{"id":"https://openalex.org/W2319958192","doi":"https://doi.org/10.1097/ccm.0b013e318211ff56","title":"Selective blockade of interleukin-6 trans-signaling improves survival in a murine polymicrobial sepsis model*","display_name":"Selective blockade of interleukin-6 trans-signaling improves survival in a murine polymicrobial sepsis model*","publication_year":2011,"publication_date":"2011-02-18","ids":{"openalex":"https://openalex.org/W2319958192","doi":"https://doi.org/10.1097/ccm.0b013e318211ff56","mag":"2319958192","pmid":"https://pubmed.ncbi.nlm.nih.gov/21336117"},"language":"en","primary_location":{"id":"doi:10.1097/ccm.0b013e318211ff56","doi":"https://doi.org/10.1097/ccm.0b013e318211ff56","is_oa":false,"landing_page_url":"https://doi.org/10.1097/ccm.0b013e318211ff56","pdf_url":null,"source":{"id":"https://openalex.org/S108732581","display_name":"Critical Care Medicine","issn_l":"0090-3493","issn":["0090-3493","1530-0293"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046281005","display_name":"Tanja Barkhausen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32021983","display_name":"Christian-Albrechts-Universit\u00e4t zu Kiel","ror":"https://ror.org/04v76ef78","country_code":"DE","type":"education","lineage":["https://openalex.org/I32021983"]},{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]},{"id":"https://openalex.org/I4210096363","display_name":"Ludwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA","ror":"https://ror.org/00a8zdv13","country_code":"AT","type":"facility","lineage":["https://openalex.org/I2799334681","https://openalex.org/I4210096363"]},{"id":"https://openalex.org/I4210105421","display_name":"Conaris","ror":"https://ror.org/01j9kqj67","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210105421"]},{"id":"https://openalex.org/I4387154999","display_name":"Cluster of Excellence \"Inflammation at Interfaces\"","ror":"https://ror.org/00ygmry26","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I315704651","https://openalex.org/I32021983","https://openalex.org/I4210112713","https://openalex.org/I4210128097","https://openalex.org/I4210152351","https://openalex.org/I4387154999","https://openalex.org/I9341345"]},{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]},{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["AT","DE"],"is_corresponding":false,"raw_author_name":"Tanja Barkhausen","raw_affiliation_strings":["Trauma Department, Hannover Medical School, Hannover, Germany","CONARIS Research Institute AG (DS, GHW), Kiel, Germany","Dr. Rose-John has stock ownership in CONARIS Research Institute AG and is an inventor on patents owned by CONARIS. Dr. Seegert and Dr. Waetzig are employed by CONARIS Research Institute AG and are inventors on patents owned by CONARIS. The remaining authors have not disclosed any potential conflicts of interest","For information regarding this article, E-mail: [email\u00a0protected]","From the Trauma Department (TB, CK), Institute for Medical Microbiology and Hospital Epidemiology (RPV), Central Animal Laboratory (MD), and Institute of Biometry (AMH), Hannover Medical School, Hannover, Germany","Institute of Biochemistry and Molecular Biology II (JS), University of D\u00fcsseldorf, D\u00fcsseldorf, Germany","Institutes of Clinical Molecular Biology (PR) and Biochemistry (AC, SRJ), University of Kiel, Kiel, Germany","Ludwig Boltzmann Institute for Experimental and Clinical Traumatology (MvG), Vienna, Austria","Saarland University Hospital (TT), Homburg/Saar, Germany","Supported, in part, by the German Excellence Initiative (Excellence Cluster \u201cInflammation at Interfaces\u201d)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Trauma Department, Hannover Medical School, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]},{"raw_affiliation_string":"CONARIS Research Institute AG (DS, GHW), Kiel, Germany","institution_ids":["https://openalex.org/I4210105421"]},{"raw_affiliation_string":"Dr. Rose-John has stock ownership in CONARIS Research Institute AG and is an inventor on patents owned by CONARIS. Dr. Seegert and Dr. Waetzig are employed by CONARIS Research Institute AG and are inventors on patents owned by CONARIS. The remaining authors have not disclosed any potential conflicts of interest","institution_ids":["https://openalex.org/I4210105421"]},{"raw_affiliation_string":"For information regarding this article, E-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"From the Trauma Department (TB, CK), Institute for Medical Microbiology and Hospital Epidemiology (RPV), Central Animal Laboratory (MD), and Institute of Biometry (AMH), Hannover Medical School, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]},{"raw_affiliation_string":"Institute of Biochemistry and Molecular Biology II (JS), University of D\u00fcsseldorf, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"Institutes of Clinical Molecular Biology (PR) and Biochemistry (AC, SRJ), University of Kiel, Kiel, Germany","institution_ids":["https://openalex.org/I32021983"]},{"raw_affiliation_string":"Ludwig Boltzmann Institute for Experimental and Clinical Traumatology (MvG), Vienna, Austria","institution_ids":["https://openalex.org/I4210096363"]},{"raw_affiliation_string":"Saarland University Hospital (TT), Homburg/Saar, Germany","institution_ids":["https://openalex.org/I91712215"]},{"raw_affiliation_string":"Supported, in part, by the German Excellence Initiative (Excellence Cluster \u201cInflammation at Interfaces\u201d)","institution_ids":["https://openalex.org/I4387154999"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007653727","display_name":"Thomas Tschernig","orcid":"https://orcid.org/0000-0002-7788-1796","observed_orcids":["https://orcid.org/0000-0002-7788-1796"]},"institutions":[{"id":"https://openalex.org/I32021983","display_name":"Christian-Albrechts-Universit\u00e4t zu Kiel","ror":"https://ror.org/04v76ef78","country_code":"DE","type":"education","lineage":["https://openalex.org/I32021983"]},{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]},{"id":"https://openalex.org/I4210096363","display_name":"Ludwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA","ror":"https://ror.org/00a8zdv13","country_code":"AT","type":"facility","lineage":["https://openalex.org/I2799334681","https://openalex.org/I4210096363"]},{"id":"https://openalex.org/I4210105421","display_name":"Conaris","ror":"https://ror.org/01j9kqj67","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210105421"]},{"id":"https://openalex.org/I4387154999","display_name":"Cluster of Excellence \"Inflammation at Interfaces\"","ror":"https://ror.org/00ygmry26","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I315704651","https://openalex.org/I32021983","https://openalex.org/I4210112713","https://openalex.org/I4210128097","https://openalex.org/I4210152351","https://openalex.org/I4387154999","https://openalex.org/I9341345"]},{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]},{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["AT","DE"],"is_corresponding":false,"raw_author_name":"Thomas Tschernig","raw_affiliation_strings":["CONARIS Research Institute AG (DS, GHW), Kiel, Germany","Dr. Rose-John has stock ownership in CONARIS Research Institute AG and is an inventor on patents owned by CONARIS. Dr. Seegert and Dr. Waetzig are employed by CONARIS Research Institute AG and are inventors on patents owned by CONARIS. The remaining authors have not disclosed any potential conflicts of interest","For information regarding this article, E-mail: [email\u00a0protected]","From the Trauma Department (TB, CK), Institute for Medical Microbiology and Hospital Epidemiology (RPV), Central Animal Laboratory (MD), and Institute of Biometry (AMH), Hannover Medical School, Hannover, Germany","Institute of Biochemistry and Molecular Biology II (JS), University of D\u00fcsseldorf, D\u00fcsseldorf, Germany","Institutes of Clinical Molecular Biology (PR) and Biochemistry (AC, SRJ), University of Kiel, Kiel, Germany","Ludwig Boltzmann Institute for Experimental and Clinical Traumatology (MvG), Vienna, Austria","Saarland University Hospital (TT), Homburg/Saar, Germany","Supported, in part, by the German Excellence Initiative (Excellence Cluster \u201cInflammation at Interfaces\u201d)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CONARIS Research Institute AG (DS, GHW), Kiel, Germany","institution_ids":["https://openalex.org/I4210105421"]},{"raw_affiliation_string":"Dr. Rose-John has stock ownership in CONARIS Research Institute AG and is an inventor on patents owned by CONARIS. Dr. Seegert and Dr. Waetzig are employed by CONARIS Research Institute AG and are inventors on patents owned by CONARIS. The remaining authors have not disclosed any potential conflicts of interest","institution_ids":["https://openalex.org/I4210105421"]},{"raw_affiliation_string":"For information regarding this article, E-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"From