{"id":"https://openalex.org/W2316319556","doi":"https://doi.org/10.1038/mto.2014.6","title":"Overcoming tumor resistance by heterologous adeno-poxvirus combination therapy","display_name":"Overcoming tumor resistance by heterologous adeno-poxvirus combination therapy","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2316319556","doi":"https://doi.org/10.1038/mto.2014.6","mag":"2316319556","pmid":"https://pubmed.ncbi.nlm.nih.gov/27119097","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4782942"},"language":"en","primary_location":{"id":"doi:10.1038/mto.2014.6","doi":"https://doi.org/10.1038/mto.2014.6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/mto.2014.6","pdf_url":"http://www.cell.com/article/S2372770516300018/pdf","source":{"id":"https://openalex.org/S2898235705","display_name":"Molecular Therapy \u2014 Oncolytics","issn_l":"2372-7705","issn":["2372-7705"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy - Oncolytics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.cell.com/article/S2372770516300018/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025335008","display_name":"Markus J. V. V\u00e4h\u00e4-Koskela","orcid":"https://orcid.org/0000-0001-7764-7820","observed_orcids":["https://orcid.org/0000-0001-7764-7820"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Markus V\u00e4h\u00e4-Koskela","raw_affiliation_strings":["Department of Pathology and Transplantation Laboratory, Cancer Gene Therapy Group, Haartman Institute, University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Transplantation Laboratory, Cancer Gene Therapy Group, Haartman Institute, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075802686","display_name":"Siri T\u00e4htinen","orcid":"https://orcid.org/0000-0003-1237-0730","observed_orcids":["https://orcid.org/0000-0003-1237-0730"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Siri T\u00e4htinen","raw_affiliation_strings":["Department of Pathology and Transplantation Laboratory, Cancer Gene Therapy Group, Haartman Institute, University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Transplantation Laboratory, Cancer Gene Therapy Group, Haartman Institute, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089489511","display_name":"Susanna A.M. Gr\u00f6nberg-V\u00e4h\u00e4-Koskela","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Susanna Gr\u00f6nberg-V\u00e4h\u00e4-Koskela","raw_affiliation_strings":["Department of Pathology and Transplantation Laboratory, Cancer Gene Therapy Group, Haartman Institute, University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Transplantation Laboratory, Cancer Gene Therapy Group, Haartman Institute, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076362852","display_name":"Kristian Taipale","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Kristian Taipale","raw_affiliation_strings":["Department of Pathology and Transplantation Laboratory, Cancer Gene Therapy Group, Haartman Institute, University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Transplantation Laboratory, Cancer Gene Therapy Group, Haartman Institute, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057638091","display_name":"Dipongkor Saha","orcid":"https://orcid.org/0000-0002-9923-5533","observed_orcids":["https://orcid.org/0000-0002-9923-5533"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Dipongkor Saha","raw_affiliation_strings":["Department of Pathology and Transplantation Laboratory, Cancer Gene Therapy Group, Haartman Institute, University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Transplantation Laboratory, Cancer Gene Therapy Group, Haartman Institute, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008644129","display_name":"Maiju Merisalo-Soikkeli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Maiju Merisalo-Soikkeli","raw_affiliation_strings":["Department of Pathology and Transplantation Laboratory, Cancer Gene Therapy Group, Haartman Institute, University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Transplantation Laboratory, Cancer Gene Therapy Group, Haartman Institute, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112068966","display_name":"M. Ahonen","orcid":"https://orcid.org/0000-0001-6217-1452","observed_orcids":["https://orcid.org/0000-0001-6217-1452"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Marko Ahonen","raw_affiliation_strings":["Department of Pathology and Transplantation Laboratory, Cancer Gene Therapy Group, Haartman Institute, University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Transplantation Laboratory, Cancer Gene Therapy Group, Haartman Institute, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006858720","display_name":"Noora