals.viamedica.pl/endokrynologia_polska/article/view/25902","source":{"id":"https://openalex.org/S4377196119","display_name":"Via Medica Journals","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Endokrynologia Polska; Vol 56, No 1 (2005); 19-24","raw_type":null},{"id":"mag:2320914947","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16335669","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:czasopisma.viamedica.pl:article/25902","doi":null,"is_oa":true,"landing_page_url":"https://journals.viamedica.pl/endokrynologia_polska/article/view/25902","pdf_url":"https://journals.viamedica.pl/endokrynologia_polska/article/view/25902","source":{"id":"https://openalex.org/S4377196119","display_name":"Via Medica Journals","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Endokrynologia Polska; Vol 56, No 1 (2005); 19-24","raw_type":null},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2320914947.pdf","grobid_xml":"https://content.openalex.org/works/W2320914947.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1978444406","https://openalex.org/W1979252165","https://openalex.org/W1981117399","https://openalex.org/W2015696391","https://openalex.org/W2015990374","https://openalex.org/W2018963910","https://openalex.org/W2024720867","https://openalex.org/W2027420898","https://openalex.org/W2040974298","https://openalex.org/W2049482156","https://openalex.org/W2053753842","https://openalex.org/W2063244503","https://openalex.org/W2073738273","https://openalex.org/W2076412734","https://openalex.org/W2077337453","https://openalex.org/W2108551042","https://openalex.org/W2114958546","https://openalex.org/W2120192015","https://openalex.org/W2132681327","https://openalex.org/W2159584933","https://openalex.org/W2169588149","https://openalex.org/W2317583984","https://openalex.org/W2318289184","https://openalex.org/W2324473093","https://openalex.org/W2333749627","https://openalex.org/W2334528090"],"related_works":["https://openalex.org/W7043833752","https://openalex.org/W2317583984","https://openalex.org/W2108551042","https://openalex.org/W2011995081","https://openalex.org/W2414518556","https://openalex.org/W2794388036","https://openalex.org/W2079685201","https://openalex.org/W2005084565","https://openalex.org/W2412133471","https://openalex.org/W2577462504"],"abstract_inverted_index":{"UNLABELLED:":[0],"The":[1,180,220],"lipodystrophy":[2],"syndrome":[3],"with":[4,33,175,189,210,229],"dyslipidaemia":[5],"and":[6,28,50,60,80,88,143,161,167,193,225,247],"insulin":[7],"resistance":[8],"is":[9],"side-effect":[10],"of":[11,24,64,72,75,119,182,207,212,222,232,245],"combined":[12],"antiretroviral":[13,40],"therapy":[14,127,133],"(CART).":[15],"AIM":[16],"OF":[17],"THE":[18],"STUDY:":[19],"to":[20,242],"describe":[21],"the":[22,205,230],"influence":[23,213],"CART":[25,153,186,197,237],"on":[26,39,61,85,132,185,214],"leptin":[27,120,144,162,215],"adiponectin":[29,95,160,168,183,208,233],"concentration":[30,96,184,216,234],"in":[31,36,55,97,204,217,227],"connection":[32],"lipids":[34,91,176],"levels":[35,177],"HIV-infected":[37],"patients":[38,58,99],"therapy.":[41,179],"BMI,":[42],"serum":[43],"leptin,":[44],"adiponectin,":[45],"triglycerides,":[46],"total":[47,190,223],"cholesterol,":[48],"HDL-":[49],"LDL-cholesterol":[51,194,226],"concentrations":[52,121,145,163,169],"were":[53,92],"measured":[54],"56":[56],"HIV(+)":[57],"before":[59,79,110,178],"CART;":[62],"average":[63],"treatment":[65,111],"duration":[66],"38.4":[67],"+/-13.2":[68],"months.":[69],"Significant":[70,138],"increase":[71,221],"BMI":[73,142],"(p=0.0268)":[74],"(22.6":[76],"+/-":[77,82,103,113,129,135],"3.3":[78],"23.5":[81],"3.4":[83],"kg/m2":[84],"therapy,":[86],"respectively)":[87],"all":[89],"analyzed":[90,218],"found.":[93],"Mean":[94,117],"treated":[98],"was":[100,146],"significantly":[101,125],"(7.256":[102],"3.551":[104],"microg/ml)":[105],"lower":[106],"than":[107,200],"mean":[108],"value":[109],"(8.395":[112],"3.568":[114],"microg/ml;":[115],"p=0.0011).":[116],"values":[118],"did":[122,170],"not":[123,171],"differ":[124],"(before":[126],"3.721":[128],"0.347":[130],"log10;":[131],"3.1737":[134],"0.353":[136],"log10).":[137],"positive":[139],"correlation":[140,158,174,228],"between":[141,159],"found":[147],"before,":[148],"as":[149,151],"well":[150],"during":[152],"(r=0.5333;":[154],"p<0.0001),":[155],"but":[156],"negative":[157],"(r=-0.2677;":[164],"p=0.042).":[165],"Leptin":[166],"revealed":[172],"significant":[173],"decrease":[181,206,231],"correlated":[187],"negatively":[188],"(r=-0.2912;":[191],"p=0.0310)":[192],"(r=-0.310;":[195],"p=0.0225).":[196],"lasting":[198],"longer":[199],"2":[201],"years":[202],"resulted":[203],"concentration,":[209],"lack":[211],"group.":[219],"cholesterol":[224],"confirms":[235],"that":[236],"induces":[238],"metabolic":[239],"disturbances":[240],"related":[241],"higher":[243],"risk":[244],"atherosclerosis":[246],"its":[248],"sequel.":[249]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}