{"id":"https://openalex.org/W2319643296","doi":"https://doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a3523","title":"Safety and Tolerability of TAL6004 in Alpha-1 Antitrypsin (AAT) Deficiency: Results of a Phase 3, Multicenter, Open-Label Study.","display_name":"Safety and Tolerability of TAL6004 in Alpha-1 Antitrypsin (AAT) Deficiency: Results of a Phase 3, Multicenter, Open-Label Study.","publication_year":2009,"publication_date":"2009-04-01","ids":{"openalex":"https://openalex.org/W2319643296","doi":"https://doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a3523","mag":"2319643296"},"language":"en","primary_location":{"id":"doi:10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a3523","doi":"https://doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a3523","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a3523","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"B62. ALPHA-1 ANTITRYPSIN: MOLECULAR, EPIDEMIOLOGICAL, AND CLINICAL FEATURES IN 2009","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057923691","display_name":"Mark Brantly","orcid":"https://orcid.org/0000-0003-0189-1565","observed_orcids":["https://orcid.org/0000-0003-0189-1565"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Brantly","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070587298","display_name":"Michael Campos","orcid":"https://orcid.org/0000-0001-5485-9062","observed_orcids":["https://orcid.org/0000-0001-5485-9062"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Campos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031174762","display_name":"Frank Kueppers","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Kueppers","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023473640","display_name":"Thomas R. Gildea","orcid":"https://orcid.org/0000-0001-9511-2790","observed_orcids":["https://orcid.org/0000-0001-9511-2790"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Gildea","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110895214","display_name":"David A. Lomas","orcid":"https://orcid.org/0000-0003-2339-6979","observed_orcids":["https://orcid.org/0000-0003-2339-6979"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Lomas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050425677","display_name":"William MacNee","orcid":"https://orcid.org/0000-0002-3692-1448","observed_orcids":["https://orcid.org/0000-0002-3692-1448"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W MacNee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057800275","display_name":"Robert A. Sandhaus","orcid":"https://orcid.org/0000-0002-7937-2485","observed_orcids":["https://orcid.org/0000-0002-7937-2485"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Sandhaus","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"J Stocks","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Stocks","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006886866","display_name":"Charlie Strange","orcid":"https://orcid.org/0000-0002-8109-8067","observed_orcids":["https://orcid.org/0000-0002-8109-8067"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Strange","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108462067","display_name":"Gerard M. Turino","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Turino","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A3523","last_page":"A3523"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.3449999988079071,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.3449999988079071,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.0697999969124794,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.05469999834895134,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-1-antitrypsin-deficiency","display_name":"alpha-1 antitrypsin deficiency","score":0.9359999895095825},{"id":"https://openalex.org/keywords/safety","display_name":"safety","score":0.45399999618530273},{"id":"https://openalex.org/keywords/tolerability","display_name":"tolerability","score":0.9890000224113464},{"id":"https://openalex.org/keywords/open-label-extension","display_name":"open-label extension","score":0.8309999704360962}],"concepts":[{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.8746055364608765},{"id":"https://openalex.org/C2780535462","wikidata":"https://www.wikidata.org/wiki/Q622437","display_name":"Alpha 1-antitrypsin deficiency","level":2,"score":0.6373793482780457},{"id":"https://openalex.org/C64943373","wikidata":"https://www.wikidata.org/wiki/Q2651003","display_name":"Alpha (finance)","level":4,"score":0.5721186995506287},{"id":"https://openalex.org/C3019800554","wikidata":"https://www.wikidata.org/wiki/Q3813242","display_name":"Open label","level":3,"score":0.5026686191558838},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43906280398368835},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4022623300552368},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.23038515448570251},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.10821554064750671},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.08436456322669983},{"id":"https://openalex.org/C49453240","wikidata":"https://www.wikidata.org/wiki/Q1592163","display_name":"Construct validity","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a3523","doi":"https://doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a3523","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a3523","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"B62. ALPHA-1 ANTITRYPSIN: MOLECULAR, EPIDEMIOLOGICAL, AND CLINICAL FEATURES IN 2009","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2331942375","https://openalex.org/W4396515810","https://openalex.org/W2328780387","https://openalex.org/W2323663100","https://openalex.org/W2004330828","https://openalex.org/W7099759412","https://openalex.org/W4311359339","https://openalex.org/W4293040356","https://openalex.org/W4230979785","https://openalex.org/W4367608930"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}