{"id":"https://openalex.org/W2317455709","doi":"https://doi.org/10.1021/bi400452v","title":"Role of a Conserved Residue R780 in Escherichia coli Multidrug Transporter AcrB","display_name":"Role of a Conserved Residue R780 in Escherichia coli Multidrug Transporter AcrB","publication_year":2013,"publication_date":"2013-09-05","ids":{"openalex":"https://openalex.org/W2317455709","doi":"https://doi.org/10.1021/bi400452v","mag":"2317455709","pmid":"https://pubmed.ncbi.nlm.nih.gov/24007302"},"language":"en","primary_location":{"id":"doi:10.1021/bi400452v","doi":"https://doi.org/10.1021/bi400452v","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi400452v","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100957302","display_name":"Lin-Liang Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linliang Yu","raw_affiliation_strings":["Department\rof Chemistry, University of Kentucky,Lexington, Kentucky 40506, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Chemistry, University of Kentucky,Lexington, Kentucky 40506, United States","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062699888","display_name":"Wei Lu","orcid":"https://orcid.org/0000-0002-1572-2909","observed_orcids":["https://orcid.org/0000-0002-1572-2909"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Lu","raw_affiliation_strings":["Department\rof Chemistry, University of Kentucky,Lexington, Kentucky 40506, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Chemistry, University of Kentucky,Lexington, Kentucky 40506, United States","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112108833","display_name":"Cui Ye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cui Ye","raw_affiliation_strings":["Department\rof Chemistry, University of Kentucky,Lexington, Kentucky 40506, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Chemistry, University of Kentucky,Lexington, Kentucky 40506, United States","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056309003","display_name":"Zhaoshuai Wang","orcid":"https://orcid.org/0000-0002-5593-368X","observed_orcids":["https://orcid.org/0000-0002-5593-368X"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhaoshuai Wang","raw_affiliation_strings":["Department\rof Chemistry, University of Kentucky,Lexington, Kentucky 40506, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Chemistry, University of Kentucky,Lexington, Kentucky 40506, United States","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102755284","display_name":"Meng Zhong","orcid":"https://orcid.org/0000-0001-9180-9929","observed_orcids":["https://orcid.org/0000-0001-9180-9929"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meng Zhong","raw_affiliation_strings":["Department\rof Chemistry, University of Kentucky,Lexington, Kentucky 40506, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Chemistry, University of Kentucky,Lexington, Kentucky 40506, United States","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009578270","display_name":"Qian Chai","orcid":"https://orcid.org/0000-0002-0938-8166","observed_orcids":["https://orcid.org/0000-0002-0938-8166"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qian Chai","raw_affiliation_strings":["Department\rof Chemistry, University of Kentucky,Lexington, Kentucky 40506, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Chemistry, University of Kentucky,Lexington, Kentucky 40506, United States","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael Sheetz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Sheetz","raw_affiliation_strings":["Center\rfor Computational Sciences, University of Kentucky, Lexington, Kentucky 40506, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center\rfor Computational Sciences, University of Kentucky, Lexington, Kentucky 40506, United States","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031469247","display_name":"Yinan Wei","orcid":"https://orcid.org/0000-0002-9936-7149","observed_orcids":["https://orcid.org/0000-0002-9936-7149"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yinan Wei","raw_affiliation_strings":["Department\rof Chemistry, University of Kentucky,Lexington, Kentucky 40506, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Chemistry, University of Kentucky,Lexington, Kentucky 40506, United