{"id":"https://openalex.org/W2320044489","doi":"https://doi.org/10.1158/1538-7445.am2013-3459","title":"Abstract 3459: Metabolomic profiling reveals significant differences between the ductal fluid from cancerous compared to unaffected breasts.","display_name":"Abstract 3459: Metabolomic profiling reveals significant differences between the ductal fluid from cancerous compared to unaffected breasts.","publication_year":2013,"publication_date":"2013-04-01","ids":{"openalex":"https://openalex.org/W2320044489","doi":"https://doi.org/10.1158/1538-7445.am2013-3459","mag":"2320044489"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2013-3459","doi":"https://doi.org/10.1158/1538-7445.am2013-3459","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2013-3459","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034298844","display_name":"Lu\u00edsa Matos do Canto","orcid":"https://orcid.org/0000-0001-9095-9431","observed_orcids":["https://orcid.org/0000-0001-9095-9431"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luisa Matos do Canto","raw_affiliation_strings":["Georgetown University, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georgetown University, Washington, DC","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081557050","display_name":"Shawna C. Willey","orcid":"https://orcid.org/0000-0002-7522-0556","observed_orcids":["https://orcid.org/0000-0002-7522-0556"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shawna C. Willey","raw_affiliation_strings":["Georgetown University, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georgetown University, Washington, DC","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002205441","display_name":"Elizabeth D. Feldman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth D. Feldman","raw_affiliation_strings":["Georgetown University, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georgetown University, Washington, DC","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003800447","display_name":"Amrita K. Cheema","orcid":"https://orcid.org/0000-0003-4877-7583","observed_orcids":["https://orcid.org/0000-0003-4877-7583"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amrita Cheema","raw_affiliation_strings":["Georgetown University, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georgetown University, Washington, DC","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080112958","display_name":"Mohammad Ranjbar","orcid":"https://orcid.org/0000-0002-8402-7942","observed_orcids":["https://orcid.org/0000-0002-8402-7942"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohammad R. Nezami Ranjbar","raw_affiliation_strings":["Georgetown University, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georgetown University, Washington, DC","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025125310","display_name":"Habtom W. Ressom","orcid":"https://orcid.org/0000-0001-9296-2132","observed_orcids":["https://orcid.org/0000-0001-9296-2132"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Habtom W. Ressom","raw_affiliation_strings":["Georgetown University, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georgetown University, Washington, DC","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108491622","display_name":"Bassem R. Haddad","orcid":"https://orcid.org/0000-0003-2679-3371","observed_orcids":["https://orcid.org/0000-0003-2679-3371"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bassem R. Haddad","raw_affiliation_strings":["Georgetown University, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georgetown University, Washington, DC","institution_ids":["https://openalex.org/I184565670"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I184565670"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"73","issue":"8_Supplement","first_page":"3459","last_page":"3459"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11667","display_name":"Advanced Chemical Sensor Technologies","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8190000057220459},{"id":"https://openalex.org/keywords/ductal-lavage","display_name":"ductal lavage","score":0.921999990940094},{"id":"https://openalex.org/keywords/metabolic-profiling","display_name":"metabolite profiling","score":0.7749999761581421},{"id":"https://openalex.org/keywords/early-detection","display_name":"early detection","score":0.6819999814033508},{"id":"https://openalex.org/keywords/ductal-carcinoma-in-situ","display_name":"ductal carcinoma in situ","score":0.9539999961853027},{"id":"https://openalex.org/keywords/invasive-breast-cancer","display_name":"invasive breast cancer","score":0.9599999785423279},{"id":"https://openalex.org/keywords/noninvasive-biomarkers","display_name":"non-invasive biomarkers","score":0.7770000100135803}],"concepts":[{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.83510422706604},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7301698327064514},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5965492725372314},{"id":"https://openalex.org/C2780862961","wikidata":"https://www.wikidata.org/wiki/Q5311598","display_name":"Ductal