{"id":"https://openalex.org/W2319225916","doi":"https://doi.org/10.1158/1538-7445.am2011-4368","title":"Abstract 4368: Targeting of head and neck cancer stem cells using salinomycin","display_name":"Abstract 4368: Targeting of head and neck cancer stem cells using salinomycin","publication_year":2011,"publication_date":"2011-04-01","ids":{"openalex":"https://openalex.org/W2319225916","doi":"https://doi.org/10.1158/1538-7445.am2011-4368","mag":"2319225916"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2011-4368","doi":"https://doi.org/10.1158/1538-7445.am2011-4368","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2011-4368","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060441430","display_name":"Selena Z. Kuo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Selena Z. Kuo","raw_affiliation_strings":["1University of California, San Diego, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of California, San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034480632","display_name":"Katherine J. Blair","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine J. Blair","raw_affiliation_strings":["1University of California, San Diego, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of California, San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042883571","display_name":"Eric L. Abhold","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric L. Abhold","raw_affiliation_strings":["1University of California, San Diego, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of California, San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040652950","display_name":"Alan Kiang","orcid":"https://orcid.org/0009-0008-4042-8884","observed_orcids":["https://orcid.org/0009-0008-4042-8884"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan Kiang","raw_affiliation_strings":["1University of California, San Diego, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of California, San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112071467","display_name":"Martin Haas","orcid":"https://orcid.org/0000-0002-5918-8656","observed_orcids":["https://orcid.org/0000-0002-5918-8656"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin Haas","raw_affiliation_strings":["1University of California, San Diego, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of California, San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089144595","display_name":"Jessica Wang\u2010Rodriguez","orcid":"https://orcid.org/0000-0001-7233-8105","observed_orcids":["https://orcid.org/0000-0001-7233-8105"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica Wang-Rodriguez","raw_affiliation_strings":["1University of California, San Diego, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of California, San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067079844","display_name":"Weg M. Ongkeko","orcid":"https://orcid.org/0000-0002-2790-2480","observed_orcids":["https://orcid.org/0000-0002-2790-2480"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weg M. Ongkeko","raw_affiliation_strings":["1University of California, San Diego, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of California, San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I36258959"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"71","issue":"8_Supplement","first_page":"4368","last_page":"4368"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/salinomycin","display_name":"salinomycin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.9829999804496765},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/self-renewal","display_name":"self-renewal","score":0.890999972820282},{"id":"https://openalex.org/keywords/cd44","display_name":"CD44","score":0.8550000190734863},{"id":"https://openalex.org/keywords/bmi1","display_name":"BMI1","score":1.0},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.8349999785423279},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":1.0},{"id":"https://openalex.org/keywords/drug-synergy","display_name":"drug synergy","score":0.8050000071525574},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.6690000295639038},{"id":"https://openalex.org/keywords/sphere-formation","display_name":"sphere formation","score":0.5950000286102295},{"id":"https://openalex.org/keywords/antibiotic-repurposing","display_name":"antibiotic