{"id":"https://openalex.org/W2319723643","doi":null,"title":"Partially Purified Pigment Extract from Streptomyces A 16-1 Induces Apoptosis of Human Carcinoma of Nasopharynx Cell (KB cells) via the Mitochondrial and Caspase-3 Pathway","display_name":"Partially Purified Pigment Extract from Streptomyces A 16-1 Induces Apoptosis of Human Carcinoma of Nasopharynx Cell (KB cells) via the Mitochondrial and Caspase-3 Pathway","publication_year":2016,"publication_date":"2016-01-26","ids":{"openalex":"https://openalex.org/W2319723643","mag":"2319723643"},"language":"en","primary_location":{"id":"mag:2319723643","doi":null,"is_oa":true,"landing_page_url":"https://103.58.148.28/index.php/wjst/article/view/2008","pdf_url":null,"source":{"id":"https://openalex.org/S2739205132","display_name":"Walailak Journal of Science and Technology (WJST)","issn_l":"1686-3933","issn":["1686-3933","2228-835X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319383","host_organization_name":"Walailak University","host_organization_lineage":["https://openalex.org/P4310319383"],"host_organization_lineage_names":["Walailak University"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Walailak Journal of Science and Technology (WJST)","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://103.58.148.28/index.php/wjst/article/view/2008","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039416255","display_name":"Chantarawan Saengkhae","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129488602","display_name":"Burapha University","ror":"https://ror.org/01ff74m36","country_code":"TH","type":"education","lineage":["https://openalex.org/I129488602"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Chantarawan Saengkhae","raw_affiliation_strings":["Faculty of Allied Health Sciences, Burapha University, Chonburi 20131"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Allied Health Sciences, Burapha University, Chonburi 20131","institution_ids":["https://openalex.org/I129488602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028181821","display_name":"Rattanaporn Srivibool","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129488602","display_name":"Burapha University","ror":"https://ror.org/01ff74m36","country_code":"TH","type":"education","lineage":["https://openalex.org/I129488602"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Rattanaporn Srivibool","raw_affiliation_strings":["Institute of Marine Science, Burapha University, Chonburi 20131"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Marine Science, Burapha University, Chonburi 20131","institution_ids":["https://openalex.org/I129488602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062162124","display_name":"Rawiwan Watanadilok","orcid":"https://orcid.org/0009-0003-5751-4707","observed_orcids":["https://orcid.org/0009-0003-5751-4707"]},"institutions":[{"id":"https://openalex.org/I129488602","display_name":"Burapha University","ror":"https://ror.org/01ff74m36","country_code":"TH","type":"education","lineage":["https://openalex.org/I129488602"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Rawiwan Watanadilok","raw_affiliation_strings":["Institute of Marine Science, Burapha University, Chonburi 20131"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Marine Science, Burapha University, Chonburi 20131","institution_ids":["https://openalex.org/I129488602"]}]},{"author_position":"last","author":{"id":null,"display_name":"Keiichi Enomoto","orcid":"https://orcid.org/0000-0002-4563-4539","observed_orcids":["https://orcid.org/0000-0002-4563-4539"]},"institutions":[{"id":"https://openalex.org/I35568498","display_name":"Kochi University of Technology","ror":"https://ror.org/00rghrr56","country_code":"JP","type":"education","lineage":["https://openalex.org/I35568498","https://openalex.org/I4405286278"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keiichi Enomoto","raw_affiliation_strings":["School of Environmental Science and Engineering, Kochi University of Technology, Tosayamada-Cho, Kami City, Kochi 782-8502"],"raw_orcid":"https://orcid.org/0000-0002-4563-4539","affiliations":[{"raw_affiliation_string":"School of Environmental Science and Engineering, Kochi University of Technology, Tosayamada-Cho, Kami City, Kochi 