{"id":"https://openalex.org/W2319252720","doi":"https://doi.org/10.1136/fetalneonatal-2012-301809.101","title":"Spontaneous platelet aggregation (SPA) predicts pre-eclampsia and intra-uterine growth restriction","display_name":"Spontaneous platelet aggregation (SPA) predicts pre-eclampsia and intra-uterine growth restriction","publication_year":2012,"publication_date":"2012-04-01","ids":{"openalex":"https://openalex.org/W2319252720","doi":"https://doi.org/10.1136/fetalneonatal-2012-301809.101","mag":"2319252720"},"language":"en","primary_location":{"id":"doi:10.1136/fetalneonatal-2012-301809.101","doi":"https://doi.org/10.1136/fetalneonatal-2012-301809.101","is_oa":false,"landing_page_url":"https://doi.org/10.1136/fetalneonatal-2012-301809.101","pdf_url":null,"source":{"id":"https://openalex.org/S35570472","display_name":"Archives of Disease in Childhood Fetal & Neonatal","issn_l":"1359-2998","issn":["1359-2998","1468-2052"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Disease in Childhood - Fetal and Neonatal Edition","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"N Burke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142762351","display_name":"Royal College of Surgeons in Ireland","ror":"https://ror.org/01hxy9878","country_code":"IE","type":"education","lineage":["https://openalex.org/I142762351"]},{"id":"https://openalex.org/I2799298456","display_name":"Rotunda Hospital","ror":"https://ror.org/05t4vgv93","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I2799298456"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"N Burke","raw_affiliation_strings":["Dept. of Obs and Gynae., Royal College of Surgeons in Ireland, Dublin, Ireland","Rotunda Hospital, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Obs and Gynae., Royal College of Surgeons in Ireland, Dublin, Ireland","institution_ids":["https://openalex.org/I142762351"]},{"raw_affiliation_string":"Rotunda Hospital, Dublin, Ireland","institution_ids":["https://openalex.org/I2799298456"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090377957","display_name":"Aoife Murray","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142762351","display_name":"Royal College of Surgeons in Ireland","ror":"https://ror.org/01hxy9878","country_code":"IE","type":"education","lineage":["https://openalex.org/I142762351"]},{"id":"https://openalex.org/I2799298456","display_name":"Rotunda Hospital","ror":"https://ror.org/05t4vgv93","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I2799298456"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"A Murray","raw_affiliation_strings":["Dept. of Obs and Gynae., Royal College of Surgeons in Ireland, Dublin, Ireland","Rotunda Hospital, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Obs and Gynae., Royal College of Surgeons in Ireland, Dublin, Ireland","institution_ids":["https://openalex.org/I142762351"]},{"raw_affiliation_string":"Rotunda Hospital, Dublin, Ireland","institution_ids":["https://openalex.org/I2799298456"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023416319","display_name":"Eimear Dunne","orcid":"https://orcid.org/0000-0001-9862-1398","observed_orcids":["https://orcid.org/0000-0001-9862-1398","https://orcid.org/0000-0002-3343-8071"]},"institutions":[{"id":"https://openalex.org/I142762351","display_name":"Royal College of Surgeons in Ireland","ror":"https://ror.org/01hxy9878","country_code":"IE","type":"education","lineage":["https://openalex.org/I142762351"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"E Dunne","raw_affiliation_strings":["Dept. of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland","institution_ids":["https://openalex.org/I142762351"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060039704","display_name":"Patrick Dicker","orcid":"https://orcid.org/0000-0002-7942-9314","observed_orcids":["https://orcid.org/0000-0002-7942-9314"]},"institutions":[{"id":"https://openalex.org/I142762351","display_name":"Royal College of Surgeons in Ireland","ror":"https://ror.org/01hxy9878","country_code":"IE","type":"education","lineage":["https://openalex.org/I142762351"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"P Dicker","raw_affiliation_strings":["Dept. of Epidemiology, Royal College of Surgeons in Ireland, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Epidemiology, Royal College of Surgeons in Ireland, Dublin, Ireland","institution_ids":["https://openalex.org/I142762351"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112355559","display_name":"Mark Dempsey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799298456","display_name":"Rotunda Hospital","ror":"https://ror.org/05t4vgv93","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I2799298456"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"M Dempsey","raw_affiliation_strings":["Rotunda Hospital, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rotunda Hospital, Dublin, Ireland","institution_ids":["https://openalex.org/I2799298456"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040358239","display_name":"Heather M. O\u2019Connor","orcid":"https://orcid.org/0000-0003-1354-5862","observed_orcids":["https://orcid.org/0000-0003-1354-5862"]},"institutions":[{"id":"https://openalex.org/I2799298456","display_name":"Rotunda Hospital","ror":"https://ror.org/05t4vgv93","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I2799298456"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"H