{"id":"https://openalex.org/W2319660964","doi":"https://doi.org/10.1249/01.mss.0000401136.78393.48","title":"Skeletal Muscle Mesenchymal Stem Cells Facilitate Exercised-Mediated Myogenesis","display_name":"Skeletal Muscle Mesenchymal Stem Cells Facilitate Exercised-Mediated Myogenesis","publication_year":2011,"publication_date":"2011-05-01","ids":{"openalex":"https://openalex.org/W2319660964","doi":"https://doi.org/10.1249/01.mss.0000401136.78393.48","mag":"2319660964"},"language":"en","primary_location":{"id":"doi:10.1249/01.mss.0000401136.78393.48","doi":"https://doi.org/10.1249/01.mss.0000401136.78393.48","is_oa":false,"landing_page_url":"https://doi.org/10.1249/01.mss.0000401136.78393.48","pdf_url":null,"source":{"id":"https://openalex.org/S14544163","display_name":"Medicine & Science in Sports & Exercise","issn_l":"0195-9131","issn":["0195-9131","1530-0315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine &amp; Science in Sports &amp; Exercise","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017481308","display_name":"Heather D. Huntsman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heather D. Huntsman","raw_affiliation_strings":["University of Illinois Champaign-Urbana, Urbana, IL","(No relationships reported)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Illinois Champaign-Urbana, Urbana, IL","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"(No relationships reported)","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Carmen Valero","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carmen Valero","raw_affiliation_strings":["University of Illinois Champaign-Urbana, Urbana, IL","(No relationships reported)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Illinois Champaign-Urbana, Urbana, IL","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"(No relationships reported)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040037697","display_name":"Kai Zou","orcid":"https://orcid.org/0000-0003-4164-7129","observed_orcids":["https://orcid.org/0000-0003-4164-7129"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kai Zou","raw_affiliation_strings":["University of Illinois Champaign-Urbana, Urbana, IL","(No relationships reported)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Illinois Champaign-Urbana, Urbana, IL","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"(No relationships reported)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023442573","display_name":"Tara N. Lueders","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tara Lueders","raw_affiliation_strings":["University of Illinois Champaign-Urbana, Urbana, IL","(No relationships reported)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Illinois Champaign-Urbana, Urbana, IL","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"(No relationships reported)","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051614460","display_name":"Marni D. Boppart","orcid":"https://orcid.org/0000-0003-0369-6974","observed_orcids":["https://orcid.org/0000-0003-0369-6974"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marni D. Boppart","raw_affiliation_strings":["University of Illinois Champaign-Urbana, Urbana, IL","(No relationships reported)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Illinois Champaign-Urbana, Urbana, IL","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"(No relationships reported)","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I157725225"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.17340211,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"43","issue":"5","first_page":"412","last_page":"412"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.01140000019222498,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myogenesis","display_name":"myogenesis","score":0.7540000081062317},{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.6990000009536743},{"id":"https://openalex.org/keywords/cardiotoxin-injury","display_name":"cardiotoxin injury","score":0.746999979019165},{"id":"https://openalex.org/keywords/alpha7-integrin","display_name":"integrin alpha7","score":0.847000002861023},{"id":"https://openalex.org/keywords/satellite-cells","display_name":"satellite cells","score":0.8009999990463257},{"id":"https://openalex.org/keywords/pax7","display_name":"Pax7","score":0.9639999866485596},{"id":"https://openalex.org/keywords/myf5","display_name":"Myf5","score":0.753000020980835},{"id":"https://openalex.org/keywords/mechanical-strain","display_name":"mechanical strain","score":0.6570000052452087},{"id":"https://openalex.org/keywords/embryonic-myosin-heavy-chain","display_name":"embryonic myosin heavy chain","score":0.9089999794960022},{"id":"https://openalex.org/keywords/muscle-regeneration","display_name":"muscle regeneration","score":0.8059999942779541},{"id":"https://openalex.org/keywords/downhill-running","display_name":"downhill running","score":0.7250000238418579},{"id":"https://openalex.org/keywords/stem-cell-niche","display_name":"stem cell