{"id":"https://openalex.org/W2320186977","doi":"https://doi.org/10.1021/ja307717w","title":"Programmable Hydrogels for Controlled Cell Catch and Release Using Hybridized Aptamers and Complementary Sequences","display_name":"Programmable Hydrogels for Controlled Cell Catch and Release Using Hybridized Aptamers and Complementary Sequences","publication_year":2012,"publication_date":"2012-09-12","ids":{"openalex":"https://openalex.org/W2320186977","doi":"https://doi.org/10.1021/ja307717w","mag":"2320186977","pmid":"https://pubmed.ncbi.nlm.nih.gov/22970862"},"language":"en","primary_location":{"id":"doi:10.1021/ja307717w","doi":"https://doi.org/10.1021/ja307717w","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ja307717w","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100751304","display_name":"Zhaoyang Zhang","orcid":"https://orcid.org/0000-0002-0656-366X","observed_orcids":["https://orcid.org/0000-0002-0656-366X"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhaoyang Zhang","raw_affiliation_strings":["Department\rof Chemical, Materials, and Biomolecular Engineering and \u2021Program of Biomedical Engineering, School of Engineering, University of Connecticut, Storrs, Connecticut 06269, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Chemical, Materials, and Biomolecular Engineering and \u2021Program of Biomedical Engineering, School of Engineering, University of Connecticut, Storrs, Connecticut 06269, United States","institution_ids":["https://openalex.org/I140172145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026348988","display_name":"Niancao Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Niancao Chen","raw_affiliation_strings":["Department\rof Chemical, Materials, and Biomolecular Engineering and \u2021Program of Biomedical Engineering, School of Engineering, University of Connecticut, Storrs, Connecticut 06269, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Chemical, Materials, and Biomolecular Engineering and \u2021Program of Biomedical Engineering, School of Engineering, University of Connecticut, Storrs, Connecticut 06269, United States","institution_ids":["https://openalex.org/I140172145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054519421","display_name":"Shihui Li","orcid":"https://orcid.org/0000-0002-4121-9119","observed_orcids":["https://orcid.org/0000-0002-4121-9119"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shihui Li","raw_affiliation_strings":["Department\rof Chemical, Materials, and Biomolecular Engineering and \u2021Program of Biomedical Engineering, School of Engineering, University of Connecticut, Storrs, Connecticut 06269, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Chemical, Materials, and Biomolecular Engineering and \u2021Program of Biomedical Engineering, School of Engineering, University of Connecticut, Storrs, Connecticut 06269, United States","institution_ids":["https://openalex.org/I140172145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005642377","display_name":"Mark R. Battig","orcid":"https://orcid.org/0000-0001-7831-6935","observed_orcids":["https://orcid.org/0000-0001-7831-6935"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark R. Battig","raw_affiliation_strings":["Department\rof Chemical, Materials, and Biomolecular Engineering and \u2021Program of Biomedical Engineering, School of Engineering, University of Connecticut, Storrs, Connecticut 06269, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Chemical, Materials, and Biomolecular Engineering and \u2021Program of Biomedical Engineering, School of Engineering, University of Connecticut, Storrs, Connecticut 06269, United States","institution_ids":["https://openalex.org/I140172145"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100424435","display_name":"Yong Wang","orcid":"https://orcid.org/0009-0001-0953-5824","observed_orcids":["https://orcid.org/0009-0001-0953-5824"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yong Wang","raw_affiliation_strings":["Department\rof Chemical, Materials, and Biomolecular Engineering and \u2021Program of Biomedical Engineering, School of Engineering, University of Connecticut, Storrs, Connecticut 06269, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Chemical, Materials, and Biomolecular Engineering and \u2021Program of Biomedical Engineering, School of Engineering, University of Connecticut, Storrs, Connecticut 06269, United States","institution_ids":["https://openalex.org/I140172145"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100424435"],"corresponding_institution_ids":["https://openalex.org/I140172145"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":4.0381,"has_fulltext":false,"cited_by_count":138,"citation_normalized_percentile":{"value":0.95475638,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"134","issue":"38","first_page":"15716","last_page":"15719"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.7310000061988831,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.7310000061988831,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.2483000010251999,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11419","display_name":"Supramolecular Self-Assembly in Materials","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-capture","display_name":"cell capture","score":0.5989999771118164},{"id":"https://openalex.org/keywords/cell-release","display_name":"cell release","score":0.8479999899864197},{"id":"https://openalex.org/keywords/aptamers","display_name":"aptamers","score":0.8830000162124634},{"id":"https://openalex.org/keywords/cell-material-interactions","display_name":"cell-material interactions","score":0.7839999794960022},{"id":"https://openalex.org/keywords/cell-isolation","display_name":"cell