{"id":"https://openalex.org/W2317575554","doi":"https://doi.org/10.1097/inf.0b013e318295a3d0","title":"Procalcitonin","display_name":"Procalcitonin","publication_year":2013,"publication_date":"2013-08-14","ids":{"openalex":"https://openalex.org/W2317575554","doi":"https://doi.org/10.1097/inf.0b013e318295a3d0","mag":"2317575554","pmid":"https://pubmed.ncbi.nlm.nih.gov/24008743"},"language":"en","primary_location":{"id":"doi:10.1097/inf.0b013e318295a3d0","doi":"https://doi.org/10.1097/inf.0b013e318295a3d0","is_oa":false,"landing_page_url":"https://doi.org/10.1097/inf.0b013e318295a3d0","pdf_url":null,"source":{"id":"https://openalex.org/S109369870","display_name":"The Pediatric Infectious Disease Journal","issn_l":"0891-3668","issn":["0891-3668","1532-0987"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Infectious Disease Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000575949","display_name":"James T. Gaensbauer","orcid":"https://orcid.org/0000-0002-0732-4150","observed_orcids":["https://orcid.org/0000-0002-0732-4150"]},"institutions":[{"id":"https://openalex.org/I151808059","display_name":"Colorado School of Public Health","ror":"https://ror.org/005x9g035","country_code":"US","type":"education","lineage":["https://openalex.org/I151808059"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James T. Gaensbauer","raw_affiliation_strings":["Department of Pediatrics, Section on Infectious Diseases Department of Pediatrics, Section of Allergy, Immunology and Rheumatology, University of Colorado School of Medicine, Aurora, CO Department of Pediatrics, Section on Infectious Diseases, University of Colorado School of Medicine, Aurora, CO, Center for Global Health, Colorado School of Public Health, Aurora, CO","Department of Pediatrics, Section of Allergy, Immunology and Rheumatology, University of Colorado School of Medicine, Aurora, CO","Department of Pediatrics, Section on Infectious Diseases","Department of Pediatrics, Section on Infectious Diseases, University of Colorado School of Medicine, Aurora, CO, Center for Global Health, Colorado School of Public Health, Aurora, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Section on Infectious Diseases Department of Pediatrics, Section of Allergy, Immunology and Rheumatology, University of Colorado School of Medicine, Aurora, CO Department of Pediatrics, Section on Infectious Diseases, University of Colorado School of Medicine, Aurora, CO, Center for Global Health, Colorado School of Public Health, Aurora, CO","institution_ids":["https://openalex.org/I151808059","https://openalex.org/I51713134"]},{"raw_affiliation_string":"Department of Pediatrics, Section of Allergy, Immunology and Rheumatology, University of Colorado School of Medicine, Aurora, CO","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]},{"raw_affiliation_string":"Department of Pediatrics, Section on Infectious Diseases","institution_ids":[]},{"raw_affiliation_string":"Department of Pediatrics, Section on Infectious Diseases, University of Colorado School of Medicine, Aurora, CO, Center for Global Health, Colorado School of Public Health, Aurora, CO","institution_ids":["https://openalex.org/I151808059","https://openalex.org/I51713134","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091906480","display_name":"Craig A. Press","orcid":"https://orcid.org/0000-0003-4435-206X","observed_orcids":["https://orcid.org/0000-0003-4435-206X"]},"institutions":[{"id":"https://openalex.org/I151808059","display_name":"Colorado School of Public Health","ror":"https://ror.org/005x9g035","country_code":"US","type":"education","lineage":["https://openalex.org/I151808059"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Craig A. Press","raw_affiliation_strings":["Department of Pediatrics, Section of Allergy, Immunology and Rheumatology, University of Colorado School of Medicine, Aurora, CO","Department of Pediatrics, Section on Infectious Diseases","Department of Pediatrics, Section on Infectious Diseases, University of Colorado School