{"id":"https://openalex.org/W2319416481","doi":"https://doi.org/10.1097/fjc.0b013e3181f801e4","title":"Antiangiogenic and Antimitotic Effects of Aspirin in Hypoxia\u2013Reoxygenation Modulation of the LOX-1-NADPH Oxidase Axis as a Potential Mechanism","display_name":"Antiangiogenic and Antimitotic Effects of Aspirin in Hypoxia\u2013Reoxygenation Modulation of the LOX-1-NADPH Oxidase Axis as a Potential Mechanism","publication_year":2010,"publication_date":"2010-09-28","ids":{"openalex":"https://openalex.org/W2319416481","doi":"https://doi.org/10.1097/fjc.0b013e3181f801e4","mag":"2319416481","pmid":"https://pubmed.ncbi.nlm.nih.gov/20881612"},"language":"en","primary_location":{"id":"doi:10.1097/fjc.0b013e3181f801e4","doi":"https://doi.org/10.1097/fjc.0b013e3181f801e4","is_oa":false,"landing_page_url":"https://doi.org/10.1097/fjc.0b013e3181f801e4","pdf_url":null,"source":{"id":"https://openalex.org/S61167191","display_name":"Journal of Cardiovascular Pharmacology","issn_l":"0160-2446","issn":["0160-2446","1533-4023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000157541","display_name":"Magomed Khaidakov","orcid":"https://orcid.org/0000-0003-4834-1077","observed_orcids":["https://orcid.org/0000-0003-4834-1077"]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Magomed Khaidakov","raw_affiliation_strings":["Division of Cardiovascular Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA","From the Division of Cardiovascular Medicine, University of Arkansas for Medical Sciences and VA Medical Center, Little Rock, AR","Received for publication May 20, 2010","Reprints: Jawahar L. Mehta, MD, PhD, Cardiovascular Medicine, University of Arkansas for Medical Sciences, 4301 West Markham Street, Slot 532, Little Rock, AR 72205 (e-mail: [email\u00a0protected] or [email\u00a0protected])","The authors report no conflicts of interest","These studies were supported by funds from the Department of Veterans Affairs, the Bayer Company, and Arkansas Bioventures","accepted August 17, 2010"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiovascular Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA","institution_ids":["https://openalex.org/I79620101"]},{"raw_affiliation_string":"From the Division of Cardiovascular Medicine, University of Arkansas for Medical Sciences and VA Medical Center, Little Rock, AR","institution_ids":["https://openalex.org/I79620101"]},{"raw_affiliation_string":"Received for publication May 20, 2010","institution_ids":[]},{"raw_affiliation_string":"Reprints: Jawahar L. Mehta, MD, PhD, Cardiovascular Medicine, University of Arkansas for Medical Sciences, 4301 West Markham Street, Slot 532, Little Rock, AR 72205 (e-mail: [email\u00a0protected] or [email\u00a0protected])","institution_ids":["https://openalex.org/I79620101"]},{"raw_affiliation_string":"The authors report no conflicts of interest","institution_ids":[]},{"raw_affiliation_string":"These studies were supported by funds from the Department of Veterans Affairs, the Bayer Company, and Arkansas Bioventures","institution_ids":[]},{"raw_affiliation_string":"accepted August 17, 2010","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080109368","display_name":"Jacob Szwedo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacob Szwedo","raw_affiliation_strings":["These studies were supported by funds from the Department of Veterans Affairs, the Bayer Company, and Arkansas Bioventures","the Division of Cardiovascular Medicine, University of Arkansas for Medical Sciences and VA Medical Center, Little Rock, AR","From the Division of Cardiovascular Medicine, University of Arkansas for Medical Sciences and VA Medical Center, Little Rock, AR","Received for publication May 20, 2010","Reprints: Jawahar L. Mehta, MD, PhD, Cardiovascular Medicine, University of Arkansas for Medical Sciences, 4301 West Markham Street, Slot 532, Little Rock, AR 72205 (e-mail: [email\u00a0protected] or [email\u00a0protected])","The authors report no conflicts of interest","accepted August 17, 2010"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"These studies were supported by funds from the Department of Veterans Affairs, the Bayer Company, and Arkansas Bioventures","institution_ids":[]},{"raw_affiliation_string":"the