{"id":"https://openalex.org/W2316255201","doi":"https://doi.org/10.1097/01.qai.0000397329.72363.9c","title":"143 HIV Transmission: The Role of Neutralizing Antibodies","display_name":"143 HIV Transmission: The Role of Neutralizing Antibodies","publication_year":2011,"publication_date":"2011-04-01","ids":{"openalex":"https://openalex.org/W2316255201","doi":"https://doi.org/10.1097/01.qai.0000397329.72363.9c","mag":"2316255201"},"language":"en","primary_location":{"id":"doi:10.1097/01.qai.0000397329.72363.9c","doi":"https://doi.org/10.1097/01.qai.0000397329.72363.9c","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.qai.0000397329.72363.9c","pdf_url":null,"source":{"id":"https://openalex.org/S157460402","display_name":"JAIDS Journal of Acquired Immune Deficiency Syndromes","issn_l":"1525-4135","issn":["1525-4135","1944-7884"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAIDS Journal of Acquired Immune Deficiency Syndromes","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075328638","display_name":"Julie M. Overbaugh","orcid":"https://orcid.org/0000-0002-0239-9444","observed_orcids":["https://orcid.org/0000-0002-0239-9444"]},"institutions":[{"id":"https://openalex.org/I12859529","display_name":"University of Nairobi","ror":"https://ror.org/02y9nww90","country_code":"KE","type":"education","lineage":["https://openalex.org/I12859529"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["KE","US"],"is_corresponding":false,"raw_author_name":"J Overbaugh","raw_affiliation_strings":["Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA","and University of Nairobi and Coast Provincial General Hospital, Kenya","Kenya"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"and University of Nairobi and Coast Provincial General Hospital, Kenya","institution_ids":["https://openalex.org/I12859529"]},{"raw_affiliation_string":"Kenya","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080080229","display_name":"Catherine A. Blish","orcid":"https://orcid.org/0000-0001-6946-7627","observed_orcids":["https://orcid.org/0000-0001-6946-7627"]},"institutions":[{"id":"https://openalex.org/I12859529","display_name":"University of Nairobi","ror":"https://ror.org/02y9nww90","country_code":"KE","type":"education","lineage":["https://openalex.org/I12859529"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["KE","US"],"is_corresponding":false,"raw_author_name":"C Blish","raw_affiliation_strings":["Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA","and University of Nairobi and Coast Provincial General Hospital, Kenya","Kenya"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"and University of Nairobi and Coast Provincial General Hospital, Kenya","institution_ids":["https://openalex.org/I12859529"]},{"raw_affiliation_string":"Kenya","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023896912","display_name":"John B. Lynch","orcid":"https://orcid.org/0000-0001-9018-8542","observed_orcids":["https://orcid.org/0000-0001-9018-8542"]},"institutions":[{"id":"https://openalex.org/I12859529","display_name":"University of Nairobi","ror":"https://ror.org/02y9nww90","country_code":"KE","type":"education","lineage":["https://openalex.org/I12859529"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["KE","US"],"is_corresponding":false,"raw_author_name":"J Lynch","raw_affiliation_strings":["Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA","and University of Nairobi and Coast Provincial General Hospital, Kenya","Kenya"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"and University of Nairobi and Coast Provincial General Hospital, Kenya","institution_ids":["https://openalex.org/I12859529"]},{"raw_affiliation_string":"Kenya","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026363921","display_name":"Nicholas M. Provine","orcid":"https://orcid.org/0000-0002-9694-2216","observed_orcids":["https://orcid.org/0000-0002-9694-2216"]},"institutions":[{"id":"https://openalex.org/I12859529","display_name":"University of Nairobi","ror":"https://ror.org/02y9nww90","country_code":"KE","type":"education","lineage":["https://openalex.org/I12859529"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["KE","US"],"is_corresponding":false,"raw_author_name":"N Provine","raw_affiliation_strings":["Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA","and University of Nairobi and Coast Provincial General Hospital, Kenya","Kenya"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"and University of Nairobi and Coast Provincial General Hospital, Kenya","institution_ids":["https://openalex.org/I12859529"]},{"raw_affiliation_string":"Kenya","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"56","issue":"Supplement 2","first_page":"58","last_page":"58"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-transmission","display_name":"HIV transmission","score":0.7260000109672546},{"id":"https://openalex.org/keywords/neutralizing-antibodies","display_name":"neutralizing antibodies","score":0.9639999866485596},{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.6869999766349792},{"id":"https://openalex.org/keywords/hiv-superinfection","display_name":"HIV