of Medicine, Aurora, CO, Center for Global Health, Colorado School of Public Health, Aurora, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Section of Allergy, Immunology and Rheumatology, University of Colorado School of Medicine, Aurora, CO","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]},{"raw_affiliation_string":"Department of Pediatrics, Section on Infectious Diseases","institution_ids":[]},{"raw_affiliation_string":"Department of Pediatrics, Section on Infectious Diseases, University of Colorado School of Medicine, Aurora, CO, Center for Global Health, Colorado School of Public Health, Aurora, CO","institution_ids":["https://openalex.org/I151808059","https://openalex.org/I51713134","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024627321","display_name":"J. Roger Hollister","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I151808059","display_name":"Colorado School of Public Health","ror":"https://ror.org/005x9g035","country_code":"US","type":"education","lineage":["https://openalex.org/I151808059"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Roger Hollister","raw_affiliation_strings":["Department of Pediatrics, Section of Allergy, Immunology and Rheumatology, University of Colorado School of Medicine, Aurora, CO","Department of Pediatrics, Section on Infectious Diseases","Department of Pediatrics, Section on Infectious Diseases, University of Colorado School of Medicine, Aurora, CO, Center for Global Health, Colorado School of Public Health, Aurora, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Section of Allergy, Immunology and Rheumatology, University of Colorado School of Medicine, Aurora, CO","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]},{"raw_affiliation_string":"Department of Pediatrics, Section on Infectious Diseases","institution_ids":[]},{"raw_affiliation_string":"Department of Pediatrics, Section on Infectious Diseases, University of Colorado School of Medicine, Aurora, CO, Center for Global Health, Colorado School of Public Health, Aurora, CO","institution_ids":["https://openalex.org/I151808059","https://openalex.org/I51713134","https://openalex.org/I921990950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034976745","display_name":"Edwin J. Asturias","orcid":"https://orcid.org/0000-0002-1275-0787","observed_orcids":["https://orcid.org/0000-0002-1275-0787"]},"institutions":[{"id":"https://openalex.org/I151808059","display_name":"Colorado School of Public Health","ror":"https://ror.org/005x9g035","country_code":"US","type":"education","lineage":["https://openalex.org/I151808059"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edwin J. Asturias","raw_affiliation_strings":["Department of Pediatrics, Section of Allergy, Immunology and Rheumatology, University of Colorado School of Medicine, Aurora, CO","Department of Pediatrics, Section on Infectious Diseases","Department of Pediatrics, Section on Infectious Diseases, University of Colorado School of Medicine, Aurora, CO, Center for Global Health, Colorado School of Public Health, Aurora, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Section of Allergy, Immunology and Rheumatology, University of Colorado School of Medicine, Aurora, CO","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]},{"raw_affiliation_string":"Department of Pediatrics, Section on Infectious Diseases","institution_ids":[]},{"raw_affiliation_string":"Department of Pediatrics, Section on Infectious Diseases, University of Colorado School of Medicine, Aurora, CO, Center for Global Health, Colorado School of Public Health, Aurora, CO","institution_ids":["https://openalex.org/I151808059","https://openalex.org/I51713134","https://openalex.org/I921990950"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2428,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.66673639,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"32","issue":"9","first_page":"1040","last_page":"1040"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14245","display_name":"Biomarkers