repurposing","score":0.6380000114440918}],"concepts":[{"id":"https://openalex.org/C2777877089","wikidata":"https://www.wikidata.org/wiki/Q411909","display_name":"Salinomycin","level":3,"score":0.9866857528686523},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.7793543338775635},{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.7235831022262573},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6540710926055908},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6062865257263184},{"id":"https://openalex.org/C2780932548","wikidata":"https://www.wikidata.org/wiki/Q1056532","display_name":"CD44","level":3,"score":0.5987008810043335},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5626121163368225},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5273733139038086},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4729464054107666},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.3510637879371643},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3490146994590759},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2545824646949768},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.22601228952407837},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.10374927520751953},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.06312292814254761},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.05671873688697815},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0484468936920166}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2011-4368","doi":"https://doi.org/10.1158/1538-7445.am2011-4368","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2011-4368","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2152939397","https://openalex.org/W1991211192","https://openalex.org/W1756841812","https://openalex.org/W2788549018","https://openalex.org/W3184917397","https://openalex.org/W2160886771","https://openalex.org/W2772113325","https://openalex.org/W2386920583","https://openalex.org/W3028597726","https://openalex.org/W2906265158"],"abstract_inverted_index":{"Abstract":[0],"Cancer":[1,217,227],"stem":[2,39,60,71,96,126,155],"cells":[3,127],"are":[4,105,167,192],"believed":[5],"to":[6,15,18,46,131,194],"play":[7],"a":[8,32,76,89,146,184],"crucial":[9],"role":[10],"in":[11,69,79,88,91,110,152,197],"cancer":[12,38,125],"recurrence":[13],"due":[14],"their":[16],"resistance":[17],"conventional":[19],"chemotherapy":[20],"and":[21,26,54,100,119,140],"capacity":[22,68],"for":[23,107,177,187,216],"self-renewal.":[24],"Gupta":[25],"colleagues":[27],"recently":[28],"reported":[29],"that":[30,64,166],"salinomycin,":[31],"livestock":[33],"antibiotic,":[34],"selectively":[35],"targets":[36],"breast":[37],"cells.":[40,61],"In":[41,82,112],"our":[42,173],"study":[43],"we":[44],"sought":[45],"determine":[47],"the":[48,95,115,161,208,213],"effect":[49],"of":[50,94,103,148,163,207,212],"salinomycin":[51,65,86,121,179],"on":[52],"head":[53],"neck":[55],"squamous":[56],"cell":[57,97,138],"carcinoma":[58],"(HNSCC)":[59],"We":[62],"observed":[63],"inhibits":[66],"self-renewal":[67],"HNSCC":[70,124,154],"cells,":[72,156],"as":[73,135,183],"shown":[74],"by":[75,137,169],"dose-dependent":[77],"decrease":[78,90],"sphere":[80],"formation.":[81],"addition,":[83],"treatment":[84,186],"with":[85,114],"resulted":[87],"mRNA":[92],"expression":[93],"markers":[98],"CD44":[99],"BMI-1,":[101],"both":[102],"which":[104],"critical":[106],"maintaining":[108],"tumorigenicity":[109],"HNSCC.":[111],"combination":[113],"chemotherapeutic":[116],"agents":[117],"cisplatin":[118],"doxorubicin,":[120],"synergistically":[122],"killed":[123],"more":[128],"effectively":[129],"compared":[130],"either":[132],"drug":[133],"alone,":[134],"demonstrated":[136],"proliferation":[139],"TUNEL":[141],"assays.":[142],"High-throughput":[143],"analysis":[144],"revealed":[145],"set":[147],"differentially":[149],"expressed":[150],"microRNAs":[151],"salinomycin-treated":[153],"warranting":[157],"further":[158,190],"investigation":[159],"into":[160],"possibility":[162],"microRNA-mediated":[164],"pathways":[165],"regulated":[168],"salinomycin.":[170],"Taken":[171],"together,":[172],"findings":[174],"indicate":[175],"promise":[176],"using":[178],"or":[180],"related":[181],"derivatives":[182],"novel":[185],"HNSCC,":[188],"although":[189],"studies":[191],"needed":[193],"confirm":[195],"efficacy":[196],"vivo.":[198],"Citation":[199],"Format:":[200],"{Authors}.":[201],"{Abstract":[202],"title}":[203],"[abstract].":[204],"In:":[205],"Proceedings":[206],"102nd":[209],"Annual":[210],"Meeting":[211],"American":[214],"Association":[215],"Research;":[218],"2011":[219],"Apr":[220],"2-6;":[221],"Orlando,":[222],"FL.":[223],"Philadelphia":[224],"(PA):":[225],"AACR;":[226],"Res":[228],"2011;71(8":[229],"Suppl):Abstract":[230],"nr":[231],"4368.":[232],"doi:10.1158/1538-7445.AM2011-4368":[233]},"counts_by_year":[],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2016-06-24T00:00:00"}