O\u2019Connor","raw_affiliation_strings":["Rotunda Hospital, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rotunda Hospital, Dublin, Ireland","institution_ids":["https://openalex.org/I2799298456"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024360785","display_name":"Zara Fonseca-Kelly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799298456","display_name":"Rotunda Hospital","ror":"https://ror.org/05t4vgv93","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I2799298456"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Z Fonseca-Kelly","raw_affiliation_strings":["Rotunda Hospital, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rotunda Hospital, Dublin, Ireland","institution_ids":["https://openalex.org/I2799298456"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050269121","display_name":"Brian Cotter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142762351","display_name":"Royal College of Surgeons in Ireland","ror":"https://ror.org/01hxy9878","country_code":"IE","type":"education","lineage":["https://openalex.org/I142762351"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"B Cotter","raw_affiliation_strings":["Dept. of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland","Dept. of Obs and Gynae., Royal College of Surgeons in Ireland, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland","institution_ids":["https://openalex.org/I142762351"]},{"raw_affiliation_string":"Dept. of Obs and Gynae., Royal College of Surgeons in Ireland, Dublin, Ireland","institution_ids":["https://openalex.org/I142762351"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074065777","display_name":"Michael Patrick Geary","orcid":"https://orcid.org/0000-0002-7387-3385","observed_orcids":["https://orcid.org/0000-0002-7387-3385"]},"institutions":[{"id":"https://openalex.org/I2799298456","display_name":"Rotunda Hospital","ror":"https://ror.org/05t4vgv93","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I2799298456"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"M Geary","raw_affiliation_strings":["Rotunda Hospital, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rotunda Hospital, Dublin, Ireland","institution_ids":["https://openalex.org/I2799298456"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083132394","display_name":"Karen Flood","orcid":"https://orcid.org/0000-0002-2118-916X","observed_orcids":["https://orcid.org/0000-0002-2118-916X"]},"institutions":[{"id":"https://openalex.org/I142762351","display_name":"Royal College of Surgeons in Ireland","ror":"https://ror.org/01hxy9878","country_code":"IE","type":"education","lineage":["https://openalex.org/I142762351"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"K Flood","raw_affiliation_strings":["Dept. of Obs and Gynae., Royal College of Surgeons in Ireland, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Obs and Gynae., Royal College of Surgeons in Ireland, Dublin, Ireland","institution_ids":["https://openalex.org/I142762351"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058650782","display_name":"Dermot J. Kenny","orcid":"https://orcid.org/0000-0001-5548-3263","observed_orcids":["https://orcid.org/0000-0001-5548-3263"]},"institutions":[{"id":"https://openalex.org/I142762351","display_name":"Royal College of Surgeons in Ireland","ror":"https://ror.org/01hxy9878","country_code":"IE","type":"education","lineage":["https://openalex.org/I142762351"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"D Kenny","raw_affiliation_strings":["Dept. of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland","institution_ids":["https://openalex.org/I142762351"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030836937","display_name":"Fergal Desmond Malone","orcid":"https://orcid.org/0009-0003-4313-4594","observed_orcids":["https://orcid.org/0009-0003-4313-4594"]},"institutions":[{"id":"https://openalex.org/I142762351","display_name":"Royal College of Surgeons in Ireland","ror":"https://ror.org/01hxy9878","country_code":"IE","type":"education","lineage":["https://openalex.org/I142762351"]},{"id":"https://openalex.org/I2799298456","display_name":"Rotunda Hospital","ror":"https://ror.org/05t4vgv93","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I2799298456"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"F Malone","raw_affiliation_strings":["Dept. of Obs and Gynae., Royal College of Surgeons in Ireland, Dublin, Ireland","Rotunda Hospital, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Obs and Gynae., Royal College of Surgeons in Ireland, Dublin, Ireland","institution_ids":["https://openalex.org/I142762351"]},{"raw_affiliation_string":"Rotunda Hospital, Dublin, Ireland","institution_ids":["https://openalex.org/I2799298456"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.29671057,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"97","issue":"Suppl 1","first_page":"A31.3","last_page":"A32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spontaneous-platelet-aggregation","display_name":"spontaneous platelet aggregation","score":0.9819999933242798},{"id":"https://openalex.org/keywords/preeclampsia","display_name":"preeclampsia","score":0.9309999942779541},{"id":"https://openalex.org/keywords/intrauterine-growth-restriction","display_name":"fetal growth