Division of Cardiovascular Medicine, University of Arkansas for Medical Sciences and VA Medical Center, Little Rock, AR","institution_ids":["https://openalex.org/I79620101"]},{"raw_affiliation_string":"From the Division of Cardiovascular Medicine, University of Arkansas for Medical Sciences and VA Medical Center, Little Rock, AR","institution_ids":["https://openalex.org/I79620101"]},{"raw_affiliation_string":"Received for publication May 20, 2010","institution_ids":[]},{"raw_affiliation_string":"Reprints: Jawahar L. Mehta, MD, PhD, Cardiovascular Medicine, University of Arkansas for Medical Sciences, 4301 West Markham Street, Slot 532, Little Rock, AR 72205 (e-mail: [email\u00a0protected] or [email\u00a0protected])","institution_ids":["https://openalex.org/I79620101"]},{"raw_affiliation_string":"The authors report no conflicts of interest","institution_ids":[]},{"raw_affiliation_string":"accepted August 17, 2010","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052121330","display_name":"Sona Mitra","orcid":"https://orcid.org/0000-0002-4964-8081","observed_orcids":["https://orcid.org/0000-0002-4964-8081"]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sona Mitra","raw_affiliation_strings":["These studies were supported by funds from the Department of Veterans Affairs, the Bayer Company, and Arkansas Bioventures","the Division of Cardiovascular Medicine, University of Arkansas for Medical Sciences and VA Medical Center, Little Rock, AR","Received for publication May 20, 2010","Reprints: Jawahar L. Mehta, MD, PhD, Cardiovascular Medicine, University of Arkansas for Medical Sciences, 4301 West Markham Street, Slot 532, Little Rock, AR 72205 (e-mail: [email\u00a0protected] or [email\u00a0protected])","The authors report no conflicts of interest","accepted August 17, 2010"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"These studies were supported by funds from the Department of Veterans Affairs, the Bayer Company, and Arkansas Bioventures","institution_ids":[]},{"raw_affiliation_string":"the Division of Cardiovascular Medicine, University of Arkansas for Medical Sciences and VA Medical Center, Little Rock, AR","institution_ids":["https://openalex.org/I79620101"]},{"raw_affiliation_string":"Received for publication May 20, 2010","institution_ids":[]},{"raw_affiliation_string":"Reprints: Jawahar L. Mehta, MD, PhD, Cardiovascular Medicine, University of Arkansas for Medical Sciences, 4301 West Markham Street, Slot 532, Little Rock, AR 72205 (e-mail: [email\u00a0protected] or [email\u00a0protected])","institution_ids":["https://openalex.org/I79620101"]},{"raw_affiliation_string":"The authors report no conflicts of interest","institution_ids":[]},{"raw_affiliation_string":"accepted August 17, 2010","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039791222","display_name":"Srinivas Ayyadevara","orcid":"https://orcid.org/0000-0002-4572-6361","observed_orcids":["https://orcid.org/0000-0002-4572-6361"]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Srinivas Ayyadevara","raw_affiliation_strings":["These studies were supported by funds from the Department of Veterans Affairs, the Bayer Company, and Arkansas Bioventures","the Division of Cardiovascular Medicine, University of Arkansas for Medical Sciences and VA Medical Center, Little Rock, AR","From the Division of Cardiovascular Medicine, University of Arkansas for Medical Sciences and VA Medical Center, Little Rock, AR","Received for publication May 20, 2010","Reprints: Jawahar L. Mehta, MD, PhD, Cardiovascular Medicine, University of Arkansas for Medical Sciences, 4301 West Markham Street, Slot 532, Little Rock, AR 72205 (e-mail: [email\u00a0protected] or [email\u00a0protected])","The authors report no conflicts of interest","accepted August 17, 2010"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"These studies were supported by funds from the Department of Veterans Affairs, the Bayer Company, and Arkansas Bioventures","institution_ids":[]},{"raw_affiliation_string":"the Division of Cardiovascular Medicine, University of Arkansas for Medical Sciences and VA Medical Center, Little Rock, AR","institution_ids":["https://openalex.org/I79620101"]},{"raw_affiliation_string":"From