in Disease Mechanisms","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/procalcitonin","display_name":"procalcitonin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tocilizumab","display_name":"tocilizumab","score":0.9679999947547913},{"id":"https://openalex.org/keywords/serious-bacterial-infection","display_name":"serious bacterial infection","score":0.8889999985694885},{"id":"https://openalex.org/keywords/staphylococcal-scalded-skin-syndrome","display_name":"staphylococcal scalded skin syndrome","score":0.875},{"id":"https://openalex.org/keywords/acute-otitis-media","display_name":"acute otitis media","score":0.9359999895095825},{"id":"https://openalex.org/keywords/juvenile-idiopathic-arthritis","display_name":"juvenile idiopathic arthritis","score":0.7739999890327454},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.7720000147819519},{"id":"https://openalex.org/keywords/erythrocyte-sedimentation-rate","display_name":"erythrocyte sedimentation rate","score":1.0},{"id":"https://openalex.org/keywords/il-6-receptor-inhibition","display_name":"IL-6 receptor inhibition","score":0.7360000014305115},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.7699999809265137},{"id":"https://openalex.org/keywords/infection-markers","display_name":"infection biomarkers","score":0.6549999713897705},{"id":"https://openalex.org/keywords/bacterial-infection-diagnosis","display_name":"bacterial infection diagnosis","score":0.44200000166893005},{"id":"https://openalex.org/keywords/amoxicillin-clavulanic-acid","display_name":"amoxicillin-clavulanic acid","score":0.6930000185966492}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9318037033081055},{"id":"https://openalex.org/C2778143017","wikidata":"https://www.wikidata.org/wiki/Q111208","display_name":"Erythrocyte sedimentation rate","level":2,"score":0.7756857872009277},{"id":"https://openalex.org/C10936531","wikidata":"https://www.wikidata.org/wiki/Q786600","display_name":"Procalcitonin","level":3,"score":0.6888893842697144},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6095972657203674},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.603460431098938},{"id":"https://openalex.org/C2778488018","wikidata":"https://www.wikidata.org/wiki/Q42395","display_name":"White blood cell","level":2,"score":0.5606309175491333},{"id":"https://openalex.org/C2780955771","wikidata":"https://www.wikidata.org/wiki/Q183425","display_name":"Abdominal pain","level":2,"score":0.5130327939987183},{"id":"https://openalex.org/C2781195455","wikidata":"https://www.wikidata.org/wiki/Q422766","display_name":"C-reactive protein","level":3,"score":0.5037619471549988},{"id":"https://openalex.org/C2778570526","wikidata":"https://www.wikidata.org/wiki/Q653197","display_name":"Rash","level":2,"score":0.5016293525695801},{"id":"https://openalex.org/C2780724011","wikidata":"https://www.wikidata.org/wiki/Q1295316","display_name":"Emergency department","level":2,"score":0.46673405170440674},{"id":"https://openalex.org/C2779802037","wikidata":"https://www.wikidata.org/wiki/Q40878","display_name":"Diarrhea","level":2,"score":0.45454972982406616},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3565707206726074},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.08180925250053406},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.0815216600894928},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002116","descriptor_name":"Calcitonin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011498","descriptor_name":"Protein Precursors","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015740","descriptor_name":"Calcitonin Gene-Related Peptide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019947","descriptor_name":"Receptors, Interleukin-6","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/inf.0b013e318295a3d0","doi":"https://doi.org/10.1097/inf.0b013e318295a3d0","is_oa":false,"landing_page_url":"https://doi.org/10.1097/inf.0b013e318295a3d0","pdf_url":null,"source":{"id":"https://openalex.org/S109369870","display_name":"The