{"id":"https://openalex.org/W2319418396","doi":"https://doi.org/10.1089/oli.1.1998.8.207","title":"Interaction of Oligodeoxynucleotides with Mycobacteria: Implications for New Therapeutic Strategies","display_name":"Interaction of Oligodeoxynucleotides with Mycobacteria: Implications for New Therapeutic Strategies","publication_year":1998,"publication_date":"1998-06-01","ids":{"openalex":"https://openalex.org/W2319418396","doi":"https://doi.org/10.1089/oli.1.1998.8.207","mag":"2319418396","pmid":"https://pubmed.ncbi.nlm.nih.gov/9669658"},"language":"en","primary_location":{"id":"doi:10.1089/oli.1.1998.8.207","doi":"https://doi.org/10.1089/oli.1.1998.8.207","is_oa":false,"landing_page_url":"https://doi.org/10.1089/oli.1.1998.8.207","pdf_url":null,"source":{"id":"https://openalex.org/S92216883","display_name":"Antisense and Nucleic Acid Drug Development","issn_l":"1087-2906","issn":["1087-2906","2168-6599"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antisense and Nucleic Acid Drug Development","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022920664","display_name":"Steve Attia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S.A. ATTIA","raw_affiliation_strings":["Department of Pharmaceutics, University of Florida, Gainesville 32610, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, University of Florida, Gainesville 32610, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030700684","display_name":"VIRGINIA E. SHEPHERD","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V.E. SHEPHERD","raw_affiliation_strings":["","University of Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"University of Florida","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066363359","display_name":"Marla N Rosenblatt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.N. ROSENBLATT","raw_affiliation_strings":["","University of Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"University of Florida","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113337893","display_name":"M K Davidson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.K. DAVIDSON","raw_affiliation_strings":["","University of Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"University of Florida","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103689052","display_name":"Jeffrey A. Hughes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.A. HUGHES","raw_affiliation_strings":["","University of Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"University of Florida","institution_ids":["https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I33213144"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.17607094,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"8","issue":"3","first_page":"207","last_page":"214"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.013500000350177288,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.008500000461935997,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oligodeoxynucleotides","display_name":"oligodeoxynucleotides","score":0.9399999976158142},{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.8309999704360962},{"id":"https://openalex.org/keywords/mycobacterium-smegmatis","display_name":"Mycobacterium smegmatis","score":1.0},{"id":"https://openalex.org/keywords/phosphorothioate-oligonucleotides","display_name":"phosphorothioate oligonucleotides","score":0.9449999928474426},{"id":"https://openalex.org/keywords/oligonucleotide-delivery","display_name":"oligonucleotide delivery","score":0.8320000171661377},{"id":"https://openalex.org/keywords/ethambutol","display_name":"ethambutol","score":0.9959999918937683},{"id":"https://openalex.org/keywords/pamam-dendrimers","display_name":"PAMAM dendrimers","score":0.9679999947547913},{"id":"https://openalex.org/keywords/antimycobacterial-drug-targets","display_name":"antimycobacterial drug targets","score":0.8130000233650208},{"id":"https://openalex.org/keywords/antisense-therapy","display_name":"antisense therapy","score":0.44200000166893005}],"concepts":[{"id":"https://openalex.org/C2779685592","wikidata":"https://www.wikidata.org/wiki/Q2853298","display_name":"Antimycobacterial","level":4,"score":0.9103703498840332},{"id":"https://openalex.org/C2776228421","wikidata":"https://www.wikidata.org/wiki/Q412318","display_name":"Ethambutol","level":4,"score":0.8279613256454468},{"id":"https://openalex.org/C2777204207","wikidata":"https://www.wikidata.org/wiki/Q606230","display_name":"Mycobacterium smegmatis","level":4,"score":0.7486158609390259},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.6464096307754517},{"id":"https://openalex.org/C129312508","wikidata":"https://www.wikidata.org/wiki/Q133686","display_name":"Oligonucleotide","level":3,"score":0.6289210319519043},{"id":"https://openalex.org/C2780374374","wikidata":"https://www.wikidata.org/wiki/Q194309","display_name":"Mycobacterium","level":3,"score":0.6161926984786987},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5527598857879639},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.47270676493644714},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.4443841576576233},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.43032339215278625},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.42781034111976624},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.3942629098892212},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.38771456480026245},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2071780562400818},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.19051861763000