isolation","score":0.8930000066757202},{"id":"https://openalex.org/keywords/regenerative-medicine","display_name":"regenerative medicine","score":0.765999972820282},{"id":"https://openalex.org/keywords/biocompatibility","display_name":"biocompatibility","score":0.6489999890327454}],"concepts":[{"id":"https://openalex.org/C128972844","wikidata":"https://www.wikidata.org/wiki/Q418722","display_name":"Aptamer","level":2,"score":0.9847424030303955},{"id":"https://openalex.org/C108586683","wikidata":"https://www.wikidata.org/wiki/Q17164826","display_name":"Self-healing hydrogels","level":2,"score":0.8553466200828552},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7717368602752686},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5641102194786072},{"id":"https://openalex.org/C1318750","wikidata":"https://www.wikidata.org/wiki/Q865663","display_name":"Biocompatible material","level":2,"score":0.5255783200263977},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.5117999911308289},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5019910335540771},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1728750467300415},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.15647989511489868},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.1532278060913086},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.10636931657791138},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.09872102737426758},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06436797976493835},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020100","descriptor_name":"Hydrogels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D052157","descriptor_name":"Aptamers, Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/ja307717w","doi":"https://doi.org/10.1021/ja307717w","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ja307717w","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},{"id":"pmid:22970862","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22970862","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320322725","display_name":"China Scholarship Council","ror":"https://ror.org/04atp4p48"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1966444688","https://openalex.org/W1970414768","https://openalex.org/W1971647685","https://openalex.org/W1993312924","https://openalex.org/W1999565973","https://openalex.org/W2003393269","https://openalex.org/W2004229423","https://openalex.org/W2006249488","https://openalex.org/W2012440525","https://openalex.org/W2018898709","https://openalex.org/W2020436098","https://openalex.org/W2023373190","https://openalex.org/W2026752436","https://openalex.org/W2030516851","https://openalex.org/W2031691795","https://openalex.org/W2042981054","https://openalex.org/W2043595274","https://openalex.org/W2047555540","https://openalex.org/W2050547995","https://openalex.org/W2059281433","https://openalex.org/W2061993110","https://openalex.org/W2065666244","https://openalex.org/W2067009806","https://openalex.org/W2067897176","https://openalex.org/W2079321730","https://openalex.org/W2080523820","https://openalex.org/W2082932879","https://openalex.org/W2083179778","https://openalex.org/W2097535374","https://openalex.org/W2104525153","https://openalex.org/W2105260274","https://openalex.org/W2106361367","https://openalex.org/W2109783713","https://openalex.org/W2115402295","https://openalex.org/W2124127180","https://openalex.org/W2124166203","https://openalex.org/W2132157235","https://openalex.org/W2133873308","https://openalex.org/W2141677597","https://openalex.org/W2163667644","https://openalex.org/W2165694975"],"related_works":["https://openalex.org/W2556190925","https://openalex.org/W2335077946","https://openalex.org/W1520874259","https://openalex.org/W2329773451","https://openalex.org/W2028259367","https://openalex.org/W2016903190","https://openalex.org/W3172806875","https://openalex.org/W2897830812","https://openalex.org/W2762089255","https://openalex.org/W2126860268"],"abstract_inverted_index":{"The":[0,102],"ability":[1],"to":[2,82,125,142],"regulate":[3],"cell-material":[4],"interactions":[5],"is":[6,116,136],"important":[7],"in":[8,58],"various":[9],"applications":[10],"such":[11],"as":[12],"regenerative":[13],"medicine":[14],"and":[15,39,108,118,138,149],"cell":[16,106,147],"separation.":[17],"This":[18],"study":[19],"successfully":[20],"demonstrates":[21],"that":[22,80],"the":[23,45,48,51,59,65,68,71,83,87,90,95,100,111,114,127,130,133],"binding":[24],"states":[25],"of":[26,47,67,86,105,113,146],"cells":[27,96,128],"on":[28],"a":[29,54,76,93,143],"hydrogel":[30,60,135],"surface":[31],"can":[32,139],"be":[33,140],"programmed":[34],"by":[35],"using":[36],"hybridized":[37,56,78],"aptamers":[38,52,72,88,115],"triggering":[40,49,69],"complementary":[41],"sequences":[42],"(CSs).":[43],"In":[44,64],"absence":[46],"CSs,":[50,70],"exhibit":[53],"stable,":[55],"state":[57,79],"for":[61],"cell-type-specific":[62],"catch.":[63],"presence":[66],"are":[73,97],"transformed":[74],"into":[75],"new":[77,144],"leads":[81],"rapid":[84],"dissociation":[85],"from":[89,99],"hydrogel.":[91,101,131],"As":[92],"result,":[94],"released":[98],"entire":[103],"procedure":[104],"catch":[107,148],"release":[109,150],"during":[110],"transformation":[112],"biocompatible":[117],"does":[119],"not":[120],"involve":[121],"any":[122],"factor":[123],"destructive":[124],"either":[126],"or":[129],"Thus,":[132],"programmable":[134],"regenerable":[137],"applied":[141],"round":[145],"when":[151],"needed.":[152]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":17},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":17},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":16},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":11}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
