{"id":"https://openalex.org/W2319449232","doi":"https://doi.org/10.1007/bf03014332","title":"Dose-response of flurbiprofen on postoperative pain and emesis after paediatric strabismus surgery","display_name":"Dose-response of flurbiprofen on postoperative pain and emesis after paediatric strabismus surgery","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W2319449232","doi":"https://doi.org/10.1007/bf03014332","mag":"2319449232","pmid":"https://pubmed.ncbi.nlm.nih.gov/8988832"},"language":"en","primary_location":{"id":"doi:10.1007/bf03014332","doi":"https://doi.org/10.1007/bf03014332","is_oa":true,"landing_page_url":"https://doi.org/10.1007/bf03014332","pdf_url":"https://link.springer.com/content/pdf/10.1007/BF03014332.pdf","source":{"id":"https://openalex.org/S4210186964","display_name":"Canadian Journal of Anesthesia/Journal canadien d anesth\u00e9sie","issn_l":"0832-610X","issn":["0832-610X","1496-8975"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canadian Journal of Anaesthesia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://link.springer.com/content/pdf/10.1007/BF03014332.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110842000","display_name":"Katsuya Mikawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089895","display_name":"Kobe University Hospital","ror":"https://ror.org/00bb55562","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210089895"]},{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsuya Mikawa","raw_affiliation_strings":["Department of Anaesthesiology, Kobe University School of Medicine, Japan","Department of Anaesthesiology, Kobe University School of Medicine, Chuo-ku, Kobe, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anaesthesiology, Kobe University School of Medicine, Japan","institution_ids":["https://openalex.org/I4210089895","https://openalex.org/I65837984"]},{"raw_affiliation_string":"Department of Anaesthesiology, Kobe University School of Medicine, Chuo-ku, Kobe, Japan","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112154593","display_name":"Kahoru Nishina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kahoru Nishina","raw_affiliation_strings":["Department of Anaesthesiology, Kobe University School of Medicine, Kusunoki-cho 7, 650, Chuo-ku, Kobe, Japan","Department of Anaesthesiology, Kobe University School of Medicine, Chuo-ku, Kobe, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anaesthesiology, Kobe University School of Medicine, Kusunoki-cho 7, 650, Chuo-ku, Kobe, Japan","institution_ids":["https://openalex.org/I65837984"]},{"raw_affiliation_string":"Department of Anaesthesiology, Kobe University School of Medicine, Chuo-ku, Kobe, Japan","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086749142","display_name":"Nobuhiro Maekawa A","orcid":"https://orcid.org/0000-0003-1583-9477","observed_orcids":["https://orcid.org/0000-0003-1583-9477"]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobuhiro Maekawa","raw_affiliation_strings":["Department of Anaesthesiology, Kobe University School of Medicine, Kusunoki-cho 7, 650, Chuo-ku, Kobe, Japan","Department of Anaesthesiology, Kobe University School of Medicine, Chuo-ku, Kobe, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anaesthesiology, Kobe University School of Medicine, Kusunoki-cho 7, 650, Chuo-ku, Kobe, Japan","institution_ids":["https://openalex.org/I65837984"]},{"raw_affiliation_string":"Department of Anaesthesiology, Kobe University School of Medicine, Chuo-ku, Kobe, Japan","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110157972","display_name":"Makoto Shiga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makoto Shiga","raw_affiliation_strings":["Department of Anaesthesiology, Kobe University School of Medicine, Kusunoki-cho 7, 650, Chuo-ku, Kobe, Japan","Department of Anaesthesiology, Kobe University School of Medicine, Chuo-ku, Kobe, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anaesthesiology, Kobe University School of Medicine, Kusunoki-cho 7, 650, Chuo-ku, Kobe, Japan","institution_ids":["https://openalex.org/I65837984"]},{"raw_affiliation_string":"Department of Anaesthesiology, Kobe University School of Medicine, Chuo-ku, Kobe, Japan","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110877992","display_name":"Hidefumi Obara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hidefumi Obara","raw_affiliation_strings":["Department of Anaesthesiology, Kobe University School of Medicine, Kusunoki-cho 7, 650, Chuo-ku, Kobe, Japan","Department of Anaesthesiology, Kobe University School of Medicine, Chuo-ku, Kobe, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anaesthesiology, Kobe University School of Medicine, Kusunoki-cho 7, 650, Chuo-ku, Kobe, Japan","institution_ids":["https://openalex.org/I65837984"]},{"raw_affiliation_string":"Department of Anaesthesiology, Kobe University School of Medicine, Chuo-ku, Kobe, Japan","institution_ids":["https://openalex.org/I65837984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":0.807,"has_fulltext":true,"cited_by_count":32,"citation_normalized_percentile":{"value":0.68505484,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"44","issue":"1","first_page":"95","last_page":"98"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.9286999702453613,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.9286999702453613,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11785","display_name":"Nausea and vomiting management","score":0.034299999475479126,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11292","display_name":"Pediatric Pain Management Techniques","score":0.028200000524520874,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/flurbiprofen","display_name":"flurbiprofen","score":1.0},{"id":"https://openalex.org/keywords/strabismus-surgery","display_name":"strabismus surgery","score":0.8709999918937683},{"id":"https://openalex.org/keywords/postoperative-pain","display_name":"postoperative pain","score":0.9049999713897705},{"id":"https://openalex.org/keywords/postoperative-nausea-and-vomiting","display_name":"postoperative nausea and vomiting","score":0.9210000038146973},{"id":"https://openalex.org/keywords/antiemetic-effect","display_name":"antiemetic