{"id":"https://openalex.org/W2318567170","doi":"https://doi.org/10.4161/cc.3.10.1187","title":"A Novel Role for Mixed Lineage Kinase 3 (MLK3) in B-Raf Activation and Cell proliferation","display_name":"A Novel Role for Mixed Lineage Kinase 3 (MLK3) in B-Raf Activation and Cell proliferation","publication_year":2004,"publication_date":"2004-10-12","ids":{"openalex":"https://openalex.org/W2318567170","doi":"https://doi.org/10.4161/cc.3.10.1187","mag":"2318567170","pmid":"https://pubmed.ncbi.nlm.nih.gov/15467451"},"language":"en","primary_location":{"id":"doi:10.4161/cc.3.10.1187","doi":"https://doi.org/10.4161/cc.3.10.1187","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cc.3.10.1187","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.3.10.1187?needAccess=true&role=button","source":{"id":"https://openalex.org/S86011449","display_name":"Cell Cycle","issn_l":"1538-4101","issn":["1538-4101","1551-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.3.10.1187?needAccess=true&role=button","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024588859","display_name":"Deborah N. Chadee","orcid":"https://orcid.org/0000-0002-5223-4701","observed_orcids":["https://orcid.org/0000-0002-5223-4701"]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deborah N. Chadee","raw_affiliation_strings":["The Molecular Cardiology Research Institute, Tufts-New England Medical Center, Boston, Massachusetts 02111, USA. dchadee@tufts-nemc.org"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Molecular Cardiology Research Institute, Tufts-New England Medical Center, Boston, Massachusetts 02111, USA. dchadee@tufts-nemc.org","institution_ids":["https://openalex.org/I1290900354"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002801100","display_name":"John M. Kyriakis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John M. Kyriakis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4734,"has_fulltext":true,"cited_by_count":35,"citation_normalized_percentile":{"value":0.60477189,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"3","issue":"10","first_page":"1227","last_page":"1229"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.7562999725341797,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.7562999725341797,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.23019999265670776,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.0066999997943639755,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mlk3","display_name":"MLK3","score":0.8629999756813049},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.875},{"id":"https://openalex.org/keywords/map3k","display_name":"MAP3K","score":0.8700000047683716},{"id":"https://openalex.org/keywords/jnk","display_name":"JNK","score":0.5350000262260437},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.9240000247955322},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9459999799728394},{"id":"https://openalex.org/keywords/oncogenic-ras","display_name":"oncogenic Ras","score":0.6940000057220459},{"id":"https://openalex.org/keywords/neurofibromatosis-type-1","display_name":"neurofibromatosis type 1","score":0.9269999861717224},{"id":"https://openalex.org/keywords/neurofibromatosis-type-2","display_name":"neurofibromatosis type 2","score":0.9929999709129333},{"id":"https://openalex.org/keywords/receptor-tyrosine-kinase-mutations","display_name":"receptor tyrosine kinase mutations","score":0.699999988079071},{"id":"https://openalex.org/keywords/cancer-therapy-targets","display_name":"cancer therapy targets","score":0.3799999952316284}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6954691410064697},{"id":"https://openalex.org/C137361374","wikidata":"https://www.wikidata.org/wiki/Q6714442","display_name":"MAP kinase kinase kinase","level":4,"score":0.6923052668571472},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.5798031091690063},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5741289854049683},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5232599973678589},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5097469687461853},{"id":"https://openalex.org/C90934575","wikidata":"https://www.wikidata.org/wiki/Q6593810","display_name":"Mitogen-activated protein kinase kinase","level":4,"score":0.49187397956848145},{"id":"https://openalex.org/C51853150","wikidata":"https://www.wikidata.org/wiki/Q14911754","display_name":"Cyclin-dependent kinase 