{"id":"https://openalex.org/W2317334758","doi":"https://doi.org/10.1158/1538-7445.am2011-1865","title":"Abstract 1865: Colon cancer chemopreventive properties of a non-cyclooxygenase inhibitory amide derivative of sulindac","display_name":"Abstract 1865: Colon cancer chemopreventive properties of a non-cyclooxygenase inhibitory amide derivative of sulindac","publication_year":2011,"publication_date":"2011-04-01","ids":{"openalex":"https://openalex.org/W2317334758","doi":"https://doi.org/10.1158/1538-7445.am2011-1865","mag":"2317334758"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2011-1865","doi":"https://doi.org/10.1158/1538-7445.am2011-1865","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2011-1865","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071802884","display_name":"Gary Anthony Piazza","orcid":"https://orcid.org/0000-0003-4418-887X","observed_orcids":["https://orcid.org/0000-0003-4418-887X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gary A. Piazza","raw_affiliation_strings":["1Southern Research Inst., Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Southern Research Inst., Birmingham, AL","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034358215","display_name":"Adam B. Keeton","orcid":"https://orcid.org/0000-0002-3053-341X","observed_orcids":["https://orcid.org/0000-0002-3053-341X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adam B. Keeton","raw_affiliation_strings":["1Southern Research Inst., Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Southern Research Inst., Birmingham, AL","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087976717","display_name":"Heather Nicole Tinsley","orcid":"https://orcid.org/0000-0003-1051-3152","observed_orcids":["https://orcid.org/0000-0003-1051-3152"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Heather N. Tinsley","raw_affiliation_strings":["1Southern Research Inst., Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Southern Research Inst., Birmingham, AL","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110327537","display_name":"Bernard D. Gary","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bernard D. Gary","raw_affiliation_strings":["1Southern Research Inst., Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Southern Research Inst., Birmingham, AL","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113728635","display_name":"Jason D. Whitt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason D. Whitt","raw_affiliation_strings":["2University of Alabama at Birmingham, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of Alabama at Birmingham, Birmingham, AL","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100341126","display_name":"Nan Li","orcid":"https://orcid.org/0000-0003-4246-2994","observed_orcids":["https://orcid.org/0000-0003-4246-2994"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nan Li","raw_affiliation_strings":["2University of Alabama at Birmingham, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of Alabama at Birmingham, Birmingham, AL","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074047848","display_name":"Evrim Gurpinar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Evrim Gurpinar","raw_affiliation_strings":["2University of Alabama at Birmingham, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of Alabama at Birmingham, Birmingham, AL","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051362659","display_name":"Yanjie Sun","orcid":"https://orcid.org/0000-0001-9382-4401","observed_orcids":["https://orcid.org/0000-0001-9382-4401"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yanjie Sun","raw_affiliation_strings":["1Southern Research Inst., Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Southern Research Inst., Birmingham, AL","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068169717","display_name":"Bini Mathew","orcid":"https://orcid.org/0000-0002-9020-110X","observed_orcids":["https://orcid.org/0000-0002-9020-110X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bini Mathew","raw_affiliation_strings":["1Southern Research Inst., Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Southern Research Inst., Birmingham, AL","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066715892","display_name":"Robert C. Reynolds","orcid":"https://orcid.org/0000-0001-9413-2247","observed_orcids":["https://orcid.org/0000-0001-9413-2247"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert C. Reynolds","raw_affiliation_strings":["1Southern Research Inst., Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Southern Research Inst., Birmingham, AL","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115592026","display_name":"Wei Zhang","orcid":"https://orcid.org/0009-0004-4280-7563","observed_orcids":["https://orcid.org/0009-0004-4280-7563"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei Zhang","raw_affiliation_strings":["1Southern Research Inst., Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Southern Research Inst., Birmingham, AL","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Raj Singh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146347","display_name":"Vivo Biosciences (United States)","ror":"https://ror.org/03d4tjj21","country_code":"US","type":"company","lineage":["https://openalex.org/I4210146347"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raj Singh","raw_affiliation_strings":["3Vivo Biosciences, Inc., Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Vivo