the Trauma Department (TB, CK), Institute for Medical Microbiology and Hospital Epidemiology (RPV), Central Animal Laboratory (MD), and Institute of Biometry (AMH), Hannover Medical School, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]},{"raw_affiliation_string":"Institute of Biochemistry and Molecular Biology II (JS), University of D\u00fcsseldorf, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"Institutes of Clinical Molecular Biology (PR) and Biochemistry (AC, SRJ), University of Kiel, Kiel, Germany","institution_ids":["https://openalex.org/I32021983"]},{"raw_affiliation_string":"Ludwig Boltzmann Institute for Experimental and Clinical Traumatology (MvG), Vienna, Austria","institution_ids":["https://openalex.org/I4210096363"]},{"raw_affiliation_string":"Saarland University Hospital (TT), Homburg/Saar, Germany","institution_ids":["https://openalex.org/I91712215"]},{"raw_affiliation_string":"Supported, in part, by the German Excellence Initiative (Excellence Cluster \u201cInflammation at Interfaces\u201d)","institution_ids":["https://openalex.org/I4387154999"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054564152","display_name":"Philip C Rosenstiel","orcid":"https://orcid.org/0000-0002-9692-8828","observed_orcids":["https://orcid.org/0000-0002-9692-8828"]},"institutions":[{"id":"https://openalex.org/I32021983","display_name":"Christian-Albrechts-Universit\u00e4t zu Kiel","ror":"https://ror.org/04v76ef78","country_code":"DE","type":"education","lineage":["https://openalex.org/I32021983"]},{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]},{"id":"https://openalex.org/I4210096363","display_name":"Ludwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA","ror":"https://ror.org/00a8zdv13","country_code":"AT","type":"facility","lineage":["https://openalex.org/I2799334681","https://openalex.org/I4210096363"]},{"id":"https://openalex.org/I4210105421","display_name":"Conaris","ror":"https://ror.org/01j9kqj67","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210105421"]},{"id":"https://openalex.org/I4387154999","display_name":"Cluster of Excellence \"Inflammation at Interfaces\"","ror":"https://ror.org/00ygmry26","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I315704651","https://openalex.org/I32021983","https://openalex.org/I4210112713","https://openalex.org/I4210128097","https://openalex.org/I4210152351","https://openalex.org/I4387154999","https://openalex.org/I9341345"]},{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]},{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["AT","DE"],"is_corresponding":false,"raw_author_name":"Philip Rosenstiel","raw_affiliation_strings":["CONARIS Research Institute AG (DS, GHW), Kiel, Germany","Dr. Rose-John has stock ownership in CONARIS Research Institute AG and is an inventor on patents owned by CONARIS. Dr. Seegert and Dr. Waetzig are employed by CONARIS Research Institute AG and are inventors on patents owned by CONARIS. The remaining authors have not disclosed any potential conflicts of interest","For information regarding this article, E-mail: [email\u00a0protected]","From the Trauma Department (TB, CK), Institute for Medical Microbiology and Hospital Epidemiology (RPV), Central Animal Laboratory (MD), and Institute of Biometry (AMH), Hannover Medical School, Hannover, Germany","Institute of Biochemistry and Molecular Biology II (JS), University of D\u00fcsseldorf, D\u00fcsseldorf, Germany","Institutes of Clinical Molecular Biology (PR) and Biochemistry (AC, SRJ), University of Kiel, Kiel, Germany","Ludwig Boltzmann Institute for Experimental and Clinical Traumatology (MvG), Vienna, Austria","Saarland University Hospital (TT), Homburg/Saar, Germany","Supported, in part, by the German Excellence Initiative (Excellence Cluster \u201cInflammation at Interfaces\u201d)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CONARIS Research Institute AG (DS, GHW), Kiel, Germany","institution_ids":["https://openalex.org/I4210105421"]},{"raw_affiliation_string":"Dr. Rose-John has stock ownership in CONARIS Research Institute AG and is an inventor on patents owned by CONARIS. Dr. Seegert and Dr. Waetzig are employed by CONARIS Research Institute AG and are inventors on patents owned by CONARIS. The remaining authors have not disclosed any potential conflicts of interest","institution_ids":["https://openalex.org/I4210105421"]},{"raw_affiliation_string":"For information regarding this article, E-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"From the Trauma Department (TB, CK), Institute for Medical Microbiology and Hospital Epidemiology (RPV), Central Animal Laboratory (MD), and Institute of Biometry (AMH), Hannover Medical School, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]},{"raw_affiliation_string":"Institute of Biochemistry and Molecular Biology II (JS), University of D\u00fcsseldorf, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"Institutes of Clinical Molecular Biology (PR) and Biochemistry (AC, SRJ), University of Kiel, Kiel, Germany","institution_ids":["https://openalex.org/I32021983"]},{"raw_affiliation_string":"Ludwig Boltzmann Institute for Experimental and Clinical Traumatology (MvG), Vienna, Austria","institution_ids":["https://openalex.org/I4210096363"]},{"raw_affiliation_string":"Saarland University Hospital (TT), Homburg/Saar, Germany","institution_ids":["https://openalex.org/I91712215"]},{"raw_affiliation_string":"Supported, in part, by the German Excellence Initiative (Excellence Cluster \u201cInflammation at Interfaces\u201d)","institution_ids":["https://openalex.org/I4387154999"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039164555","display_name":"Martijn van Griensven","orcid":"https://orcid.org/0000-0001-5104-9881","observed_orcids":["https://orcid.org/0000-0001-5104-9881"]},"institutions":[{"id":"https://openalex.org/I32021983","display_name":"Christian-Albrechts-Universit\u00e4t zu Kiel","ror":"https://ror.org/04v76ef78","country_code":"DE","type":"education","lineage":["https://openalex.org/I32021983"]},{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]},{"id":"https://openalex.org/I4210096363","display_name":"Ludwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA","ror":"https://ror.org/00a8zdv13","country_code":"AT","type":"facility","lineage":["https://openalex.org/I2799334681","https://openalex.org/I4210096363"]},{"id":"https://openalex.org/I4210105421","display_name":"Conaris","ror":"https://ror.org/01j9kqj67","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210105421"]},{"id":"https://openalex.org/I4387154999","display_name":"Cluster of Excellence \"Inflammation at Interfaces\"","ror":"https://ror.org/00ygmry26","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I315704651","https://openalex.org/I32021983","https://openalex.org/I4210112713","https://openalex.org/I4210128097","https://openalex.org/I4210152351","https://openalex.org/I4387154999","https://openalex.org/I9341345"]},{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]},{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["AT","DE"],"is_corresponding":false,"raw_author_name":"Martijn van Griensven","raw_affiliation_strings":["CONARIS Research Institute AG (DS, GHW), Kiel, Germany","Dr. Rose-John has stock ownership in CONARIS Research Institute AG and is an inventor on patents owned by CONARIS. Dr. Seegert and Dr. Waetzig are employed by CONARIS Research Institute AG and are inventors on patents owned by CONARIS. The remaining authors have not disclosed any potential conflicts of interest","For information regarding this article, E-mail: [email\u00a0protected]","From the Trauma Department (TB, CK), Institute for Medical Microbiology and Hospital Epidemiology (RPV), Central Animal Laboratory (MD), and Institute of Biometry (AMH), Hannover Medical School, Hannover, Germany","Institute of Biochemistry and Molecular Biology II (JS), University of D\u00fcsseldorf, D\u00fcsseldorf, Germany","Institutes of Clinical Molecular Biology (PR) and Biochemistry (AC, SRJ), University of Kiel, Kiel, Germany","Ludwig Boltzmann Institute for Experimental and Clinical Traumatology (MvG), Vienna, Austria","Saarland University Hospital (TT), Homburg/Saar, Germany","Supported, in part, by the German Excellence Initiative (Excellence Cluster \u201cInflammation at Interfaces\u201d)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CONARIS Research Institute AG (DS, GHW), Kiel, Germany","institution_ids":["https://openalex.org/I4210105421"]},{"raw_affiliation_string":"Dr. Rose-John has stock ownership in CONARIS Research Institute AG and is an inventor on patents owned by CONARIS. Dr. Seegert and Dr. Waetzig are employed by CONARIS Research Institute AG and are inventors on patents owned by CONARIS. The remaining authors have not disclosed any potential conflicts of interest","institution_ids":["https://openalex.org/I4210105421"]},{"raw_affiliation_string":"For