the Division of Cardiovascular Medicine, University of Arkansas for Medical Sciences and VA Medical Center, Little Rock, AR","institution_ids":["https://openalex.org/I79620101"]},{"raw_affiliation_string":"Received for publication May 20, 2010","institution_ids":[]},{"raw_affiliation_string":"Reprints: Jawahar L. Mehta, MD, PhD, Cardiovascular Medicine, University of Arkansas for Medical Sciences, 4301 West Markham Street, Slot 532, Little Rock, AR 72205 (e-mail: [email\u00a0protected] or [email\u00a0protected])","institution_ids":["https://openalex.org/I79620101"]},{"raw_affiliation_string":"The authors report no conflicts of interest","institution_ids":[]},{"raw_affiliation_string":"accepted August 17, 2010","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083200304","display_name":"Maxim G. Dobretsov","orcid":"https://orcid.org/0000-0001-6007-9775","observed_orcids":["https://orcid.org/0000-0001-6007-9775"]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maxim Dobretsov","raw_affiliation_strings":["These studies were supported by funds from the Department of Veterans Affairs, the Bayer Company, and Arkansas Bioventures","the Division of Cardiovascular Medicine, University of Arkansas for Medical Sciences and VA Medical Center, Little Rock, AR","From the Division of Cardiovascular Medicine, University of Arkansas for Medical Sciences and VA Medical Center, Little Rock, AR","Received for publication May 20, 2010","Reprints: Jawahar L. Mehta, MD, PhD, Cardiovascular Medicine, University of Arkansas for Medical Sciences, 4301 West Markham Street, Slot 532, Little Rock, AR 72205 (e-mail: [email\u00a0protected] or [email\u00a0protected])","The authors report no conflicts of interest","accepted August 17, 2010"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"These studies were supported by funds from the Department of Veterans Affairs, the Bayer Company, and Arkansas Bioventures","institution_ids":[]},{"raw_affiliation_string":"the Division of Cardiovascular Medicine, University of Arkansas for Medical Sciences and VA Medical Center, Little Rock, AR","institution_ids":["https://openalex.org/I79620101"]},{"raw_affiliation_string":"From the Division of Cardiovascular Medicine, University of Arkansas for Medical Sciences and VA Medical Center, Little Rock, AR","institution_ids":["https://openalex.org/I79620101"]},{"raw_affiliation_string":"Received for publication May 20, 2010","institution_ids":[]},{"raw_affiliation_string":"Reprints: Jawahar L. Mehta, MD, PhD, Cardiovascular Medicine, University of Arkansas for Medical Sciences, 4301 West Markham Street, Slot 532, Little Rock, AR 72205 (e-mail: [email\u00a0protected] or [email\u00a0protected])","institution_ids":["https://openalex.org/I79620101"]},{"raw_affiliation_string":"The authors report no conflicts of interest","institution_ids":[]},{"raw_affiliation_string":"accepted August 17, 2010","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111578005","display_name":"Jingjun L\u00fc","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jingjun Lu","raw_affiliation_strings":["These studies were supported by funds from the Department of Veterans Affairs, the Bayer Company, and Arkansas Bioventures","the Division of Cardiovascular Medicine, University of Arkansas for Medical Sciences and VA Medical Center, Little Rock, AR","From the Division of Cardiovascular Medicine, University of Arkansas for Medical Sciences and VA Medical Center, Little Rock, AR","Received for publication May 20, 2010","Reprints: Jawahar L. Mehta, MD, PhD, Cardiovascular Medicine, University of Arkansas for Medical Sciences, 4301 West Markham Street, Slot 532, Little Rock, AR 72205 (e-mail: [email\u00a0protected] or [email\u00a0protected])","The authors report no conflicts of interest","accepted August 17, 2010"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"These studies were supported by funds from the Department of Veterans Affairs, the Bayer Company, and Arkansas Bioventures","institution_ids":[]},{"raw_affiliation_string":"the Division of Cardiovascular Medicine, University of Arkansas for Medical Sciences and VA Medical Center, Little Rock, AR","institution_ids":["https://openalex.org/I79620101"]},{"raw_affiliation_string":"From