Biosciences, Inc., Birmingham, AL","institution_ids":["https://openalex.org/I4210146347"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016292580","display_name":"Lori U. Coward","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83321563","display_name":"Samford University","ror":"https://ror.org/0040cz635","country_code":"US","type":"education","lineage":["https://openalex.org/I83321563"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lori Coward","raw_affiliation_strings":["4Samford University, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Samford University, Birmingham, AL","institution_ids":["https://openalex.org/I83321563"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064917276","display_name":"Greg S. Gorman","orcid":"https://orcid.org/0000-0003-4306-8884","observed_orcids":["https://orcid.org/0000-0003-4306-8884"]},"institutions":[{"id":"https://openalex.org/I83321563","display_name":"Samford University","ror":"https://ror.org/0040cz635","country_code":"US","type":"education","lineage":["https://openalex.org/I83321563"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Greg Gorman","raw_affiliation_strings":["4Samford University, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Samford University, Birmingham, AL","institution_ids":["https://openalex.org/I83321563"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021533593","display_name":"Yulia Y. Maxuitenko","orcid":"https://orcid.org/0000-0001-5518-4941","observed_orcids":["https://orcid.org/0000-0001-5518-4941"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yulia Y. Maxuitenko","raw_affiliation_strings":["1Southern Research Inst., Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Southern Research Inst., Birmingham, AL","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076077003","display_name":"William E. Grizzle","orcid":"https://orcid.org/0000-0001-9245-0401","observed_orcids":["https://orcid.org/0000-0001-9245-0401"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Grizzle","raw_affiliation_strings":["2University of Alabama at Birmingham, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of Alabama at Birmingham, Birmingham, AL","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030196668","display_name":"Wen\u2010Chi Chang","orcid":"https://orcid.org/0000-0002-0347-1516","observed_orcids":["https://orcid.org/0000-0002-0347-1516"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wen-Chi Chang","raw_affiliation_strings":["5Fox Chase Cancer Center, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Fox Chase Cancer Center, Philadelphia, PA","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022569332","display_name":"Margie L. Clapper","orcid":"https://orcid.org/0000-0001-7712-5109","observed_orcids":["https://orcid.org/0000-0001-7712-5109"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margie Clapper","raw_affiliation_strings":["5Fox Chase Cancer Center, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Fox Chase Cancer Center, Philadelphia, PA","institution_ids":["https://openalex.org/I1289437631"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"71","issue":"8_Supplement","first_page":"1865","last_page":"1865"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.014100000262260437,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colon-cancer-chemoprevention","display_name":"colon cancer chemoprevention","score":0.8939999938011169},{"id":"https://openalex.org/keywords/tumor-cell-growth-inhibition","display_name":"tumor cell growth inhibition","score":0.734000027179718},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9380000233650208},{"id":"https://openalex.org/keywords/protein-kinase-g","display_name":"protein kinase G","score":0.9350000023841858},{"id":"https://openalex.org/keywords/tumor-selectivity","display_name":"tumor selectivity","score":0.7590000033378601},{"id":"https://openalex.org/keywords/tumor-xenografts","display_name":"tumor xenografts","score":0.6809999942779541},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9539999961853027}],"concepts":[{"id":"https://openalex.org/C2776241388","wikidata":"https://www.wikidata.org/wiki/Q963093","display_name":"Sulindac","level":3,"score":0.8701480627059937},{"id":"https://openalex.org/C2779689624","wikidata":"https://www.wikidata.org/wiki/Q410251","display_name":"Cyclooxygenase","level":3,"score":0.5650798082351685},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5568552017211914},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5267752408981323},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5104178786277771},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5060068964958191},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.45909011363983154},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.4576292634010315},{"id":"https://openalex.org/C62826618","wikidata":"https://www.wikidata.org/wiki/Q424304","display_name":"Phosphodiesterase","level":3,"score":0.45059287548065186},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4371032416820526},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.367329478263855},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29052263498306274},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27278798818588257},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25657233595848083},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2551935613155365},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.15799322724342346},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C2778484