States","institution_ids":["https://openalex.org/I143302722"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5031469247"],"corresponding_institution_ids":["https://openalex.org/I143302722"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.768,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.67981621,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"52","issue":"39","first_page":"6790","last_page":"6796"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.913100004196167,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.913100004196167,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.07940000295639038,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acrb","display_name":"AcrB","score":0.9779999852180481},{"id":"https://openalex.org/keywords/multidrug-efflux-pumps","display_name":"multidrug efflux pumps","score":0.9589999914169312},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9079999923706055},{"id":"https://openalex.org/keywords/protein-stability","display_name":"protein stability","score":0.8579999804496765},{"id":"https://openalex.org/keywords/acra","display_name":"AcrA","score":0.6800000071525574},{"id":"https://openalex.org/keywords/tolc","display_name":"TolC","score":0.972000002861023},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.6169999837875366},{"id":"https://openalex.org/keywords/site-directed-mutagenesis","display_name":"site-directed mutagenesis","score":0.7710000276565552},{"id":"https://openalex.org/keywords/denaturation","display_name":"denaturation","score":0.6380000114440918}],"concepts":[{"id":"https://openalex.org/C201663137","wikidata":"https://www.wikidata.org/wiki/Q21198990","display_name":"Periplasmic space","level":4,"score":0.7195241451263428},{"id":"https://openalex.org/C200082930","wikidata":"https://www.wikidata.org/wiki/Q22327148","display_name":"Efflux","level":2,"score":0.6273915767669678},{"id":"https://openalex.org/C2776403692","wikidata":"https://www.wikidata.org/wiki/Q898416","display_name":"Trimer","level":3,"score":0.5948222875595093},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5344732403755188},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5340819358825684},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5187128186225891},{"id":"https://openalex.org/C115335371","wikidata":"https://www.wikidata.org/wiki/Q142943","display_name":"Membrane transport protein","level":4,"score":0.5184159278869629},{"id":"https://openalex.org/C2910769707","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multidrug Resistance-Associated Proteins","level":5,"score":0.5057568550109863},{"id":"https://openalex.org/C65871279","wikidata":"https://www.wikidata.org/wiki/Q42884945","display_name":"Inner membrane","level":3,"score":0.5025479793548584},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.4944326877593994},{"id":"https://openalex.org/C146587185","wikidata":"https://www.wikidata.org/wiki/Q258248","display_name":"Bacterial outer membrane","level":4,"score":0.4928622245788574},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.4734513461589813},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.4524579644203186},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.44310781359672546},{"id":"https://openalex.org/C57581600","wikidata":"https://www.wikidata.org/wiki/Q2449730","display_name":"Transport protein","level":2,"score":0.44284898042678833},{"id":"https://openalex.org/C46371251","wikidata":"https://www.wikidata.org/wiki/Q4886486","display_name":"Cell envelope","level":4,"score":0.425503134727478},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3557884693145752},{"id":"https://openalex.org/C44312359","wikidata":"https://www.wikidata.org/wiki/Q286958","display_name":"ATP-binding cassette transporter","level":4,"score":0.28893595933914185},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.1996898055076599},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.17751091718673706},{"id":"https://openalex.org/C2779546866","wikidata":"https://www.wikidata.org/wiki/Q531306","display_name":"Dimer","level":2,"score":0.08624517917633057},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07818454504013062},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000409","descriptor_name":"Alanine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000409","descriptor_name":"Alanine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D027425","descriptor_name":"ATP-Binding Cassette, Sub-Family C Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D027425","descriptor_name":"ATP-Binding Cassette, Sub-Family C Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D027425","descriptor_name":"ATP-Binding Cassette, Sub-Family C Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi400452v","doi":"https://doi.org/10.1021/bi400452v","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi400452v","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:24007302","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24007302","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.504800021648407,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W124728936","https://openalex.org/W1556495968","https://openalex.org/W1785018154","https://openalex.org/W1948806874","https://openalex.org/W1964509770","https://openalex.org/W1973714359","https://openalex.org/W1979973356","https://openalex.org/W1985400607","https://openalex.org/W2028787442","https://openalex.org/W2035081851","https://openalex.org/W2042669181","https://openalex.org/W2056659809","https://openalex.org/W2068119233","https://openalex.org/W2070196678","https://openalex.org/W2073629943","https://openalex.org/W2079146663","https://openalex.org/W2090791841","https://openalex.org/W2117867117","https://openalex.org/W2121303975","https://openalex.org/W2132067013","https://openalex.org/W2134483159","https://openalex.org/W2138825607","https://openalex.org/W2138857675","https://openalex.org/W2142318169","https://openalex.org/W2149485676","https://openalex.org/W2149849374","https://openalex.org/W2150093310","https://openalex.org/W2153601116","https://openalex.org/W2170213289","https://openalex.org/W2170503951"],"related_works":["https://openalex.org/W2041419642","https://openalex.org/W2028787442","https://openalex.org/W3177149307","https://openalex.org/W2056998008","https://openalex.org/W3170772575","https://openalex.org/W2142318169","https://openalex.org/W1938266246","https://openalex.org/W204789324","https://openalex.org/W7100805664","https://openalex.org/W2138354421"],"abstract_inverted_index":{"Multidrug":[0],"efflux":[1,13,250],"pumps":[2],"play":[3,69],"important":[4,70],"roles":[5,71],"in":[6,15,72,223],"bacteria":[7,17],"drug":[8],"resistance.":[9],"A":[10],"major":[11],"multidrug":[12],"system":[14],"Gram-negative":[16],"is":[18,204],"composed":[19],"of":[20,47,100,111,123,166,174,182,188,243,248],"the":[21,51,65,116,120,126,147,164,175,180,193,215,218,224,241],"inner":[22],"membrane":[23,27,32],"transporter":[24],"AcrB,":[25],"outer":[26],"protein":[28,34,150,197,216,244],"channel":[29],"TolC,":[30],"and":[31,50,56,80,140,190,227,238,246],"fusion":[33],"AcrA.":[35,230],"These":[36,199],"three":[37],"proteins":[38],"form":[39],"a":[40,59,82,109,155,169],"large":[41],"complex":[42],"that":[43,68,146,173,192,202],"spans":[44],"both":[45,138],"layers":[46],"cell":[48,225],"membranes":[49],"periplasmic":[52],"space.":[53],"AcrB":[54,73,207],"exists":[55],"functions":[57],"as":[58],"homotrimer.":[60],"To":[61,178],"identify":[62],"residues":[63,104],"at":[64],"trimer":[66,106,112,135],"interface":[67],"function,":[74],"we":[75,144,153,185],"conducted":[76],"site":[77],"directed":[78],"mutagenesis":[79],"discovered":[81],"key":[83],"residue,":[84],"R780.":[85],"Although":[86],"R780K":[87],"was":[88,114,211],"partially":[89],"functional,":[90],"all":[91],"other":[92,103],"R780":[93,101,203,210],"mutants":[94],"tested":[95],"were":[96],"completely":[97],"nonfunctional.":[98],"Replacement":[99],"by":[102,133,213],"disrupted":[105],"association.":[107],"However,":[108,231],"decrease":[110,242],"stability":[113,245],"not":[115,130],"lone":[117],"cause":[118],"for":[119,206],"observed":[121],"loss":[122,128,247],"activity,":[124],"because":[125],"activity":[127,165,183],"could":[129],"be":[131],"restored":[132,163],"strengthening":[134],"interaction.":[136],"Using":[137],"heat":[139],"chemical":[141],"denaturation":[142,187],"methods,":[143],"found":[145,191],"mutation":[148,195],"decreased":[149],"stability.":[151,198,208],"Finally,":[152],"identified":[154],"repressor":[156,194],"mutation,":[157],"M774K,":[158],"through":[159],"random":[160],"mutagenesis.":[161],"It":[162],"AcrBR780A":[167],"to":[168,172,240],"level":[170],"close":[171],"wild-type":[176],"protein.":[177],"examine":[179],"mechanism":[181],"restoration,":[184],"monitored":[186],"AcrBR780A/M774K":[189],"improved":[196],"results":[200],"suggest":[201],"critical":[205],"When":[209],"replaced":[212],"Ala,":[214],"retained":[217],"overall":[219],"structure,":[220],"still":[221],"trimerized":[222],"membrane,":[226],"interacted":[228],"with":[229],"local":[232],"structural":[233],"rearrangement":[234],"might":[235],"have":[236],"occurred":[237],"lead":[239],"substrate":[249],"activity.":[251]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