effect","score":0.7099999785423279},{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.6840000152587891},{"id":"https://openalex.org/keywords/pediatric-surgery","display_name":"pediatric surgery","score":0.6809999942779541},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.7360000014305115},{"id":"https://openalex.org/keywords/diclofenac","display_name":"diclofenac","score":0.781000018119812},{"id":"https://openalex.org/keywords/opioid-sparing-analgesia","display_name":"opioid-sparing analgesia","score":0.7680000066757202}],"concepts":[{"id":"https://openalex.org/C2781000538","wikidata":"https://www.wikidata.org/wiki/Q419890","display_name":"Flurbiprofen","level":2,"score":0.9435042142868042},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9128343462944031},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.838650107383728},{"id":"https://openalex.org/C2780852908","wikidata":"https://www.wikidata.org/wiki/Q127076","display_name":"Vomiting","level":2,"score":0.6692206263542175},{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.6600621938705444},{"id":"https://openalex.org/C2780580376","wikidata":"https://www.wikidata.org/wiki/Q186889","display_name":"Nausea","level":2,"score":0.5639432072639465},{"id":"https://openalex.org/C2779826273","wikidata":"https://www.wikidata.org/wiki/Q244408","display_name":"Diclofenac","level":2,"score":0.45269519090652466},{"id":"https://openalex.org/C2776859179","wikidata":"https://www.wikidata.org/wiki/Q760341","display_name":"Strabismus surgery","level":3,"score":0.45177289843559265},{"id":"https://openalex.org/C2778573518","wikidata":"https://www.wikidata.org/wiki/Q7316656","display_name":"Retching","level":3,"score":0.4179118871688843},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.361206978559494},{"id":"https://openalex.org/C2776864138","wikidata":"https://www.wikidata.org/wiki/Q7620839","display_name":"Strabismus","level":2,"score":0.2943829298019409}],"mesh":[{"descriptor_ui":"D000077149","descriptor_name":"Sevoflurane","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000769","descriptor_name":"Anesthesia, Inhalation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000932","descriptor_name":"Antiemetics","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000932","descriptor_name":"Antiemetics","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004008","descriptor_name":"Diclofenac","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004008","descriptor_name":"Diclofenac","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004987","descriptor_name":"Ethers","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005480","descriptor_name":"Flurbiprofen","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005480","descriptor_name":"Flurbiprofen","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008738","descriptor_name":"Methyl Ethers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009325","descriptor_name":"Nausea","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D009609","descriptor_name":"Nitrous Oxide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010147","descriptor_name":"Pain Measurement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010149","descriptor_name":"Postoperative Pain","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D010919","descriptor_name":"Placebos","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011292","descriptor_name":"Premedication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013285","descriptor_name":"Strabismus","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D014839","descriptor_name":"Vomiting","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016037","descriptor_name":"Single-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018685","descriptor_name":"Anesthetics, Inhalation","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/bf03014332","doi":"https://doi.org/10.1007/bf03014332","is_oa":true,"landing_page_url":"https://doi.org/10.1007/bf03014332","pdf_url":"https://link.springer.com/content/pdf/10.1007/BF03014332.pdf","source":{"id":"https://openalex.org/S4210186964","display_name":"Canadian Journal of Anesthesia/Journal canadien d anesth\u00e9sie","issn_l":"0832-610X","issn":["0832-610X","1496-8975"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canadian Journal of Anaesthesia","raw_type":"journal-article"},{"id":"pmid:8988832","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8988832","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canadian journal of anaesthesia = Journal canadien d'anesthesie","raw_type":"Clinical Trial"}],"best_oa_location":{"id":"doi:10.1007/bf03014332","doi":"https://doi.org/10.1007/bf03014332","is_oa":true,"landing_page_url":"https://doi.org/10.1007/bf03014332","pdf_url":"https://link.springer.com/content/pdf/10.1007/BF03014332.pdf","source":{"id":"https://openalex.org/S4210186964","display_name":"Canadian Journal of Anesthesia/Journal canadien d anesth\u00e9sie","issn_l":"0832-610X","issn":["0832-610X","1496-8975"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canadian Journal of Anaesthesia","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2319449232.pdf","grobid_xml":"https://content.openalex.org/works/W2319449232.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W312966848","https://openalex.org/W1709124203","https://openalex.org/W1964634806","https://openalex.org/W1965643774","https://openalex.org/W1986286802","https://openalex.org/W1991546382","https://openalex.org/W1992158149","https://openalex.org/W1995193933","https://openalex.org/W2005181906","https://openalex.org/W2008929189","https://openalex.org/W2018051976","https://openalex.org/W2031492219","https://openalex.org/W2039962516","https://openalex.org/W2041436792","https://openalex.org/W2047816891","https://openalex.org/W2091115857","https://openalex.org/W2153428922","https://openalex.org/W2160206403","https://openalex.org/W2474665190"],"related_works":["https://openalex.org/W2087670273","https://openalex.org/W2384830218","https://openalex.org/W2039056356","https://openalex.org/W2005225669","https://openalex.org/W1984779375","https://openalex.org/W2024233053","https://openalex.org/W1597024317","https://openalex.org/W2137904679","https://openalex.org/W2043243608","https://openalex.org/W2077655960"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}