{"id":"https://openalex.org/W2319983854","doi":"https://doi.org/10.1097/shk.0000000000000155","title":"Toll-Like Receptor 4 Plays a Central Role in Cardiac Dysfunction During Trauma Hemorrhage Shock","display_name":"Toll-Like Receptor 4 Plays a Central Role in Cardiac Dysfunction During Trauma Hemorrhage Shock","publication_year":2014,"publication_date":"2014-02-25","ids":{"openalex":"https://openalex.org/W2319983854","doi":"https://doi.org/10.1097/shk.0000000000000155","mag":"2319983854","pmid":"https://pubmed.ncbi.nlm.nih.gov/24569510","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4057968"},"language":"en","primary_location":{"id":"doi:10.1097/shk.0000000000000155","doi":"https://doi.org/10.1097/shk.0000000000000155","is_oa":false,"landing_page_url":"https://doi.org/10.1097/shk.0000000000000155","pdf_url":null,"source":{"id":"https://openalex.org/S174819509","display_name":"Shock","issn_l":"1073-2322","issn":["1073-2322","1540-0514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Shock","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4057968","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100461924","display_name":"Xia Zhang","orcid":"https://orcid.org/0000-0002-7996-4843","observed_orcids":["https://orcid.org/0000-0002-7996-4843"]},"institutions":[{"id":"https://openalex.org/I119443389","display_name":"East Tennessee State University","ror":"https://ror.org/05rfqv493","country_code":"US","type":"education","lineage":["https://openalex.org/I119443389"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xia Zhang","raw_affiliation_strings":["Departments of *Surgery and \u2020Biometry and Medical Computing, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of *Surgery and \u2020Biometry and Medical Computing, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee","institution_ids":["https://openalex.org/I119443389"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100432081","display_name":"Lu Chen","orcid":"https://orcid.org/0000-0002-3797-3872","observed_orcids":["https://orcid.org/0000-0002-3797-3872"]},"institutions":[{"id":"https://openalex.org/I119443389","display_name":"East Tennessee State University","ror":"https://ror.org/05rfqv493","country_code":"US","type":"education","lineage":["https://openalex.org/I119443389"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chen Lu","raw_affiliation_strings":["Departments of Surgery, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN, 37614-0575"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Surgery, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN, 37614-0575","institution_ids":["https://openalex.org/I119443389"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048376353","display_name":"Ming Gao","orcid":"https://orcid.org/0000-0003-1626-4580","observed_orcids":["https://orcid.org/0000-0003-1626-4580"]},"institutions":[{"id":"https://openalex.org/I119443389","display_name":"East Tennessee State University","ror":"https://ror.org/05rfqv493","country_code":"US","type":"education","lineage":["https://openalex.org/I119443389"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ming Gao","raw_affiliation_strings":["Departments of Surgery, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN, 37614-0575"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Surgery, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN, 37614-0575","institution_ids":["https://openalex.org/I119443389"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039861195","display_name":"Xin-Yun Cao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119443389","display_name":"East Tennessee State University","ror":"https://ror.org/05rfqv493","country_code":"US","type":"education","lineage":["https://openalex.org/I119443389"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xinyun Cao","raw_affiliation_strings":["Departments of Surgery, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN, 37614-0575"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Surgery, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN, 37614-0575","institution_ids":["https://openalex.org/I119443389"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028927398","display_name":"Tuanzhu Ha","orcid":"https://orcid.org/0000-0001-8244-4585","observed_orcids":["https://orcid.org/0000-0001-8244-4585"]},"institutions":[{"id":"https://openalex.org/I119443389","display_name":"East Tennessee State University","ror":"https://ror.org/05rfqv493","country_code":"US","type":"education","lineage":["https://openalex.org/I119443389"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tuanzhu Ha","raw_affiliation_strings":["Departments of Surgery, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN, 37614-0575"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Surgery, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN, 37614-0575","institution_ids":["https://openalex.org/I119443389"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113501842","display_name":"John H. Kalbfleisch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119443389","display_name":"East Tennessee State University","ror":"https://ror.org/05rfqv493","country_code":"US","type":"education","lineage":["https://openalex.org/I119443389"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John H. Kalbfleisch","raw_affiliation_strings":["Biometry and Medical Computing, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biometry and Medical Computing, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee","institution_ids":["https://openalex.org/I119443389"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033677559","display_name":"David L. Williams","orcid":"https://orcid.org/0000-0002-4586-9290","observed_orcids":["https://orcid.org/0000-0002-4586-9290"]},"institutions":[{"id":"https://openalex.org/I119443389","display_name":"East Tennessee State University","ror":"https://ror.org/05rfqv493","country_code":"US","type":"education","lineage":["https://openalex.org/I119443389"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David