4","level":5,"score":0.4574631154537201},{"id":"https://openalex.org/C132149769","wikidata":"https://www.wikidata.org/wiki/Q899651","display_name":"Mitogen-activated protein kinase","level":3,"score":0.42016202211380005},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4153777062892914},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.31975042819976807},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10660269856452942}],"mesh":[{"descriptor_ui":"D000097767","descriptor_name":"Mitogen-Activated Protein Kinase Kinase Kinase 11","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019908","descriptor_name":"Proto-Oncogene Proteins c-raf","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020930","descriptor_name":"MAP Kinase Kinase Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4161/cc.3.10.1187","doi":"https://doi.org/10.4161/cc.3.10.1187","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cc.3.10.1187","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.3.10.1187?needAccess=true&role=button","source":{"id":"https://openalex.org/S86011449","display_name":"Cell Cycle","issn_l":"1538-4101","issn":["1538-4101","1551-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"journal-article"},{"id":"pmid:15467451","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15467451","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell cycle (Georgetown, Tex.)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4161/cc.3.10.1187","doi":"https://doi.org/10.4161/cc.3.10.1187","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cc.3.10.1187","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.3.10.1187?needAccess=true&role=button","source":{"id":"https://openalex.org/S86011449","display_name":"Cell Cycle","issn_l":"1538-4101","issn":["1538-4101","1551-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2318567170.pdf","grobid_xml":"https://content.openalex.org/works/W2318567170.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2087073346","https://openalex.org/W2105024940","https://openalex.org/W2083064598","https://openalex.org/W1967835627","https://openalex.org/W2145966802","https://openalex.org/W3163482333","https://openalex.org/W1996200050","https://openalex.org/W2330940668","https://openalex.org/W2093114816","https://openalex.org/W7043016083"],"abstract_inverted_index":{"The":[0,22,119],"extracellular":[1],"signal-regulated":[2],"kinase":[3,167],"(ERK)":[4],"group":[5,48],"of":[6,45,49,56,67,70,82,103,112,121,161,175],"MAPKs":[7],"is":[8,35],"essential":[9],"for":[10,90,142],"cell":[11,98,150],"proliferation,":[12],"including":[13],"that":[14,54],"stimulated":[15],"by":[16,58,133],"mitogens,":[17],"oncogenic":[18,108],"ras":[19,169],"and":[20,62,72,86,100,149,171],"raf.":[21],"Raf":[23],"kinases":[24],"(especially":[25],"B-Raf)":[26],"are":[27,131],"ERK-specific,":[28],"mitogen-activated":[29],"MAP3Ks.":[30],"Mixed":[31],"lineage":[32],"kinase-3":[33],"(MLK3)":[34],"a":[36,42,139],"MAP3K":[37],"previously":[38],"thought":[39],"to":[40,158,172],"be":[41,156],"selective":[43],"regulator":[44],"the":[46,101,159,173],"JNK":[47,68],"MAPKs.":[50],"Surprisingly,":[51],"we":[52],"found":[53],"silencing":[55,94,134],"mlk3":[57,77,95],"RNAi":[59],"suppresses":[60],"mitogen":[61],"cytokine":[63],"activation":[64],"not":[65],"only":[66],"but":[69],"ERK":[71,147],"p38":[73],"as":[74],"well.":[75],"Silencing":[76],"also":[78],"blocks":[79],"mitogen-stimulated":[80],"phosphorylation":[81],"B-Raf":[83,91,145],"at":[84],"Thr598":[85],"Ser601-a":[87],"step":[88],"required":[89],"activation.":[92],"Finally,":[93],"prevents":[96],"serum-stimulated":[97],"proliferation":[99,102,120],"tumor":[104,122],"cells":[105,123],"bearing":[106],"either":[107],"Ki-Ras":[109],"or":[110,116,129,168,177],"loss":[111],"function":[113],"neurofibromatosis-1":[114],"(NF1)":[115],"NF2":[117,178],"mutations.":[118],"with":[124,163],"activating":[125],"mutations":[126],"in":[127,144],"B-raf":[128],"raf-1":[130],"unaffected":[132],"mlk3.":[135],"These":[136],"results":[137],"define":[138],"new":[140],"role":[141],"MLK3":[143,154],"activation,":[146],"signaling":[148],"proliferation.":[151],"Accordingly,":[152],"targeting":[153],"could":[155],"beneficial":[157],"treatment":[160,174],"tumors":[162],"activated":[164],"receptor":[165],"tyrosine":[166],"mutations,":[170],"NF1":[176],"tumors.":[179]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}