{"id":"https://openalex.org/W2317310331","doi":"https://doi.org/10.4161/cc.5.19.3316","title":"Aurora-A Kinase and Inhibitor-2 Regulate the Cyclin Threshold for Mitotic Entry in Xenopus Early Embryonic Cell Cycles","display_name":"Aurora-A Kinase and Inhibitor-2 Regulate the Cyclin Threshold for Mitotic Entry in Xenopus Early Embryonic Cell Cycles","publication_year":2006,"publication_date":"2006-09-28","ids":{"openalex":"https://openalex.org/W2317310331","doi":"https://doi.org/10.4161/cc.5.19.3316","mag":"2317310331","pmid":"https://pubmed.ncbi.nlm.nih.gov/16969136"},"language":"en","primary_location":{"id":"doi:10.4161/cc.5.19.3316","doi":"https://doi.org/10.4161/cc.5.19.3316","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cc.5.19.3316","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.5.19.3316?needAccess=true&role=button","source":{"id":"https://openalex.org/S86011449","display_name":"Cell Cycle","issn_l":"1538-4101","issn":["1538-4101","1551-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.5.19.3316?needAccess=true&role=button","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060886372","display_name":"David L. Satinover","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David L. Satinover","raw_affiliation_strings":["Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074981380","display_name":"David L. Brautigan","orcid":"https://orcid.org/0000-0003-1687-5250","observed_orcids":["https://orcid.org/0000-0003-1687-5250"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David L. Brautigan","raw_affiliation_strings":["Center for Cell Signaling and Department of Microbiology ; Charlottesville , Virginia USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cell Signaling and Department of Microbiology ; Charlottesville , Virginia USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072633316","display_name":"P. Todd Stukenberg","orcid":"https://orcid.org/0000-0002-6788-2111","observed_orcids":["https://orcid.org/0000-0002-6788-2111"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. Todd Stukenberg","raw_affiliation_strings":["Department of Biochemistry and Molecular Genetics ; University of Virginia School of Medicine ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Genetics ; University of Virginia School of Medicine ;","institution_ids":["https://openalex.org/I51556381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I51556381"],"apc_list":null,"apc_paid":null,"fwci":1.5149,"has_fulltext":true,"cited_by_count":37,"citation_normalized_percentile":{"value":0.80689498,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"5","issue":"19","first_page":"2268","last_page":"2274"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aurora-a-kinase","display_name":"AURKA","score":0.9729999899864197},{"id":"https://openalex.org/keywords/inhibitor-2","display_name":"inhibitor-2","score":0.8640000224113464},{"id":"https://openalex.org/keywords/mitotic-entry","display_name":"mitotic entry","score":0.9909999966621399},{"id":"https://openalex.org/keywords/cdk1-activation","display_name":"CDK1 activation","score":0.9610000252723694},{"id":"https://openalex.org/keywords/pp1-phosphatase","display_name":"PP1 phosphatase","score":0.7829999923706055}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7605999708175659},{"id":"https://openalex.org/C9743823","wikidata":"https://www.wikidata.org/wiki/Q5198264","display_name":"Cyclin B","level":5,"score":0.7531311511993408},{"id":"https://openalex.org/C28179978","wikidata":"https://www.wikidata.org/wiki/Q5198263","display_name":"Cyclin A2","level":5,"score":0.7238132357597351},{"id":"https://openalex.org/C16438837","wikidata":"https://www.wikidata.org/wiki/Q5198260","display_name":"Cyclin A","level":5,"score":0.7095525860786438},{"id":"https://openalex.org/C124320809","wikidata":"https://www.wikidata.org/wiki/Q46292","display_name":"Cyclin-dependent kinase","level":4,"score":0.6760818958282471},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6745332479476929},{"id":"https://openalex.org/C11882975","wikidata":"https://www.wikidata.org/wiki/Q24781041","display_name":"Cyclin D","level":5,"score":0.5849900245666504},{"id":"https://openalex.org/C2778437423","wikidata":"https://www.wikidata.org/wiki/Q5198265","display_name":"Cyclin B1","level":5,"score":0.5666226148605347},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.48974132537841797},{"id":"https://openalex.org/C175738201","wikidata":"https://www.wikidata.org/wiki/Q5198255","display_name":"Cyclin-dependent kinase complex","level":5,"score":0.4566241502761841},{"id":"https://openalex.org/C120089663","wikidata":"https://www.wikidata.org/wiki/Q59250999","display_name":"Cyclin","level":4,"score":0.4119432270526886},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3712904453277588},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.36712247133255005},{"id":"https://openalex.org/C120504264","wikidata":"https://www.wikidata.org/wiki/Q1147372","display_name":"Cyclin-dependent kinase 1","level":4,"score":0.3381900191307068},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19614189863204956},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.13511210680007935}],"mesh":[{"descriptor_ui":"D000097847","descriptor_name":"Protein Phosphatase Inhibitory Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004625","descriptor_name":"Embryo, Nonmammalian","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008938","descriptor_name":"Mitosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010749","descriptor_name":"Phosphoprotein