Rouvinen-Lagerstr\u00f6m","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Noora Rouvinen-Lagerstr\u00f6m","raw_affiliation_strings":["Department of Pathology and Transplantation Laboratory, Cancer Gene Therapy Group, Haartman Institute, University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Transplantation Laboratory, Cancer Gene Therapy Group, Haartman Institute, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063072564","display_name":"Mari Hirvinen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Mari Hirvinen","raw_affiliation_strings":["Division of Biopharmaceutics and Pharmacokinetics, Faculty of Pharmacy, Immunovirotherapy Group, University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biopharmaceutics and Pharmacokinetics, Faculty of Pharmacy, Immunovirotherapy Group, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054688234","display_name":"Ville Veckman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801770344","display_name":"Finnish Institute of Occupational Health","ror":"https://ror.org/030wyr187","country_code":"FI","type":"facility","lineage":["https://openalex.org/I2801770344"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Ville Veckman","raw_affiliation_strings":["Unit of Excellence for Immunotoxicology, Finnish Institute of Occupational Health, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Excellence for Immunotoxicology, Finnish Institute of Occupational Health, Helsinki, Finland","institution_ids":["https://openalex.org/I2801770344"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013065472","display_name":"Sampsa Matikainen","orcid":"https://orcid.org/0000-0001-9234-799X","observed_orcids":["https://orcid.org/0000-0001-9234-799X"]},"institutions":[{"id":"https://openalex.org/I2801770344","display_name":"Finnish Institute of Occupational Health","ror":"https://ror.org/030wyr187","country_code":"FI","type":"facility","lineage":["https://openalex.org/I2801770344"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Sampsa Matikainen","raw_affiliation_strings":["Unit of Excellence for Immunotoxicology, Finnish Institute of Occupational Health, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Excellence for Immunotoxicology, Finnish Institute of Occupational Health, Helsinki, Finland","institution_ids":["https://openalex.org/I2801770344"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101463592","display_name":"Fang Zhao","orcid":"https://orcid.org/0000-0002-8105-1189","observed_orcids":["https://orcid.org/0000-0002-8105-1189"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Fang Zhao","raw_affiliation_strings":["Advanced Microscopy Unit, Haartman Institute, University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Advanced Microscopy Unit, Haartman Institute, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044882291","display_name":"P\u00e4ivi I. Pakarinen","orcid":"https://orcid.org/0000-0002-1275-7356","observed_orcids":["https://orcid.org/0000-0002-1275-7356"]},"institutions":[{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"P\u00e4ivi Pakarinen","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland","institution_ids":["https://openalex.org/I2800394112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058386645","display_name":"Jarmo Salo","orcid":"https://orcid.org/0000-0002-0872-7576","observed_orcids":["https://orcid.org/0000-0002-0872-7576"]},"institutions":[{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Jarmo Salo","raw_affiliation_strings":["Division of General Thoracic and Esophageal Surgery, Department of Cardiothoracic Surgery, Helsinki University Central Hospital, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of General Thoracic and Esophageal Surgery, Department of Cardiothoracic Surgery, Helsinki University Central Hospital, Helsinki, Finland","institution_ids":["https://openalex.org/I2800394112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018878912","display_name":"Anna Kanerva","orcid":"https://orcid.org/0000-0003-3355-7393","observed_orcids":["https://orcid.org/0000-0003-3355-7393"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Anna Kanerva","raw_affiliation_strings":["Department of Pathology and Transplantation Laboratory, Cancer Gene Therapy Group, Haartman Institute, University of Helsinki, Helsinki, Finland; Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland","Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland","Department of Pathology and Transplantation Laboratory, Cancer Gene Therapy Group, Haartman Institute, University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Transplantation Laboratory, Cancer Gene Therapy Group, Haartman Institute, University of