the Division of Cardiovascular Medicine, University of Arkansas for Medical Sciences and VA Medical Center, Little Rock, AR","institution_ids":["https://openalex.org/I79620101"]},{"raw_affiliation_string":"Received for publication May 20, 2010","institution_ids":[]},{"raw_affiliation_string":"Reprints: Jawahar L. Mehta, MD, PhD, Cardiovascular Medicine, University of Arkansas for Medical Sciences, 4301 West Markham Street, Slot 532, Little Rock, AR 72205 (e-mail: [email\u00a0protected] or [email\u00a0protected])","institution_ids":["https://openalex.org/I79620101"]},{"raw_affiliation_string":"The authors report no conflicts of interest","institution_ids":[]},{"raw_affiliation_string":"accepted August 17, 2010","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113520521","display_name":"Jawahar L. Mehta","orcid":"https://orcid.org/0000-0003-0384-2097","observed_orcids":["https://orcid.org/0000-0003-0384-2097"]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jawahar L Mehta","raw_affiliation_strings":["These studies were supported by funds from the Department of Veterans Affairs, the Bayer Company, and Arkansas Bioventures","the Division of Cardiovascular Medicine, University of Arkansas for Medical Sciences and VA Medical Center, Little Rock, AR","From the Division of Cardiovascular Medicine, University of Arkansas for Medical Sciences and VA Medical Center, Little Rock, AR","Received for publication May 20, 2010","Reprints: Jawahar L. Mehta, MD, PhD, Cardiovascular Medicine, University of Arkansas for Medical Sciences, 4301 West Markham Street, Slot 532, Little Rock, AR 72205 (e-mail: [email\u00a0protected] or [email\u00a0protected])","The authors report no conflicts of interest","accepted August 17, 2010"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"These studies were supported by funds from the Department of Veterans Affairs, the Bayer Company, and Arkansas Bioventures","institution_ids":[]},{"raw_affiliation_string":"the Division of Cardiovascular Medicine, University of Arkansas for Medical Sciences and VA Medical Center, Little Rock, AR","institution_ids":["https://openalex.org/I79620101"]},{"raw_affiliation_string":"From the Division of Cardiovascular Medicine, University of Arkansas for Medical Sciences and VA Medical Center, Little Rock, AR","institution_ids":["https://openalex.org/I79620101"]},{"raw_affiliation_string":"Received for publication May 20, 2010","institution_ids":[]},{"raw_affiliation_string":"Reprints: Jawahar L. Mehta, MD, PhD, Cardiovascular Medicine, University of Arkansas for Medical Sciences, 4301 West Markham Street, Slot 532, Little Rock, AR 72205 (e-mail: [email\u00a0protected] or [email\u00a0protected])","institution_ids":["https://openalex.org/I79620101"]},{"raw_affiliation_string":"The authors report no conflicts of interest","institution_ids":[]},{"raw_affiliation_string":"accepted August 17, 2010","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I79620101"],"apc_list":null,"apc_paid":null,"fwci":1.3018,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.78939044,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"56","issue":"6","first_page":"635","last_page":"641"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.8500999808311462,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.8500999808311462,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.05590000003576279,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.02500000037252903,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aspirin","display_name":"aspirin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hypoxia-reoxygenation","display_name":"hypoxia/reoxygenation","score":0.9760000109672546},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9430000185966492},{"id":"https://openalex.org/keywords/adherens-junctions","display_name":"adherens junctions","score":0.8899999856948853},{"id":"https://openalex.org/keywords/lox-1","display_name":"LOX-1","score":0.968999981880188},{"id":"https://openalex.org/keywords/nadph-oxidase","display_name":"NADPH