carcinoma","level":4,"score":0.587316632270813},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.466489315032959},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.38039901852607727},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3412051200866699},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33829593658447266},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.19335567951202393},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1457744836807251}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2013-3459","doi":"https://doi.org/10.1158/1538-7445.am2013-3459","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2013-3459","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2531154626","https://openalex.org/W4232438204","https://openalex.org/W4280548444","https://openalex.org/W4385411419","https://openalex.org/W4396591809","https://openalex.org/W2593199338","https://openalex.org/W2965667766","https://openalex.org/W2072759523","https://openalex.org/W44151464","https://openalex.org/W4317881705"],"abstract_inverted_index":{"Abstract":[0],"Introduction:":[1],"There":[2],"is":[3,25,209,365],"significant":[4,240,294,377,437],"need":[5],"to":[6,10,50,56,123,214,236,389,446],"develop":[7,57,390],"new":[8],"methods":[9],"improve":[11,395],"breast":[12,22,77,99,137,145,373],"cancer":[13],"(BC)":[14],"screening":[15],"and":[16,102,119,138,172,202,229,245,327,337,352,381],"early":[17,37,61,396],"detection.":[18],"Metabolomic":[19,85,164,434],"analysis":[20,165,171,235,370],"of":[21,33,46,63,204,226,280,284,292,304,359,371,398,452,457],"ductal":[23,66,82,90,374,441],"fluid":[24,67,92,375,442],"an":[26,36,58,391],"exciting":[27],"opportunity":[28],"for":[29,60,182,192,197,250,287,362,408,461],"improving":[30],"the":[31,76,111,135,139,142,173,187,220,224,243,278,281,293,305,316,333,341,372,405,440,453,458],"detection":[32,62,397],"BC":[34],"at":[35],"stage.":[38],"We":[39,185,232,331],"hypothesize":[40],"that":[41,393],"differences":[42,334,378,385,438],"between":[43,242,335,379,439],"metabolomic":[44],"profiles":[45,86],"tumor":[47,244,338],"cells":[48,52],"compared":[49,445],"normal":[51,144,246,336,382],"can":[53,68],"be":[54,69,387],"used":[55,186,254,388],"assay":[59,392],"BC.":[64,399],"Breast":[65,104],"obtained":[70,94,309],"in":[71,89,110,177,223],"a":[72,159,402],"non-invasive":[73],"way":[74],"from":[75,95,114,134,141,219,404,443],"via":[78],"nipple":[79],"aspiration":[80],"or":[81],"lavage.":[83],"Approach:":[84],"were":[87,108,131,175,267,308],"evaluated":[88],"lavage":[91],"samples":[93,107,130,286,339],"54":[96],"patients":[97,115],"with":[98,116,239,263,296],"tumors":[100],"(DCIS":[101],"Invasive":[103],"Cancer).":[105],"The":[106],"collected":[109],"operating":[112],"room":[113],"unilateral":[117],"disease":[118],"confirmed":[120],"diagnosis,":[121],"prior":[122],"their":[124],"surgery.":[125],"For":[126],"each":[127,183,288],"patient,":[128],"two":[129],"obtained:":[132],"one":[133],"affected":[136],"other":[140],"contralateral":[143],"(control).":[146],"Each":[147],"patient":[148],"served":[149],"as":[150],"her":[151],"own":[152],"control.":[153],"Metabolite":[154,318],"extraction":[155,162],"was":[156,166,300],"performed":[157,167,233],"using":[158,168],"sequential":[160],"solvent":[161],"protocol.":[163],"UPLC-TOF":[169],"MS":[170],"data":[174],"acquired":[176],"duplicate":[178],"(two":[179],"technical":[180],"replicates)":[181],"sample.":[184],"XCMS":[188],"package":[189],"(Scripps":[190],"Center":[191],"Metabolomics,":[193],"La":[194],"Jolla,":[195],"CA)":[196],"peak":[198,200],"detection,":[199],"matching,":[201],"correction":[203],"retention":[205],"time":[206],"shift.":[207],"This":[208],"followed":[210],"by":[211,401],"ion":[212],"annotation":[213],"identify":[215,237],"derivative":[216],"ions":[217,238,262,295,307],"originating":[218],"same":[221],"compound":[222],"forms":[225],"adduct,":[227],"isotopes,":[228],"in-source":[230],"fragments.":[231],"statistical":[234,350],"difference":[241],"samples.":[247],"To":[248],"correct":[249],"multiple":[251],"testing,":[252],"we":[253,271,354],"q-values":[255],"based":[256,276],"on":[257,277,349],"Storey's":[258],"pFDR":[259],"method.":[260],"Significant":[261],"q-value":[264],"<":[265],"0.1":[266],"selected.":[268,301],"In":[269],"addition,":[270],"calculated":[272],"fold":[273],"change":[274],"(FC)":[275],"median":[279],"relative":[282],"intensity":[283],"tumor/normal":[285],"pair.":[289],"A":[290],"subset":[291],"|FC|":[297],">":[298],"1.5":[299],"Putative":[302],"identifications":[303],"selected":[306,355],"through":[310],"mass-based":[311],"search":[312],"against":[313],"four":[314],"databases:":[315],"Human":[317],"DataBase":[319],"(HMDB),":[320],"Metlin,":[321],"Madison":[322],"Metabolomics":[323],"Consortium":[324],"Database":[325],"(MMCD),":[326],"LIPID":[328],"MAPS.":[329],"Results:":[330],"analyzed":[332],"excluding":[340],"subjects":[342],"who":[343],"received":[344],"preoperative":[345],"treatment":[346],"(n=8).":[347],"Based":[348],"significance":[351],"FC,":[353],"39":[356],"ions.":[357],"Verification":[358],"putative":[360],"IDs":[361],"these":[363],"metabolites":[364],"underway.":[366],"Conclusion:":[367],"Our":[368],"metabolomics":[369],"reveals":[376,436],"cancerous":[380,444],"breasts.":[383,448],"These":[384],"may":[386,394],"Supported":[400],"Grant":[403],"Avon":[406],"Foundation":[407],"Women":[409],"Citation":[410],"Format:":[411],"Luisa":[412],"Matos":[413],"do":[414],"Canto,":[415],"Shawna":[416],"C.":[417],"Willey,":[418],"Elizabeth":[419],"D.":[420],"Feldman,":[421],"Amrita":[422],"Cheema,":[423],"Mohammad":[424],"R.":[425,432],"Nezami":[426],"Ranjbar,":[427],"Habtom":[428],"W.":[429],"Ressom,":[430],"Bassem":[431],"Haddad.":[433],"profiling":[435],"unaffected":[447],"[abstract].":[449],"In:":[450],"Proceedings":[451],"104th":[454],"Annual":[455],"Meeting":[456],"American":[459],"Association":[460],"Cancer":[462,472],"Research;":[463],"2013":[464],"Apr":[465],"6-10;":[466],"Washington,":[467],"DC.":[468],"Philadelphia":[469],"(PA):":[470],"AACR;":[471],"Res":[473],"2013;73(8":[474],"Suppl):Abstract":[475],"nr":[476],"3459.":[477],"doi:10.1158/1538-7445.AM2013-3459":[478]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}
