{"id":"https://openalex.org/W2319294148","doi":"https://doi.org/10.3181/00379727-122-31205","title":"Influence of Stress on the Growth Hormone (GH) Content of the Pituitary of the Rat","display_name":"Influence of Stress on the Growth Hormone (GH) Content of the Pituitary of the Rat","publication_year":1966,"publication_date":"1966-06-01","ids":{"openalex":"https://openalex.org/W2319294148","doi":"https://doi.org/10.3181/00379727-122-31205","mag":"2319294148","pmid":"https://pubmed.ncbi.nlm.nih.gov/5980575"},"language":"en","primary_location":{"id":"doi:10.3181/00379727-122-31205","doi":"https://doi.org/10.3181/00379727-122-31205","is_oa":false,"landing_page_url":"https://doi.org/10.3181/00379727-122-31205","pdf_url":null,"source":{"id":"https://openalex.org/S67514239","display_name":"Experimental Biology and Medicine","issn_l":"0071-3384","issn":["0071-3384","1535-3699","1535-3702"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Biology and Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020375677","display_name":"L. Krulich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Krulich","raw_affiliation_strings":["Departments of Physiology, University of Pennsylvania School of Medicine, Philadelphia, and University of Texas, Southwestern Medical School, Dallas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Physiology, University of Pennsylvania School of Medicine, Philadelphia, and University of Texas, Southwestern Medical School, Dallas","institution_ids":["https://openalex.org/I79576946","https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069185819","display_name":"Samuel M. McCann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. M. McCann","raw_affiliation_strings":["Departments of Physiology, University of Pennsylvania School of Medicine, Philadelphia, and University of Texas, Southwestern Medical School, Dallas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Physiology, University of Pennsylvania School of Medicine, Philadelphia, and University of Texas, Southwestern Medical School, Dallas","institution_ids":["https://openalex.org/I79576946","https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":null,"fwci":0.6265,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.7448489,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"122","issue":"2","first_page":"612","last_page":"616"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/growth-hormone","display_name":"growth hormone","score":0.9319999814033508},{"id":"https://openalex.org/keywords/pituitary-gland","display_name":"pituitary gland","score":0.9359999895095825},{"id":"https://openalex.org/keywords/stress","display_name":"stress","score":0.8679999709129333},{"id":"https://openalex.org/keywords/splenectomy","display_name":"splenectomy","score":0.8870000243186951},{"id":"https://openalex.org/keywords/formalin-injection","display_name":"formalin injection","score":0.9010000228881836},{"id":"https://openalex.org/keywords/cold-exposure","display_name":"cold exposure","score":0.7099999785423279},{"id":"https://openalex.org/keywords/fasting","display_name":"fasting","score":0.9660000205039978},{"id":"https://openalex.org/keywords/hypophysectomy","display_name":"hypophysectomy","score":0.9509999752044678},{"id":"https://openalex.org/keywords/growth-hormone-secretion","display_name":"growth hormone secretion","score":0.5019999742507935},{"id":"https://openalex.org/keywords/carbohydrate-supply","display_name":"carbohydrate supply","score":0.4869999885559082},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.47699999809265137}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7964324951171875},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7902531623840332},{"id":"https://openalex.org/C2780104272","wikidata":"https://www.wikidata.org/wiki/Q933496","display_name":"Hypophysectomy","level":3,"score":0.7306426763534546},{"id":"https://openalex.org/C2777658017","wikidata":"https://www.wikidata.org/wiki/Q156871","display_name":"Pituitary gland","level":3,"score":0.6759831309318542},{"id":"https://openalex.org/C2779029589","wikidata":"https://www.wikidata.org/wiki/Q356002","display_name":"Anterior pituitary","level":3,"score":0.49052876234054565},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45118552446365356},{"id":"https://openalex.org/C2984496839","wikidata":"https://www.wikidata.org/wiki/Q29956617","display_name":"Growth hormone","level":3,"score":0.43125152587890625},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35413575172424316},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.3002775311470032},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24553027749061584}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001681","descriptor_name":"Biological Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003080","descriptor_name":"Cold Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004838","descriptor_name":"Epiphyses","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005215","descriptor_name":"Fasting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005557","descriptor_name":"Formaldehyde","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007016","descriptor_name":"Hypophysectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010902","descriptor_name":"Pituitary Gland","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D013006","descriptor_name":"Growth Hormone","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013016","descriptor_name":"Sound","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013156","descriptor_name":"Splenectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D013977","descriptor_name":"Tibia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3181/00379727-122-31205","doi":"https://doi.org/10.3181/00379727-122-31205","is_oa":false,"landing_page_url":"https://doi.org/10.3181/00379727-122-31205","pdf_url":null,"source":{"id":"https://openalex.org/S67514239","display_name":"Experimental Biology and Medicine","issn_l":"0071-3384","issn":["0071-3384","1535-3699","1535-3702"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Biology and Medicine","raw_type":"journal-article"},{"id":"pmid:5980575","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5980575","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4000000059604645,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2325332794","https://openalex.org/W2319253799","https://openalex.org/W2085263437","https://openalex.org/W1965559741","https://openalex.org/W2333493391","https://openalex.org/W2064334152","https://openalex.org/W2326811042","https://openalex.org/W2324871307","https://openalex.org/W2162162075","https://openalex.org/W2104171929"],"abstract_inverted_index":{"Pituitary":[0],"GH":[1,29,37,53,132,145],"activity":[2,38,54],"was":[3,31,95,120],"estimated":[4],"by":[5,33,155,163],"the":[6,66,117,131,135,148,166],"tibial":[7],"epiphyseal":[8],"cartilage":[9],"test":[10],"in":[11,27,36,65,97,147,165],"hypophysectomized":[12],"rats.":[13],"Experimental":[14],"animals":[15],"were":[16],"exposed":[17],"to":[18,57,78,105],"5":[19],"different":[20],"stimuli.":[21],"Splenectomy":[22],"evoked":[23],"a":[24,34,63,79,87,123,156],"transient":[25],"decrease":[26],"pituitary":[28,52,75,90],"which":[30],"followed":[32],"rise":[35],"apparent":[39],"within":[40],"60":[41,58,84],"minutes":[42,59,72,85],"of":[43,51,81,89,116,125,134,158,168],"operation.":[44],"Formalin":[45],"injections":[46],"similarly":[47],"produced":[48,86],"an":[49,101],"elevation":[50],"at":[55],"30":[56,71],"after":[60,114],"injection.":[61],"Ringing":[62],"doorbell":[64],"animal's":[67],"cage":[68],"intermittently":[69],"for":[70,83],"also":[73],"elevated":[74],"GH.":[76,91],"Exposure":[77],"temperature":[80],"3\u00b0C":[82],"depletion":[88,110],"A":[92],"biphasic":[93],"response":[94],"observed":[96],"fasting,":[98],"that":[99,122,144],"is":[100,150],"initial":[102],"depletion,":[103],"return":[104],"base":[106],"line,":[107],"and":[108,153],"finally":[109],"observable":[111],"64-88":[112],"hours":[113],"onset":[115],"fast.":[118],"It":[119],"concluded":[121],"variety":[124,157],"apparently":[126],"unrelated":[127],"stimuli":[128],"could":[129],"alter":[130],"content":[133],"pituitary.":[136],"Taken":[137],"together":[138],"with":[139],"other":[140],"evidence":[141],"it":[142],"appears":[143],"secretion":[146],"rat":[149],"very":[151],"labile":[152],"influenced":[154],"stresses":[159],"as":[160,162],"well":[161],"alterations":[164],"supply":[167],"available":[169],"carbohydrate.":[170]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}