Phosphatases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014981","descriptor_name":"Xenopus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018844","descriptor_name":"Cyclin-Dependent Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019926","descriptor_name":"Cyclin B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D029867","descriptor_name":"Xenopus Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D064127","descriptor_name":"Aurora Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4161/cc.5.19.3316","doi":"https://doi.org/10.4161/cc.5.19.3316","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cc.5.19.3316","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.5.19.3316?needAccess=true&role=button","source":{"id":"https://openalex.org/S86011449","display_name":"Cell Cycle","issn_l":"1538-4101","issn":["1538-4101","1551-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"journal-article"},{"id":"pmid:16969136","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16969136","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell cycle (Georgetown, Tex.)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4161/cc.5.19.3316","doi":"https://doi.org/10.4161/cc.5.19.3316","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cc.5.19.3316","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.5.19.3316?needAccess=true&role=button","source":{"id":"https://openalex.org/S86011449","display_name":"Cell Cycle","issn_l":"1538-4101","issn":["1538-4101","1551-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1016461134","display_name":null,"funder_award_id":"HD07528","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G2298522829","display_name":null,"funder_award_id":"GM 56362","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2362169364","display_name":null,"funder_award_id":"GM56362","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G2616237310","display_name":"Dissection of the Inner Centromere Regulatory Network","funder_award_id":"R01GM063045","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7131155698","display_name":null,"funder_award_id":"GM63045-06","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8271834098","display_name":"Phosphorylation & Function of Inhibitor-2","funder_award_id":"R01GM056362","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000031543","display_name":null,"funder_award_id":"HD07528","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2317310331.pdf","grobid_xml":"https://content.openalex.org/works/W2317310331.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2056044063","https://openalex.org/W1984507712","https://openalex.org/W2805533573","https://openalex.org/W2118146226","https://openalex.org/W2067131033","https://openalex.org/W2091168885","https://openalex.org/W2807131271","https://openalex.org/W2033923680","https://openalex.org/W2059706603","https://openalex.org/W2067721485"],"abstract_inverted_index":{"The":[0,31],"abrupt":[1],"activation":[2,24],"of":[3,10,17,25,29,38,72,90,105,113,122,131,166,176,192,200,221,245],"CDK1":[4],"during":[5],"mitotic":[6,81,141,246],"entry":[7,82,142],"requires":[8],"suppression":[9],"CDK":[11,205],"activity":[12],"until":[13],"a":[14,26,171,235],"threshold":[15,44,53,187,211],"concentration":[16,37,199],"cyclin":[18,39,69,151,168,185,201,209],"B":[19,40,152,169,186,202,210],"is":[20,54],"synthesized,":[21],"triggering":[22],"the":[23,36,43,91,103,129,135,138,164,184,190,198,208,219,226,241],"large":[27],"pool":[28],"CDK.":[30],"cellular":[32],"mechanisms":[33],"that":[34,51,66,120,137,203],"define":[35],"at":[41],"which":[42,158],"occurs":[45],"are":[46,159,232],"unknown.":[47],"Here":[48],"we":[49,154],"demonstrate":[50,228],"this":[52],"regulated":[55],"by":[56,88,102,163,217],"Aurora-A":[57,95,194,223],"kinase":[58],"and":[59,83],"phosphatase":[60],"Inhibitor-2.":[61],"In":[62],"Xenopus":[63],"CSF":[64,144],"extracts":[65,97,145],"actively":[67],"translate":[68],"B1,":[70],"immunodepletion":[71],"either":[73,222],"endogenous":[74,77,177],"xInhibitor-2":[75,111,178],"or":[76,179,195,215,224],"xAurora-A":[78],"caused":[79],"delayed":[80],"normal":[84],"timing":[85],"was":[86,124],"restored":[87],"addition":[89,104,165,191],"respective":[92],"recombinant":[93,167],"proteins.":[94],"depleted":[96],"also":[98],"could":[99,212],"be":[100,213],"rescued":[101],"full-length":[106],"xInhibitor-2,":[107],"but":[108],"not":[109],"an":[110],"truncated":[112],"its":[114],"PP1":[115,123],"binding":[116],"motif.":[117],"This":[118],"demonstrates":[119],"inhibition":[121],"required":[125,238],"to":[126,148,239],"compensate":[127],"for":[128],"absence":[130],"Aurora-A.":[132],"To":[133],"test":[134],"hypothesis":[136],"delays":[139],"in":[140,143,150,170,234],"were":[146],"due":[147],"increases":[149],"thresholds,":[153],"employed":[155],"interphase":[156],"extracts,":[157],"driven":[160],"into":[161],"mitosis":[162],"nonlinear":[172],"(threshold)":[173],"dose-response.":[174],"Neutralization":[175],"xAurora":[180],"with":[181],"antibodies":[182],"increased":[183],"concentration.":[188],"Alternatively,":[189],"exogenous":[193],"Inhibitor-2":[196],"lowered":[197,216],"triggered":[204],"activation.":[206],"Because":[207],"raised":[214],"changing":[218],"amount":[220],"Inhibitor-2,":[225],"results":[227],"these":[229],"regulatory":[230],"proteins":[231],"involved":[233],"signaling":[236],"loop":[237],"create":[240],"switching":[242],"behavior":[243],"characteristic":[244],"entry.":[247]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}