{"id":"https://openalex.org/W2320829007","doi":"https://doi.org/10.1097/00041552-200209000-00012","title":"A family of calcium-permeable channels in the kidney: distinct roles in renal calcium handling","display_name":"A family of calcium-permeable channels in the kidney: distinct roles in renal calcium handling","publication_year":2002,"publication_date":"2002-09-01","ids":{"openalex":"https://openalex.org/W2320829007","doi":"https://doi.org/10.1097/00041552-200209000-00012","mag":"2320829007","pmid":"https://pubmed.ncbi.nlm.nih.gov/12187321"},"language":"en","primary_location":{"id":"doi:10.1097/00041552-200209000-00012","doi":"https://doi.org/10.1097/00041552-200209000-00012","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00041552-200209000-00012","pdf_url":null,"source":{"id":"https://openalex.org/S185853653","display_name":"Current Opinion in Nephrology & Hypertension","issn_l":"1062-4821","issn":["1062-4821","1080-8221","1473-6543"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Nephrology and Hypertension","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030989787","display_name":"Ji\u2010Bin Peng","orcid":"https://orcid.org/0000-0003-1380-342X","observed_orcids":["https://orcid.org/0000-0003-1380-342X"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ji-Bin Peng","raw_affiliation_strings":["Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. jpeng@rics.bwh.harvard.edu","CNT: distal connecting tubule","DCT: distal convoluted tubule","Membrane Biology Program and Renal Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA","PCR: polymerase chain reaction","PTH: parathyroid hormone","TRP: transient receptor potential","VDR: vitamin D receptor","e-mails: [email\u00a0protected] or [email\u00a0protected]","to Ji-Bin Peng or Matthias A. Hediger, Harvard Institutes of Medicine, Room 570, 77 Avenue Louis Pasteur, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. jpeng@rics.bwh.harvard.edu","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"CNT: distal connecting tubule","institution_ids":[]},{"raw_affiliation_string":"DCT: distal convoluted tubule","institution_ids":[]},{"raw_affiliation_string":"Membrane Biology Program and Renal Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"PCR: polymerase chain reaction","institution_ids":[]},{"raw_affiliation_string":"PTH: parathyroid hormone","institution_ids":[]},{"raw_affiliation_string":"TRP: transient receptor potential","institution_ids":[]},{"raw_affiliation_string":"VDR: vitamin D receptor","institution_ids":[]},{"raw_affiliation_string":"e-mails: [email\u00a0protected] or [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"to Ji-Bin Peng or Matthias A. Hediger, Harvard Institutes of Medicine, Room 570, 77 Avenue Louis Pasteur, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078842111","display_name":"Matthias A. Hediger","orcid":"https://orcid.org/0000-0003-1946-027X","observed_orcids":["https://orcid.org/0000-0003-1946-027X"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Matthias A. Hediger","raw_affiliation_strings":["CNT: distal connecting tubule","DCT: distal convoluted tubule","Membrane Biology Program and Renal Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA","PCR: polymerase chain reaction","PTH: parathyroid hormone","TRP: transient receptor potential","VDR: vitamin D receptor","e-mails: [email\u00a0protected] or [email\u00a0protected]","to Ji-Bin Peng or Matthias A. Hediger, Harvard Institutes of Medicine, Room 570, 77 Avenue Louis Pasteur, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNT: distal connecting tubule","institution_ids":[]},{"raw_affiliation_string":"DCT: distal convoluted tubule","institution_ids":[]},{"raw_affiliation_string":"Membrane Biology Program and Renal Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"PCR: polymerase chain reaction","institution_ids":[]},{"raw_affiliation_string":"PTH: parathyroid hormone","institution_ids":[]},{"raw_affiliation_string":"TRP: transient receptor potential","institution_ids":[]},{"raw_affiliation_string":"VDR: vitamin D receptor","institution_ids":[]},{"raw_affiliation_string":"e-mails: [email\u00a0protected] or [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"to Ji-Bin Peng or Matthias A. Hediger, Harvard Institutes of Medicine, Room 