676","wikidata":"https://www.wikidata.org/wiki/Q20707196","display_name":"Nonsteroidal","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2011-1865","doi":"https://doi.org/10.1158/1538-7445.am2011-1865","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2011-1865","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2111263798","https://openalex.org/W4317624063","https://openalex.org/W2100910673","https://openalex.org/W2007303100","https://openalex.org/W2095927721","https://openalex.org/W3022222270","https://openalex.org/W1996683553","https://openalex.org/W1972751623","https://openalex.org/W2318723596","https://openalex.org/W2012530020"],"abstract_inverted_index":{"Abstract":[0],"Previous":[1],"studies":[2,217,312],"have":[3,45,80],"concluded":[4],"that":[5,21,44,213,319,352],"the":[6,10,94,200,219,237,264,290,334,357,368,425,430],"mechanism":[7,165],"responsible":[8],"for":[9,28,112,339,360,404,433],"antineoplastic":[11],"properties":[12],"of":[13,96,105,146,161,166,178,183,196,202,205,221,287,298,304,324,330,350,370,424,429],"NSAIDs":[14],"is":[15,170,214],"cyclooxygenase":[16],"(COX)":[17],"independent,":[18],"which":[19,187,243],"suggests":[20],"more":[22,124],"selective":[23],"drugs":[24],"can":[25],"be":[26,191],"developed":[27,403],"cancer":[29,406],"chemoprevention":[30],"by":[31,250,256,271,295,309,410],"targeting":[32],"such":[33],"mechanisms.":[34],"With":[35],"this":[36],"paradigm,":[37],"we":[38],"are":[39,401],"synthesizing":[40],"novel":[41],"sulindac":[42,65,113,275,344,373,385],"derivatives":[43,386],"reduced":[46,246],"COX":[47,118,377],"inhibitory":[48,55,77],"activity,":[49,78],"but":[50,150],"enhanced":[51],"tumor":[52,85,100,132,140,162,208,225,248,254,261,322,348,361],"cell":[53,86,133,141,209,362],"growth":[54,87,95,134,201,262,340,363],"activity.":[56],"A":[57],"prototypic":[58],"dimethylethyl":[59],"amide":[60,67],"derivative":[61],"referred":[62],"to":[63,72,83,156,190,374,397],"as":[64,307,393,395],"sulfide":[66,114],"(SSA)":[68],"was":[69,121,233,281,293],"previously":[70],"reported":[71],"lack":[73],"COX-1":[74],"or":[75],"COX-2":[76],"yet":[79],"improved":[81],"potency":[82,389],"inhibit":[84],"in":[88,128,138,223,236,242,263,289,313,335],"vitro.":[89],"For":[90],"example,":[91],"SSA":[92,120,143,167,198,232,258,288,325,331],"inhibited":[93,199,260],"human":[97,152,265],"HT-29":[98,130,147,266,291,316],"colon":[99,131,247,267,405],"cells":[101,300,306],"with":[102,109,172,216,387],"IC50":[103,337,358],"values":[104],"1-2":[106],"\u00b5M":[107,111],"compared":[108],"70-90":[110],"(SS),":[115],"a":[116,136,203,327],"non-selective":[117],"inhibitor.":[119],"also":[122,188,259],"appreciably":[123,332,354],"effective":[125],"than":[126,356],"SS":[127,351],"inhibiting":[129],"using":[135],"3-dimensional":[137],"vitro":[139,336],"model.":[142],"induced":[144,168],"apoptosis":[145,169],"carcinoma":[148],"cells,":[149],"normal":[151],"colonocytes":[153],"were":[154,353],"insensitive":[155],"treatment,":[157],"suggesting":[158],"an":[159,192,211],"element":[160],"selectivity.":[163],"The":[164,284],"associated":[171,378],"cGMP":[173],"phosphodiesterase":[174],"(PDE)":[175],"inhibition,":[176],"elevation":[177],"intracellular":[179],"cGMP,":[180],"and":[181,230,253,301,321,347,390,414],"activation":[182],"protein":[184],"kinase":[185],"G,":[186],"appears":[189],"important":[193],"off-target":[194],"effect":[195,212],"SS.":[197],"variety":[204],"histologically":[206],"diverse":[207],"lines,":[210],"consistent":[215],"showing":[218],"overexpression":[220],"PDE5":[222],"various":[224],"types,":[226],"including":[227],"colorectal":[228],"adenomas":[229],"carcinomas.":[231],"well":[234,394],"tolerated":[235,279,328],"FCCC":[238],"Min":[239],"mouse":[240,268],"model":[241,270,292],"oral":[244,399],"administration":[245],"multiplicity":[249],"approximately":[251,272],"80%":[252],"incidence":[255],"50%.":[257],"xenograft":[269],"60%,":[273],"while":[274,380],"at":[276],"its":[277],"maximum":[278],"dose":[280,329],"marginally":[282],"effective.":[283],"antitumor":[285],"activity":[286],"accompanied":[294],"decreased":[296],"numbers":[297,303],"proliferating":[299],"increased":[302],"apoptotic":[305],"determined":[308],"immunohistochemistry.":[310],"Pharmacokinetic":[311],"mice":[314],"bearing":[315],"xenografts":[317],"revealed":[318],"plasma":[320,346],"levels":[323,349],"from":[326],"exceeded":[333],"value":[338,359],"inhibition.":[341,364],"In":[342],"contrast,":[343],"generated":[345],"less":[355],"These":[365],"results":[366],"support":[367],"feasibility":[369],"chemically":[371],"modifying":[372],"design":[375],"out":[376],"toxicities,":[379],"increasing":[381],"anticancer":[382],"efficacy.":[383],"Newer":[384],"higher":[388],"target":[391],"selectivity,":[392],"formulations":[396],"improve":[398],"bioavailability":[400],"being":[402],"chemoprevention.":[407],"Funding":[408],"provided":[409],"NIH/NCI":[411],"grants":[412],"CA131378":[413],"CA148817.":[415],"Citation":[416],"Format:":[417],"{Authors}.":[418],"{Abstract":[419],"title}":[420],"[abstract].":[421],"In:":[422],"Proceedings":[423],"102nd":[426],"Annual":[427],"Meeting":[428],"American":[431],"Association":[432],"Cancer":[434,444],"Research;":[435],"2011":[436],"Apr":[437],"2-6;":[438],"Orlando,":[439],"FL.":[440],"Philadelphia":[441],"(PA):":[442],"AACR;":[443],"Res":[445],"2011;71(8":[446],"Suppl):Abstract":[447],"nr":[448],"1865.":[449],"doi:10.1158/1538-7445.AM2011-1865":[450]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
