{"id":"https://openalex.org/W2320146444","doi":"https://doi.org/10.1016/s0025-7125(16)30649-6","title":"Hepatocellular Carcinoma: Molecular Biology of Its Growth and Relationship to Hepatitis B Virus Infection","display_name":"Hepatocellular Carcinoma: Molecular Biology of Its Growth and Relationship to Hepatitis B Virus Infection","publication_year":1989,"publication_date":"1989-07-01","ids":{"openalex":"https://openalex.org/W2320146444","doi":"https://doi.org/10.1016/s0025-7125(16)30649-6","mag":"2320146444","pmid":"https://pubmed.ncbi.nlm.nih.gov/2542706"},"language":"en","primary_location":{"id":"doi:10.1016/s0025-7125(16)30649-6","doi":"https://doi.org/10.1016/s0025-7125(16)30649-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0025-7125(16)30649-6","pdf_url":null,"source":{"id":"https://openalex.org/S33396077","display_name":"Medical Clinics of North America","issn_l":"0025-7125","issn":["0025-7125","1557-9859"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Clinics of North America","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022731052","display_name":"Adrian M. Di Bisceglie","orcid":"https://orcid.org/0000-0002-6075-9305","observed_orcids":["https://orcid.org/0000-0002-6075-9305"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Adrian M. Di Bisceglie","raw_affiliation_strings":["Liver Diseases Section, National Institutes of Health, Bethesda, Maryland","Visiting Scientist, Liver Diseases Section, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liver Diseases Section, National Institutes of Health, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238"]},{"raw_affiliation_string":"Visiting Scientist, Liver Diseases Section, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5022731052"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"],"apc_list":{"value":3350,"currency":"USD","value_usd":3350},"apc_paid":null,"fwci":0.0989,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.20952381,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"73","issue":"4","first_page":"985","last_page":"997"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":1.0},{"id":"https://openalex.org/keywords/hepatitis-b-virus","display_name":"hepatitis B virus","score":0.9670000076293945},{"id":"https://openalex.org/keywords/hbv-integration","display_name":"HBV DNA integration","score":0.9070000052452087},{"id":"https://openalex.org/keywords/hepatocarcinogenesis","display_name":"hepatocarcinogenesis","score":0.890999972820282},{"id":"https://openalex.org/keywords/chronic-hepatitis-b","display_name":"chronic hepatitis B","score":0.9430000185966492},{"id":"https://openalex.org/keywords/c-myc-oncogene","display_name":"c-myc oncogene","score":0.7630000114440918},{"id":"https://openalex.org/keywords/igf-ii","display_name":"insulin-like growth factor II","score":0.781000018119812},{"id":"https://openalex.org/keywords/retinoic-acid-receptor","display_name":"retinoic acid receptor","score":0.9879999756813049},{"id":"https://openalex.org/keywords/tumor-growth-factors","display_name":"tumor growth factors","score":0.7329999804496765},{"id":"https://openalex.org/keywords/liver-cancer-prevention","display_name":"liver cancer prevention","score":0.6899999976158142}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8409439325332642},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.8180050849914551},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.5962607264518738},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.5630220770835876},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5226231217384338},{"id":"https://openalex.org/C3020804797","wikidata":"https://www.wikidata.org/wiki/Q1983841","display_name":"Hepatitis virus","level":3,"score":0.45482686161994934},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.43076834082603455},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3092838227748871},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.302242636680603}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006509","descriptor_name":"Hepatitis B","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006509","descriptor_name":"Hepatitis B","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006514","descriptor_name":"Hepatitis B Surface Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006515","descriptor_name":"Hepatitis B virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006515","descriptor_name":"Hepatitis B virus","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D006521","descriptor_name":"Hepatitis, Chronic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0025-7125(16)30649-6","doi":"https://doi.org/10.1016/s0025-7125(16)30649-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0025-7125(16)30649-6","pdf_url":null,"source":{"id":"https://openalex.org/S33396077","display_name":"Medical Clinics of North America","issn_l":"0025-7125","issn":["0025-7125","1557-9859"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Clinics of North America","raw_type":"journal-article"},{"id":"pmid:2542706","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2542706","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Medical clinics of North America","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8899999856948853}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":75,"referenced_works":["https://openalex.org/W121205233","https://openalex.org/W159685084","https://openalex.org/W187398889","https://openalex.org/W314782195","https://openalex.org/W634821999","https://openalex.org/W1517671009","https://openalex.org/W1540837394","https://openalex.org/W1545092918","https://openalex.org/W1569235975","https://openalex.org/W1589671693","https://openalex.org/W1610910186","https://openalex.org/W1676199213","https://openalex.org/W1715102258","https://openalex.org/W1810538270","https://openalex.org/W1963709642","https://openalex.org/W1966547350","https://openalex.org/W1971902162","https://openalex.org/W1974841001","https://openalex.org/W1980865611","https://openalex.org/W1981463697","https://openalex.org/W1985071608","https://openalex.org/W2005757822","https://openalex.org/W2007706733","https://openalex.org/W2011844018","https://openalex.org/W2013054809","https://openalex.org/W2013248996","https://openalex.org/W2014977320","https://openalex.org/W2023116031","https://openalex.org/W2026347117","https://openalex.org/W2032696875","https://openalex.org/W2034356992","https://openalex.org/W2037468270","https://openalex.org/W2037903080","https://openalex.org/W2038181352","https://openalex.org/W2039113927","https://openalex.org/W2039627575","https://openalex.org/W2043183809","https://openalex.org/W2044828812","https://openalex.org/W2049343162","https://openalex.org/W2058629256","https://openalex.org/W2059402906","https://openalex.org/W2063719086","https://openalex.org/W2065412511","https://openalex.org/W2065446700","https://openalex.org/W2070110505","https://openalex.org/W2080485848","https://openalex.org/W2080570870","https://openalex.org/W2080778726","https://openalex.org/W2089552556","https://openalex.org/W2091830377","https://openalex.org/W2092823699","https://openalex.org/W2096808350","https://openalex.org/W2113519250","https://openalex.org/W2116355872","https://openalex.org/W2134316443","https://openalex.org/W2137529921","https://openalex.org/W2147946931","https://openalex.org/W2150001528","https://openalex.org/W2156477890","https://openalex.org/W2160801393","https://openalex.org/W2167120153","https://openalex.org/W2169690444","https://openalex.org/W2247704019","https://openalex.org/W2274218765","https://openalex.org/W2314218964","https://openalex.org/W2339907477","https://openalex.org/W2409793681","https://openalex.org/W2418151270","https://openalex.org/W2472542903","https://openalex.org/W2928347465","https://openalex.org/W3148219121","https://openalex.org/W4246892132","https://openalex.org/W4285719527","https://openalex.org/W4293873698","https://openalex.org/W6713929388"],"related_works":["https://openalex.org/W2369885713","https://openalex.org/W2079994391","https://openalex.org/W2002076753","https://openalex.org/W3101072197","https://openalex.org/W2892098484","https://openalex.org/W2029519104","https://openalex.org/W2045788853","https://openalex.org/W2071019693","https://openalex.org/W2197175733","https://openalex.org/W2904331741"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