782-8502","institution_ids":["https://openalex.org/I35568498"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2625,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.53990878,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"14","issue":"1","first_page":"51","last_page":"63"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12673","display_name":"Microbial Metabolism and Applications","score":0.9448000192642212,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12673","display_name":"Microbial Metabolism and Applications","score":0.9448000192642212,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.042399998754262924,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.009600000455975533,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nasopharyngeal-carcinoma","display_name":"nasopharyngeal carcinoma","score":0.9350000023841858},{"id":"https://openalex.org/keywords/kb-cells","display_name":"KB cells","score":0.9890000224113464},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9819999933242798},{"id":"https://openalex.org/keywords/mitochondrial-pathway","display_name":"mitochondrial pathway","score":0.7099999785423279},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9789999723434448},{"id":"https://openalex.org/keywords/mitochondrial-membrane-depolarization","display_name":"mitochondrial depolarization","score":0.9629999995231628},{"id":"https://openalex.org/keywords/dna-fragmentation","display_name":"DNA fragmentation","score":0.781000018119812},{"id":"https://openalex.org/keywords/secondary-metabolites","display_name":"secondary metabolites","score":0.7369999885559082},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.6679999828338623},{"id":"https://openalex.org/keywords/soil-bacteria","display_name":"soil bacteria","score":0.37299999594688416}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7595012187957764},{"id":"https://openalex.org/C2779920670","wikidata":"https://www.wikidata.org/wiki/Q1144013","display_name":"Streptomyces","level":3,"score":0.6625815629959106},{"id":"https://openalex.org/C43759708","wikidata":"https://www.wikidata.org/wiki/Q3749256","display_name":"DNA fragmentation","level":4,"score":0.6452962756156921},{"id":"https://openalex.org/C64584667","wikidata":"https://www.wikidata.org/wiki/Q161179","display_name":"Pigment","level":2,"score":0.5998580455780029},{"id":"https://openalex.org/C191015642","wikidata":"https://www.wikidata.org/wiki/Q1132459","display_name":"Fragmentation (computing)","level":2,"score":0.5265132188796997},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4882645606994629},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.4710127115249634},{"id":"https://openalex.org/C12519072","wikidata":"https://www.wikidata.org/wiki/Q14914370","display_name":"Caspase 3","level":4,"score":0.46856218576431274},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44450944662094116},{"id":"https://openalex.org/C4141045","wikidata":"https://www.wikidata.org/wiki/Q83183","display_name":"Depolarization","level":2,"score":0.44369998574256897},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4428877830505371},{"id":"https://openalex.org/C51724486","wikidata":"https://www.wikidata.org/wiki/Q908955","display_name":"Column chromatography","level":2,"score":0.44014987349510193},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.41101667284965515},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4092636704444885},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3607799708843231},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3599923253059387},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.34030812978744507},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.31804606318473816},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.16932213306427002},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.11991134285926819},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2319723643","doi":null,"is_oa":true,"landing_page_url":"https://103.58.148.28/index.php/wjst/article/view/2008","pdf_url":null,"source":{"id":"https://openalex.org/S2739205132","display_name":"Walailak Journal of Science and Technology (WJST)","issn_l":"1686-3933","issn":["1686-3933","2228-835X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319383","host_organization_name":"Walailak University","host_organization_lineage":["https://openalex.org/P4310319383"],"host_organization_lineage_names":["Walailak