oxidase","score":0.9660000205039978},{"id":"https://openalex.org/keywords/p47phox","display_name":"p47phox","score":0.9750000238418579},{"id":"https://openalex.org/keywords/ve-cadherin","display_name":"VE-cadherin","score":0.8859999775886536},{"id":"https://openalex.org/keywords/beta-catenin","display_name":"\u03b2-catenin","score":0.9120000004768372},{"id":"https://openalex.org/keywords/endothelial-nitric-oxide-synthase","display_name":"endothelial nitric oxide synthase","score":0.8309999704360962},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.6840000152587891},{"id":"https://openalex.org/keywords/tube-formation","display_name":"tube formation","score":0.824999988079071},{"id":"https://openalex.org/keywords/antimitotic-effect","display_name":"antimitotic effect","score":0.6819999814033508},{"id":"https://openalex.org/keywords/atherogenesis","display_name":"atherogenesis","score":0.7160000205039978},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.6209999918937683}],"concepts":[{"id":"https://openalex.org/C201508349","wikidata":"https://www.wikidata.org/wiki/Q45173","display_name":"Adherens junction","level":4,"score":0.8835279941558838},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5958506464958191},{"id":"https://openalex.org/C2779719074","wikidata":"https://www.wikidata.org/wiki/Q2038057","display_name":"NADPH oxidase","level":3,"score":0.5898615121841431},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.5871111154556274},{"id":"https://openalex.org/C2777411675","wikidata":"https://www.wikidata.org/wiki/Q1232438","display_name":"Umbilical vein","level":3,"score":0.537712812423706},{"id":"https://openalex.org/C2777834122","wikidata":"https://www.wikidata.org/wiki/Q5939177","display_name":"Human umbilical vein endothelial cell","level":4,"score":0.47238731384277344},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.446732759475708},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.44177767634391785},{"id":"https://openalex.org/C2778608917","wikidata":"https://www.wikidata.org/wiki/Q6787805","display_name":"Matrigel","level":3,"score":0.42167484760284424},{"id":"https://openalex.org/C2781380885","wikidata":"https://www.wikidata.org/wiki/Q17859848","display_name":"VE-cadherin","level":4,"score":0.42023056745529175},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4045577645301819},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37562504410743713},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.32152116298675537},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2304776906967163},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.20247137546539307},{"id":"https://openalex.org/C149402561","wikidata":"https://www.wikidata.org/wiki/Q24776048","display_name":"Cadherin","level":3,"score":0.1757512390613556},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.11707893013954163},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.10233289003372192},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.08891385793685913},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001241","descriptor_name":"Aspirin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007365","descriptor_name":"Intercellular Junctions","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007365","descriptor_name":"Intercellular Junctions","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015687","descriptor_name":"Cell Hypoxia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015687","descriptor_name":"Cell Hypoxia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019255","descriptor_name":"NADPH Oxidases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D050256","descriptor_name":"Antimitotic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051127","descriptor_name":"Scavenger Receptors, Class E","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/fjc.0b013e3181f801e4","doi":"https://doi.org/10.1097/fjc.0b013e3181f801e4","is_oa":false,"landing_page_url":"https://doi.org/10.1097/fjc.0b013e3181f801e4","pdf_url":null,"source":{"id":"https://openalex.org/S61167191","display_name":"Journal of Cardiovascular Pharmacology","issn_l":"0160-2446","issn":["0160-2446","1533-4023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Pharmacology","raw_type":"journal-article"},{"id":"pmid:20881612","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20881612","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cardiovascular