570, 77 Avenue Louis Pasteur, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5030989787","https://openalex.org/A5078842111"],"corresponding_institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"],"apc_list":null,"apc_paid":null,"fwci":0.5902,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.54081633,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"11","issue":"5","first_page":"555","last_page":"561"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.8300999999046326,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.8300999999046326,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.04989999905228615,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.025800000876188278,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calcium-permeable-channels","display_name":"calcium-permeable channels","score":0.9380000233650208},{"id":"https://openalex.org/keywords/transient-receptor-potential-channels","display_name":"TRP channels","score":0.7770000100135803},{"id":"https://openalex.org/keywords/renal-calcium-handling","display_name":"renal calcium handling","score":0.7929999828338623},{"id":"https://openalex.org/keywords/calcium-homeostasis","display_name":"calcium homeostasis","score":0.8259999752044678},{"id":"https://openalex.org/keywords/osmolarity-sensing","display_name":"osmolarity sensing","score":0.8820000290870667},{"id":"https://openalex.org/keywords/gitelman-syndrome","display_name":"Gitelman syndrome","score":0.7950000166893005},{"id":"https://openalex.org/keywords/bartter-syndrome","display_name":"Bartter syndrome","score":0.9670000076293945},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":0.9440000057220459}],"concepts":[{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.815868616104126},{"id":"https://openalex.org/C155520015","wikidata":"https://www.wikidata.org/wiki/Q14891586","display_name":"TRPV6","level":4,"score":0.746209979057312},{"id":"https://openalex.org/C155164980","wikidata":"https://www.wikidata.org/wiki/Q304043","display_name":"Transient receptor potential channel","level":3,"score":0.6514903903007507},{"id":"https://openalex.org/C87975464","wikidata":"https://www.wikidata.org/wiki/Q910704","display_name":"Calcium metabolism","level":3,"score":0.5471840500831604},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.5009071826934814},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.4896138310432434},{"id":"https://openalex.org/C201571599","wikidata":"https://www.wikidata.org/wiki/Q5018840","display_name":"Calcium signaling","level":3,"score":0.48160693049430847},{"id":"https://openalex.org/C18699975","wikidata":"https://www.wikidata.org/wiki/Q14905735","display_name":"Voltage-dependent calcium channel","level":3,"score":0.45577314496040344},{"id":"https://openalex.org/C181080969","wikidata":"https://www.wikidata.org/wiki/Q60097","display_name":"Calcium in biology","level":3,"score":0.44598591327667236},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4300650954246521},{"id":"https://openalex.org/C30979828","wikidata":"https://www.wikidata.org/wiki/Q2487620","display_name":"T-type calcium channel","level":4,"score":0.42648860812187195},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4068918824195862},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40136146545410156},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37119540572166443},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3432301878929138},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.21815833449363708},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2172016203403473},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17406600713729858}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002412","descriptor_name":"Cations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014807","descriptor_name":"Vitamin D","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D027682","descriptor_name":"Cation Transport Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050916","descriptor_name":"TRPV Cation Channels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00041552-200209000-00012","doi":"https://doi.org/10.1097/00041552-200209000-00012","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00041552-200209000-00012","pdf_url":null,"source":{"id":"https://openalex.org/S185853653","display_name":"Current