{"id":"https://openalex.org/W2319002707","doi":"https://doi.org/10.1016/j.joca.2016.01.681","title":"Accelerated cartilage degradation and increased chondrocyte apoptosis in GADD45\u03b2 knockout mice subjected to a surgical model of OA","display_name":"Accelerated cartilage degradation and increased chondrocyte apoptosis in GADD45\u03b2 knockout mice subjected to a surgical model of OA","publication_year":2016,"publication_date":"2016-03-20","ids":{"openalex":"https://openalex.org/W2319002707","doi":"https://doi.org/10.1016/j.joca.2016.01.681","mag":"2319002707"},"language":"en","primary_location":{"id":"doi:10.1016/j.joca.2016.01.681","doi":"https://doi.org/10.1016/j.joca.2016.01.681","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.joca.2016.01.681","pdf_url":"http://www.oarsijournal.com/article/S1063458416007007/pdf","source":{"id":"https://openalex.org/S13054843","display_name":"Osteoarthritis and Cartilage","issn_l":"1063-4584","issn":["1063-4584","1522-9653"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Osteoarthritis and Cartilage","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.oarsijournal.com/article/S1063458416007007/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111651215","display_name":"Darren A. Plumb","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1281539108","display_name":"Hospital for Special Surgery","ror":"https://ror.org/03zjqec80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1281539108"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D.A. Plumb","raw_affiliation_strings":["Hosp. for Special Surgery, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hosp. for Special Surgery, New York, NY, USA","institution_ids":["https://openalex.org/I1281539108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047465430","display_name":"Cecilia L. Dragomir","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1281539108","display_name":"Hospital for Special Surgery","ror":"https://ror.org/03zjqec80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1281539108"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C.L. Dragomir","raw_affiliation_strings":["Hosp. for Special Surgery, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hosp. for Special Surgery, New York, NY, USA","institution_ids":["https://openalex.org/I1281539108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036903219","display_name":"Justin Quinn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1281539108","display_name":"Hospital for Special Surgery","ror":"https://ror.org/03zjqec80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1281539108"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Quinn","raw_affiliation_strings":["Hosp. for Special Surgery, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hosp. for Special Surgery, New York, NY, USA","institution_ids":["https://openalex.org/I1281539108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109930255","display_name":"Kirsty L. Culley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1281539108","display_name":"Hospital for Special Surgery","ror":"https://ror.org/03zjqec80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1281539108"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K.L. Culley","raw_affiliation_strings":["Hosp. for Special Surgery, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hosp. for Special Surgery, New York, NY, USA","institution_ids":["https://openalex.org/I1281539108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016488518","display_name":"Jun Chang","orcid":"https://orcid.org/0000-0002-6000-0358","observed_orcids":["https://orcid.org/0000-0002-6000-0358"]},"institutions":[{"id":"https://openalex.org/I1281539108","display_name":"Hospital for Special Surgery","ror":"https://ror.org/03zjqec80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1281539108"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Chang","raw_affiliation_strings":["Hosp. for Special Surgery, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hosp. for Special Surgery, New York, NY, USA","institution_ids":["https://openalex.org/I1281539108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042460348","display_name":"Elisabeth B. Wondimu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1281539108","display_name":"Hospital for Special Surgery","ror":"https://ror.org/03zjqec80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1281539108"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E.B. Wondimu","raw_affiliation_strings":["Hosp. for Special Surgery, New York, NY, USA","Weill Cornell Med. Coll., New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hosp. for Special Surgery, New York, NY, USA","institution_ids":["https://openalex.org/I1281539108"]},{"raw_affiliation_string":"Weill Cornell Med. Coll., New York, NY, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009342847","display_name":"Mary B. Goldring","orcid":"https://orcid.org/0000-0001-5407-9293","observed_orcids":["https://orcid.org/0000-0001-5407-9293"]},"institutions":[{"id":"https://openalex.org/I1281539108","display_name":"Hospital for Special Surgery","ror":"https://ror.org/03zjqec80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1281539108"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.B. Goldring","raw_affiliation_strings":["Hosp. for Special Surgery, New