University"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Walailak Journal of Science and Technology (WJST)","raw_type":null}],"best_oa_location":{"id":"mag:2319723643","doi":null,"is_oa":true,"landing_page_url":"https://103.58.148.28/index.php/wjst/article/view/2008","pdf_url":null,"source":{"id":"https://openalex.org/S2739205132","display_name":"Walailak Journal of Science and Technology (WJST)","issn_l":"1686-3933","issn":["1686-3933","2228-835X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319383","host_organization_name":"Walailak University","host_organization_lineage":["https://openalex.org/P4310319383"],"host_organization_lineage_names":["Walailak University"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Walailak Journal of Science and Technology (WJST)","raw_type":null},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W570108","https://openalex.org/W34291945","https://openalex.org/W1501345984","https://openalex.org/W1961082018","https://openalex.org/W1979958385","https://openalex.org/W1985089556","https://openalex.org/W1988145535","https://openalex.org/W1995908223","https://openalex.org/W2008757142","https://openalex.org/W2015809962","https://openalex.org/W2038954212","https://openalex.org/W2041101607","https://openalex.org/W2045327763","https://openalex.org/W2050265381","https://openalex.org/W2051716249","https://openalex.org/W2052236805","https://openalex.org/W2054637097","https://openalex.org/W2081872634","https://openalex.org/W2086680495","https://openalex.org/W2143245942","https://openalex.org/W2161808171","https://openalex.org/W2169633254","https://openalex.org/W2170100758","https://openalex.org/W2736855307","https://openalex.org/W3004118171","https://openalex.org/W3144870107"],"related_works":["https://openalex.org/W4391192429","https://openalex.org/W4365458427","https://openalex.org/W4390745256","https://openalex.org/W2162657943","https://openalex.org/W7220200886","https://openalex.org/W1803816139","https://openalex.org/W7138970819","https://openalex.org/W7098732039","https://openalex.org/W2899778222","https://openalex.org/W2347768288"],"abstract_inverted_index":{"The":[0,31,62,130],"genus":[1],"Streptomycetes":[2],"are":[3],"very":[4],"important":[5],"bacteria":[6],"which":[7,98,154],"produce":[8],"secondary":[9],"metabolites":[10],"used":[11],"in":[12,28,144],"clinical":[13],"cancer":[14],"therapy":[15],"and":[16,42,64,83,104,114,124,150,178],"other":[17],"pharmacological":[18],"activities.":[19],"Streptomyces":[20,51],"A":[21,52],"16-1":[22,53],"was":[23,74,155],"isolated":[24],"from":[25,50,68],"coastal":[26],"soil":[27],"Chonburi,":[29],"Thailand.":[30],"objective":[32],"of":[33,44,57,71,133,142,152,170],"this":[34],"study":[35],"is":[36],"to":[37],"examine":[38],"the":[39,45,69,96,105,159,167,176],"apoptotic":[40],"effects":[41,169],"mechanisms":[43,132],"partially":[46],"purified":[47],"pigment":[48,101],"extract":[49,67],"against":[54],"human":[55],"carcinoma":[56],"nasopharynx":[58],"cell":[59,134],"(KB":[60],"cells).":[61],"methanol":[63,87],"ethyl":[65],"acetate":[66],"fermentation":[70],"ISP2":[72],"broth":[73],"fractionated":[75],"by":[76,158],"using":[77],"column":[78],"chromatography":[79],"with":[80,89,138],"stationery-phase":[81],"silica-gel":[82],"mobile":[84],"phase":[85],"chloroform:":[86],"mixtures":[88],"increasing":[90],"polarity.":[91],"Among":[92],"9":[93],"fractions":[94,97,172],"(Fr),":[95],"contained":[99],"red":[100],"were":[102,117,136,173],"selected":[103],"calculated":[106],"IC50":[107],"values":[108],"for":[109],"Fr":[110,112,115],"5,":[111],"6":[113],"7":[116],"0.04":[118],"\u00b1":[119,122,126],"0.005,":[120],"0.20":[121],"0.02,":[123],"0.55":[125],"0.05":[127],"\u03bcg/ml,":[128],"respectively.":[129],"molecular":[131],"death":[135],"associated":[137],"DNA":[139],"fragmentation,":[140],"accumulation":[141],"cells":[143],"sub-G1":[145],"phase,":[146],"mitochondrial":[147,177],"membrane":[148],"depolarization,":[149],"activation":[151],"caspase-3,":[153],"significantly":[156],"diminished":[157],"caspase-3":[160,179],"inhibitor.":[161],"These":[162],"first":[163],"findings":[164],"demonstrate":[165],"that":[166],"pro-apoptotic":[168],"these":[171],"mediated":[174],"through":[175],"pathway.":[180]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}