Helsinki, Helsinki, Finland; Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland","institution_ids":["https://openalex.org/I2800394112"]},{"raw_affiliation_string":"Department of Pathology and Transplantation Laboratory, Cancer Gene Therapy Group, Haartman Institute, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031533220","display_name":"Vincenzo Cerullo","orcid":"https://orcid.org/0000-0003-4901-3796","observed_orcids":["https://orcid.org/0000-0003-4901-3796"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Vincenzo Cerullo","raw_affiliation_strings":["Division of Biopharmaceutics and Pharmacokinetics, Faculty of Pharmacy, Immunovirotherapy Group, University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biopharmaceutics and Pharmacokinetics, Faculty of Pharmacy, Immunovirotherapy Group, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062078543","display_name":"Akseli Hemminki","orcid":"https://orcid.org/0000-0001-7103-8530","observed_orcids":["https://orcid.org/0000-0001-7103-8530"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Akseli Hemminki","raw_affiliation_strings":["Department of Pathology and Transplantation Laboratory, Cancer Gene Therapy Group, Haartman Institute, University of Helsinki, Helsinki, Finland; TILT Biotherapeutics Ltd, Helsinki, Finland","Department of Pathology and Transplantation Laboratory, Cancer Gene Therapy Group, Haartman Institute, University of Helsinki, Helsinki, Finland","TILT Biotherapeutics Ltd, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Transplantation Laboratory, Cancer Gene Therapy Group, Haartman Institute, University of Helsinki, Helsinki, Finland; TILT Biotherapeutics Ltd, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Department of Pathology and Transplantation Laboratory, Cancer Gene Therapy Group, Haartman Institute, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"TILT Biotherapeutics Ltd, Helsinki, Finland","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5025335008"],"corresponding_institution_ids":["https://openalex.org/I133731052"],"apc_list":{"value":3900,"currency":"USD","value_usd":3900},"apc_paid":{"value":3900,"currency":"USD","value_usd":3900},"fwci":0.3468,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.61408882,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"1","issue":null,"first_page":"14006","last_page":"14006"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oncolytic-viruses","display_name":"oncolytic viruses","score":0.9399999976158142},{"id":"https://openalex.org/keywords/adenovirus","display_name":"adenovirus","score":0.9300000071525574},{"id":"https://openalex.org/keywords/vaccinia-virus","display_name":"vaccinia virus","score":1.0},{"id":"https://openalex.org/keywords/tumor-resistance","display_name":"tumor resistance","score":0.7329999804496765},{"id":"https://openalex.org/keywords/antiviral-immunity","display_name":"antiviral immunity","score":0.8980000019073486},{"id":"https://openalex.org/keywords/antiviral-innate-immunity","display_name":"antiviral innate immunity","score":0.7680000066757202},{"id":"https://openalex.org/keywords/viral-replication","display_name":"viral replication","score":0.3179999887943268},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.6380000114440918}],"concepts":[{"id":"https://openalex.org/C2780115692","wikidata":"https://www.wikidata.org/wiki/Q5747302","display_name":"Heterologous","level":3,"score":0.7663147449493408},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5498998165130615},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41195985674858093},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.396979421377182},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0993611216545105},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06152820587158203}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1038/mto.2014.6","doi":"https://doi.org/10.1038/mto.2014.6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/mto.2014.6","pdf_url":"http://www.cell.com/article/S2372770516300018/pdf","source":{"id":"https://openalex.org/S2898235705","display_name":"Molecular Therapy \u2014 Oncolytics","issn_l":"2372-7705","issn":["2372-7705"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy - Oncolytics","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3810820","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4782942","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4782942","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4782942","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Ther Oncolytics","raw_type":"Text"},{"id":"pmid:27119097","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27119097","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular therapy oncolytics","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:9b01b1c35c2c4311bda6e7bc3f0a87b4","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/9b01b1c35c2c4311bda6e7bc3f0a87b4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Therapy: Oncolytics, Vol 1, Iss C (2014)","raw_type":"article"},{"id":"pmh:oai:helda.helsinki.fi:10138/217894","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/217894","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1038/mto.2014.6","doi":"https://doi.org/10.1038/mto.2014.6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/mto.2014.6","pdf_url":"http://www.cell.com/article/S2372770516300018/pdf","source":{"id":"https://openalex.org/S2898235705","display_name":"Molecular Therapy \u2014 Oncolytics","issn_l":"2372-7705","issn":["2372-7705"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy - Oncolytics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2316319556.pdf"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W143033122","https://openalex.org/W1494855809","https://openalex.org/W1572160541","https://openalex.org/W1966766953","https://openalex.org/W1970060539","https://openalex.org/W1972664535","https://openalex.org/W1973901905","https://openalex.org/W1976664080","https://openalex.org/W1984714304","https://openalex.org/W1992144732","https://openalex.org/W1996450306","https://openalex.org/W1999896748","https://openalex.org/W2001040275","https://openalex.org/W2010349266","https://openalex.org/W2016231826","https://openalex.org/W2018127420","https://openalex.org/W2035835672","https://openalex.org/W2036869628","https://openalex.org/W2048013519","https://openalex.org/W2052131522","https://openalex.org/W2053837657","https://openalex.org/W2057384762","https://openalex.org/W2075459892","https://openalex.org/W2083091426","https://openalex.org/W2091980326","https://openalex.org/W2092872746","https://openalex.org/W2096232093","https://openalex.org/W2097849707","https://openalex.org/W2106396782","https://openalex.org/W2107030294","https://openalex.org/W2108595427","https://openalex.org/W2108883303","https://openalex.org/W2110168283","https://openalex.org/W2110659339","https://openalex.org/W2115746682","https://openalex.org/W2116971967","https://openalex.org/W2118455905","https://openalex.org/W2119707632","https://openalex.org/W2128605803","https://openalex.org/W2136730083","https://openalex.org/W2143113338","https://openalex.org/W2144556129","https://openalex.org/W2144883118","https://openalex.org/W2146671000","https://openalex.org/W2148377255","https://openalex.org/W2155043397","https://openalex.org/W2165275806","https://openalex.org/W2165857138","https://openalex.org/W2417754549","https://openalex.org/W2432889701"],"related_works":["https://openalex.org/W2073178293","https://openalex.org/W2471718232","https://openalex.org/W2038304191","https://openalex.org/W1481876294","https://openalex.org/W2136730083","https://openalex.org/W3105702876","https://openalex.org/W2053827873","https://openalex.org/W2563595159","https://openalex.org/W1984714304","https://openalex.org/W2999300004"],"abstract_inverted_index":{"Successful":[0],"cancer":[1],"control":[2],"relies":[3],"on":[4,11],"overcoming":[5],"resistance":[6],"to":[7,59],"cell":[8],"death":[9],"and":[10,31,52,92,107],"activation":[12],"of":[13,42,100,115,118,123],"host":[14],"antitumor":[15,50],"immunity.":[16],"Oncolytic":[17],"viruses":[18],"are":[19,112],"particularly":[20],"attractive":[21],"in":[22,81,89,113],"this":[23,65],"regard,":[24],"as":[25],"they":[26],"lyse":[27],"infected":[28],"tumor":[29],"cells":[30],"trigger":[32],"robust":[33],"immune":[34],"responses":[35],"during":[36],"the":[37,43,72],"infection.":[38],"However,":[39],"repeated":[40],"injections":[41,99],"same":[44],"virus":[45,62,74,121],"promote":[46],"antiviral":[47,57,90],"rather":[48],"than":[49],"immunity":[51],"tumors":[53],"may":[54],"mount":[55],"innate":[56,93],"defenses":[58],"restrict":[60],"oncolytic":[61,104],"replication.":[63],"In":[64],"article,":[66],"we":[67],"have":[68],"explored":[69],"if":[70],"alternating":[71,98],"therapy":[73,122],"could":[75],"circumvent":[76],"these":[77],"problems.":[78],"We":[79],"demonstrate":[80],"two":[82,101],"virus-resistant":[83],"animal":[84],"models":[85],"a":[86],"substantial":[87],"delay":[88],"immune-":[91],"cellular":[94],"response":[95],"induction":[96],"by":[97],"immunologically":[102],"distinct":[103],"viruses,":[105],"adenovirus,":[106],"vaccinia":[108],"virus.":[109],"Our":[110],"results":[111],"support":[114],"clinical":[116],"development":[117],"heterologous":[119],"adeno-/vaccinia":[120],"cancer.":[124]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}