restriction","score":0.9419999718666077},{"id":"https://openalex.org/keywords/light-transmission-aggregometry","display_name":"light transmission aggregometry","score":0.7730000019073486},{"id":"https://openalex.org/keywords/gestational-age","display_name":"gestational age","score":0.8309999704360962},{"id":"https://openalex.org/keywords/pregnancy-complications","display_name":"pregnancy complications","score":0.6309999823570251}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7543500661849976},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.7389800548553467},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.686786413192749},{"id":"https://openalex.org/C2778780700","wikidata":"https://www.wikidata.org/wiki/Q1671598","display_name":"Intrauterine growth restriction","level":4,"score":0.629178524017334},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.5092705488204956},{"id":"https://openalex.org/C99476002","wikidata":"https://www.wikidata.org/wiki/Q42297","display_name":"Analysis of variance","level":2,"score":0.5036885142326355},{"id":"https://openalex.org/C2781276381","wikidata":"https://www.wikidata.org/wiki/Q552348","display_name":"Eclampsia","level":3,"score":0.4908016622066498},{"id":"https://openalex.org/C3019714739","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"First trimester","level":4,"score":0.4583842158317566},{"id":"https://openalex.org/C102959455","wikidata":"https://www.wikidata.org/wiki/Q7313954","display_name":"Repeated measures design","level":2,"score":0.4569545090198517},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.4462592601776123},{"id":"https://openalex.org/C2778376644","wikidata":"https://www.wikidata.org/wiki/Q2253111","display_name":"Gestational age","level":3,"score":0.4184160828590393},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35726702213287354},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11093848943710327},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1136/fetalneonatal-2012-301809.101","doi":"https://doi.org/10.1136/fetalneonatal-2012-301809.101","is_oa":false,"landing_page_url":"https://doi.org/10.1136/fetalneonatal-2012-301809.101","pdf_url":null,"source":{"id":"https://openalex.org/S35570472","display_name":"Archives of Disease in Childhood Fetal & Neonatal","issn_l":"1359-2998","issn":["1359-2998","1468-2052"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Disease in Childhood - Fetal and Neonatal Edition","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2280509801","https://openalex.org/W2120253173","https://openalex.org/W2324442466","https://openalex.org/W2007237148","https://openalex.org/W1993972672","https://openalex.org/W2048396951","https://openalex.org/W2394825243","https://openalex.org/W2128464782","https://openalex.org/W2946012217","https://openalex.org/W2043026090"],"abstract_inverted_index":{"Platelet":[0],"function":[1,57,81,91],"has":[2],"not":[3,216],"been":[4],"well":[5],"characterised":[6],"in":[7,21,36,60,84,93,168,177,199,205,212,218,222],"pregnancy.":[8,170,207],"We":[9,189],"used":[10,124],"a":[11,33,104,112,195,241],"modification":[12],"of":[13,98,182,237],"light":[14],"transmission":[15],"aggregometry":[16],"to":[17,31,125],"prospectively":[18],"assess":[19],"SPA":[20,143,200,238],"normal":[22,54,99,169,206],"and":[23,42,64,72,132,149,161],"complicated":[24],"pregnancies.":[25,247],"The":[26,135],"study":[27,109],"was":[28,58,82,123,174],"powered":[29],"(80%)":[30],"detect":[32],"6%":[34],"change":[35,45],"platelet":[37,56,80,90,179,213],"aggregation":[38,180,214],"across":[39],"the":[40,61,85,94,119,130,147,155,162,178,192,219],"time-points":[41],"an":[43],"8%":[44],"for":[46,115,191,244],"PET":[47,131,186,228],"or":[48,187,229],"IUGR.":[49,188,230],"In":[50,66,171,208],"50":[51],"patients":[52,68,74,183,225],"with":[53,69,75,108,129,184,201,226],"pregnancy,":[55],"assessed":[59,83],"three":[62],"trimesters":[63],"post-natally.":[65],"35":[67],"pre-eclampsia":[70],"(PET)":[71],"18":[73],"intra-uterine":[76],"growth":[77],"restriction":[78],"(IUGR)":[79],"third":[86,220],"trimester.":[87],"Comparisons":[88],"between":[89,118,146],"assays":[92],"four":[95],"time":[96,194],"points":[97],"pregnancy":[100],"were":[101],"made":[102],"using":[103],"mixed":[105],"effects":[106],"model":[107],"participant":[110],"as":[111,139],"random-effect,":[113],"allowing":[114],"possible":[116],"correlations":[117],"repeated":[120],"assessments.":[121],"ANOVA":[122],"compare":[126],"these":[127],"assessments":[128],"IUGR":[133],"groups.":[134],"results":[136,232],"are":[137],"presented":[138],"Bonferroni":[140],"adjusted":[141],"p-values.":[142],"increased":[144],"significantly":[145],"1st":[148],"2nd":[150],"trimester":[151,157,221],"(7%":[152],"increase,":[153,159,166],"p-value=0.0001);":[154],"3rd":[156],"(9%":[158],"p-value=0.0020)":[160],"post-natal":[163],"assessment":[164],"(15%":[165],"p-value=0.0002)":[167],"contrast":[172,209],"there":[173],"no":[175],"increase":[176,198,211],"profile":[181],"either":[185,227],"demonstrate":[190],"first":[193],"significant":[196],"incremental":[197],"advancing":[202],"gestational":[203],"age":[204],"this":[210],"does":[215],"occur":[217],"platelets":[223],"from":[224],"These":[231],"suggest":[233],"that":[234],"sequential":[235],"analysis":[236],"may":[239],"be":[240],"novel":[242],"marker":[243],"at":[245],"risk":[246]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2016-06-24T00:00:00"}