{"id":"https://openalex.org/W2317343296","doi":"https://doi.org/10.1158/1538-7445.am2013-1902","title":"Abstract 1902: Characterization of choline phospholipid metabolism in pancreatic cancer cells.","display_name":"Abstract 1902: Characterization of choline phospholipid metabolism in pancreatic cancer cells.","publication_year":2013,"publication_date":"2013-04-01","ids":{"openalex":"https://openalex.org/W2317343296","doi":"https://doi.org/10.1158/1538-7445.am2013-1902","mag":"2317343296"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2013-1902","doi":"https://doi.org/10.1158/1538-7445.am2013-1902","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2013-1902","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071657407","display_name":"Tariq Kazim Shah","orcid":"https://orcid.org/0000-0002-0099-5859","observed_orcids":["https://orcid.org/0000-0002-0099-5859"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tariq Shah","raw_affiliation_strings":["Johns Hopkins University School of Medicine, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University School of Medicine, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070553254","display_name":"Flonn\u00e9 B. Wildes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Flonne Wildes","raw_affiliation_strings":["Johns Hopkins University School of Medicine, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University School of Medicine, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068651161","display_name":"Yelena Mironchik","orcid":"https://orcid.org/0000-0002-0330-5446","observed_orcids":["https://orcid.org/0000-0002-0330-5446"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yelena Mironchik","raw_affiliation_strings":["Johns Hopkins University School of Medicine, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University School of Medicine, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026291909","display_name":"Marie\u2010France Penet","orcid":"https://orcid.org/0000-0002-9132-7433","observed_orcids":["https://orcid.org/0000-0002-9132-7433"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marie-France Penet","raw_affiliation_strings":["Johns Hopkins University School of Medicine, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University School of Medicine, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048073439","display_name":"Anirban Maitra","orcid":"https://orcid.org/0000-0001-7923-9978","observed_orcids":["https://orcid.org/0000-0001-7923-9978","https://orcid.org/0000-0003-0298-9775"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anirban Maitra","raw_affiliation_strings":["Johns Hopkins University School of Medicine, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University School of Medicine, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009487218","display_name":"Zaver M. Bhujwalla","orcid":"https://orcid.org/0000-0002-6617-9360","observed_orcids":["https://orcid.org/0000-0002-6617-9360"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zaver M. Bhujwalla","raw_affiliation_strings":["Johns Hopkins University School of Medicine, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University School of Medicine, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"73","issue":"8_Supplement","first_page":"1902","last_page":"1902"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.8740000128746033},{"id":"https://openalex.org/keywords/choline-kinase-alpha","display_name":"choline kinase alpha","score":0.8529999852180481},{"id":"https://openalex.org/keywords/phosphorylcholine","display_name":"phosphorylcholine","score":0.8109999895095825},{"id":"https://openalex.org/keywords/total-choline","display_name":"total choline","score":0.7940000295639038},{"id":"https://openalex.org/keywords/1h-magnetic-resonance-spectroscopy","display_name":"1H magnetic resonance spectroscopy","score":0.8970000147819519},{"id":"https://openalex.org/keywords/pancreatic-cancer-cell-lines","display_name":"pancreatic cancer cell lines","score":0.824999988079071},{"id":"https://openalex.org/keywords/metastatic-pancreatic-cancer","display_name":"metastatic