{"id":"https://openalex.org/W2320549790","doi":null,"title":"MECHANISMS OF ANTICANCER DRUG ACTION Chapter II","display_name":"MECHANISMS OF ANTICANCER DRUG ACTION Chapter II","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W2320549790","mag":"2320549790"},"language":"en","primary_location":{"id":"mag:2320549790","doi":null,"is_oa":false,"landing_page_url":"https://link.springer.com/chapter/10.1007/0-387-23695-3_2","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001339980","display_name":"Sebastian Wesselborg","orcid":"https://orcid.org/0000-0002-5236-942X","observed_orcids":["https://orcid.org/0000-0002-5236-942X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sebastian Wesselborg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5016924764","display_name":"Kirsten Lauber","orcid":"https://orcid.org/0000-0002-8141-0452","observed_orcids":["https://orcid.org/0000-0002-8141-0452"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kirsten Lauber","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8141-0452","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anticancer-drug-mechanism","display_name":"anticancer drug mechanism","score":0.7879999876022339},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7889999747276306},{"id":"https://openalex.org/keywords/apoptosis-signaling-pathway","display_name":"apoptosis signaling","score":0.8080000281333923},{"id":"https://openalex.org/keywords/dna-damaging-agents","display_name":"DNA-damaging agents","score":0.7979999780654907},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.7570000290870667},{"id":"https://openalex.org/keywords/tumor-cell-survival","display_name":"tumor cell survival","score":0.4880000054836273},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.9129999876022339},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.578000009059906}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6805050373077393},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6376773118972778},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5562352538108826},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.524183452129364},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5152032971382141},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.4860263466835022},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4786873459815979},{"id":"https://openalex.org/C86380466","wikidata":"https://www.wikidata.org/wiki/Q5308872","display_name":"Drug action","level":3,"score":0.47441479563713074},{"id":"https://openalex.org/C3018146709","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Anticancer drug","level":3,"score":0.4727894961833954},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.45728039741516113},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4463229179382324},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4442148804664612},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.43123260140419006},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.40428465604782104},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.386196106672287},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.2165493667125702},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.18612495064735413},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10058042407035828},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.09143048524856567}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2320549790","doi":null,"is_oa":false,"landing_page_url":"https://link.springer.com/chapter/10.1007/0-387-23695-3_2","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":258,"referenced_works":["https://openalex.org/W20453933","https://openalex.org/W45894429","https://openalex.org/W50394454","https://openalex.org/W132441100","https://openalex.org/W142202837","https://openalex.org/W146240628","https://openalex.org/W161930446","https://openalex.org/W172276776","https://openalex.org/W178450542","https://openalex.org/W1480948328","https://openalex.org/W1484817497","https://openalex.org/W1487506158","https://openalex.org/W1492587973","https://openalex.org/W1493702629","https://openalex.org/W1497251274","https://openalex.org/W1498586399","https://openalex.org/W1500830863","https://openalex.org/W1505612226","https://openalex.org/W1515564094","https://openalex.org/W1522763255","https://openalex.org/W1524836561","https://openalex.org/W1526235586","https://openalex.org/W1527997848","https://openalex.org/W1530002036","https://openalex.org/W1533153036","https://openalex.org/W1534924266","https://openalex.org/W1545446999","https://openalex.org/W1550247880","https://openalex.org/W1554372630","https://openalex.org/W1556888230","https://openalex.org/W1572617528","https://openalex.org/W1587890084","https://openalex.org/W1590471414","https://openalex.org/W1591166893","