information regarding this article, E-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"From the Trauma Department (TB, CK), Institute for Medical Microbiology and Hospital Epidemiology (RPV), Central Animal Laboratory (MD), and Institute of Biometry (AMH), Hannover Medical School, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]},{"raw_affiliation_string":"Institute of Biochemistry and Molecular Biology II (JS), University of D\u00fcsseldorf, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"Institutes of Clinical Molecular Biology (PR) and Biochemistry (AC, SRJ), University of Kiel, Kiel, Germany","institution_ids":["https://openalex.org/I32021983"]},{"raw_affiliation_string":"Ludwig Boltzmann Institute for Experimental and Clinical Traumatology (MvG), Vienna, Austria","institution_ids":["https://openalex.org/I4210096363"]},{"raw_affiliation_string":"Saarland University Hospital (TT), Homburg/Saar, Germany","institution_ids":["https://openalex.org/I91712215"]},{"raw_affiliation_string":"Supported, in part, by the German Excellence Initiative (Excellence Cluster \u201cInflammation at Interfaces\u201d)","institution_ids":["https://openalex.org/I4387154999"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042682468","display_name":"Ralf\u2010Peter Vonberg","orcid":"https://orcid.org/0000-0001-7706-8511","observed_orcids":["https://orcid.org/0000-0001-7706-8511"]},"institutions":[{"id":"https://openalex.org/I32021983","display_name":"Christian-Albrechts-Universit\u00e4t zu Kiel","ror":"https://ror.org/04v76ef78","country_code":"DE","type":"education","lineage":["https://openalex.org/I32021983"]},{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]},{"id":"https://openalex.org/I4210096363","display_name":"Ludwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA","ror":"https://ror.org/00a8zdv13","country_code":"AT","type":"facility","lineage":["https://openalex.org/I2799334681","https://openalex.org/I4210096363"]},{"id":"https://openalex.org/I4210105421","display_name":"Conaris","ror":"https://ror.org/01j9kqj67","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210105421"]},{"id":"https://openalex.org/I4387154999","display_name":"Cluster of Excellence \"Inflammation at Interfaces\"","ror":"https://ror.org/00ygmry26","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I315704651","https://openalex.org/I32021983","https://openalex.org/I4210112713","https://openalex.org/I4210128097","https://openalex.org/I4210152351","https://openalex.org/I4387154999","https://openalex.org/I9341345"]},{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]},{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["AT","DE"],"is_corresponding":false,"raw_author_name":"Ralf-Peter Vonberg","raw_affiliation_strings":["CONARIS Research Institute AG (DS, GHW), Kiel, Germany","Dr. Rose-John has stock ownership in CONARIS Research Institute AG and is an inventor on patents owned by CONARIS. Dr. Seegert and Dr. Waetzig are employed by CONARIS Research Institute AG and are inventors on patents owned by CONARIS. The remaining authors have not disclosed any potential conflicts of interest","For information regarding this article, E-mail: [email\u00a0protected]","From the Trauma Department (TB, CK), Institute for Medical Microbiology and Hospital Epidemiology (RPV), Central Animal Laboratory (MD), and Institute of Biometry (AMH), Hannover Medical School, Hannover, Germany","Institute of Biochemistry and Molecular Biology II (JS), University of D\u00fcsseldorf, D\u00fcsseldorf, Germany","Institutes of Clinical Molecular Biology (PR) and Biochemistry (AC, SRJ), University of Kiel, Kiel, Germany","Ludwig Boltzmann Institute for Experimental and Clinical Traumatology (MvG), Vienna, Austria","Saarland University Hospital (TT), Homburg/Saar, Germany","Supported, in part, by the German Excellence Initiative (Excellence Cluster \u201cInflammation at Interfaces\u201d)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CONARIS Research Institute AG (DS, GHW), Kiel, Germany","institution_ids":["https://openalex.org/I4210105421"]},{"raw_affiliation_string":"Dr. Rose-John has stock ownership in CONARIS Research Institute AG and is an inventor on patents owned by CONARIS. Dr. Seegert and Dr. Waetzig are employed by CONARIS Research Institute AG and are inventors on patents owned by CONARIS. The remaining authors have not disclosed any potential conflicts of interest","institution_ids":["https://openalex.org/I4210105421"]},{"raw_affiliation_string":"For information regarding this article, E-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"From the Trauma Department (TB, CK), Institute for Medical Microbiology and Hospital Epidemiology (RPV), Central Animal Laboratory (MD), and Institute of Biometry (AMH), Hannover Medical School, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]},{"raw_affiliation_string":"Institute of Biochemistry and Molecular Biology II (JS), University of D\u00fcsseldorf, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"Institutes of Clinical Molecular Biology (PR) and Biochemistry (AC, SRJ), University of Kiel, Kiel, Germany","institution_ids":["https://openalex.org/I32021983"]},{"raw_affiliation_string":"Ludwig Boltzmann Institute for Experimental and Clinical Traumatology (MvG), Vienna, Austria","institution_ids":["https://openalex.org/I4210096363"]},{"raw_affiliation_string":"Saarland University Hospital (TT), Homburg/Saar, Germany","institution_ids":["https://openalex.org/I91712215"]},{"raw_affiliation_string":"Supported, in part, by the German Excellence Initiative (Excellence Cluster \u201cInflammation at Interfaces\u201d)","institution_ids":["https://openalex.org/I4387154999"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039050511","display_name":"Martina Maria Dorsch","orcid":"https://orcid.org/0000-0002-2435-0174","observed_orcids":["https://orcid.org/0000-0002-2435-0174"]},"institutions":[{"id":"https://openalex.org/I32021983","display_name":"Christian-Albrechts-Universit\u00e4t zu Kiel","ror":"https://ror.org/04v76ef78","country_code":"DE","type":"education","lineage":["https://openalex.org/I32021983"]},{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]},{"id":"https://openalex.org/I4210096363","display_name":"Ludwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA","ror":"https://ror.org/00a8zdv13","country_code":"AT","type":"facility","lineage":["https://openalex.org/I2799334681","https://openalex.org/I4210096363"]},{"id":"https://openalex.org/I4210105421","display_name":"Conaris","ror":"https://ror.org/01j9kqj67","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210105421"]},{"id":"https://openalex.org/I4387154999","display_name":"Cluster of Excellence \"Inflammation at Interfaces\"","ror":"https://ror.org/00ygmry26","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I315704651","https://openalex.org/I32021983","https://openalex.org/I4210112713","https://openalex.org/I4210128097","https://openalex.org/I4210152351","https://openalex.org/I4387154999","https://openalex.org/I9341345"]},{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]},{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["AT","DE"],"is_corresponding":false,"raw_author_name":"Martina Dorsch","raw_affiliation_strings":["CONARIS Research Institute AG (DS, GHW), Kiel, Germany","Dr. Rose-John has stock ownership in CONARIS Research Institute AG and is an inventor on patents owned by CONARIS. Dr. Seegert and Dr. Waetzig are employed by CONARIS Research Institute AG and are inventors on patents owned by CONARIS. The remaining authors have not disclosed any potential conflicts of interest","For information regarding this article, E-mail: [email\u00a0protected]","From the Trauma Department (TB, CK), Institute for Medical Microbiology and Hospital Epidemiology (RPV), Central Animal Laboratory (MD), and Institute of Biometry (AMH), Hannover Medical School, Hannover, Germany","Institute of Biochemistry and Molecular Biology II (JS), University of D\u00fcsseldorf, D\u00fcsseldorf, Germany","Institutes of Clinical Molecular Biology (PR) and Biochemistry (AC, SRJ), University of Kiel, Kiel, Germany","Ludwig Boltzmann Institute for Experimental and Clinical Traumatology (MvG), Vienna, Austria","Saarland University Hospital (TT), Homburg/Saar, Germany","Supported, in part, by the German Excellence Initiative (Excellence Cluster \u201cInflammation at Interfaces\u201d)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CONARIS Research Institute AG (DS, GHW), Kiel, Germany","institution_ids":["https://openalex.org/I4210105421"]},{"raw_affiliation_string":"Dr. Rose-John has stock ownership in CONARIS Research Institute AG and is an inventor on patents owned by CONARIS. Dr. Seegert and Dr. Waetzig are employed by CONARIS Research Institute AG and are inventors on patents owned by CONARIS. The remaining