{"id":"https://openalex.org/W2316630134","doi":"https://doi.org/10.1097/00042560-199805010-00003","title":"SCID Mice With HIV Encephalitis Develop Behavioral Abnormalities","display_name":"SCID Mice With HIV Encephalitis Develop Behavioral Abnormalities","publication_year":1998,"publication_date":"1998-05-01","ids":{"openalex":"https://openalex.org/W2316630134","doi":"https://doi.org/10.1097/00042560-199805010-00003","mag":"2316630134","pmid":"https://pubmed.ncbi.nlm.nih.gov/9593453"},"language":"en","primary_location":{"id":"doi:10.1097/00042560-199805010-00003","doi":"https://doi.org/10.1097/00042560-199805010-00003","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00042560-199805010-00003","pdf_url":null,"source":{"id":"https://openalex.org/S4210183002","display_name":"Journal of Acquired Immune Deficiency Syndromes & Human Retrovirology","issn_l":"1077-9450","issn":["1077-9450","2331-6993"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-b","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113361396","display_name":"N. Avgeropoulos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"N. Avgeropoulos","raw_affiliation_strings":["Department of Neurology, Medical University of South Carolina, Charleston 29425, USA","\"Department of Neurology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Medical University of South Carolina, Charleston 29425, USA","institution_ids":["https://openalex.org/I153297377"]},{"raw_affiliation_string":"\"Department of Neurology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101779844","display_name":"Brian M. Kelley","orcid":"https://orcid.org/0000-0002-6603-4559","observed_orcids":["https://orcid.org/0000-0002-6603-4559"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. Kelley","raw_affiliation_strings":["Medical University of South Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University of South Carolina","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111665152","display_name":"L.D. Middaugh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Middaugh","raw_affiliation_strings":["Medical University of South Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University of South Carolina","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108800643","display_name":"Salvatore J. Arrigo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Arrigo","raw_affiliation_strings":["Medical University of South Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University of South Carolina","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057472361","display_name":"Yuri Persidsky","orcid":"https://orcid.org/0000-0003-1345-6077","observed_orcids":["https://orcid.org/0000-0003-1345-6077"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y. Persidsky","raw_affiliation_strings":["Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, U.S.A","University of Nebraska Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, U.S.A","institution_ids":["https://openalex.org/I59130452"]},{"raw_affiliation_string":"University of Nebraska Medical Center","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058974129","display_name":"Howard Eliot Gendelman","orcid":"https://orcid.org/0000-0002-7831-0370","observed_orcids":["https://orcid.org/0000-0002-7831-0370"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. E. Gendelman","raw_affiliation_strings":["Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, U.S.A","Pharmacology & Experimental Neuroscience (PEN)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, U.S.A","institution_ids":["https://openalex.org/I59130452"]},{"raw_affiliation_string":"Pharmacology & Experimental Neuroscience (PEN)","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058209103","display_name":"William R. Tyor","orcid":"https://orcid.org/0000-0002-0661-4842","observed_orcids":["https://orcid.org/0000-0002-0661-4842"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]},{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"W. R. Tyor","raw_affiliation_strings":["Department of Neurology, \u2020Department of Psychiatry, and \u2021Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina","Department of Neurology, \u2020Department of Psychiatry, and \u2021Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina; and \u00a7Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, U.S.A","Medical University of South Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, \u2020Department of Psychiatry, and \u2021Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina","institution_ids":["https://openalex.org/I153297377"]},{"raw_affiliation_string":"Department of Neurology, \u2020Department of Psychiatry, and \u2021Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina; and \u00a7Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, U.S.A","institution_ids":["https://openalex.org/I153297377","https://openalex.org/I59130452"]},{"raw_affiliation_string":"Medical University of South Carolina","institution_ids":["https://openalex.org/I153297377"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5058209103","https://openalex.org/A5113361396"],"corresponding_institution_ids":["https://openalex.org/I153297377","https://openalex.org/I59130452"],"apc_list":null,"apc_paid":null,"fwci":0.7926,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.696,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"18","issue":"1","first_page":"13","last_page":"20"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-encephalitis","display_name":"HIV encephalitis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/scid-mice","display_name":"SCID mice","score":0.8019999861717224},{"id":"https://openalex.org/keywords/animal-models","display_name":"animal models","score":0.6389999985694885},{"id":"https://openalex.org/keywords/xenografts","display_name":"xenografts","score":0.7429999709129333},{"id":"https://openalex.org/keywords/astrocyte-activation","display_name":"astrocyte activation","score":0.8410000205039978},{"id":"https://openalex.org/keywords/multinucleated-giant-cells","display_name":"multinucleated giant cells","score":0.9779999852180481},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.8410000205039978},{"id":"https://openalex.org/keywords/behavioral-abnormalities","display_name":"behavioral abnormalities","score":0.6909999847412109},{"id":"https://openalex.org/keywords/morris-water-maze","display_name":"Morris water maze","score":0.7049999833106995},{"id":"https://openalex.org/keywords/microglial-nodules","display_name":"microglial nodules","score":0.9039999842643738}],"concepts":[{"id":"https://openalex.org/C2779965356","wikidata":"https://www.wikidata.org/wiki/Q4811564","display_name":"Astrogliosis","level":3,"score":0.9721912145614624},{"id":"https://openalex.org/C77076574","wikidata":"https://www.wikidata.org/wiki/Q2152526","display_name":"Giant cell","level":2,"score":0.6238164901733398},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5962788462638855},{"id":"https://openalex.org/C83455156","wikidata":"https://www.wikidata.org/wiki/Q199615","display_name":"Encephalitis","level":3,"score":0.5766178369522095},{"id":"https://openalex.org/C2777682930","wikidata":"https://www.wikidata.org/wiki/Q1531490","display_name":"Gliosis","level":2,"score":0.42852693796157837},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40356388688087463},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3944729268550873},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36706775426864624},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3304482102394104},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.22029346227645874},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.21036934852600098},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14486956596374512}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003720","descriptor_name":"Densitometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005904","descriptor_name":"Glial Fibrillary Acidic Protein","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009043","descriptor_name":"Motor Activity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015526","descriptor_name":"AIDS Dementia Complex","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015526","descriptor_name":"AIDS Dementia Complex","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D016513","descriptor_name":"Mice, SCID","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016655","descriptor_name":"HIV Core Protein p24","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00042560-199805010-00003","doi":"https://doi.org/10.1097/00042560-199805010-00003","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00042560-199805010-00003","pdf_url":null,"source":{"id":"https://openalex.org/S4210183002","display_name":"Journal of Acquired Immune Deficiency Syndromes & Human