{"id":"https://openalex.org/W2317008293","doi":"https://doi.org/10.1097/00019606-200203000-00005","title":"PTEN Mutation Is Rare in Chondrosarcoma","display_name":"PTEN Mutation Is Rare in Chondrosarcoma","publication_year":2002,"publication_date":"2002-03-01","ids":{"openalex":"https://openalex.org/W2317008293","doi":"https://doi.org/10.1097/00019606-200203000-00005","mag":"2317008293","pmid":"https://pubmed.ncbi.nlm.nih.gov/11854598"},"language":"en","primary_location":{"id":"doi:10.1097/00019606-200203000-00005","doi":"https://doi.org/10.1097/00019606-200203000-00005","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00019606-200203000-00005","pdf_url":null,"source":{"id":"https://openalex.org/S99097673","display_name":"Diagnostic Molecular Pathology","issn_l":"1052-9551","issn":["1052-9551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diagnostic Molecular Pathology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102077137","display_name":"Chuzhao Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chuzhao Lin","raw_affiliation_strings":["Department of Orthopaedics, Brown University School of Medicine, Providence, Rhode Island 02912, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Brown University School of Medicine, Providence, Rhode Island 02912, USA","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039081630","display_name":"Patricia A. Meitner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patricia A. Meitner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5086701763","display_name":"Richard M. Terek","orcid":"https://orcid.org/0000-0002-6322-6790","observed_orcids":["https://orcid.org/0000-0002-6322-6790"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard M. Terek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6007,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.83638425,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"11","issue":"1","first_page":"22","last_page":"26"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chondrosarcoma","display_name":"chondrosarcoma","score":0.9490000009536743},{"id":"https://openalex.org/keywords/pten-mutation","display_name":"PTEN mutation","score":0.9290000200271606},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.8870000243186951},{"id":"https://openalex.org/keywords/extraskeletal-myxoid-chondrosarcoma","display_name":"extraskeletal myxoid chondrosarcoma","score":0.9660000205039978},{"id":"https://openalex.org/keywords/metastatic-chondrosarcoma","display_name":"metastatic chondrosarcoma","score":0.8209999799728394},{"id":"https://openalex.org/keywords/tumor-derived-cell-lines","display_name":"tumor-derived cell lines","score":0.6460000276565552}],"concepts":[{"id":"https://openalex.org/C113324615","wikidata":"https://www.wikidata.org/wiki/Q472302","display_name":"Login","level":2,"score":0.7774562835693359},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6797735691070557},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.5741564631462097},{"id":"https://openalex.org/C108827166","wikidata":"https://www.wikidata.org/wiki/Q175975","display_name":"Internet privacy","level":1,"score":0.5472509264945984},{"id":"https://openalex.org/C2779235478","wikidata":"https://www.wikidata.org/wiki/Q286576","display_name":"Register (sociolinguistics)","level":2,"score":0.4394886791706085},{"id":"https://openalex.org/C169093310","wikidata":"https://www.wikidata.org/wiki/Q3702971","display_name":"Personally identifiable information","level":2,"score":0.4356991648674011},{"id":"https://openalex.org/C23123220","wikidata":"https://www.wikidata.org/wiki/Q816826","display_name":"Information retrieval","level":1,"score":0.3313952386379242},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.22283917665481567},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002813","descriptor_name":"Chondrosarcoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002813","descriptor_name":"Chondrosarcoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002813","descriptor_name":"Chondrosarcoma","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010744","descriptor_name":"Phosphoric Monoester Hydrolases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010744","descriptor_name":"Phosphoric Monoester Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014178","descriptor_name":"Translocation, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017027","descriptor_name":"Protein Tyrosine Phosphatases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051059","descriptor_name":"PTEN Phosphohydrolase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00019606-200203000-00005","doi":"https://doi.org/10.1097/00019606-200203000-00005","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00019606-200203000-00005","pdf_url":null,"source":{"id":"https://openalex.org/S99097673","display_name":"Diagnostic Molecular Pathology","issn_l":"1052-9551","issn":["1052-9551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diagnostic Molecular Pathology","raw_type":"journal-article"},{"id":"pmid:11854598","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11854598","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diagnostic molecular pathology : the American journal of surgical pathology, part B","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W178370525","https://openalex.org/W1521079087","https://openalex.org/W1565532031","https://openalex.org/W1593108703","https://openalex.org/W1651628650","https://openalex.org/W1854233595","https://openalex.org/W1980947871","https://openalex.org/W1983646864","https://openalex.org/W1985167677","https://openalex.org/W2027882288","https://openalex.org/W2037104776","https://openalex.org/W2037237101","https://openalex.org/W2050911367","https://openalex.org/W2068345721","https://openalex.org/W2080620375","https://openalex.org/W2088526108","https://openalex.org/W2117905749","https://openalex.org/W2130743654","https://openalex.org/W2134812217","https://openalex.org/W2155870124","https://openalex.org/W2156473964","https://openalex.org/W2161810908","https://openalex.org/W2165865627","https://openalex.org/W4294216491","https://openalex.org/W4322701952"],"related_works":["https://openalex.org/W2435266976","https://openalex.org/W1980947871","https://openalex.org/W1994327005","https://openalex.org/W7030157459","https://openalex.org/W2054561158","https://openalex.org/W2082089929","https://openalex.org/W1565872041","https://openalex.org/W2037104776","https://openalex.org/W7214179415","https://openalex.org/W2167749260"],"abstract_inverted_index":{"Chondrosarcoma":[0],"is":[1,48,64,105],"the":[2,14,20,56,59,110,124],"second":[3],"most":[4],"common":[5],"primary":[6],"malignant":[7],"neoplasm":[8],"of":[9,22,31,33,41,61,112,117,119,126],"bone":[10],"in":[11,19,39,81,87,96,109],"adults,":[12],"but":[13],"major":[15],"genetic":[16],"events":[17],"involved":[18],"progression":[21],"this":[23],"often-fatal":[24],"cancer":[25],"remain":[26],"to":[27],"be":[28],"elucidated.":[29],"Loss":[30],"heterozygosity":[32,120],"chromosome":[34,51],"10q":[35,122],"has":[36],"been":[37],"reported":[38],"67%":[40],"chondrosarcoma.":[42,101,113],"The":[43,69,114],"tumor":[44,128],"suppressor":[45,129],"gene":[46],"PTEN":[47,62,90,104],"located":[49],"on":[50,121],"10q,":[52],"specifically":[53],"10q23,":[54],"raising":[55],"possibility":[57],"that":[58],"loss":[60,118],"function":[63],"responsible":[65],"for":[66,79],"some":[67],"chondrosarcomas.":[68],"authors":[70],"examined":[71],"40":[72],"chondrosarcoma":[73],"tumors":[74],"and":[75],"tumor-derived":[76],"cell":[77],"lines":[78],"alterations":[80],"PTEN.":[82],"Only":[83],"one":[84],"mutation":[85],"resulting":[86],"a":[88,97],"truncated":[89],"protein":[91],"was":[92,95],"detected,":[93],"which":[94],"metastasized":[98],"extraskeletal":[99],"myxoid":[100],"Thus,":[102],"mutated":[103],"an":[106],"uncommon":[107],"event":[108],"development":[111],"high":[115],"frequency":[116],"suggests":[123],"presence":[125],"additional":[127],"genes":[130],"at":[131],"these":[132],"loci.":[133]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