L. Williams","raw_affiliation_strings":["Departments of Surgery, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN, 37614-0575"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Surgery, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN, 37614-0575","institution_ids":["https://openalex.org/I119443389"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058503442","display_name":"Chuanfu Li","orcid":"https://orcid.org/0000-0002-3023-9755","observed_orcids":["https://orcid.org/0000-0002-3023-9755"]},"institutions":[{"id":"https://openalex.org/I119443389","display_name":"East Tennessee State University","ror":"https://ror.org/05rfqv493","country_code":"US","type":"education","lineage":["https://openalex.org/I119443389"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chuanfu Li","raw_affiliation_strings":["Departments of Surgery, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN, 37614-0575"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Surgery, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN, 37614-0575","institution_ids":["https://openalex.org/I119443389"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113733163","display_name":"Race L. Kao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119443389","display_name":"East Tennessee State University","ror":"https://ror.org/05rfqv493","country_code":"US","type":"education","lineage":["https://openalex.org/I119443389"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Race L. Kao","raw_affiliation_strings":["Address reprint requests to Race L. Kao, PhD, Department of Surgery, PO Box 70575, J. H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614. E-mail: [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Address reprint requests to Race L. Kao, PhD, Department of Surgery, PO Box 70575, J. H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614. E-mail: [email\u00a0protected]","institution_ids":["https://openalex.org/I119443389"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5028927398","https://openalex.org/A5033677559","https://openalex.org/A5039861195","https://openalex.org/A5048376353","https://openalex.org/A5058503442","https://openalex.org/A5100432081","https://openalex.org/A5100461924","https://openalex.org/A5113733163"],"corresponding_institution_ids":["https://openalex.org/I119443389"],"apc_list":null,"apc_paid":null,"fwci":0.8451,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.71914376,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"42","issue":"1","first_page":"31","last_page":"37"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.5360999703407288,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.5360999703407288,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.4043000042438507,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.019099999219179153,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cardiac-dysfunction","display_name":"cardiac dysfunction","score":0.9610000252723694},{"id":"https://openalex.org/keywords/tlr4-antagonist","display_name":"TLR4 antagonist","score":0.8100000023841858},{"id":"https://openalex.org/keywords/phosphoinositide-3-kinase-akt-signaling","display_name":"phosphatidylinositol 3-kinase/Akt signaling","score":0.9559999704360962},{"id":"https://openalex.org/keywords/nf-kappab-activation","display_name":"NF-\u03baB activation","score":0.7749999761581421},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8949999809265137},{"id":"https://openalex.org/keywords/myeloperoxidase","display_name":"myeloperoxidase","score":0.972000002861023},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.6340000033378601},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.7179999947547913},{"id":"https://openalex.org/keywords/myocardial-function","display_name":"myocardial function","score":0.4519999921321869}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7151457071304321},{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.7085902094841003},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.573824405670166},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4606729745864868},{"id":"https://openalex.org/C2781300812","wikidata":"https://www.wikidata.org/wiki/Q178061","display_name":"Shock (circulatory)","level":2,"score":0.4456261396408081},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.440030038356781},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4282950460910797},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.28638046979904175}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008050","descriptor_name":"Lipid A","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D008050","descriptor_name":"Lipid A","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012771","descriptor_name":"Shock, Hemorrhagic","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D012771","descriptor_name":"Shock, Hemorrhagic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012771","descriptor_name":"Shock, Hemorrhagic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017695","descriptor_name":"Soft Tissue Injuries","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020556","descriptor_name":"Neutrophil Infiltration","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020556","descriptor_name":"Neutrophil Infiltration","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1097/shk.0000000000000155","doi":"https://doi.org/10.1097/shk.0000000000000155","is_oa":false,"landing_page_url":"https://doi.org/10.1097/shk.0000000000000155","pdf_url":null,"source":{"id":"https://openalex.org/S174819509","display_name":"Shock","issn_l":"1073-2322","issn":["1073-2322","1540-0514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Shock","raw_type":"journal-article"},{"id":"pmid:24569510","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24569510","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Shock (Augusta, Ga.)","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3445735","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4057968","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4057968","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4057968","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Shock","raw_type":"Text"},{"id":"pmh:oai:dc.etsu.edu:etsu-works-17009","doi":null,"is_oa":false,"landing_page_url":"https://dc.etsu.edu/etsu-works/15743","pdf_url":null,"source":{"id":"https://openalex.org/S4377196424","display_name":"Digital Commons - East Tennessee State University (East Tennessee State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I119443389","host_organization_name":"East Tennessee State University","host_organization_lineage":["https://openalex.org/I119443389"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ETSU Faculty Works","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3445735","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4057968","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3702555361","display_name":"Amelioration of Sepsis by Macrophage Activation","funder_award_id":"R01GM053522","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3844563540","display_name":"Role of Toll-Like Receptor Signaling in Cardiac Ischemia","funder_award_id":"R01HL071837","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4092167702","display_name":"Innate Immunity in Trauma Hemorrhage","funder_award_id":"R15GM093878","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G94186973","display_name":"Innate Immunity and Cardiovascular Function in Sepsis","funder_award_id":"R01GM083016","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W185902258","https://openalex.org/W1902812581","https://openalex.org/W1965594477","https://openalex.org/W1979209535","https://openalex.org/W1985454477","https://openalex.org/W1994197895","https://openalex.org/W1999333729","https://openalex.org/W2000889366","https://openalex.org/W2012217217","https://openalex.org/W2023810559","https://openalex.org/W2028882937","https://openalex.org/W2049197565","https://openalex.org/W2055094488","https://openalex.org/W2057051316","https://openalex.org/W2059829735","https://openalex.org/W2070732456","https://openalex.org/W2076122670","https://openalex.org/W2080503511","https://openalex.org/W2088227226","https://openalex.org/W2097767970","https://openalex.org/W2100476936","https://openalex.org/W2111260918","https://openalex.org/W2114041096","https://openalex.org/W2130655121","https://openalex.org/W2131126547","https://openalex.org/W2132136466","https://openalex.org/W2132647449","https://openalex.org/W2135050229","https://openalex.org/W2147140242","https://openalex.org/W2153794985","https://openalex.org/W2156563694","https://openalex.org/W2158533497","https://openalex.org/W2161681729","https://openalex.org/W2183290946","https://openalex.org/W2614832988"],"related_works":["https://openalex.org/W2051266478","https://openalex.org/W2054215464","https://openalex.org/W2033052999","https://openalex.org/W2360826293","https://openalex.org/W185902258","https://openalex.org/W4252260461","https://openalex.org/W2332433442","https://openalex.org/W2126472646","https://openalex.org/W2023810559","https://openalex.org/W2167636398"],"abstract_inverted_index":{"Cardiac":[0,99,131],"dysfunction":[1,41,53,232,269],"is":[2],"a":[3,31,90,108,152,216,257],"major":[4],"consequence":[5],"that":[6,19,75,169,213],"contributes":[7],"to":[8,73,89,157],"the":[9,35,47,86,180,240,263],"high":[10],"mortality":[11],"of":[12,38,49,94,151,182,189,239,267],"trauma-hemorrhage":[13],"(TH)":[14],"patients.":[15,272],"Recent":[16],"evidence":[17],"suggests":[18],"innate":[20],"immune":[21],"and":[22,63,82,101,113,204,244,259,265],"inflammatory":[23],"responses":[24],"mediated":[25],"by":[26,78],"Toll-like":[27,56,223,251],"receptors":[28],"(TLRs)":[29],"play":[30],"critical":[32],"role":[33,48,218],"in":[34,51,133,147,179,184,219,246,270],"pathophysiologic":[36],"mechanisms":[37],"acute":[39],"organ":[40],"during":[42],"TH.":[43,55,140],"This":[44],"study":[45],"investigated":[46],"TLR4":[50,153,173,190,214,228],"cardiac":[52,142,164,221,231,268],"following":[54,139,233],"receptor":[57,224,252],"4-deficient":[58],"(TLR4-/-,":[59],"n":[60,67,124,128],"=":[61,68,125,129],"7/group)":[62],"age-matched":[64],"wild-type":[65],"(WT,":[66,123],"8/group)":[69],"mice":[70,119,135,159],"were":[71,105],"subjected":[72],"TH":[74,271],"was":[76,136,144],"induced":[77],"soft":[79],"tissue":[80],"injury":[81],"blood":[83,115],"withdrawal":[84],"from":[85],"jugular":[87],"vein":[88],"mean":[91,102],"arterial":[92,103],"pressure":[93,104],"35":[95],"\u00b1":[96],"5":[97],"mmHg.":[98],"function":[100,132,143],"measured":[106],"with":[107],"Millar":[109],"system":[110],"before,":[111],"during,":[112],"after":[114],"withdrawal.":[116],"Sham":[117],"surgical-operated":[118],"served":[120],"as":[121,198,200],"control":[122],"9/group;":[126],"TLR4-/-,":[127],"10/group).":[130],"WT":[134,158],"significantly":[137,161],"reduced":[138],"However,":[141],"well":[145,199],"preserved":[146],"TLR4-/-":[148,171],"mice.":[149],"Administration":[150],"antagonist":[154,174],"(3":[155],"mg/kg)":[156],"also":[160],"attenuated":[162,176,191,230],"TH-induced":[163,177,192,220],"dysfunction.":[165,222],"Western":[166],"blot":[167],"showed":[168],"either":[170],"or":[172,227],"markedly":[175],"decreases":[178],"levels":[181],"phosphorylated-Akt":[183],"myocardium.":[185],"In":[186],"addition,":[187],"inhibition":[188,229],"myocardial":[193],"nuclear":[194,247],"factor":[195,207,248],"\u03baB-binding":[196,249],"activity":[197,203],"lung":[201],"myeloperoxidase":[202],"tumor":[205],"necrosis":[206],"\u03b1":[208],"production.":[209],"The":[210],"data":[211],"indicate":[212],"plays":[215],"central":[217],"4":[225,253],"deficiency":[226],"TH,":[234],"which":[235],"may":[236,255],"involve":[237],"activation":[238],"phosphoinositide":[241],"3-kinase/Akt":[242],"signaling":[243],"decrease":[245],"activity.":[250],"antagonism":[254],"be":[256],"new":[258],"novel":[260],"approach":[261],"for":[262],"treatment":[264],"management":[266]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
