{"id":"https://openalex.org/W2319225909","doi":"https://doi.org/10.1055/s-0034-1372182","title":"Dual role of B7 costimulation in obesity-related non-alcoholic steatohepatitis (NASH) and metabolic dysregulation","display_name":"Dual role of B7 costimulation in obesity-related non-alcoholic steatohepatitis (NASH) and metabolic dysregulation","publication_year":2014,"publication_date":"2014-03-05","ids":{"openalex":"https://openalex.org/W2319225909","doi":"https://doi.org/10.1055/s-0034-1372182","mag":"2319225909"},"language":"en","primary_location":{"id":"doi:10.1055/s-0034-1372182","doi":"https://doi.org/10.1055/s-0034-1372182","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0034-1372182","pdf_url":null,"source":{"id":"https://openalex.org/S67343978","display_name":"Experimental and Clinical Endocrinology & Diabetes","issn_l":"0947-7349","issn":["0947-7349","1439-3646"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Clinical Endocrinology & Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049519602","display_name":"Antonios Chatzigeorgiou","orcid":"https://orcid.org/0000-0002-7039-4223","observed_orcids":["https://orcid.org/0000-0002-7039-4223"]},"institutions":[{"id":"https://openalex.org/I78650965","display_name":"Technische Universit\u00e4t Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A Chatzigeorgiou","raw_affiliation_strings":["Department of Clinical Pathobiochemistry, University of Dresden, Dresden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pathobiochemistry, University of Dresden, Dresden, Germany","institution_ids":["https://openalex.org/I78650965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049883349","display_name":"Rub\u00e9n Garc\u00eda-Mart\u00edn","orcid":"https://orcid.org/0000-0003-2049-4960","observed_orcids":["https://orcid.org/0000-0003-2049-4960"]},"institutions":[{"id":"https://openalex.org/I78650965","display_name":"Technische Universit\u00e4t Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"R Garcia-Martin","raw_affiliation_strings":["Department of Clinical Pathobiochemistry, University of Dresden, Dresden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pathobiochemistry, University of Dresden, Dresden, Germany","institution_ids":["https://openalex.org/I78650965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052465281","display_name":"KJ Chung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78650965","display_name":"Technische Universit\u00e4t Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"KJ Chung","raw_affiliation_strings":["Department of Clinical Pathobiochemistry, University of Dresden, Dresden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pathobiochemistry, University of Dresden, Dresden, Germany","institution_ids":["https://openalex.org/I78650965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004023214","display_name":"Vasileia Ismini Alexaki","orcid":"https://orcid.org/0000-0003-3935-8985","observed_orcids":["https://orcid.org/0000-0003-3935-8985"]},"institutions":[{"id":"https://openalex.org/I78650965","display_name":"Technische Universit\u00e4t Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"I Alexaki","raw_affiliation_strings":["Department of Clinical Pathobiochemistry, University of Dresden, Dresden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pathobiochemistry, University of Dresden, Dresden, Germany","institution_ids":["https://openalex.org/I78650965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079674226","display_name":"Anne Klotzsche\u2013von Ameln","orcid":"https://orcid.org/0009-0000-9192-9648","observed_orcids":["https://orcid.org/0009-0000-9192-9648"]},"institutions":[{"id":"https://openalex.org/I78650965","display_name":"Technische Universit\u00e4t Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A Klotzsche-von Ameln","raw_affiliation_strings":["Department of Clinical Pathobiochemistry, University of Dresden, Dresden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pathobiochemistry, University of Dresden, Dresden, Germany","institution_ids":["https://openalex.org/I78650965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020151709","display_name":"G. Siegert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78650965","display_name":"Technische Universit\u00e4t Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"G Siegert","raw_affiliation_strings":["Institute for Clinical Chemistry and Laboratory Medicine, University of Dresden, Dresden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Clinical Chemistry and Laboratory Medicine, University of Dresden, Dresden, Germany","institution_ids":["https://openalex.org/I78650965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006906048","display_name":"Stefan Richard Bornstein","orcid":"https://orcid.org/0000-0002-5211-2536","observed_orcids":["https://orcid.org/0000-0002-5211-2536"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Bornstein","raw_affiliation_strings":["Department of Medicine III, Dresden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine III, Dresden, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069173292","display_name":"Esther Lutgens","orcid":"https://orcid.org/0000-0002-2609-5744","observed_orcids":["https://orcid.org/0000-0002-2609-5744"]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"E Lutgens","raw_affiliation_strings":["Dept. of Medical Biochemistry, subdivision Experimental Vascular Biology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Medical Biochemistry, subdivision Experimental Vascular Biology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I887064364"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086672334","display_name":"Triantafyllos Chavakis","orcid":"https://orcid.org/0000-0002-1869-5141","observed_orcids":["https://orcid.org/0000-0002-1869-5141"]},"institutions":[{"id":"https://openalex.org/I78650965","display_name":"Technische Universit\u00e4t Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"T Chavakis","raw_affiliation_strings":["Department of Clinical Pathobiochemistry, University of Dresden, Dresden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pathobiochemistry, University of