Retrovirology","issn_l":"1077-9450","issn":["1077-9450","2331-6993"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-b","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology","raw_type":"journal-article"},{"id":"pmid:9593453","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9593453","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8199999928474426,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W144457579","https://openalex.org/W326708618","https://openalex.org/W1042014336","https://openalex.org/W1525259648","https://openalex.org/W1576895063","https://openalex.org/W1589707187","https://openalex.org/W1614954929","https://openalex.org/W1790169325","https://openalex.org/W1817103017","https://openalex.org/W1963886127","https://openalex.org/W1965569942","https://openalex.org/W1970832843","https://openalex.org/W1973008091","https://openalex.org/W1974060304","https://openalex.org/W1980131626","https://openalex.org/W1983447850","https://openalex.org/W1999320884","https://openalex.org/W2000684605","https://openalex.org/W2003401087","https://openalex.org/W2005807968","https://openalex.org/W2008288694","https://openalex.org/W2008638696","https://openalex.org/W2012547110","https://openalex.org/W2018073475","https://openalex.org/W2024285818","https://openalex.org/W2026995847","https://openalex.org/W2033451989","https://openalex.org/W2045939131","https://openalex.org/W2050344241","https://openalex.org/W2054233291","https://openalex.org/W2077012020","https://openalex.org/W2078993207","https://openalex.org/W2083602426","https://openalex.org/W2092580120","https://openalex.org/W2092841915","https://openalex.org/W2096997912","https://openalex.org/W2097972613","https://openalex.org/W2099664289","https://openalex.org/W2117337460","https://openalex.org/W2132586158","https://openalex.org/W2133655326","https://openalex.org/W2151780554","https://openalex.org/W2169211575","https://openalex.org/W2311639754","https://openalex.org/W2340058544","https://openalex.org/W2424215543","https://openalex.org/W2487928998","https://openalex.org/W2517842230"],"related_works":["https://openalex.org/W2149484912","https://openalex.org/W1576895063","https://openalex.org/W2092841915","https://openalex.org/W1983161892","https://openalex.org/W2004895789","https://openalex.org/W2052134573","https://openalex.org/W307300299","https://openalex.org/W1973008091","https://openalex.org/W3084520991","https://openalex.org/W2001442929"],"abstract_inverted_index":{"Severe":[0],"combined":[1],"immunodeficient":[2],"(SCID)":[3],"mice":[4,61,117,140,162,200],"inoculated":[5],"intracerebrally":[6],"(i.c.)":[7],"with":[8,20,69,121,145,164,190,201,216],"HIV-infected":[9,71,116,161,188],"human":[10,72,79,209],"monocytes":[11,73],"develop":[12,44,204],"brain":[13],"pathology":[14],"similar":[15],"to":[16,52],"that":[17,115,146,198],"in":[18,103,125,143,160,187],"humans":[19],"HIV":[21,49,202,247],"encephalitis.":[22],"This":[23],"includes":[24],"HIV-positive":[25],"macrophages":[26,80,186],"and":[27,34,51,132,173,224,249],"multinucleated":[28,185,226],"giant":[29,227],"cells,":[30],"astrogliosis,":[31,219],"microglial":[32],"nodules,":[33],"neuronal":[35],"dropout.":[36],"These":[37,211,229],"xenografts":[38],"survive":[39],"about":[40],"1":[41,155],"month.":[42],"To":[43],"a":[45,104],"model":[46,239],"of":[47,100,134,138,147,150,168,178,208,222,235,243,246],"chronic":[48],"encephalitis":[50,203,248],"assay":[53],"the":[54,111,126,220,233,244],"resulting":[55],"behavioral":[56,97,205,212],"abnormalities,":[57],"we":[58],"reinoculated":[59],"SCID":[60,199,237],"i.c.":[62],"every":[63],"4":[64,131],"weeks":[65],"for":[66,96,241,250],"3":[67],"months":[68,109],"either":[70],"(n":[74,81,88],"=":[75,82,89],"5)":[76],"or":[77,84],"uninfected":[78],"4)":[83],"administered":[85],"no":[86],"inoculation":[87,113],"6);":[90],"these":[91],"three":[92],"groups":[93],"were":[94],"monitored":[95],"abnormalities.":[98],"Tests":[99],"cognitive":[101],"function":[102],"Morris":[105],"water":[106,127],"maze":[107,128],"3.5":[108],"after":[110],"first":[112],"suggested":[114,175],"performed":[118],"poorly":[119],"compared":[120,163,189],"controls.":[122,148,165],"Following":[123],"testing":[124],"on":[129],"days":[130],"5":[133],"acquisition,":[135],"motor":[136],"activity":[137],"infected":[139],"was":[141,158],"reduced":[142],"comparison":[144],"Retention":[149],"goal":[151],"location":[152],"when":[153],"tested":[154],"week":[156],"later":[157],"impaired":[159],"Histopathologic":[166],"analysis":[167],"brains":[169],"revealed":[170],"significant":[171],"astrogliosis":[172],"strongly":[174],"higher":[176],"numbers":[177],"major":[179],"histocompatibility":[180],"complex":[181],"(MHC)":[182],"class":[183],"II-positive":[184],"control":[191],"mice.":[192],"Thus,":[193],"our":[194],"preliminary":[195],"studies":[196,230,242],"indicate":[197],"abnormalities":[206,213],"reminiscent":[207],"disease.":[210],"are":[214],"associated":[215],"significantly":[217],"increased":[218],"presence":[221],"HIV,":[223],"probably":[225],"cells.":[228],"further":[231],"support":[232],"use":[234],"this":[236],"animal":[238],"system":[240],"pathogenesis":[245],"drug":[251],"interventions.":[252]},"counts_by_year":[{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}