{"id":"https://openalex.org/W2315904808","doi":"https://doi.org/10.1097/00007632-199705150-00009","title":"Chemonucleolysis With Human Stromelysin-1","display_name":"Chemonucleolysis With Human Stromelysin-1","publication_year":1997,"publication_date":"1997-05-01","ids":{"openalex":"https://openalex.org/W2315904808","doi":"https://doi.org/10.1097/00007632-199705150-00009","mag":"2315904808","pmid":"https://pubmed.ncbi.nlm.nih.gov/9160468"},"language":"en","primary_location":{"id":"doi:10.1097/00007632-199705150-00009","doi":"https://doi.org/10.1097/00007632-199705150-00009","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007632-199705150-00009","pdf_url":null,"source":{"id":"https://openalex.org/S4026894","display_name":"Spine","issn_l":"0362-2436","issn":["0362-2436","1528-1159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Spine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063931975","display_name":"Hirotaka Haro","orcid":"https://orcid.org/0000-0002-5630-9600","observed_orcids":["https://orcid.org/0000-0002-5630-9600"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirotaka Haro","raw_affiliation_strings":["Department of Orthopaedic Surgery, Faculty of Medicine, Tokyo Medical and Dental University","1-5-45, Yushima","Acceptance date: November 13, 1996","Acknowledgment date: May 30, 1996","Address reprint requests to Hirotaka Haro, MD","Bunkyo-ku, Tokyo, 113, Japan","Department of Orthopaedic Surgery","Device status category: 1","First revision date: September 1, 1996","From the Department of Orthopaedic Surgery, Faculty of Medicine, Tokyo Medical and Dental University","Tokyo Medical and Dental University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Faculty of Medicine, Tokyo Medical and Dental University","institution_ids":["https://openalex.org/I125602781"]},{"raw_affiliation_string":"1-5-45, Yushima","institution_ids":[]},{"raw_affiliation_string":"Acceptance date: November 13, 1996","institution_ids":[]},{"raw_affiliation_string":"Acknowledgment date: May 30, 1996","institution_ids":[]},{"raw_affiliation_string":"Address reprint requests to Hirotaka Haro, MD","institution_ids":[]},{"raw_affiliation_string":"Bunkyo-ku, Tokyo, 113, Japan","institution_ids":[]},{"raw_affiliation_string":"Department of Orthopaedic Surgery","institution_ids":[]},{"raw_affiliation_string":"Device status category: 1","institution_ids":[]},{"raw_affiliation_string":"First revision date: September 1, 1996","institution_ids":[]},{"raw_affiliation_string":"From the Department of Orthopaedic Surgery, Faculty of Medicine, Tokyo Medical and Dental University","institution_ids":["https://openalex.org/I125602781"]},{"raw_affiliation_string":"Tokyo Medical and Dental University","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032458528","display_name":"Shunichi Murakami","orcid":"https://orcid.org/0000-0002-4594-4553","observed_orcids":["https://orcid.org/0000-0002-4594-4553"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shunichi Murakami","raw_affiliation_strings":["Acceptance date: November 13, 1996","Acknowledgment date: May 30, 1996","Device status category: 1","First revision date: September 1, 1996","the Department of Orthopaedic Surgery, Faculty of Medicine, Tokyo Medical and Dental University","1-5-45, Yushima","Address reprint requests to Hirotaka Haro, MD","Bunkyo-ku, Tokyo, 113, Japan","Department of Orthopaedic Surgery","From the Department of Orthopaedic Surgery, Faculty of Medicine, Tokyo Medical and Dental University","Tokyo Medical and Dental University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acceptance date: November 13, 1996","institution_ids":[]},{"raw_affiliation_string":"Acknowledgment date: May 30, 1996","institution_ids":[]},{"raw_affiliation_string":"Device status category: 1","institution_ids":[]},{"raw_affiliation_string":"First revision date: September 1, 1996","institution_ids":[]},{"raw_affiliation_string":"the Department of Orthopaedic Surgery, Faculty of Medicine, Tokyo Medical and Dental University","institution_ids":["https://openalex.org/I125602781"]},{"raw_affiliation_string":"1-5-45, Yushima","institution_ids":[]},{"raw_affiliation_string":"Address reprint requests to Hirotaka Haro, MD","institution_ids":[]},{"raw_affiliation_string":"Bunkyo-ku, Tokyo, 113, Japan","institution_ids":[]},{"raw_affiliation_string":"Department of Orthopaedic Surgery","institution_ids":[]},{"raw_affiliation_string":"From the Department of Orthopaedic Surgery, Faculty of Medicine, Tokyo Medical and Dental University","institution_ids":["https://openalex.org/I125602781"]},{"raw_affiliation_string":"Tokyo Medical and Dental University","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041774890","display_name":"Hiromichi Komori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiromichi Komori","raw_affiliation_strings":["Acceptance date: November 13, 1996","Acknowledgment date: May 30, 1996","Device status category: 1","First revision