York, NY, USA","Weill Cornell Med. Coll., New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hosp. for Special Surgery, New York, NY, USA","institution_ids":["https://openalex.org/I1281539108"]},{"raw_affiliation_string":"Weill Cornell Med. Coll., New York, NY, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056567815","display_name":"Miguel Otero","orcid":"https://orcid.org/0000-0002-4945-2994","observed_orcids":["https://orcid.org/0000-0002-4945-2994"]},"institutions":[{"id":"https://openalex.org/I1281539108","display_name":"Hospital for Special Surgery","ror":"https://ror.org/03zjqec80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1281539108"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Otero","raw_affiliation_strings":["Hosp. for Special Surgery, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hosp. for Special Surgery, New York, NY, USA","institution_ids":["https://openalex.org/I1281539108"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3700,"currency":"USD","value_usd":3700},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.02767503,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":null,"first_page":"S381","last_page":"S381"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11218","display_name":"Hip disorders and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gadd45b","display_name":"GADD45B","score":0.7699999809265137},{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/articular-cartilage-degeneration","display_name":"articular cartilage degeneration","score":0.9300000071525574},{"id":"https://openalex.org/keywords/chondrocyte-apoptosis","display_name":"chondrocyte apoptosis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/destabilization-of-the-medial-meniscus","display_name":"destabilization of the medial meniscus","score":0.9160000085830688},{"id":"https://openalex.org/keywords/type-x-collagen","display_name":"type X collagen","score":0.9110000133514404},{"id":"https://openalex.org/keywords/runx2","display_name":"Runx2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/collagenase-activity","display_name":"collagenase activity","score":0.7639999985694885},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.8629999756813049},{"id":"https://openalex.org/keywords/jnk-map-kinase","display_name":"JNK MAP kinase","score":0.9879999756813049},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9380000233650208},{"id":"https://openalex.org/keywords/chondrocyte-hypertrophy","display_name":"chondrocyte hypertrophy","score":0.9039999842643738},{"id":"https://openalex.org/keywords/articular-cartilage-homeostasis","display_name":"articular cartilage homeostasis","score":0.7200000286102295}],"concepts":[{"id":"https://openalex.org/C2781403057","wikidata":"https://www.wikidata.org/wiki/Q775480","display_name":"Chondrocyte","level":3,"score":0.7110961675643921},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.5975234508514404},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.5666378140449524},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.49366268515586853},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4806615114212036},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.45779022574424744},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.44978392124176025},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.38968896865844727},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3891878128051758},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34251636266708374},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2643454074859619},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.25318729877471924},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.16327637434005737},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07194328308105469},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.joca.2016.01.681","doi":"https://doi.org/10.1016/j.joca.2016.01.681","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.joca.2016.01.681","pdf_url":"http://www.oarsijournal.com/article/S1063458416007007/pdf","source":{"id":"https://openalex.org/S13054843","display_name":"Osteoarthritis and Cartilage","issn_l":"1063-4584","issn":["1063-4584","1522-9653"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Osteoarthritis and Cartilage","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.joca.2016.01.681","doi":"https://doi.org/10.1016/j.joca.2016.01.681","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.joca.2016.01.681","pdf_url":"http://www.oarsijournal.com/article/S1063458416007007/pdf","source":{"id":"https://openalex.org/S13054843","display_name":"Osteoarthritis and Cartilage","issn_l":"1063-4584","issn":["1063-4584","1522-9653"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Osteoarthritis and Cartilage","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2319002707.pdf","grobid_xml":"https://content.openalex.org/works/W2319002707.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2168573645","https://openalex.org/W2952256561","https://openalex.org/W2782189204","https://openalex.org/W2285466782","https://openalex.org/W2735986024","https://openalex.org/W1969830786","https://openalex.org/W2016794473","https://openalex.org/W3000558321","https://openalex.org/W2590689600","https://openalex.org/W2043125425"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}