pancreatic cancer","score":0.5690000057220459},{"id":"https://openalex.org/keywords/liver-and-lung-metastasis","display_name":"liver and lung metastasis","score":0.640999972820282},{"id":"https://openalex.org/keywords/panc-1-cells","display_name":"PANC-1 cells","score":0.5049999952316284}],"concepts":[{"id":"https://openalex.org/C2780601828","wikidata":"https://www.wikidata.org/wiki/Q5104339","display_name":"Choline kinase","level":5,"score":0.7695940732955933},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.7406166791915894},{"id":"https://openalex.org/C125593758","wikidata":"https://www.wikidata.org/wiki/Q15315135","display_name":"Telomerase reverse transcriptase","level":4,"score":0.7229058146476746},{"id":"https://openalex.org/C2776923060","wikidata":"https://www.wikidata.org/wiki/Q576895","display_name":"Phosphocholine","level":5,"score":0.6980766654014587},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5954118967056274},{"id":"https://openalex.org/C2781123555","wikidata":"https://www.wikidata.org/wiki/Q193166","display_name":"Choline","level":2,"score":0.5192177891731262},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5107548236846924},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.49202677607536316},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.4790864586830139},{"id":"https://openalex.org/C2780258809","wikidata":"https://www.wikidata.org/wiki/Q414143","display_name":"Gemcitabine","level":3,"score":0.43534818291664124},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.42505860328674316},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4155486226081848},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41387641429901123},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3954022526741028},{"id":"https://openalex.org/C94581717","wikidata":"https://www.wikidata.org/wiki/Q331839","display_name":"Telomerase","level":3,"score":0.34835195541381836},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.20771163702011108},{"id":"https://openalex.org/C2776330855","wikidata":"https://www.wikidata.org/wiki/Q650187","display_name":"Phosphatidylcholine","level":4,"score":0.1102452278137207},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09567633271217346},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07686489820480347},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2013-1902","doi":"https://doi.org/10.1158/1538-7445.am2013-1902","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2013-1902","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1976004696","https://openalex.org/W2356034206","https://openalex.org/W2156233892","https://openalex.org/W2567028639","https://openalex.org/W1564219900","https://openalex.org/W2370606885","https://openalex.org/W1913058187","https://openalex.org/W2378954657","https://openalex.org/W1948988765","https://openalex.org/W2383305782"],"abstract_inverted_index":{"Abstract":[0],"Pancreatic":[1,181],"cancer":[2,20,227,382,407,421,456],"has":[3,114],"a":[4,142,276,298],"current":[5],"5-year":[6],"survival":[7],"rate":[8],"of":[9,19,57,76,97,120,144,250,258,315,376,401,431,450,461,466],"less":[10],"than":[11],"3%,":[12],"accounting":[13],"for":[14,52,88,127,168,178,303,333,470],"the":[15,23,74,121,128,217,353,363,373,399,429,462,467],"fourth":[16],"largest":[17],"number":[18],"deaths":[21],"in":[22,28,73,91,112,141,322,328,348,419,428,454],"US.":[24],"Poor":[25],"prognosis":[26],"is,":[27],"part,":[29],"due":[30,105],"to":[31,38,41,106,117,136,162,272,293,352,390,404,411],"its":[32],"diagnosis":[33,75],"at":[34,297],"late":[35],"stages":[36],"and":[37,43,84,87,154,173,203,222,243,325,346,370,379,408],"limited":[39],"response":[40,410],"chemotherapy":[42],"radiotherapy.":[44],"Currently,":[45],"there":[46],"are":[47],"no":[48],"noninvasive":[49],"markers":[50],"available":[51],"early":[53],"diagnosis.":[54],"The":[55,413],"development":[56,400],"novel":[58,426],"therapeutic":[59],"strategies":[60],"is":[61,70],"also":[62,360,424],"critically":[63],"important.":[64],"1H":[65,94,134,171,402],"magnetic":[66],"resonance":[67