date: September 1, 1996","the Department of Orthopaedic Surgery, Faculty of Medicine, Tokyo Medical and Dental University","1-5-45, Yushima","Address reprint requests to Hirotaka Haro, MD","Bunkyo-ku, Tokyo, 113, Japan","Department of Orthopaedic Surgery","From the Department of Orthopaedic Surgery, Faculty of Medicine, Tokyo Medical and Dental University","Tokyo Medical and Dental University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acceptance date: November 13, 1996","institution_ids":[]},{"raw_affiliation_string":"Acknowledgment date: May 30, 1996","institution_ids":[]},{"raw_affiliation_string":"Device status category: 1","institution_ids":[]},{"raw_affiliation_string":"First revision date: September 1, 1996","institution_ids":[]},{"raw_affiliation_string":"the Department of Orthopaedic Surgery, Faculty of Medicine, Tokyo Medical and Dental University","institution_ids":["https://openalex.org/I125602781"]},{"raw_affiliation_string":"1-5-45, Yushima","institution_ids":[]},{"raw_affiliation_string":"Address reprint requests to Hirotaka Haro, MD","institution_ids":[]},{"raw_affiliation_string":"Bunkyo-ku, Tokyo, 113, Japan","institution_ids":[]},{"raw_affiliation_string":"Department of Orthopaedic Surgery","institution_ids":[]},{"raw_affiliation_string":"From the Department of Orthopaedic Surgery, Faculty of Medicine, Tokyo Medical and Dental University","institution_ids":["https://openalex.org/I125602781"]},{"raw_affiliation_string":"Tokyo Medical and Dental University","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030396786","display_name":"Atsushi Okawa","orcid":"https://orcid.org/0000-0003-0227-8658","observed_orcids":["https://orcid.org/0000-0003-0227-8658"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsushi Okawa","raw_affiliation_strings":["Acceptance date: November 13, 1996","Acknowledgment date: May 30, 1996","Device status category: 1","First revision date: September 1, 1996","the Department of Orthopaedic Surgery, Faculty of Medicine, Tokyo Medical and Dental University","1-5-45, Yushima","Address reprint requests to Hirotaka Haro, MD","Bunkyo-ku, Tokyo, 113, Japan","Department of Orthopaedic Surgery","From the Department of Orthopaedic Surgery, Faculty of Medicine, Tokyo Medical and Dental University","Tokyo Medical and Dental University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acceptance date: November 13, 1996","institution_ids":[]},{"raw_affiliation_string":"Acknowledgment date: May 30, 1996","institution_ids":[]},{"raw_affiliation_string":"Device status category: 1","institution_ids":[]},{"raw_affiliation_string":"First revision date: September 1, 1996","institution_ids":[]},{"raw_affiliation_string":"the Department of Orthopaedic Surgery, Faculty of Medicine, Tokyo Medical and Dental University","institution_ids":["https://openalex.org/I125602781"]},{"raw_affiliation_string":"1-5-45, Yushima","institution_ids":[]},{"raw_affiliation_string":"Address reprint requests to Hirotaka Haro, MD","institution_ids":[]},{"raw_affiliation_string":"Bunkyo-ku, Tokyo, 113, Japan","institution_ids":[]},{"raw_affiliation_string":"Department of Orthopaedic Surgery","institution_ids":[]},{"raw_affiliation_string":"From the Department of Orthopaedic Surgery, Faculty of Medicine, Tokyo Medical and Dental University","institution_ids":["https://openalex.org/I125602781"]},{"raw_affiliation_string":"Tokyo Medical and Dental University","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110215115","display_name":"Kenichi Shinomiya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenichi Shinomiya","raw_affiliation_strings":["Acceptance date: November 13, 1996","Acknowledgment date: May 30, 1996","Device status category: 1","First revision date: September 1, 1996","the Department of Orthopaedic Surgery, Faculty of Medicine, Tokyo Medical and Dental University","1-5-45, Yushima","Address reprint requests to Hirotaka Haro, MD","Bunkyo-ku, Tokyo, 113, Japan","Department of Orthopaedic Surgery","From the Department of Orthopaedic Surgery, Faculty of Medicine, Tokyo Medical and Dental University","Tokyo Medical and Dental University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acceptance date: November 13, 1996","institution_ids":[]},{"raw_affiliation_string":"Acknowledgment date: May 30, 1996","institution_ids":[]},{"raw_affiliation_string":"Device status category: 1","institution_ids":[]},{"raw_affiliation_string":"First revision date: September 1, 1996","institution_ids":[]},{"raw_affiliation_string":"the Department of Orthopaedic Surgery, Faculty of Medicine, Tokyo Medical and Dental University","institution_ids":["https://openalex.org/I125602781"]},{"raw_affiliation_string":"1-5-45, Yushima","institution_ids":[]},{"raw_affiliation_string":"Address reprint requests to Hirotaka Haro, MD","institution_ids":[]},{"raw_affiliation_string":"Bunkyo-ku, Tokyo, 113, Japan","institution_ids":[]},{"raw_affiliation_string":"Department of Orthopaedic