Dresden, Dresden, Germany","institution_ids":["https://openalex.org/I78650965"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.757,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.75231334,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"122","issue":"03","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.8529999852180481,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.8529999852180481,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.11599999666213989,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.009800000116229057,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd80","display_name":"CD80","score":0.9829999804496765},{"id":"https://openalex.org/keywords/cd86","display_name":"CD86","score":1.0},{"id":"https://openalex.org/keywords/non-alcoholic-steatohepatitis","display_name":"nonalcoholic steatohepatitis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.7889999747276306},{"id":"https://openalex.org/keywords/metabolic-dysfunction","display_name":"metabolic dysfunction","score":0.8859999775886536},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.8479999899864197},{"id":"https://openalex.org/keywords/impaired-glucose-tolerance","display_name":"impaired glucose tolerance","score":0.7120000123977661},{"id":"https://openalex.org/keywords/hepatic-steatosis","display_name":"hepatic steatosis","score":0.8140000104904175},{"id":"https://openalex.org/keywords/liver-inflammation","display_name":"liver inflammation","score":0.9020000100135803},{"id":"https://openalex.org/keywords/adipose-tissue-inflammation","display_name":"adipose tissue inflammation","score":0.9940000176429749},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/diet-induced-obesity","display_name":"diet-induced obesity","score":0.8080000281333923},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.38199999928474426}],"concepts":[{"id":"https://openalex.org/C2779478299","wikidata":"https://www.wikidata.org/wiki/Q2335423","display_name":"Steatohepatitis","level":4,"score":0.8702080845832825},{"id":"https://openalex.org/C2776175330","wikidata":"https://www.wikidata.org/wiki/Q1365091","display_name":"Steatosis","level":2,"score":0.6844737529754639},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.5934300422668457},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5845838785171509},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.5786604881286621},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5543743371963501},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.5480067133903503},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5338519811630249},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.4506238102912903},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43207815289497375},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4277251362800598},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38286903500556946},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.37796255946159363},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.263594388961792},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0699985921382904}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1055/s-0034-1372182","doi":"https://doi.org/10.1055/s-0034-1372182","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0034-1372182","pdf_url":null,"source":{"id":"https://openalex.org/S67343978","display_name":"Experimental and Clinical Endocrinology & Diabetes","issn_l":"0947-7349","issn":["0947-7349","1439-3646"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Clinical Endocrinology & Diabetes","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7799999713897705}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1548116773","https://openalex.org/W2016481373","https://openalex.org/W83564749","https://openalex.org/W2921048138","https://openalex.org/W2980061850","https://openalex.org/W2987745771","https://openalex.org/W7095648786","https://openalex.org/W3009189519","https://openalex.org/W2471062988","https://openalex.org/W2160956885"],"abstract_inverted_index":{"The":[0,42,103,211],"inflammatory":[1],"state":[2],"present":[3],"in":[4,40,54,64,76,130,141,143,155,158,189,203,231,243],"obesity":[5,73],"contributes":[6],"to":[7,32,97,100,135,181,225],"obesity-related":[8,65,89,207,217,265],"metabolic":[9,90,104,174,221,266],"dysregulation,":[10,91],"including":[11],"non-alcoholic":[12],"steatohepatitis":[13,98],"(NASH)":[14],"and":[15,27,38,46,84,94,116,164,186,191,220,268],"insulin":[16],"resistance.":[17],"Intercellular":[18],"interactions":[19,53],"between":[20,24],"immune":[21,25,56],"cells":[22,26,30,128],"or":[23],"hepatic":[28,115,184],"parenchymal":[29],"contribute":[31],"the":[33,59,137,173,204,226],"exacerbation":[34],"of":[35,51,61,81,106,125,139,152,161,168,176,183,200,206,214,229,241,249],"liver":[36,66,190,218],"inflammation":[37,67,188],"steatosis":[39,185,219],"obesity.":[41],"co-stimulatory":[43],"molecules":[44,154],"B7.1":[45,83,163],"B7.2":[47,85],"are":[48,256],"important":[49],"regulators":[50],"cell-cell":[52],"several":[55],"processes;":[57],"however,":[58],"role":[60,138,199],"B7":[62,153,201,250],"co-stimulation":[63,202,251],"is":[68],"still":[69],"unknown.":[70],"Here,":[71],"diet-induced":[72],"(DIO)":[74],"studies":[75],"mice":[77,157,233,236],"with":[78,121],"genetic":[79,212],"inactivation":[80,213],"both":[82,162],"(Dko)":[86],"revealed":[87],"aggravated":[88],"glucose":[92],"intolerance":[93],"enhanced":[95],"progression":[96],"due":[99,224],"B7.1/B7.2-double":[101,107],"deficiency.":[102],"phenotype":[105,175],"deficiency":[108],"upon":[109],"DIO":[110,142],"was":[111,179],"accompanied":[112],"by":[113],"increased":[114],"adipose":[117,192],"tissue":[118],"inflammation,":[119],"associated":[120],"largely":[122],"reduced":[123,187],"numbers":[124],"regulatory":[126],"T":[127],"(Tregs)":[129],"these":[131,232],"organs.":[132],"In":[133,246],"order":[134],"assess":[136],"B7co-stimulation":[140],"a":[144,197,237,260],"non-Treg":[145],"lacking":[146],"environment,":[147],"we":[148],"performed":[149],"antibody-mediated":[150],"inhibition":[151,248],"wild-type":[156],"DIO.":[159],"Antibody-blockade":[160],"B7.2,":[165],"but":[166],"not":[167],"either":[169],"one":[170],"alone,":[171],"improved":[172],"DIO-mice,":[177],"which":[178],"linked":[180],"amelioration":[182],"tissue.":[193],"Our":[194],"study":[195],"demonstrates":[196],"dual":[198],"course":[205],"sequelae,":[208],"particularly":[209],"NASH.":[210,270],"B7.1/B7.2":[215],"deteriorates":[216],"dysregulation":[222,267],"likely":[223],"intrinsic":[227],"absence":[228],"Tregs":[230,255],"rendering":[234],"Dko":[235],"novel":[238,261],"murine":[239],"model":[240],"NASH":[242],"future":[244],"studies.":[245],"contrast,":[247],"under":[252],"conditions,":[253],"where":[254],"present,":[257],"may":[258],"provide":[259],"therapeutic":[262],"approach":[263],"for":[264],"especially":[269]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}