authors have not disclosed any potential conflicts of interest","institution_ids":["https://openalex.org/I4210105421"]},{"raw_affiliation_string":"For information regarding this article, E-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"From the Trauma Department (TB, CK), Institute for Medical Microbiology and Hospital Epidemiology (RPV), Central Animal Laboratory (MD), and Institute of Biometry (AMH), Hannover Medical School, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]},{"raw_affiliation_string":"Institute of Biochemistry and Molecular Biology II (JS), University of D\u00fcsseldorf, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"Institutes of Clinical Molecular Biology (PR) and Biochemistry (AC, SRJ), University of Kiel, Kiel, Germany","institution_ids":["https://openalex.org/I32021983"]},{"raw_affiliation_string":"Ludwig Boltzmann Institute for Experimental and Clinical Traumatology (MvG), Vienna, Austria","institution_ids":["https://openalex.org/I4210096363"]},{"raw_affiliation_string":"Saarland University Hospital (TT), Homburg/Saar, Germany","institution_ids":["https://openalex.org/I91712215"]},{"raw_affiliation_string":"Supported, in part, by the German Excellence Initiative (Excellence Cluster \u201cInflammation at Interfaces\u201d)","institution_ids":["https://openalex.org/I4387154999"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075606517","display_name":"Annika Mueller-Heine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32021983","display_name":"Christian-Albrechts-Universit\u00e4t zu Kiel","ror":"https://ror.org/04v76ef78","country_code":"DE","type":"education","lineage":["https://openalex.org/I32021983"]},{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]},{"id":"https://openalex.org/I4210096363","display_name":"Ludwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA","ror":"https://ror.org/00a8zdv13","country_code":"AT","type":"facility","lineage":["https://openalex.org/I2799334681","https://openalex.org/I4210096363"]},{"id":"https://openalex.org/I4210105421","display_name":"Conaris","ror":"https://ror.org/01j9kqj67","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210105421"]},{"id":"https://openalex.org/I4387154999","display_name":"Cluster of Excellence \"Inflammation at Interfaces\"","ror":"https://ror.org/00ygmry26","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I315704651","https://openalex.org/I32021983","https://openalex.org/I4210112713","https://openalex.org/I4210128097","https://openalex.org/I4210152351","https://openalex.org/I4387154999","https://openalex.org/I9341345"]},{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]},{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["AT","DE"],"is_corresponding":false,"raw_author_name":"Annika Mueller-Heine","raw_affiliation_strings":["CONARIS Research Institute AG (DS, GHW), Kiel, Germany","Dr. Rose-John has stock ownership in CONARIS Research Institute AG and is an inventor on patents owned by CONARIS. Dr. Seegert and Dr. Waetzig are employed by CONARIS Research Institute AG and are inventors on patents owned by CONARIS. The remaining authors have not disclosed any potential conflicts of interest","For information regarding this article, E-mail: [email\u00a0protected]","From the Trauma Department (TB, CK), Institute for Medical Microbiology and Hospital Epidemiology (RPV), Central Animal Laboratory (MD), and Institute of Biometry (AMH), Hannover Medical School, Hannover, Germany","Institute of Biochemistry and Molecular Biology II (JS), University of D\u00fcsseldorf, D\u00fcsseldorf, Germany","Institutes of Clinical Molecular Biology (PR) and Biochemistry (AC, SRJ), University of Kiel, Kiel, Germany","Ludwig Boltzmann Institute for Experimental and Clinical Traumatology (MvG), Vienna, Austria","Saarland University Hospital (TT), Homburg/Saar, Germany","Supported, in part, by the German Excellence Initiative (Excellence Cluster \u201cInflammation at Interfaces\u201d)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CONARIS Research Institute AG (DS, GHW), Kiel, Germany","institution_ids":["https://openalex.org/I4210105421"]},{"raw_affiliation_string":"Dr. Rose-John has stock ownership in CONARIS Research Institute AG and is an inventor on patents owned by CONARIS. Dr. Seegert and Dr. Waetzig are employed by CONARIS Research Institute AG and are inventors on patents owned by CONARIS. The remaining authors have not disclosed any potential conflicts of interest","institution_ids":["https://openalex.org/I4210105421"]},{"raw_affiliation_string":"For information regarding this article, E-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"From the Trauma Department (TB, CK), Institute for Medical Microbiology and Hospital Epidemiology (RPV), Central Animal Laboratory (MD), and Institute of Biometry (AMH), Hannover Medical School, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]},{"raw_affiliation_string":"Institute of Biochemistry and Molecular Biology II (JS), University of D\u00fcsseldorf, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"Institutes of Clinical Molecular Biology (PR) and Biochemistry (AC, SRJ), University of Kiel, Kiel, Germany","institution_ids":["https://openalex.org/I32021983"]},{"raw_affiliation_string":"Ludwig Boltzmann Institute for Experimental and Clinical Traumatology (MvG), Vienna, Austria","institution_ids":["https://openalex.org/I4210096363"]},{"raw_affiliation_string":"Saarland University Hospital (TT), Homburg/Saar, Germany","institution_ids":["https://openalex.org/I91712215"]},{"raw_affiliation_string":"Supported, in part, by the German Excellence Initiative (Excellence Cluster \u201cInflammation at Interfaces\u201d)","institution_ids":["https://openalex.org/I4387154999"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006634561","display_name":"Athena Chalaris","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32021983","display_name":"Christian-Albrechts-Universit\u00e4t zu Kiel","ror":"https://ror.org/04v76ef78","country_code":"DE","type":"education","lineage":["https://openalex.org/I32021983"]},{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]},{"id":"https://openalex.org/I4210096363","display_name":"Ludwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA","ror":"https://ror.org/00a8zdv13","country_code":"AT","type":"facility","lineage":["https://openalex.org/I2799334681","https://openalex.org/I4210096363"]},{"id":"https://openalex.org/I4210105421","display_name":"Conaris","ror":"https://ror.org/01j9kqj67","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210105421"]},{"id":"https://openalex.org/I4387154999","display_name":"Cluster of Excellence \"Inflammation at Interfaces\"","ror":"https://ror.org/00ygmry26","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I315704651","https://openalex.org/I32021983","https://openalex.org/I4210112713","https://openalex.org/I4210128097","https://openalex.org/I4210152351","https://openalex.org/I4387154999","https://openalex.org/I9341345"]},{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]},{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["AT","DE"],"is_corresponding":false,"raw_author_name":"Athena Chalaris","raw_affiliation_strings":["CONARIS Research Institute AG (DS, GHW), Kiel, Germany","Dr. Rose-John has stock ownership in CONARIS Research Institute AG and is an inventor on patents owned by CONARIS. Dr. Seegert and Dr. Waetzig are employed by CONARIS Research Institute AG and are inventors on patents owned by CONARIS. The remaining authors have not disclosed any potential conflicts of interest","For information regarding this article, E-mail: [email\u00a0protected]","From the Trauma Department (TB, CK), Institute for Medical Microbiology and Hospital Epidemiology (RPV), Central Animal Laboratory (MD), and Institute of Biometry (AMH), Hannover Medical School, Hannover, Germany","Institute of Biochemistry and Molecular Biology II (JS), University of D\u00fcsseldorf, D\u00fcsseldorf, Germany","Institutes of Clinical Molecular Biology (PR) and Biochemistry (AC, SRJ), University of Kiel, Kiel, Germany","Ludwig Boltzmann Institute for Experimental and Clinical Traumatology (MvG), Vienna, Austria","Saarland University Hospital (TT), Homburg/Saar, Germany","Supported, in part, by the German Excellence Initiative (Excellence Cluster \u201cInflammation at Interfaces\u201d)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CONARIS Research Institute AG (DS, GHW), Kiel, Germany","institution_ids":["https://openalex.org/I4210105421"]},{"raw_affiliation_string":"Dr. Rose-John has stock ownership in CONARIS Research Institute AG and is an inventor on patents owned by CONARIS. Dr. Seegert and Dr. Waetzig are employed by CONARIS Research Institute AG and are inventors on patents owned by CONARIS. The remaining authors have not disclosed any potential conflicts of interest","institution_ids":["https://openalex.org/I4210105421"]},{"raw_affiliation_string":"For