Pediatric Infectious Disease Journal","issn_l":"0891-3668","issn":["0891-3668","1532-0987"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Infectious Disease Journal","raw_type":"journal-article"},{"id":"pmid:24008743","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24008743","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Pediatric infectious disease journal","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W1992612216","https://openalex.org/W2035505806","https://openalex.org/W2050604996","https://openalex.org/W2085544415","https://openalex.org/W2162824139","https://openalex.org/W4245232102"],"related_works":["https://openalex.org/W3139276545","https://openalex.org/W2329084855","https://openalex.org/W2077639483","https://openalex.org/W2411820663","https://openalex.org/W4398228980","https://openalex.org/W2070227578","https://openalex.org/W2402225073","https://openalex.org/W1994221584","https://openalex.org/W1991598927","https://openalex.org/W3018978707"],"abstract_inverted_index":{"To":[0],"the":[1,5,19,29,54,69,91,197,235,266,328,337,350,371,392,399,405,477,484,502,506,517,529,563],"Editors:":[2],"We":[3],"report":[4],"case":[6],"of":[7,53,71,107,123,137,217,238,268,277,286,339,356,384,394,408,432,450,464,479,509,521,567,581,592,595,601,604,613,620,623,633],"a":[8,13,50,118,178,243,293,317,353,381,388,455,462,494],"21-year-old":[9,79],"female":[10,80],"who":[11],"developed":[12,177],"serious":[14,72],"bacterial":[15,287,340,544,568],"infection":[16,56,73],"while":[17,535],"receiving":[18,76],"anti-interleukin-6":[20],"(IL-6)":[21],"receptor":[22,558],"monoclonal":[23,498],"antibody":[24,499],"tocilizumab":[25],"and":[26,33,57,85,99,113,134,140,153,159,175,187,206,230,253,289,311,377,386,403,415,424,448,513,516,533,598],"in":[27,68,74,345,348,367,391,398,440,442,457,461,511,540,549],"whom":[28],"C-reactive":[30],"protein":[31],"(CRP)":[32],"erythrocyte":[34],"sedimentation":[35],"rate":[36],"(ESR)":[37],"responses":[38],"were":[39,164],"blunted":[40],"by":[41,241,301,327,370],"her":[42,58,104,269],"immunosuppressive":[43],"therapy.":[44],"Serum":[45],"procalcitonin":[46,245,522],"(PCT),":[47],"however,":[48],"remained":[49],"useful":[51],"marker":[52,566],"acute":[55,170,198,395,489],"subsequent":[59,189,290],"clinical":[60],"improvement,":[61],"suggesting":[62],"an":[63,135,524],"important":[64],"role":[65,390,508],"for":[66,628],"PCT":[67,276,342,363,438,485,537,560],"diagnosis":[70],"patients":[75,553],"tocilizumab.":[77,108],"A":[78],"with":[81,94,125,149,182,191,196,204,468,487,556],"juvenile":[82],"idiopathic":[83],"arthritis":[84],"chronic":[86],"abdominal":[87,96,151],"pain":[88,152],"presented":[89],"to":[90,306,323,349,427,531,538,542],"emergency":[92],"department":[93],"fever,":[95],"pain,":[97],"vomiting":[98],"diarrhea":[100],"1":[101,146,263],"day":[102,147,168,251,302],"after":[103,214,304],"biweekly":[105],"infusion":[106],"Physical":[109],"examination":[110],"was":[111,142,154,173,202,210,247,283,547],"unrevealing,":[112],"routine":[114],"laboratory":[115],"testing":[116,163,224],"showed":[117,226,292],"white":[119],"blood":[120],"cell":[121],"count":[122],"8300/mm3":[124],"70%":[126],"neutrophils,":[127],"CRP":[128,231,402,423,512,532],"<0.5":[129],"mg/dL":[130],"(normal":[131,280],"<1.0":[132],"mg/dL)":[133],"ESR":[136,229,514,534],"3":[138,257],"mm/hr,":[139],"she":[141,176],"discharged.":[143],"She":[144,201,209],"returned":[145],"later":[148],"worsened":[150],"hospitalized.":[155],"Abdominal":[156],"computed":[157],"tomography":[158],"pelvic":[160],"inflammatory":[161],"disease":[162],"negative.":[165],"On":[166],"hospital":[167,250],"2,":[169],"otitis":[171,199],"media":[172],"noted,":[174],"generalized":[179],"erythrodermal":[180],"rash":[181],"bullous":[183],"sloughing":[184],"consistent":[185],"clinically":[186],"on":[188,219,249,256,333,483,584,616],"biopsy":[190],"staphylococcal":[192],"scalded-skin":[193],"syndrome":[194],"associated":[195],"media.":[200],"treated":