https://openalex.org/W1595168222","https://openalex.org/W1598971691","https://openalex.org/W1599806854","https://openalex.org/W1604195255","https://openalex.org/W1604468403","https://openalex.org/W1616121322","https://openalex.org/W1629770860","https://openalex.org/W1650797637","https://openalex.org/W1656708631","https://openalex.org/W1657827244","https://openalex.org/W1660403641","https://openalex.org/W1752995067","https://openalex.org/W1845459216","https://openalex.org/W1870720170","https://openalex.org/W1893561328","https://openalex.org/W1905806846","https://openalex.org/W1911252495","https://openalex.org/W1915589840","https://openalex.org/W1919566582","https://openalex.org/W1925670358","https://openalex.org/W1964224010","https://openalex.org/W1964617786","https://openalex.org/W1964667627","https://openalex.org/W1964897853","https://openalex.org/W1966292443","https://openalex.org/W1970525491","https://openalex.org/W1971274526","https://openalex.org/W1971967721","https://openalex.org/W1972183604","https://openalex.org/W1972304655","https://openalex.org/W1973109581","https://openalex.org/W1976883744","https://openalex.org/W1977499961","https://openalex.org/W1978018492","https://openalex.org/W1978480779","https://openalex.org/W1979319210","https://openalex.org/W1979995768","https://openalex.org/W1982332661","https://openalex.org/W1984390541","https://openalex.org/W1988864413","https://openalex.org/W1990522751","https://openalex.org/W1992667313","https://openalex.org/W1995061287","https://openalex.org/W1995463051","https://openalex.org/W1995741673","https://openalex.org/W1997879915","https://openalex.org/W1999194714","https://openalex.org/W2003107854","https://openalex.org/W2005770035","https://openalex.org/W2006652614","https://openalex.org/W2007010211","https://openalex.org/W2007706369","https://openalex.org/W2008715871","https://openalex.org/W2010478401","https://openalex.org/W2011007189","https://openalex.org/W2012173926","https://openalex.org/W2012209476","https://openalex.org/W2012333728","https://openalex.org/W2013346353","https://openalex.org/W2013993442","https://openalex.org/W2014380713","https://openalex.org/W2014875885","https://openalex.org/W2015362281","https://openalex.org/W2016198585","https://openalex.org/W2017728303","https://openalex.org/W2018746081","https://openalex.org/W2020883829","https://openalex.org/W2024019848","https://openalex.org/W2024039001","https://openalex.org/W2024996523","https://openalex.org/W2025963365","https://openalex.org/W2027534174","https://openalex.org/W2027686496","https://openalex.org/W2028048630","https://openalex.org/W2032077813","https://openalex.org/W2032096654","https://openalex.org/W2032361307","https://openalex.org/W2034213169","https://openalex.org/W2034295054","https://openalex.org/W2034549690","https://openalex.org/W2035153917","https://openalex.org/W2035493275","https://openalex.org/W2035768602","https://openalex.org/W2035982561","https://openalex.org/W2036009804","https://openalex.org/W2038114873","https://openalex.org/W2039444414","https://openalex.org/W2039601589","https://openalex.org/W2039810057","https://openalex.org/W2040172490","https://openalex.org/W2041980363","https://openalex.org/W2042263343","https://openalex.org/W2042316019","https://openalex.org/W2042409437","https://openalex.org/W2042923408","https://openalex.org/W2042928863","https://openalex.org/W2043310375","https://openalex.org/W2043978867","https://openalex.org/W2044079387","https://openalex.org/W2045086385","https://openalex.org/W2045563337","https://openalex.org/W2045796964","https://openalex.org/W2046546728","https://openalex.org/W2047056744","https://openalex.org/W2047571097","https://openalex.org/W2049137769","https://openalex.org/W2049873418","https://openalex.org/W2053301688","https://openalex.org/W2054717287","https://openalex.org/W2055349083","https://openalex.org/W2057343842","https://openalex.org/W2060683243","https://openalex.org/W2060820237","https://openalex.org/W2061497413","https://openalex.org/W2062853648","https://openalex.org/W2063017603","https://openalex.org/W2064580048","https://openalex.org/W2066226580","https://openalex.org/W2066266564","https://openalex.org/W2066441074","https://openalex.org/W2066598150","https://openalex.org/W2070437897","https://openalex.org/W2072188392","https://openalex.org/W2074152898","https://openalex.org/W2076229621","https://openalex.org/W2078581194","https://openalex.org/W2080156248","https://openalex.org/W2080333440","https://openalex.org/W2081211388","https://openalex.org/W2081894694","https://openalex.org/W2082259697","https://openalex.org/W2083077527","https://openalex.org/W2083458436","https://openalex.org/W2084733813","https://openalex.org/W2087079563","https://openalex.org/W2087288637","https://openalex.org/W2087450028","https://openalex.org