information regarding this article, E-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"From the Trauma Department (TB, CK), Institute for Medical Microbiology and Hospital Epidemiology (RPV), Central Animal Laboratory (MD), and Institute of Biometry (AMH), Hannover Medical School, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]},{"raw_affiliation_string":"Institute of Biochemistry and Molecular Biology II (JS), University of D\u00fcsseldorf, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"Institutes of Clinical Molecular Biology (PR) and Biochemistry (AC, SRJ), University of Kiel, Kiel, Germany","institution_ids":["https://openalex.org/I32021983"]},{"raw_affiliation_string":"Ludwig Boltzmann Institute for Experimental and Clinical Traumatology (MvG), Vienna, Austria","institution_ids":["https://openalex.org/I4210096363"]},{"raw_affiliation_string":"Saarland University Hospital (TT), Homburg/Saar, Germany","institution_ids":["https://openalex.org/I91712215"]},{"raw_affiliation_string":"Supported, in part, by the German Excellence Initiative (Excellence Cluster \u201cInflammation at Interfaces\u201d)","institution_ids":["https://openalex.org/I4387154999"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088470216","display_name":"J\u00fcrgen Scheller","orcid":"https://orcid.org/0000-0001-9932-1055","observed_orcids":["https://orcid.org/0000-0001-9932-1055"]},"institutions":[{"id":"https://openalex.org/I32021983","display_name":"Christian-Albrechts-Universit\u00e4t zu Kiel","ror":"https://ror.org/04v76ef78","country_code":"DE","type":"education","lineage":["https://openalex.org/I32021983"]},{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]},{"id":"https://openalex.org/I4210096363","display_name":"Ludwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA","ror":"https://ror.org/00a8zdv13","country_code":"AT","type":"facility","lineage":["https://openalex.org/I2799334681","https://openalex.org/I4210096363"]},{"id":"https://openalex.org/I4210105421","display_name":"Conaris","ror":"https://ror.org/01j9kqj67","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210105421"]},{"id":"https://openalex.org/I4387154999","display_name":"Cluster of Excellence \"Inflammation at Interfaces\"","ror":"https://ror.org/00ygmry26","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I315704651","https://openalex.org/I32021983","https://openalex.org/I4210112713","https://openalex.org/I4210128097","https://openalex.org/I4210152351","https://openalex.org/I4387154999","https://openalex.org/I9341345"]},{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]},{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["AT","DE"],"is_corresponding":false,"raw_author_name":"J\u00fcrgen Scheller","raw_affiliation_strings":["CONARIS Research Institute AG (DS, GHW), Kiel, Germany","Dr. Rose-John has stock ownership in CONARIS Research Institute AG and is an inventor on patents owned by CONARIS. Dr. Seegert and Dr. Waetzig are employed by CONARIS Research Institute AG and are inventors on patents owned by CONARIS. The remaining authors have not disclosed any potential conflicts of interest","For information regarding this article, E-mail: [email\u00a0protected]","From the Trauma Department (TB, CK), Institute for Medical Microbiology and Hospital Epidemiology (RPV), Central Animal Laboratory (MD), and Institute of Biometry (AMH), Hannover Medical School, Hannover, Germany","Institute of Biochemistry and Molecular Biology II (JS), University of D\u00fcsseldorf, D\u00fcsseldorf, Germany","Institutes of Clinical Molecular Biology (PR) and Biochemistry (AC, SRJ), University of Kiel, Kiel, Germany","Ludwig Boltzmann Institute for Experimental and Clinical Traumatology (MvG), Vienna, Austria","Saarland University Hospital (TT), Homburg/Saar, Germany","Supported, in part, by the German Excellence Initiative (Excellence Cluster \u201cInflammation at Interfaces\u201d)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CONARIS Research Institute AG (DS, GHW), Kiel, Germany","institution_ids":["https://openalex.org/I4210105421"]},{"raw_affiliation_string":"Dr. Rose-John has stock ownership in CONARIS Research Institute AG and is an inventor on patents owned by CONARIS. Dr. Seegert and Dr. Waetzig are employed by CONARIS Research Institute AG and are inventors on patents owned by CONARIS. The remaining authors have not disclosed any potential conflicts of interest","institution_ids":["https://openalex.org/I4210105421"]},{"raw_affiliation_string":"For information regarding this article, E-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"From the Trauma Department (TB, CK), Institute for Medical Microbiology and Hospital Epidemiology (RPV), Central Animal Laboratory (MD), and Institute of Biometry (AMH), Hannover Medical School, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]},{"raw_affiliation_string":"Institute of Biochemistry and Molecular Biology II (JS), University of D\u00fcsseldorf, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"Institutes of Clinical Molecular Biology (PR) and Biochemistry (AC, SRJ), University of Kiel, Kiel, Germany","institution_ids":["https://openalex.org/I32021983"]},{"raw_affiliation_string":"Ludwig Boltzmann Institute for Experimental and Clinical Traumatology (MvG), Vienna, Austria","institution_ids":["https://openalex.org/I4210096363"]},{"raw_affiliation_string":"Saarland University Hospital (TT), Homburg/Saar, Germany","institution_ids":["https://openalex.org/I91712215"]},{"raw_affiliation_string":"Supported, in part, by the German Excellence Initiative (Excellence Cluster \u201cInflammation at Interfaces\u201d)","institution_ids":["https://openalex.org/I4387154999"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089057275","display_name":"Stefan Rose\u2010John","orcid":"https://orcid.org/0000-0002-7519-3279","observed_orcids":["https://orcid.org/0000-0002-7519-3279"]},"institutions":[{"id":"https://openalex.org/I32021983","display_name":"Christian-Albrechts-Universit\u00e4t zu Kiel","ror":"https://ror.org/04v76ef78","country_code":"DE","type":"education","lineage":["https://openalex.org/I32021983"]},{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]},{"id":"https://openalex.org/I4210096363","display_name":"Ludwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA","ror":"https://ror.org/00a8zdv13","country_code":"AT","type":"facility","lineage":["https://openalex.org/I2799334681","https://openalex.org/I4210096363"]},{"id":"https://openalex.org/I4210105421","display_name":"Conaris","ror":"https://ror.org/01j9kqj67","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210105421"]},{"id":"https://openalex.org/I4387154999","display_name":"Cluster of Excellence \"Inflammation at Interfaces\"","ror":"https://ror.org/00ygmry26","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I315704651","https://openalex.org/I32021983","https://openalex.org/I4210112713","https://openalex.org/I4210128097","https://openalex.org/I4210152351","https://openalex.org/I4387154999","https://openalex.org/I9341345"]},{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]},{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["AT","DE"],"is_corresponding":false,"raw_author_name":"Stefan Rose-John","raw_affiliation_strings":["CONARIS Research Institute AG (DS, GHW), Kiel, Germany","Dr. Rose-John has stock ownership in CONARIS Research Institute AG and is an inventor on patents owned by CONARIS. Dr. Seegert and Dr. Waetzig are employed by CONARIS Research Institute AG and are inventors on patents owned by CONARIS. The remaining authors have not disclosed any potential conflicts of interest","For information regarding this article, E-mail: [email\u00a0protected]","From the Trauma Department (TB, CK), Institute for Medical Microbiology and Hospital Epidemiology (RPV), Central Animal Laboratory (MD), and Institute of Biometry (AMH), Hannover Medical School, Hannover, Germany","Institute of Biochemistry and Molecular Biology II (JS), University of D\u00fcsseldorf, D\u00fcsseldorf, Germany","Institutes of Clinical Molecular Biology (PR) and Biochemistry (AC, SRJ), University of Kiel, Kiel, Germany","Ludwig Boltzmann Institute for Experimental and Clinical Traumatology (MvG), Vienna, Austria","Saarland University Hospital (TT), Homburg/Saar, Germany","Supported, in part, by the German Excellence Initiative (Excellence Cluster \u201cInflammation at Interfaces\u201d)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CONARIS Research Institute AG (DS, GHW), Kiel, Germany","institution_ids":["https://openalex.org/I4210105421"]},{"raw_affiliation_string":"Dr. Rose-John has stock ownership in CONARIS Research Institute AG and is an inventor on patents owned by CONARIS. Dr. Seegert and Dr. Waetzig are employed by CONARIS Research Institute AG and are inventors on patents owned by CONARIS. The remaining