{"id":"https://openalex.org/W2317829167","doi":"https://doi.org/10.1158/1538-7445.am2012-802","title":"Abstract 802: A key role for ARF in drug resistance in invasive bladder cancer","display_name":"Abstract 802: A key role for ARF in drug resistance in invasive bladder cancer","publication_year":2012,"publication_date":"2012-04-01","ids":{"openalex":"https://openalex.org/W2317829167","doi":"https://doi.org/10.1158/1538-7445.am2012-802","mag":"2317829167"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2012-802","doi":"https://doi.org/10.1158/1538-7445.am2012-802","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2012-802","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074810793","display_name":"Takashi Kobayashi","orcid":"https://orcid.org/0000-0002-7240-4851","observed_orcids":["https://orcid.org/0000-0002-7240-4851","https://orcid.org/0000-0001-6098-6172"]},"institutions":[{"id":"https://openalex.org/I4390039230","display_name":"Herbert Irving Comprehensive Cancer Center","ror":"https://ror.org/051kc1939","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039230"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Takashi Kobayashi","raw_affiliation_strings":["1Herbert Irving Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Herbert Irving Cancer Center, New York, NY","institution_ids":["https://openalex.org/I4390039230"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042583205","display_name":"Joan C. Delto","orcid":"https://orcid.org/0000-0002-5685-5775","observed_orcids":["https://orcid.org/0000-0002-5685-5775"]},"institutions":[{"id":"https://openalex.org/I4390039230","display_name":"Herbert Irving Comprehensive Cancer Center","ror":"https://ror.org/051kc1939","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039230"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joan C. Delto","raw_affiliation_strings":["1Herbert Irving Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Herbert Irving Cancer Center, New York, NY","institution_ids":["https://openalex.org/I4390039230"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033587895","display_name":"Cory T. Abate-Shen","orcid":"https://orcid.org/0000-0002-5021-0570","observed_orcids":["https://orcid.org/0000-0002-5021-0570"]},"institutions":[{"id":"https://openalex.org/I4390039230","display_name":"Herbert Irving Comprehensive Cancer Center","ror":"https://ror.org/051kc1939","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039230"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cory Abate-Shen","raw_affiliation_strings":["1Herbert Irving Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Herbert Irving Cancer Center, New York, NY","institution_ids":["https://openalex.org/I4390039230"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4390039230"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"72","issue":"8_Supplement","first_page":"802","last_page":"802"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/invasive-bladder-cancer","display_name":"invasive bladder cancer","score":0.8889999985694885},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.8009999990463257},{"id":"https://openalex.org/keywords/p19arf","display_name":"p19ARF","score":0.8640000224113464},{"id":"https://openalex.org/keywords/p14arf","display_name":"p14ARF","score":0.9629999995231628},{"id":"https://openalex.org/keywords/pi3k-mtor-pathway","display_name":"PI3K/mTOR pathway","score":0.9449999928474426},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.8050000071525574},{"id":"https://openalex.org/keywords/pten","display_name":"PTEN","score":0.9869999885559082},{"id":"https://openalex.org/keywords/cisplatin-resistance","display_name":"cisplatin resistance","score":0.7670000195503235},{"id":"https://openalex.org/keywords/docetaxel-resistance","display_name":"docetaxel resistance","score":0.9380000233650208},{"id":"https://openalex.org/keywords/rapamycin-resistance","display_name":"rapamycin resistance","score":0.9660000205039978},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.5640000104904175},{"id":"https://openalex.org/keywords/gene-expression-signatures","display_name":"gene expression signatures","score":0.7279999852180481},{"id":"https://openalex.org/keywords/survival-prediction","display_name":"survival prediction","score":0.5230000019073486},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.6230000257492065},{"id":"https://openalex.org/keywords/recurrence","display_name":"recurrence","score":0.35600000619888306}],"concepts":[{"id":"https://openalex.org/C2780352672","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder cancer","level":3,"score":0.8309797048568726},{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.7748426795005798},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6586920022964478},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5844349265098572},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5761803388595581},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.5755758881568909},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.5570514798164368},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5146194696426392},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4541950821876526},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.45385488867759705},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3517861068248749},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1820312738418579},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.18062788248062134},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.11911004781723022},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2012-802","doi":"https://doi.org/10.1158/1538-7445.am2012-802","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2012-802","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2314243735","https://openalex.org/W2133741150","https://openalex.org/W2579848668","https://openalex.org/W2741516516","https://openalex.org/W2147711252","https://openalex.org/W7162453143","https://openalex.org/W2887234794","https://openalex.org/W2257626178","https://openalex.org/W2068415131","https://openalex.org/W1567064250"],"abstract_inverted_index":{"Abstract":[0],"Although":[1],"most":[2,64],"superficial":[3],"bladder":[4,26,50,87,116,128,138,211,228,281,307,332,346],"cancers":[5,212],"can":[6],"be":[7],"removed":[8],"transurethrally":[9],"with":[10,21,38,142,157,256,317],"excellent":[11],"prognosis,":[12],"clinical":[13,31],"outcome":[14],"is":[15,28,35,61,77,219,269],"much":[16],"more":[17],"problematic":[18],"for":[19,45,85,266,343,366],"patients":[20,65],"muscle-invasive":[22],"disease.":[23],"Indeed,":[24,145],"invasive":[25,86,115,227,345],"cancer":[27,51,88,117,229,282,308,333,347],"a":[29,72,78,92,204,264,339],"major":[30],"challenge":[32],"since":[33,63],"it":[34,314],"highly":[36],"associated":[37],"postoperative":[39],"recurrence":[40],"and":[41,55,125,131,310],"metastasis.":[42],"Current":[43],"treatments":[44],"those":[46,141],"lethal":[47],"forms":[48],"of":[49,95,99,107,114,123,178,183,188,195,203,209,223,226,258,288,301,320,357,362],"include":[52],"systemic":[53],"chemotherapy":[54],"molecular":[56,97],"targeted":[57,181],"therapy;":[58],"however,":[59],"survival":[60,225],"poor":[62,143,224],"develop":[66],"resistance":[67,109,189,268,330],"to":[68,80,154,242],"the":[69,96,120,155,186,236,239,243,358,363],"drugs":[70],"within":[71],"short":[73],"timeframe.":[74],"Clearly,":[75],"there":[76],"need":[79],"identify":[81],"novel":[82],"therapeutic":[83,341],"options":[84],"as":[89,91],"well":[90],"greater":[93],"understanding":[94],"mechanisms":[98,106],"drug":[100,108,191,233,267,329],"resistance.":[101,165],"We":[102,166,274],"have":[103,167,275],"been":[104],"investigating":[105],"using":[110],"genetically-engineered":[111],"mouse":[112,237],"models":[113],"based":[118],"on":[119,331],"combinatorial":[121],"deletion":[122,182],"p53":[124,130],"Pten":[126],"in":[127,136,235,249,279,290,303,311],"epithelium.":[129],"PTEN":[132,172],"are":[133],"frequently":[134],"inactivated":[135],"human":[137,210,280,306],"cancers,":[139],"particularly":[140],"prognosis.":[144],"allograft":[146],"tumors":[147,174,245],"established":[148],"from":[149],"these":[150,170],"mice":[151],"responded":[152],"initially":[153],"treatment":[156,234],"cisplatin,":[158],"docetaxel,":[159],"or":[160,297],"rapamycin":[161],"but":[162],"eventually":[163],"developed":[164],"observed":[168,276],"that":[169,215,263,293,326],"p53;":[171],"deficient":[173],"express":[175,294],"robust":[176],"levels":[177],"p19Arf,":[179],"while":[180],"Arf":[184,217,327],"retards":[185],"aquisition":[187],"following":[190,232,286,298],"treatment.":[192],"The":[193],"significance":[194],"this":[196],"expression":[197,207,218,300],"was":[198,315],"further":[199],"suggested":[200],"by":[201,334],"analysis":[202],"published":[205],"gene":[206,253],"profile":[208],"which":[213],"revealed":[214],"high":[216],"an":[220],"independent":[221],"predictor":[222],"patients.":[230,348],"Furthermore,":[231],"model,":[238],"Arf-positive,":[240],"compared":[241],"Arf-negative,":[244],"were":[246],"significantly":[247],"enriched":[248],"extracellular":[250],"matrix/integrin":[251],"signaling":[252],"signature":[254],"consistent":[255],"activation":[257,319],"downstream":[259],"PI3K-mTOR":[260,321,336],"pathway,":[261,337],"suggesting":[262],"model":[265],"via":[270],"PI3K":[271],"pathway":[272],"activation.":[273],"similar":[277],"results":[278],"cell":[283],"lines":[284],"either":[285],"knock-down":[287],"p14Arf":[289,296,302],"J82":[291],"cells":[292],"endogenous":[295],"forced":[299],"ARF-negative":[304],"UMUC3":[305],"cells,":[309],"both":[312],"cases":[313],"coincident":[316],"deregulated":[318],"pathway.":[322],"Thus,":[323],"we":[324],"propose":[325],"confers":[328],"activating":[335],"highlighting":[338],"potential":[340],"target":[342],"advanced":[344],"Citation":[349],"Format:":[350],"{Authors}.":[351],"{Abstract":[352],"title}":[353],"[abstract].":[354],"In:":[355],"Proceedings":[356],"103rd":[359],"Annual":[360],"Meeting":[361],"American":[364],"Association":[365],"Cancer":[367,378],"Research;":[368],"2012":[369],"Mar":[370],"31-Apr":[371],"4;":[372],"Chicago,":[373],"IL.":[374],"Philadelphia":[375],"(PA):":[376],"AACR;":[377],"Res":[379],"2012;72(8":[380],"Suppl):Abstract":[381],"nr":[382],"802.":[383],"doi:1538-7445.AM2012-802":[384]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-06-24T00:00:00"}