[203],"ampicillin-sulbactam":[205],"slowly":[207],"improved.":[208],"discharged":[211],"completely":[212],"recovered":[213],"8":[215],"days":[216],"hospitalization":[218],"oral":[220],"amoxicillin-clavulanic":[221],"acid.":[222],"Blood":[223],"throughout":[225],"persistently":[227],"low":[228],"(Table":[232],"1).":[233],"Given":[234,505],"suspected":[236],"inhibition":[237],"these":[239],"markers":[240],"tocilizumab,":[242],"serum":[244,260],"test":[246],"ordered":[248],"5":[252,303],"retrospectively":[254],"performed":[255],"prior":[258],"frozen":[259],"samples,":[261],"including":[262,401],"taken":[264],"at":[265],"time":[267],"initial":[270,275],"Emergency":[271],"Department":[272,580,591,612],"presentation.":[273],"The":[274],"15.96":[278],"ng/mL":[279,300],"0.0\u20130.5":[281],"ng/mL)":[282],"highly":[284],"suggestive":[285],"infection,":[288,341,545],"values":[291],"clear":[294],"trend":[295],"toward":[296],"normalization,":[297],"reaching":[298],"0.54":[299],"exposure":[305],"antistaphylococcal":[307],"therapy.TABLE":[308],"1:":[309],"Laboratory":[310],"Temperature":[312],"Values":[313],"During":[314],"Hospital":[315],"CourseProcalcitonin,":[316],"116":[318],"amino":[319],"acid":[320],"peptide":[321],"precursor":[322],"calcitonin,":[324],"is":[325,343,365,380,445,493],"transcribed":[326],"calcitonin-related":[329],"polypeptide":[330],"alpha":[331],"gene":[332],"chromosome":[334],"11.":[335],"In":[336,552],"setting":[338],"released":[344],"large":[346],"quantities":[347],"circulation":[351],"from":[352],"wide":[354],"range":[355],"differentiated":[357],"parenchymal":[358],"tissues,":[359],"particularly":[360],"fat":[361],"cells.1":[362],"release":[364,439],"driven":[366],"vivo":[368,443],"primarily":[369],"proinflammatory":[372],"cytokines":[373],"tumor":[374,416],"necrosis":[375,417],"factor-\u03b1":[376],"IL-1\u00df.2":[378],"IL-6":[379,435,451,503,510,525,557],"critical":[382],"mediator":[383],"inflammation":[385],"plays":[387],"central":[389,507],"induction":[393],"phase":[396,490],"reactants":[397],"liver,":[400],"fibrinogen,":[404],"primary":[406],"driver":[407],"elevated":[409],"ESR.":[410],"Other":[411],"cytokines,":[412],"notably":[413],"IL-1":[414],"factor-\u03b1,":[418],"which":[419],"can":[420,436,452],"also":[421],"elevate":[422,539],"ESR,":[425],"appear":[426],"do":[428],"so":[429],"through":[430],"stimulation":[431],"IL-6.3":[433],"Although":[434],"stimulate":[437],"vitro,":[441],"it":[444],"not":[446],"essential":[447],"elevation":[449],"occur":[453],"without":[454],"rise":[456],"PCT,":[458],"as":[459,546],"demonstrated":[460,548],"study":[463],"360":[465],"febrile":[466],"children":[467],"proven":[469],"viral":[470],"infections.4,5":[471],"Little":[472],"published":[473],"information":[474],"exists":[475],"demonstrating":[476],"effects":[478],"biological":[480],"immunosuppressant":[481],"agents":[482],"compared":[486],"other":[488],"reactants.":[491],"Tocilizumab":[492],"mouse":[495],"derived,":[496],"humanized":[497],"directed":[500],"against":[501],"receptor.":[504],"elevation,":[515],"distinct":[518],"alternate":[519],"pathways":[520],"release,":[523],"inhibitor":[526],"should":[527],"blunt":[528],"response":[530,541],"allowing":[536],"severe":[543],"this":[550],"case.":[551],"undergoing":[554],"therapy":[555],"inhibitors,":[559],"may":[561],"be":[562],"preferred":[564],"surrogate":[565],"infection.":[569],"James":[570],"T.":[571],"Gaensbauer,":[572],"MD,":[573,578],"MScPH":[574],"Craig":[575],"A.":[576],"Press,":[577],"PhD":[579],"Pediatrics":[582,593,614],"Section":[583,594,615],"Infectious":[585,617],"Diseases":[586,618],"J.":[587,609],"Roger":[588],"Hollister,":[589],"MD":[590,611],"Allergy,":[596],"Immunology":[597],"Rheumatology":[599],"University":[600,619],"Colorado":[602,621,631],"School":[603,622,632],"Medicine":[605,624],"Aurora,":[606,625,636],"CO":[607,626,637],"Edwin":[608],"Asturias,":[610],"Center":[627],"Global":[629],"Health":[630,635],"Public":[634]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}