authors have not disclosed any potential conflicts of interest","institution_ids":["https://openalex.org/I4210105421"]},{"raw_affiliation_string":"For information regarding this article, E-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"From the Trauma Department (TB, CK), Institute for Medical Microbiology and Hospital Epidemiology (RPV), Central Animal Laboratory (MD), and Institute of Biometry (AMH), Hannover Medical School, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]},{"raw_affiliation_string":"Institute of Biochemistry and Molecular Biology II (JS), University of D\u00fcsseldorf, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"Institutes of Clinical Molecular Biology (PR) and Biochemistry (AC, SRJ), University of Kiel, Kiel, Germany","institution_ids":["https://openalex.org/I32021983"]},{"raw_affiliation_string":"Ludwig Boltzmann Institute for Experimental and Clinical Traumatology (MvG), Vienna, Austria","institution_ids":["https://openalex.org/I4210096363"]},{"raw_affiliation_string":"Saarland University Hospital (TT), Homburg/Saar, Germany","institution_ids":["https://openalex.org/I91712215"]},{"raw_affiliation_string":"Supported, in part, by the German Excellence Initiative (Excellence Cluster \u201cInflammation at Interfaces\u201d)","institution_ids":["https://openalex.org/I4387154999"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026244899","display_name":"Dirk Seegert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32021983","display_name":"Christian-Albrechts-Universit\u00e4t zu Kiel","ror":"https://ror.org/04v76ef78","country_code":"DE","type":"education","lineage":["https://openalex.org/I32021983"]},{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]},{"id":"https://openalex.org/I4210096363","display_name":"Ludwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA","ror":"https://ror.org/00a8zdv13","country_code":"AT","type":"facility","lineage":["https://openalex.org/I2799334681","https://openalex.org/I4210096363"]},{"id":"https://openalex.org/I4210105421","display_name":"Conaris","ror":"https://ror.org/01j9kqj67","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210105421"]},{"id":"https://openalex.org/I4387154999","display_name":"Cluster of Excellence \"Inflammation at Interfaces\"","ror":"https://ror.org/00ygmry26","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I315704651","https://openalex.org/I32021983","https://openalex.org/I4210112713","https://openalex.org/I4210128097","https://openalex.org/I4210152351","https://openalex.org/I4387154999","https://openalex.org/I9341345"]},{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]},{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["AT","DE"],"is_corresponding":false,"raw_author_name":"Dirk Seegert","raw_affiliation_strings":["CONARIS Research Institute AG (DS, GHW), Kiel, Germany","Dr. Rose-John has stock ownership in CONARIS Research Institute AG and is an inventor on patents owned by CONARIS. Dr. Seegert and Dr. Waetzig are employed by CONARIS Research Institute AG and are inventors on patents owned by CONARIS. The remaining authors have not disclosed any potential conflicts of interest","For information regarding this article, E-mail: [email\u00a0protected]","From the Trauma Department (TB, CK), Institute for Medical Microbiology and Hospital Epidemiology (RPV), Central Animal Laboratory (MD), and Institute of Biometry (AMH), Hannover Medical School, Hannover, Germany","Institute of Biochemistry and Molecular Biology II (JS), University of D\u00fcsseldorf, D\u00fcsseldorf, Germany","Institutes of Clinical Molecular Biology (PR) and Biochemistry (AC, SRJ), University of Kiel, Kiel, Germany","Ludwig Boltzmann Institute for Experimental and Clinical Traumatology (MvG), Vienna, Austria","Saarland University Hospital (TT), Homburg/Saar, Germany","Supported, in part, by the German Excellence Initiative (Excellence Cluster \u201cInflammation at Interfaces\u201d)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CONARIS Research Institute AG (DS, GHW), Kiel, Germany","institution_ids":["https://openalex.org/I4210105421"]},{"raw_affiliation_string":"Dr. Rose-John has stock ownership in CONARIS Research Institute AG and is an inventor on patents owned by CONARIS. Dr. Seegert and Dr. Waetzig are employed by CONARIS Research Institute AG and are inventors on patents owned by CONARIS. The remaining authors have not disclosed any potential conflicts of interest","institution_ids":["https://openalex.org/I4210105421"]},{"raw_affiliation_string":"For information regarding this article, E-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"From the Trauma Department (TB, CK), Institute for Medical Microbiology and Hospital Epidemiology (RPV), Central Animal Laboratory (MD), and Institute of Biometry (AMH), Hannover Medical School, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]},{"raw_affiliation_string":"Institute of Biochemistry and Molecular Biology II (JS), University of D\u00fcsseldorf, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"Institutes of Clinical Molecular Biology (PR) and Biochemistry (AC, SRJ), University of Kiel, Kiel, Germany","institution_ids":["https://openalex.org/I32021983"]},{"raw_affiliation_string":"Ludwig Boltzmann Institute for Experimental and Clinical Traumatology (MvG), Vienna, Austria","institution_ids":["https://openalex.org/I4210096363"]},{"raw_affiliation_string":"Saarland University Hospital (TT), Homburg/Saar, Germany","institution_ids":["https://openalex.org/I91712215"]},{"raw_affiliation_string":"Supported, in part, by the German Excellence Initiative (Excellence Cluster \u201cInflammation at Interfaces\u201d)","institution_ids":["https://openalex.org/I4387154999"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014868321","display_name":"Christian Krettek","orcid":"https://orcid.org/0000-0001-9807-0020","observed_orcids":["https://orcid.org/0000-0001-9807-0020"]},"institutions":[{"id":"https://openalex.org/I32021983","display_name":"Christian-Albrechts-Universit\u00e4t zu Kiel","ror":"https://ror.org/04v76ef78","country_code":"DE","type":"education","lineage":["https://openalex.org/I32021983"]},{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]},{"id":"https://openalex.org/I4210096363","display_name":"Ludwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA","ror":"https://ror.org/00a8zdv13","country_code":"AT","type":"facility","lineage":["https://openalex.org/I2799334681","https://openalex.org/I4210096363"]},{"id":"https://openalex.org/I4210105421","display_name":"Conaris","ror":"https://ror.org/01j9kqj67","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210105421"]},{"id":"https://openalex.org/I4387154999","display_name":"Cluster of Excellence \"Inflammation at Interfaces\"","ror":"https://ror.org/00ygmry26","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I315704651","https://openalex.org/I32021983","https://openalex.org/I4210112713","https://openalex.org/I4210128097","https://openalex.org/I4210152351","https://openalex.org/I4387154999","https://openalex.org/I9341345"]},{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]},{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["AT","DE"],"is_corresponding":false,"raw_author_name":"Christian Krettek","raw_affiliation_strings":["CONARIS Research Institute AG (DS, GHW), Kiel, Germany","Dr. Rose-John has stock ownership in CONARIS Research Institute AG and is an inventor on patents owned by CONARIS. Dr. Seegert and Dr. Waetzig are employed by CONARIS Research Institute AG and are inventors on patents owned by CONARIS. The remaining authors have not disclosed any potential conflicts of interest","For information regarding this article, E-mail: [email\u00a0protected]","From the Trauma Department (TB, CK), Institute for Medical Microbiology and Hospital Epidemiology (RPV), Central Animal Laboratory (MD), and Institute of Biometry (AMH), Hannover Medical School, Hannover, Germany","Institute of Biochemistry and Molecular Biology II (JS), University of D\u00fcsseldorf, D\u00fcsseldorf, Germany","Institutes of Clinical Molecular Biology (PR) and Biochemistry (AC, SRJ), University of Kiel, Kiel, Germany","Ludwig Boltzmann Institute for Experimental and Clinical Traumatology (MvG), Vienna, Austria","Saarland University Hospital (TT), Homburg/Saar, Germany","Supported, in part, by the German Excellence Initiative (Excellence Cluster \u201cInflammation at Interfaces\u201d)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CONARIS Research Institute AG (DS, GHW), Kiel, Germany","institution_ids":["https://openalex.org/I4210105421"]},{"raw_affiliation_string":"Dr. Rose-John has stock ownership in CONARIS Research Institute AG and is an inventor on patents owned by CONARIS. Dr. Seegert and Dr. Waetzig are employed by CONARIS Research Institute AG and are inventors on patents owned by CONARIS. The remaining authors have