pharmacology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1937673325","https://openalex.org/W1969518503","https://openalex.org/W1972168890","https://openalex.org/W1974195387","https://openalex.org/W1989173642","https://openalex.org/W2009795091","https://openalex.org/W2012095617","https://openalex.org/W2014569663","https://openalex.org/W2014995450","https://openalex.org/W2029573752","https://openalex.org/W2031246957","https://openalex.org/W2037943855","https://openalex.org/W2063449407","https://openalex.org/W2066618129","https://openalex.org/W2067525107","https://openalex.org/W2069427619","https://openalex.org/W2070770334","https://openalex.org/W2074802089","https://openalex.org/W2077762036","https://openalex.org/W2090150679","https://openalex.org/W2093045792","https://openalex.org/W2101634508","https://openalex.org/W2107713376","https://openalex.org/W2116628576","https://openalex.org/W2129214570","https://openalex.org/W2133586647","https://openalex.org/W2137555841","https://openalex.org/W2147125269"],"related_works":["https://openalex.org/W1989797365","https://openalex.org/W2318997203","https://openalex.org/W2314415330","https://openalex.org/W2046131759","https://openalex.org/W109590490","https://openalex.org/W2314663442","https://openalex.org/W2102648412","https://openalex.org/W2131525005","https://openalex.org/W2113338664","https://openalex.org/W2765334389"],"abstract_inverted_index":{"Hypoxia\u2013reoxygenation":[0],"(HR)":[1,47],"is":[2,20],"a":[3,40],"primary":[4],"driver":[5],"of":[6,16,27,34,43,52,67,71,87,94,102,107,121,140,149,170,175,194,200,214,226,233],"angiogenesis":[7,49,158],"in":[8,55,118,126,147],"both":[9],"atherogenesis":[10],"and":[11,50,105,113,124,156,189,197,217,228,242],"tumorigenesis.":[12],"The":[13],"main":[14],"target":[15],"hypoxia-driven":[17],"proangiogenic":[18],"signaling":[19],"adherens":[21,53,103,150,215],"junctions":[22,104,151,216],"responsible":[23],"for":[24],"contact":[25],"inhibition":[26],"endothelial":[28,60,75,176,185],"cells.":[29],"We":[30],"analyzed":[31],"the":[32,65,119,136,153,167,191,195,212,229],"effects":[33,66],"hypoxia":[35],"(8\u201312":[36],"hours)":[37,46],"followed":[38],"by":[39],"brief":[41],"period":[42],"reoxygenation":[44],"(2":[45],"on":[48,69,91,152,184,204],"integrity":[51,213],"junction":[54],"cultured":[56],"human":[57,72],"umbilical":[58,73],"vein":[59,74],"cells":[61,96],"as":[62,64,159,161],"well":[63,160],"aspirin":[68,141,210],"modulation":[70],"cells'":[76],"response":[77,221],"to":[78,82,132,222],"HR.":[79],"Cells":[80],"exposed":[81],"HR":[83,99,116,163,223],"displayed":[84],"considerable":[85],"enhancement":[86],"tube":[88],"formation":[89],"(angiogenesis)":[90],"matrigel.":[92],"Immunocytostaining":[93],"near-confluent":[95],"revealed":[97],"that":[98,209],"caused":[100,164],"disruption":[101],"internalization":[106],"their":[108],"components":[109],"VE-cadherin,":[110],"p120":[111],"catenin,":[112],"b-catenin.":[114],"Additionally,":[115],"resulted":[117,146],"appearance":[120],"binucleated":[122],"cells,":[123],"VE-cadherin":[125],"colocalization":[127],"with":[128],"b-catenin":[129],"was":[130],"found":[131],"be":[133],"positioned":[134],"between":[135],"separating":[137],"nuclei.":[138],"Presence":[139],"(acetylsalicylic":[142],"acid,":[143],"1":[144],"mM)":[145],"preservation":[148],"cellular":[154],"membrane":[155],"prevented":[157],"mitosis.":[162],"upregulation":[165],"LOX-1,":[166],"p47(phox)":[168,198,231],"subunit":[169,199],"NADPH,":[171],"while":[172],"reducing":[173],"transcription":[174],"nitric":[177,186],"oxide":[178,187],"synthase.":[179],"Aspirin":[180],"had":[181],"no":[182],"effect":[183],"synthase":[188],"canceled":[190],"transcriptional":[192],"activation":[193],"LOX-1":[196,227],"NADPH":[201,234,239],"oxidase.":[202],"Based":[203],"these":[205],"data,":[206],"we":[207],"hypothesize":[208],"preserves":[211],"thus":[218,237],"blunts":[219],"angiogenic":[220],"through":[224],"downregulation":[225],"LOX-1-mediated":[230],"component":[232],"oxidase":[235,240],"transcription,":[236],"preventing":[238],"assembly":[241],"function.":[243]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