/W2088291142","https://openalex.org/W2089082314","https://openalex.org/W2089623763","https://openalex.org/W2090202756","https://openalex.org/W2091267060","https://openalex.org/W2092863749","https://openalex.org/W2093340998","https://openalex.org/W2093730092","https://openalex.org/W2094126824","https://openalex.org/W2094629286","https://openalex.org/W2095424453","https://openalex.org/W2096199626","https://openalex.org/W2096950793","https://openalex.org/W2098712698","https://openalex.org/W2102443458","https://openalex.org/W2102986716","https://openalex.org/W2104773672","https://openalex.org/W2104979289","https://openalex.org/W2106258762","https://openalex.org/W2106284224","https://openalex.org/W2106567289","https://openalex.org/W2111714805","https://openalex.org/W2111877855","https://openalex.org/W2112968535","https://openalex.org/W2114635439","https://openalex.org/W2114712927","https://openalex.org/W2114980992","https://openalex.org/W2115491208","https://openalex.org/W2116045049","https://openalex.org/W2116145077","https://openalex.org/W2119299816","https://openalex.org/W2119326933","https://openalex.org/W2119683782","https://openalex.org/W2119908949","https://openalex.org/W2120473562","https://openalex.org/W2120633856","https://openalex.org/W2120939161","https://openalex.org/W2122482353","https://openalex.org/W2123935768","https://openalex.org/W2124637558","https://openalex.org/W2125988618","https://openalex.org/W2126959399","https://openalex.org/W2127140763","https://openalex.org/W2128559106","https://openalex.org/W2130866079","https://openalex.org/W2135368384","https://openalex.org/W2137276707","https://openalex.org/W2139439596","https://openalex.org/W2142911981","https://openalex.org/W2143996326","https://openalex.org/W2147092104","https://openalex.org/W2148200419","https://openalex.org/W2149811610","https://openalex.org/W2151190428","https://openalex.org/W2153689486","https://openalex.org/W2154563532","https://openalex.org/W2155363874","https://openalex.org/W2157999078","https://openalex.org/W2159650080","https://openalex.org/W2160224004","https://openalex.org/W2160912752","https://openalex.org/W2162646039","https://openalex.org/W2162653594","https://openalex.org/W2163459725","https://openalex.org/W2165012318","https://openalex.org/W2166510809","https://openalex.org/W2167478584","https://openalex.org/W2167490100","https://openalex.org/W2167534720","https://openalex.org/W2168070336","https://openalex.org/W2168747001","https://openalex.org/W2168851383","https://openalex.org/W2170846829","https://openalex.org/W2171342364","https://openalex.org/W2187031962","https://openalex.org/W2253032222","https://openalex.org/W2268045557","https://openalex.org/W2290539832","https://openalex.org/W2314104762","https://openalex.org/W2320656371","https://openalex.org/W2321659793","https://openalex.org/W2324600056","https://openalex.org/W2327000633","https://openalex.org/W2329105219","https://openalex.org/W2335526988","https://openalex.org/W2400208457","https://openalex.org/W2400694579"],"related_works":["https://openalex.org/W2079176745","https://openalex.org/W2056149397","https://openalex.org/W2133246687","https://openalex.org/W2062943475","https://openalex.org/W2102382046","https://openalex.org/W3152964134","https://openalex.org/W54138192","https://openalex.org/W2408954743","https://openalex.org/W2012883094","https://openalex.org/W2024936447"],"abstract_inverted_index":{"1.":[0],"SUMMARY":[1],"Activation":[2],"of":[3,10,27,34,44,61,74,83,90,94],"the":[4,11,24,31,40,45,49,55,71,75,80,95,100,108,111],"endogenous":[5],"suicide":[6],"program":[7,47],"is":[8,38],"one":[9],"major":[12],"mechanisms":[13,82],"by":[14,20,104],"that":[15,98,110],"cancer":[16,50],"cells":[17],"are":[18],"eliminated":[19],"antitumor":[21],"agents.":[22],"Though":[23],"primary":[25],"site":[26],"action":[28],"might":[29,118],"differ,":[30],"basic":[32],"outcome":[33],"most":[35],"anticancer":[36,85,105],"drugs":[37,86,106],"usually":[39],"same":[41],"-":[42],"induction":[43],"apoptotic":[46,56,101],"in":[48,78],"cell.":[51],"Conversely,":[52],"defects":[53],"within":[54],"signaling":[57,77],"machinery":[58,102],"convey":[59],"resistance":[60,89],"tumors":[62],"to":[63,115,120],"chemotherapy.":[64],"In":[65],"this":[66],"review":[67],"we":[68],"will":[69],"summarize":[70],"current":[72],"knowledge":[73],"apoptosis":[76,117],"tumorigenesis,":[79],"molecular":[81,96],"DNA-damaging":[84],"and":[87,107,125],"drug":[88,126],"tumor":[91,112],"cells.":[92],"Understanding":[93],"events":[97],"regulate":[99],"induced":[103],"measures":[109],"cell":[113],"takes":[114],"avoid":[116],"help":[119],"develop":[121],"new":[122],"therapeutic":[123],"strategies":[124],"development.":[127]},"counts_by_year":[],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2016-06-24T00:00:00"}