],"spectroscopy":[68],"(MRS)":[69],"being":[71],"evaluated":[72],"other":[77,211,392],"solid":[78],"malignancies":[79],"such":[80],"as":[81,197],"brain,":[82],"prostate":[83],"breast":[85],"cancer,":[86],"monitoring":[89],"therapy":[90],"brain":[92],"cancer.":[93,433],"MR":[95],"spectra":[96,296],"these":[98],"tumors":[99],"show":[100],"elevated":[101,344],"total":[102],"choline":[103,122,138,334,388,415,451],"(tCho)":[104],"increased":[107],"phosphocholine":[108],"(PC).":[109],"This":[110],"increase":[111],"PC":[113,345],"been":[115],"attributed":[116],"high":[118,169,386],"expression":[119,321],"kinase":[123],"(Chk)-\u03b1":[124],"gene.":[125],"Here,":[126],"first":[129],"time,":[130],"we":[131],"have":[132],"used":[133,161,177,196,292],"MRS":[135,172,403],"characterize":[137],"phospholipid":[139,452],"metabolism":[140,416,453],"panel":[143],"pancreatic":[145,150,157,198,220,226,309,355,381,406,420,432,455],"adenocarcinomas":[146,350],"cell":[147,152,158,166,174,212,234,281,310,341,365,393],"lines.":[148,366],"Eight":[149],"adenocarcinoma":[151,364],"lines":[153,213,235,311,394],"one":[155],"immortalized":[156,199,354],"line":[159],"were":[160,176,195,206,214,223,236,245,291,359],"obtain":[163],"water":[164,339],"soluble":[165,340],"extracts":[167,266,282,342],"resolution":[170],"lysates":[175],"immunoblotting.":[179],"Human":[180],"Nestin":[182],"Expressing":[183],"(HPNE)":[184],"cells,":[185],"stably":[186],"expressing":[187],"human":[188],"telomerase":[189],"reverse":[190],"transcriptase":[191],"(hTERT),":[192],"hTERT-HPNE":[193,329],"cells":[194,205,286,356,383,422],"cells.":[200,330,457],"hTERT-HPNE,":[201],"Panc-1":[202],"BxPC-3":[204],"obtained":[207,215,254,337],"from":[208,216,225,238,247,255,283,307,338],"ATCC.":[209],"All":[210],"Johns":[218],"Hopkins":[219],"xenobank":[221],"derived":[224,237,246],"patients.":[228],"Panc-1,":[229,368],"BxPC-3,":[230],"Pa09C,":[231],"Pa28C,":[232],"Pa20C":[233],"primary":[239],"adenocarcinomas.":[240],"While":[241,367],"Pa02C":[242],"Pa03C":[244],"liver":[248],"metastasis":[249,257],"adenocarcinoma,":[251],"Pa04C":[252],"was":[253,268],"lung":[256],"adenocarcinoma.":[259],"For":[260],"immunoblots":[261],"studies,":[262],"60":[263],"\u03bcg":[264],"whole-cell":[265],"protein":[267],"resolved":[269],"on":[270],"SDS-PAGE":[271],"detect":[273,405],"Chk-\u03b1":[274,316],"using":[275,288],"custom-made":[277],"Chk":[278],"antibody.":[279],"Water-soluble":[280],"approximately":[284],"1.5x107":[285],"made":[287],"dual-phase":[289],"extraction":[290],"acquire":[294],"proton":[295],"500":[299],"MHz":[300],"Bruker":[301],"spectrometer":[302],"metabolite":[304],"quantitation.":[305],"Immunoblots":[306],"various":[308],"showed":[312,343,372,384],"different":[313],"level":[314,327],"overexpression":[317],"with":[318],"very":[319],"low":[320],"Pa04C,":[323],"Pa28C":[324],"undetectable":[326],"Quantitative":[331],"data":[332,397],"containing":[335],"metabolites":[336],"tCho":[347],"all":[349,391],"relative":[351],"(p<0.05).":[357,395],"Differences":[358],"observed":[361,417],"within":[362],"Pa09c":[369],"Pa20c":[371,378],"highest":[374],"amounts":[375],"PC,":[377],"Pa03c":[380],"significantly":[385],"free":[387],"compared":[389],"These":[396],"support":[398],"monitor":[409],"treatment.":[412],"aberrant":[414],"here":[418],"may":[423],"provide":[425],"targets":[427],"treatment":[430],"Citation":[434],"Format:":[435],"Tariq":[436],"Shah,":[437],"Flonne":[438],"Wildes,":[439],"Yelena":[440],"Mironchik,":[441],"Marie-France":[442],"Penet,":[443],"Anirban":[444],"Maitra,":[445],"Zaver":[446],"M.":[447],"Bhujwalla.":[448],"Characterization":[449],"[abstract].":[458],"In:":[459],"Proceedings":[460],"104th":[463],"Annual":[464],"Meeting":[465],"American":[468],"Association":[469],"Cancer":[471,481],"Research;":[472],"2013":[473],"Apr":[474],"6-10;":[475],"Washington,":[476],"DC.":[477],"Philadelphia":[478],"(PA):":[479],"AACR;":[480],"Res":[482],"2013;73(8":[483],"Suppl):Abstract":[484],"nr":[485],"1902.":[486],"doi:10.1158/1538-7445.AM2013-1902":[487]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}