superinfection","score":0.8119999766349792},{"id":"https://openalex.org/keywords/hiv-acquisition","display_name":"HIV acquisition","score":0.6320000290870667},{"id":"https://openalex.org/keywords/passive-transfer-of-immunity","display_name":"passive transfer","score":0.43700000643730164},{"id":"https://openalex.org/keywords/breastfed-infants","display_name":"breast-fed infants","score":0.7239999771118164},{"id":"https://openalex.org/keywords/women-living-with-hiv","display_name":"women living with HIV","score":0.6869999766349792}],"concepts":[{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.7169365882873535},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6573857069015503},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6508609056472778},{"id":"https://openalex.org/C14086860","wikidata":"https://www.wikidata.org/wiki/Q337120","display_name":"Neutralization","level":3,"score":0.6155939102172852},{"id":"https://openalex.org/C761482","wikidata":"https://www.wikidata.org/wiki/Q118093","display_name":"Transmission (telecommunications)","level":2,"score":0.57736736536026},{"id":"https://openalex.org/C2779261636","wikidata":"https://www.wikidata.org/wiki/Q7003054","display_name":"Neutralizing antibody","level":3,"score":0.5764716863632202},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5005114078521729},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42950019240379333},{"id":"https://openalex.org/C2779617845","wikidata":"https://www.wikidata.org/wiki/Q1563808","display_name":"Superinfection","level":3,"score":0.42529892921447754},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4115757346153259},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.23917090892791748},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1097/01.qai.0000397329.72363.9c","doi":"https://doi.org/10.1097/01.qai.0000397329.72363.9c","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.qai.0000397329.72363.9c","pdf_url":null,"source":{"id":"https://openalex.org/S157460402","display_name":"JAIDS Journal of Acquired Immune Deficiency Syndromes","issn_l":"1525-4135","issn":["1525-4135","1944-7884"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAIDS Journal of Acquired Immune Deficiency Syndromes","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1979529463","https://openalex.org/W2094414302","https://openalex.org/W2157960645","https://openalex.org/W969468495","https://openalex.org/W2154805031","https://openalex.org/W2765496770","https://openalex.org/W7095557427","https://openalex.org/W4410193074","https://openalex.org/W7025180005","https://openalex.org/W7100945475"],"abstract_inverted_index":{"At":[0],"present,":[1],"it":[2],"is":[3,26],"unknown":[4],"whether":[5,61],"the":[6,34,66,74,121,128,157,171],"presence":[7,172],"of":[8,43,55,76,100,113,130,149,159,173,181,184,206,217],"HIV-specific":[9,125],"neutralizing":[10,176,194],"antibodies":[11,126,177,195],"(NAbs)":[12],"provides":[13],"any":[14],"protection":[15],"from":[16],"infection":[17,203],"in":[18,33,69,119],"individuals":[19],"naturally":[20],"exposed":[21,91],"to":[22,41,89,92,132,162,211],"HIV.":[23,57,133],"Although":[24],"here":[25],"evidence":[27,148],"that":[28,51,193,196],"select":[29,46],"NAbs":[30,108],"can":[31,72],"protect":[32,212],"SHIV/macaque":[35],"model,":[36],"these":[37,114,190],"studies":[38,191],"were":[39],"limited":[40],"analysis":[42],"a":[44,117,142,200],"few":[45],"neutralization":[47],"sensitive":[48],"challenge":[49],"strains":[50,216],"are":[52,197,204],"not":[53,146,166,179,205],"representative":[54],"circulating":[56,215],"We":[58],"have":[59,106],"examined":[60],"NAbs,":[62],"when":[63],"present":[64],"at":[65,127,156],"levels":[67],"found":[68],"natural":[70,201],"HIV-infection,":[71],"reduce":[73],"risk":[75,183],"HIV":[77,83,101,107,185,202],"acquisition":[78,186],"using":[79],"two":[80],"cohorts:":[81],"1)":[82],"positive":[84,102],"high-risk":[85,135],"women":[86,163],"who":[87,104,138,164],"continue":[88],"be":[90],"new":[93],"source":[94],"partners":[95],"and":[96],"2)":[97],"breastfeeding":[98],"infants":[99],"mothers,":[103],"may":[105],"through":[109],"passive":[110],"transfer.":[111],"Both":[112],"settings":[115],"provide":[116],"situation":[118],"which":[120],"individual":[122],"has":[123],"pre-existing":[124],"time":[129,158],"exposure":[131],"Among":[134],"women,":[136],"those":[137],"became":[139],"superinfected":[140],"by":[141,199],"second":[143],"partner":[144],"did":[145,165,178],"show":[147],"notably":[150],"weak":[151],"or":[152,209],"narrow":[153],"NAb":[154],"responses":[155],"superinfection":[160],"compared":[161],"become":[167],"superinfected.":[168],"In":[169],"infants,":[170],"broad":[174],"potent":[175],"impact":[180],"their":[182],"after":[187],"birth.":[188],"Together,":[189],"suggest":[192],"elicited":[198],"sufficient":[207],"breadth":[208],"potency":[210],"against":[213],"diverse":[214],"HIV-1.":[218]},"counts_by_year":[],"updated_date":"2026-09-23T05:00:35.095934","created_date":"2016-06-24T00:00:00"}