488},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18808749318122864},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.1811559498310089},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1565486490726471},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10807013511657715},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.09263366460800171},{"id":"https://openalex.org/C2778607973","wikidata":"https://www.wikidata.org/wiki/Q422652","display_name":"Rifampicin","level":3,"score":0.08229944109916687},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004977","descriptor_name":"Ethambutol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009161","descriptor_name":"Mycobacterium","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009838","descriptor_name":"Oligodeoxyribonucleotides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009838","descriptor_name":"Oligodeoxyribonucleotides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1089/oli.1.1998.8.207","doi":"https://doi.org/10.1089/oli.1.1998.8.207","is_oa":false,"landing_page_url":"https://doi.org/10.1089/oli.1.1998.8.207","pdf_url":null,"source":{"id":"https://openalex.org/S92216883","display_name":"Antisense and Nucleic Acid Drug Development","issn_l":"1087-2906","issn":["1087-2906","2168-6599"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antisense and Nucleic Acid Drug Development","raw_type":"journal-article"},{"id":"pmid:9669658","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9669658","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antisense & nucleic acid drug development","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3691873329","display_name":null,"funder_award_id":"R29 HL55770-02","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320310009","display_name":"University of Florida","ror":"https://ror.org/02y3ad647"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W60020971","https://openalex.org/W79912825","https://openalex.org/W1435647736","https://openalex.org/W1774527113","https://openalex.org/W1849697331","https://openalex.org/W1948299140","https://openalex.org/W1987389660","https://openalex.org/W1990548509","https://openalex.org/W1997107662","https://openalex.org/W2016026936","https://openalex.org/W2023104469","https://openalex.org/W2044910887","https://openalex.org/W2046774967","https://openalex.org/W2069775700","https://openalex.org/W2070093106","https://openalex.org/W2080844915","https://openalex.org/W2090893088","https://openalex.org/W2098334967","https://openalex.org/W2098644908","https://openalex.org/W2114685191","https://openalex.org/W2142177142","https://openalex.org/W2154578380","https://openalex.org/W2159367333","https://openalex.org/W2188749901","https://openalex.org/W2312441583"],"related_works":["https://openalex.org/W1987389660","https://openalex.org/W2969598113","https://openalex.org/W2181933385","https://openalex.org/W1729577505","https://openalex.org/W1980461918","https://openalex.org/W2071389288","https://openalex.org/W2014441589","https://openalex.org/W3122400957","https://openalex.org/W2104376275","https://openalex.org/W2130583246"],"abstract_inverted_index":{"The":[0,172],"use":[1,100,181],"of":[2,18,27,35,41,81,101,127,141,164,174,182],"synthetic":[3],"oligonucleotides":[4],"(ONs)":[5],"to":[6,31,48,55,58,88,119,157,168],"systematically":[7],"address":[8],"new":[9,19],"pharmacologic":[10],"targets":[11,21],"in":[12],"mycobacteria":[13,51,165,190],"would":[14],"enhance":[15],"the":[16,33,39,66,68,79,99,112,128,139,142,145,169,183],"introduction":[17],"molecular":[20],"for":[22,199],"drug":[23],"intervention.":[24],"Oligonucleotides'":[25],"mechanism":[26],"action":[28],"allows":[29],"researchers":[30],"pursue":[32],"importance":[34],"particular":[36],"proteins":[37],"without":[38],"requirement":[40],"having":[42],"purified":[43],"samples.":[44],"For":[45],"this":[46,63,75],"approach":[47],"be":[49,53,71,120,136,192],"effective,":[50],"must":[52,70],"able":[54],"transport":[56],"ONs":[57,87],"their":[59],"cytoplasm,":[60],"and":[61,84,94,106,130],"if":[62],"is":[64],"not":[65,167],"case,":[67],"agents":[69],"otherwise":[72],"delivered.":[73],"In":[74,97],"report,":[76],"we":[77],"characterize":[78],"ability":[80],"phosphorothioate":[82],"(PS)":[83],"phosphorodiester":[85],"(PD)":[86],"interact":[89],"with":[90,144,149,161,189],"both":[91,162],"Mycobacterium":[92,95],"smegmatis":[93],"tuberculosis.":[96],"addition,":[98],"delivery":[102,146,185],"enhancer":[103],"compounds,":[104],"ethambutol":[105,150],"PAMAM":[107],"dendrimer,":[108],"was":[109,117,155],"evaluated":[110],"on":[111],"ON-mycobacteria":[113],"interaction.":[114,132],"ON":[115,133,159,187],"interaction":[116,134,160],"demonstrated":[118,156],"concentration-dependent,":[121],"suggesting":[122],"a":[123],"possibly":[124],"active":[125],"component":[126],"oligonucleotide":[129],"bacteria":[131,143],"could":[135],"increased":[137],"by":[138],"coincubation":[140],"adjuvants.":[147],"Treatment":[148],"or":[151],"dendrimers":[152],"(fourth":[153],"generation)":[154],"increase":[158],"species":[163],"although":[166],"same":[170],"extent.":[171],"results":[173],"these":[175],"preliminary":[176],"experiments":[177],"indicate":[178],"that":[179],"through":[180],"proper":[184],"adjuvant,":[186],"interactions":[188],"can":[191],"increased.":[193],"These":[194],"findings":[195],"may":[196],"have":[197],"implications":[198],"probing":[200],"future":[201],"antimycobacterial":[202],"therapeutic":[203],"targets.":[204]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}