Opinion in Nephrology & Hypertension","issn_l":"1062-4821","issn":["1062-4821","1080-8221","1473-6543"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Nephrology and Hypertension","raw_type":"journal-article"},{"id":"pmid:12187321","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12187321","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in nephrology and hypertension","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.428600013256073}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W154320948","https://openalex.org/W1495409864","https://openalex.org/W1511198581","https://openalex.org/W1513561540","https://openalex.org/W1521828067","https://openalex.org/W1545384325","https://openalex.org/W1634886886","https://openalex.org/W1854281558","https://openalex.org/W1938250799","https://openalex.org/W1967156349","https://openalex.org/W1969597161","https://openalex.org/W1979766583","https://openalex.org/W1981494335","https://openalex.org/W2001536559","https://openalex.org/W2006398626","https://openalex.org/W2009572905","https://openalex.org/W2009883068","https://openalex.org/W2010795846","https://openalex.org/W2016434510","https://openalex.org/W2031943544","https://openalex.org/W2034179234","https://openalex.org/W2042832021","https://openalex.org/W2056461924","https://openalex.org/W2060647763","https://openalex.org/W2063120593","https://openalex.org/W2069800034","https://openalex.org/W2073272788","https://openalex.org/W2079100054","https://openalex.org/W2079861710","https://openalex.org/W2080133117","https://openalex.org/W2081730365","https://openalex.org/W2097403739","https://openalex.org/W2098144310","https://openalex.org/W2107705149","https://openalex.org/W2113557381","https://openalex.org/W2120038848","https://openalex.org/W2128158693","https://openalex.org/W2135567029","https://openalex.org/W2135722864","https://openalex.org/W2146430779","https://openalex.org/W2148772545","https://openalex.org/W2150070295","https://openalex.org/W2156165752","https://openalex.org/W2171770945","https://openalex.org/W2172201122","https://openalex.org/W2313093061","https://openalex.org/W2339995413","https://openalex.org/W2398990476","https://openalex.org/W2402880833"],"related_works":["https://openalex.org/W2414451313","https://openalex.org/W2314460223","https://openalex.org/W4394951976","https://openalex.org/W2426272809","https://openalex.org/W2183274716","https://openalex.org/W7217327009","https://openalex.org/W7062469742","https://openalex.org/W7160618254","https://openalex.org/W2085915179","https://openalex.org/W2178569498"],"abstract_inverted_index":{"PURPOSE":[0],"OF":[1],"REVIEW:":[2],"Calcium":[3,20,100],"is":[4,21],"an":[5],"essential":[6],"intracellular":[7],"messenger":[8],"and":[9,26,93,133],"a":[10,70],"major":[11],"component":[12],"of":[13,17,53,72,83,129],"the":[14,18,24,29,51,57,60,103],"mineral":[15],"phase":[16],"skeleton.":[19],"absorbed":[22],"in":[23,28,40,50,63,102,108],"intestine":[25],"reabsorbed":[27],"kidney.":[30],"The":[31],"underlying":[32],"transepithelial":[33,64],"calcium":[34,41,54,65,90,112],"transport":[35,55],"mechanisms":[36,92],"play":[37,105],"crucial":[38],"roles":[39,107],"homeostasis.":[42,113],"In":[43],"this":[44],"review,":[45],"we":[46],"present":[47],"new":[48],"developments":[49],"area":[52],"at":[56],"apical":[58],"membrane,":[59],"first":[61],"step":[62],"transport.":[66],"RECENT":[67],"FINDINGS:":[68],"Recently,":[69],"group":[71],"transient":[73],"receptor":[74],"potential":[75],"(TRP)-related":[76],"calcium-permeable":[77],"channels":[78,85,101],"has":[79],"been":[80],"identified.":[81],"Several":[82],"these":[84],"serve":[86],"as":[87,96,124],"important":[88,106],"epithelial":[89],"entry":[91],"possibly":[94],"also":[95],"osmolarity":[97],"sensors.":[98],"SUMMARY:":[99],"kidney":[104],"maintaining":[109],"total":[110],"body":[111],"Their":[114],"dysfunction":[115],"may":[116],"be":[117],"associated":[118],"with":[119],"several":[120],"human":[121],"diseases":[122],"such":[123],"hypercaliuric":[125],"nephrolithiasis,":[126],"certain":[127],"forms":[128],"osteoporosis,":[130],"Gitelman's":[131],"disease":[132],"Bartter's":[134],"syndrome.":[135]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