niche","score":0.527999997138977}],"concepts":[{"id":"https://openalex.org/C2778463287","wikidata":"https://www.wikidata.org/wiki/Q18029725","display_name":"MYF5","level":5,"score":0.76009601354599},{"id":"https://openalex.org/C2778106681","wikidata":"https://www.wikidata.org/wiki/Q416095","display_name":"MyoD","level":4,"score":0.7596118450164795},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.7217974066734314},{"id":"https://openalex.org/C2909145422","wikidata":"https://www.wikidata.org/wiki/Q2118956","display_name":"Cardiotoxin","level":3,"score":0.7116405367851257},{"id":"https://openalex.org/C3763915","wikidata":"https://www.wikidata.org/wiki/Q3331437","display_name":"Myogenesis","level":3,"score":0.685217022895813},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.6693078279495239},{"id":"https://openalex.org/C6997183","wikidata":"https://www.wikidata.org/wiki/Q271727","display_name":"Myosin","level":2,"score":0.5659836530685425},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.5220941305160522},{"id":"https://openalex.org/C2775872116","wikidata":"https://www.wikidata.org/wiki/Q943203","display_name":"Gastrocnemius muscle","level":3,"score":0.5013961791992188},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46539485454559326},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46484583616256714},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.45243480801582336},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.43889158964157104},{"id":"https://openalex.org/C97816823","wikidata":"https://www.wikidata.org/wiki/Q166726","display_name":"Myogenin","level":4,"score":0.4376080334186554},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.35643070936203003},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3263280391693115},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3128643035888672},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18416953086853027}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1249/01.mss.0000401136.78393.48","doi":"https://doi.org/10.1249/01.mss.0000401136.78393.48","is_oa":false,"landing_page_url":"https://doi.org/10.1249/01.mss.0000401136.78393.48","pdf_url":null,"source":{"id":"https://openalex.org/S14544163","display_name":"Medicine & Science in Sports & Exercise","issn_l":"0195-9131","issn":["0195-9131","1530-0315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine &amp; Science in Sports &amp; Exercise","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2055917728","https://openalex.org/W2029167258","https://openalex.org/W2002258016","https://openalex.org/W2016383197","https://openalex.org/W2734978951","https://openalex.org/W3089235728","https://openalex.org/W2104821101","https://openalex.org/W2321289588","https://openalex.org/W3175133006","https://openalex.org/W2080496193"],"abstract_inverted_index":{"Multipotent":[0],"mesenchymal-like":[1],"stem":[2,165],"cells":[3,166,235],"appear":[4],"in":[5,36,173,202,222,226,242,264],"skeletal":[6,37,243],"muscle":[7,14,38,66,79,94,134,244,281],"following":[8,40,69,214,250],"cardiotoxin-mediated":[9],"injury":[10],"and":[11,16,88,175,193,262,276,283],"contribute":[12,63,278],"to":[13,53,57,64,113,127,162,170,238,266,279],"regeneration":[15],"healing.":[17],"We":[18],"have":[19],"recently":[20],"demonstrated":[21],"that":[22,273],"transgenic":[23],"expression":[24],"of":[25,34,44,49,95,103,117,123,144,154,180,207,216,245],"the":[26,32,55,129,152,155,158,178,239],"\u03b17":[27],"integrin":[28],"is":[29],"prerequisite":[30],"for":[31,160,177],"presence":[33,179],"MSCs":[35],"(mMSCs)":[39],"a":[41,115,120,219],"single":[42,121],"bout":[43,122],"exercise.":[45,70],"PURPOSE:":[46],"The":[47,100],"purpose":[48],"this":[50,231],"study":[51,271],"was":[52,106,136,200],"determine":[54,151],"extent":[56,241],"which":[58],"mMSCs":[59,73,161,249,253,274],"directly":[60,277],"or":[61,288],"indirectly":[62,275],"new":[65,197],"fiber":[67,198],"growth":[68,199,282],"METHOD:":[71],"Sca-1+CD45-":[72],"were":[74,167,212,236],"isolated":[75],"from":[76],"\u03b17Tg":[77],"gastrocnemius":[78],"by":[80,187],"FACS,":[81],"labeled":[82],"with":[83,108,218,230,248],"lipophilic":[84],"dye":[85],"I":[86],"(DiI),":[87],"injected":[89,107,204,247],"(4":[90],"\u00d7":[91],"104)":[92],"into":[93],"wild":[96],"type":[97],"recipient":[98],"mice.":[99],"contralateral":[101],"leg":[102],"each":[104],"mouse":[105],"saline.":[109],"One":[110],"hr":[111],"prior":[112],"injection,":[114],"subset":[116],"mice":[118,246],"completed":[119],"downhill":[124],"running":[125],"exercise":[126,208,251],"reestablish":[128],"post-exercise":[130],"microenvironment.":[131],"De":[132],"novo":[133],"synthesis":[135],"quantified":[137],"one":[138],"wk":[139],"later":[140],"using":[141],"immunofluorescence":[142],"detection":[143],"embryonic":[145],"myosin":[146],"heavy":[147],"chain":[148],"(eMHC).":[149],"To":[150],"impact":[153],"microenvironment":[156],"on":[157,191,255],"ability":[159],"become":[163],"myogenic,":[164],"also":[168,285],"subjected":[169],"biaxial":[171],"strain":[172],"vitro":[174],"examined":[176],"myogenic":[181],"transcriptional":[182],"factors":[183],"(myf5,":[184],"Pax7,":[185],"myoD)":[186],"RT-PCR":[188],"when":[189],"plated":[190,254],"gelatin":[192],"laminin.":[194],"RESULTS:":[195],"No":[196],"detected":[201],"saline":[203],"legs,":[205],"regardless":[206],"condition.":[209],"eMHC+DiI-":[210,223],"fibers":[211,224],"present":[213],"injection":[215],"mMSCs,":[217],"marked":[220],"increase":[221],"observed":[225],"exercised":[227],"muscle.":[228],"Consistent":[229],"observation,":[232],"Pax7+":[233],"satellite":[234],"elevated":[237],"greatest":[240],"(P<0.05).":[252],"gelatin,":[256],"but":[257],"not":[258],"laminin,":[259],"upregulated":[260],"myf-5":[261],"Pax7":[263],"response":[265],"mechanical":[267],"strain.":[268],"CONCLUSIONS:":[269],"This":[270],"demonstrates":[272],"exercise-induced":[280],"may":[284],"underlie":[286],"age":[287],"neuromuscular":[289],"disease-related":[290],"functional":[291],"deficits.":[292]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}