not disclosed any potential conflicts of interest","institution_ids":["https://openalex.org/I4210105421"]},{"raw_affiliation_string":"For information regarding this article, E-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"From the Trauma Department (TB, CK), Institute for Medical Microbiology and Hospital Epidemiology (RPV), Central Animal Laboratory (MD), and Institute of Biometry (AMH), Hannover Medical School, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]},{"raw_affiliation_string":"Institute of Biochemistry and Molecular Biology II (JS), University of D\u00fcsseldorf, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"Institutes of Clinical Molecular Biology (PR) and Biochemistry (AC, SRJ), University of Kiel, Kiel, Germany","institution_ids":["https://openalex.org/I32021983"]},{"raw_affiliation_string":"Ludwig Boltzmann Institute for Experimental and Clinical Traumatology (MvG), Vienna, Austria","institution_ids":["https://openalex.org/I4210096363"]},{"raw_affiliation_string":"Saarland University Hospital (TT), Homburg/Saar, Germany","institution_ids":["https://openalex.org/I91712215"]},{"raw_affiliation_string":"Supported, in part, by the German Excellence Initiative (Excellence Cluster \u201cInflammation at Interfaces\u201d)","institution_ids":["https://openalex.org/I4387154999"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013428965","display_name":"Georg H. Waetzig","orcid":"https://orcid.org/0000-0001-8289-2097","observed_orcids":["https://orcid.org/0000-0001-8289-2097"]},"institutions":[{"id":"https://openalex.org/I32021983","display_name":"Christian-Albrechts-Universit\u00e4t zu Kiel","ror":"https://ror.org/04v76ef78","country_code":"DE","type":"education","lineage":["https://openalex.org/I32021983"]},{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]},{"id":"https://openalex.org/I4210096363","display_name":"Ludwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA","ror":"https://ror.org/00a8zdv13","country_code":"AT","type":"facility","lineage":["https://openalex.org/I2799334681","https://openalex.org/I4210096363"]},{"id":"https://openalex.org/I4210105421","display_name":"Conaris","ror":"https://ror.org/01j9kqj67","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210105421"]},{"id":"https://openalex.org/I4387154999","display_name":"Cluster of Excellence \"Inflammation at Interfaces\"","ror":"https://ror.org/00ygmry26","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I315704651","https://openalex.org/I32021983","https://openalex.org/I4210112713","https://openalex.org/I4210128097","https://openalex.org/I4210152351","https://openalex.org/I4387154999","https://openalex.org/I9341345"]},{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]},{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["AT","DE"],"is_corresponding":false,"raw_author_name":"Georg H. Waetzig","raw_affiliation_strings":["CONARIS Research Institute AG (DS, GHW), Kiel, Germany","Dr. Rose-John has stock ownership in CONARIS Research Institute AG and is an inventor on patents owned by CONARIS. Dr. Seegert and Dr. Waetzig are employed by CONARIS Research Institute AG and are inventors on patents owned by CONARIS. The remaining authors have not disclosed any potential conflicts of interest","For information regarding this article, E-mail: [email\u00a0protected]","From the Trauma Department (TB, CK), Institute for Medical Microbiology and Hospital Epidemiology (RPV), Central Animal Laboratory (MD), and Institute of Biometry (AMH), Hannover Medical School, Hannover, Germany","Institute of Biochemistry and Molecular Biology II (JS), University of D\u00fcsseldorf, D\u00fcsseldorf, Germany","Institutes of Clinical Molecular Biology (PR) and Biochemistry (AC, SRJ), University of Kiel, Kiel, Germany","Ludwig Boltzmann Institute for Experimental and Clinical Traumatology (MvG), Vienna, Austria","Saarland University Hospital (TT), Homburg/Saar, Germany","Supported, in part, by the German Excellence Initiative (Excellence Cluster \u201cInflammation at Interfaces\u201d)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CONARIS Research Institute AG (DS, GHW), Kiel, Germany","institution_ids":["https://openalex.org/I4210105421"]},{"raw_affiliation_string":"Dr. Rose-John has stock ownership in CONARIS Research Institute AG and is an inventor on patents owned by CONARIS. Dr. Seegert and Dr. Waetzig are employed by CONARIS Research Institute AG and are inventors on patents owned by CONARIS. The remaining authors have not disclosed any potential conflicts of interest","institution_ids":["https://openalex.org/I4210105421"]},{"raw_affiliation_string":"For information regarding this article, E-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"From the Trauma Department (TB, CK), Institute for Medical Microbiology and Hospital Epidemiology (RPV), Central Animal Laboratory (MD), and Institute of Biometry (AMH), Hannover Medical School, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]},{"raw_affiliation_string":"Institute of Biochemistry and Molecular Biology II (JS), University of D\u00fcsseldorf, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"Institutes of Clinical Molecular Biology (PR) and Biochemistry (AC, SRJ), University of Kiel, Kiel, Germany","institution_ids":["https://openalex.org/I32021983"]},{"raw_affiliation_string":"Ludwig Boltzmann Institute for Experimental and Clinical Traumatology (MvG), Vienna, Austria","institution_ids":["https://openalex.org/I4210096363"]},{"raw_affiliation_string":"Saarland University Hospital (TT), Homburg/Saar, Germany","institution_ids":["https://openalex.org/I91712215"]},{"raw_affiliation_string":"Supported, in part, by the German Excellence Initiative (Excellence Cluster \u201cInflammation at Interfaces\u201d)","institution_ids":["https://openalex.org/I4387154999"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":9.1815,"has_fulltext":false,"cited_by_count":169,"citation_normalized_percentile":{"value":0.98172677,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"39","issue":"6","first_page":"1407","last_page":"1413"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.8403000235557556,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.8403000235557556,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.13899999856948853,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.010900000110268593,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9800000190734863},{"id":"https://openalex.org/keywords/il-6-trans-signaling","display_name":"IL-6 trans-signaling","score":0.9279999732971191},{"id":"https://openalex.org/keywords/soluble-gp130","display_name":"soluble gp130","score":0.8389999866485596},{"id":"https://openalex.org/keywords/sgp130fc","display_name":"sgp130Fc","score":0.9739999771118164},{"id":"https://openalex.org/keywords/soluble-il-6-receptor","display_name":"soluble IL-6 receptor","score":0.8859999775886536},{"id":"https://openalex.org/keywords/anti-il-6-antibody","display_name":"anti-IL-6 antibody","score":0.9100000262260437},{"id":"https://openalex.org/keywords/polymicrobial-sepsis","display_name":"polymicrobial sepsis","score":0.9490000009536743},{"id":"https://openalex.org/keywords/cecal-ligation-and-puncture","display_name":"cecal ligation and puncture","score":0.996999979019165},{"id":"https://openalex.org/keywords/sepsis-mortality","display_name":"sepsis mortality","score":0.7049999833106995},{"id":"https://openalex.org/keywords/cytokine-inhibition","display_name":"cytokine inhibition","score":0.5299999713897705},{"id":"https://openalex.org/keywords/il-6-receptor-signaling","display_name":"IL-6 receptor signaling","score":0.4959999918937683},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.39899998903274536}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8045604228973389},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.6538453698158264},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.6441116333007812},{"id":"https://openalex.org/C126037660","wikidata":"https://www.wikidata.org/wiki/Q21116066","display_name":"Glycoprotein 130","level":4,"score":0.5687704086303711},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.522922158241272},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.49647146463394165},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4824807941913605},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4601673483848572},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.420354425907135},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4166125953197479},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3877643644809723},{"id":"https://openalex.org/C11988809","wikidata":"https://www.wikidata.org/wiki/Q412889","display_name":"Interleukin 6","level":3,"score":0.3072177469730377},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2906748056411743},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09730061888694763},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09317997097969055}],"mesh":[{"descriptor_ui":"D000093242","descriptor_name":"Interleukin-6 Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057134","descriptor_name":"Antibodies, Neutralizing","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1097/ccm.0b013e318211ff56","doi":"https://doi.org/10.1097/ccm.0b013e318211ff56","is_oa":false,"landing_page_url":"https://doi.org/10.1097/ccm.0b013e318211ff56","pdf_url":null,"source":{"id":"https://openalex.org/S108732581","display_name":"Critical Care Medicine","issn_l":"0090-3493","issn":["0090-3493","1530-0293"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care Medicine","raw_type":"journal-article"},{"id":"pmid:21336117","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21336117","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical care medicine","raw_type":"Journal Article"},{"id":"pmh:oai:cris.maastrichtuniversity.nl:openaire_cris_publications/25bb0ed4-a5c8-4e08-b666-6e6e8218d99f","doi":null,"is_oa":false,"landing_page_url":"https://cris.maastrichtuniversity.nl/en/publications/25bb0ed4-a5c8-4e08-b666-6e6e8218d99f","pdf_url":null,"source":{"id":"https://openalex.org/S4306402616","display_name":"Research Publications (Maastricht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I34352273","host_organization_name":"Maastricht University","host_organization_lineage":["https://openalex.org/I34352273"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Barkhausen, T, Tschernig, T, Rosenstiel, P, van Griensven, M, Vonberg, R-P, Dorsch, M, Mueller-Heine, A, Chalaris, A, Scheller, J, Rose-John, S, Seegert, D, Krettek, C & Waetzig, G H 2011, 'Selective blockade of interleukin-6 trans-signaling improves survival in a murine polymicrobial sepsis model', Critical Care Medicine, vol. 39, no. 6, pp. 1407-13. https://doi.org/10.1097/CCM.0b013e318211ff56","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:mediatum.ub.tum.de:node/1587098","doi":null,"is_oa":false,"landing_page_url":"https://mediatum.ub.tum.de/1587098","pdf_url":null,"source":{"id":"https://openalex.org/S4306400453","display_name":"mediaTUM \u2013 the media and publications repository of the Technical University Munich (Technical University Munich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I62916508","host_organization_name":"Technical University of Munich","host_organization_lineage":["https://openalex.org/I62916508"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},{"id":"pmh:um:oai:cris.maastrichtuniversity.nl:publications/25bb0ed4-a5c8-4e08-b666-6e6e8218d99f","doi":null,"is_oa":false,"landing_page_url":"https://cris.maastrichtuniversity.nl/en/publications/25bb0ed4-a5c8-4e08-b666-6e6e8218d99f","pdf_url":null,"source":{"id":"https://openalex.org/S4306402616","display_name":"Research Publications (Maastricht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I34352273","host_organization_name":"Maastricht University","host_organization_lineage":["https://openalex.org/I34352273"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Critical Care Medicine, 39(6), 1407 - 13. LIPPINCOTT WILLIAMS &amp; WILKINS","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W57713311","https://openalex.org/W60534776","https://openalex.org/W95285739","https://openalex.org/W196618629","https://openalex.org/W1487227918","https://openalex.org/W1549568102","https://openalex.org/W1569271652","https://openalex.org/W1579900509","https://openalex.org/W1597588755","https://openalex.org/W1681184579","https://openalex.org/W1776476655","https://openalex.org/W1840567140","https://openalex.org/W1902385211","https://openalex.org/W1904767156","https://openalex.org/W1904816508","https://openalex.org/W1969791558","https://openalex.org/W1978172024","https://openalex.org/W1981772756","https://openalex.org/W1986978782","https://openalex.org/W2005896876","https://openalex.org/W2006708761","https://openalex.org/W2010077858","https://openalex.org/W2018261512","https://openalex.org/W2018498519","https://openalex.org/W2022483849","https://openalex.org/W2028781657","https://openalex.org/W2029527585","https://openalex.org/W2029619625","https://openalex.org/W2034636095","https://openalex.org/W2036988498","https://openalex.org/W2070743921","https://openalex.org/W2071693928","https://openalex.org/W2080354420","https://openalex.org/W2082626794","https://openalex.org/W2099752249","https://openalex.org/W2101596544","https://openalex.org/W2108705609","https://openalex.org/W2110833630","https://openalex.org/W2117419448","https://openalex.org/W2132123340","https://openalex.org/W2137342836","https://openalex.org/W2145478309","https://openalex.org/W2152168109","https://openalex.org/W2163458407","https://openalex.org/W2165144163","https://openalex.org/W2165782050","https://openalex.org/W2171999559","https://openalex.org/W2419360016","https://openalex.org/W4299294244"],"related_works":["https://openalex.org/W6962436799","https://openalex.org/W4365140550","https://openalex.org/W2082981069","https://openalex.org/W2070474339","https://openalex.org/W2117419448","https://openalex.org/W168973904","https://openalex.org/W1692255419","https://openalex.org/W2522977978","https://openalex.org/W2922497275","https://openalex.org/W2051005236"],"abstract_inverted_index":{"OBJECTIVE:":[0],"The":[1,61],"pleiotropic":[2],"cytokine":[3],"interleukin":[4],"(IL)-6":[5],"seems":[6],"to":[7,67,130,236,248,264],"play":[8],"a":[9,21,76,87,101,122,127],"pivotal":[10],"role":[11],"in":[12,17,100,141,278],"sepsis,":[13],"but":[14],"contradictory":[15],"findings":[16],"animal":[18],"models":[19],"impede":[20],"rationale":[22],"for":[23,300],"therapies":[24],"directed":[25],"against":[26],"IL-6.":[27],"IL-6":[28,44,73,84,293],"signals":[29],"by":[30,57,271,295],"two":[31],"mechanisms":[32],"via":[33],"the":[34,93,135,203,279,301],"ubiquitous":[35],"transmembrane":[36],"glycoprotein":[37],"130":[38],"(gp130):":[39],"\"classic\"":[40],"signaling":[41,74],"using":[42,49],"membrane-bound":[43],"receptor":[45],"(IL-6R)":[46],"and":[47,80,92,105,126,191,221,225,242,305],"trans-signaling":[48,85,294],"soluble":[50,58],"IL-6R":[51],"(sIL-6R).":[52],"Trans-signaling":[53],"is":[54],"selectively":[55],"inhibited":[56],"gp130":[59],"(sgp130).":[60],"aim":[62],"of":[63,72,83,90,96,160,274,292,303],"this":[64],"study":[65,125,129],"was":[66,139,269,284],"systematically":[68],"compare":[69],"complete":[70,272],"blockade":[71,82],"(using":[75,86],"neutralizing":[77],"anti-IL-6":[78,165],"antibody)":[79],"selective":[81],"fusion":[88],"protein":[89],"sgp130":[91],"crystallizable":[94],"fragment":[95],"immunoglobulin":[97],"G1,":[98],"sgp130Fc)":[99],"standardized":[102],"cecal":[103],"ligation":[104],"puncture":[106],"(CLP)":[107],"sepsis":[108,304],"model.":[109],"DESIGN:":[110],"Animal":[111,114],"study.":[112],"SETTING:":[113],"laboratory.":[115],"SUBJECTS:":[116],"C57BL/6J":[117],"mice.":[118],"INTERVENTIONS:":[119],"We":[120],"performed":[121,140],"96-hr":[123,136],"dose-response":[124],"24-hr":[128,204],"investigate":[131],"short-term":[132],"mechanisms.":[133],"In":[134,202,234,250],"study,":[137,205],"CLP":[138,259],"120":[142],"randomized":[143,208],"mice":[144,146,150,206],"(20":[145],"received":[147,175],"vehicle,":[148],"10":[149,213],"per":[151],"dose":[152],"group).":[153],"Mice":[154],"were":[155,194,207],"treated":[156],"with":[157,212,239,287],"equimolar":[158],"doses":[159],"sgp130Fc":[161,178,185,240,254,267,296],"(0.01/0.1/1/10":[162],"mg/kg)":[163,167],"or":[164,182],"(0.008/0.08/0.8/8":[166],"24":[168,179,186,228,256],"hrs":[169,180,187,199,257],"before":[170,181],"CLP.":[171,189,201],"Two":[172],"additional":[173],"groups":[174,211],"0.5":[176],"mg/kg":[177,184,253],"1":[183,252],"after":[188,200,227,258,281],"Survival":[190],"activity":[192],"scores":[193],"obtained":[195],"daily":[196],"until":[197],"96":[198],"into":[209],"four":[210],"animals":[214],"each":[215],"(sham/vehicle,":[216],"CLP/vehicle,":[217],"CLP/anti-IL-6":[218],"[0.8":[219],"mg/kg],":[220],"CLP/sgp130Fc":[222],"[1":[223],"mg/kg])":[224],"killed":[226],"hrs.":[229],"MEASUREMENTS":[230],"AND":[231],"MAIN":[232],"RESULTS:":[233],"contrast":[235],"anti-IL-6,":[237],"pretreatment":[238],"significantly":[241],"dose-dependently":[243],"increased":[244,260],"survival":[245,261],"from":[246,262],"45%":[247,263],"100%.":[249],"addition,":[251],"administered":[255],"80%.":[265],"Mechanistically,":[266],"efficacy":[268],"reflected":[270],"prevention":[273],"epithelial":[275],"cell":[276],"apoptosis":[277],"jejunum":[280],"CLP,":[282],"which":[283],"not":[285],"achieved":[286],"anti-IL-6.":[288],"CONCLUSION:":[289],"Selective":[290],"inhibition":[291],"has":[297],"considerable":[298],"potential":[299],"treatment":[302],"related":[306],"disorders.":[307]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":20},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