Surgery","institution_ids":[]},{"raw_affiliation_string":"From the Department of Orthopaedic Surgery, Faculty of Medicine, Tokyo Medical and Dental University","institution_ids":["https://openalex.org/I125602781"]},{"raw_affiliation_string":"Tokyo Medical and Dental University","institution_ids":["https://openalex.org/I125602781"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I125602781"],"apc_list":null,"apc_paid":null,"fwci":1.4567,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.83104417,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"22","issue":"10","first_page":"1098","last_page":"1104"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10238","display_name":"Spine and Intervertebral Disc Pathology","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10238","display_name":"Spine and Intervertebral Disc Pathology","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11518","display_name":"Cervical and Thoracic Myelopathy","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stromelysin-1","display_name":"stromelysin-1","score":0.8999999761581421},{"id":"https://openalex.org/keywords/chemonucleolysis","display_name":"chemonucleolysis","score":0.9559999704360962},{"id":"https://openalex.org/keywords/herniated-nucleus-pulposus","display_name":"herniated nucleus pulposus","score":0.996999979019165},{"id":"https://openalex.org/keywords/proteoglycan-degradation","display_name":"proteoglycan degradation","score":0.8849999904632568},{"id":"https://openalex.org/keywords/intervertebral-disc","display_name":"intervertebral disc","score":0.7170000076293945},{"id":"https://openalex.org/keywords/granulation-tissue","display_name":"granulation tissue","score":0.8180000185966492}],"concepts":[{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.761378288269043},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7321757674217224},{"id":"https://openalex.org/C2777755357","wikidata":"https://www.wikidata.org/wiki/Q502781","display_name":"Intervertebral disc","level":2,"score":0.636939287185669},{"id":"https://openalex.org/C2779335624","wikidata":"https://www.wikidata.org/wiki/Q407976","display_name":"Proteoglycan","level":3,"score":0.601695716381073},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.5835946202278137},{"id":"https://openalex.org/C2910007452","wikidata":"https://www.wikidata.org/wiki/Q21114943","display_name":"Matrix Metalloproteinase 3","level":3,"score":0.5774006247520447},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.5579125881195068},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5290113091468811},{"id":"https://openalex.org/C55728118","wikidata":"https://www.wikidata.org/wiki/Q425402","display_name":"Metalloproteinase","level":3,"score":0.5141956806182861},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.49566972255706787},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.46997398138046265},{"id":"https://openalex.org/C153074725","wikidata":"https://www.wikidata.org/wiki/Q407553","display_name":"Glycosaminoglycan","level":2,"score":0.4604978561401367},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.358794629573822},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15428411960601807},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13155832886695862},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007403","descriptor_name":"Intervertebral Disc","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D007404","descriptor_name":"Intervertebral Disc Chemolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007405","descriptor_name":"Intervertebral Disc Displacement","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019278","descriptor_name":"Matrix Metalloproteinase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019278","descriptor_name":"Matrix Metalloproteinase 3","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019278","descriptor_name":"Matrix Metalloproteinase 3","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00007632-199705150-00009","doi":"https://doi.org/10.1097/00007632-199705150-00009","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007632-199705150-00009","pdf_url":null,"source":{"id":"https://openalex.org/S4026894","display_name":"Spine","issn_l":"0362-2436","issn":["0362-2436","1528-1159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Spine","raw_type":"journal-article"},{"id":"pmid:9160468","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9160468","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Spine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W635471586","https://openalex.org/W1523015364","https://openalex.org/W1523927558","https://openalex.org/W1590922852","https://openalex.org/W1658991581","https://openalex.org/W1788104986","https://openalex.org/W1893500736","https://openalex.org/W1964570311","https://openalex.org/W1970026238","https://openalex.org/W1982172588","https://openalex.org/W1996986107","https://openalex.org/W2006663753","https://openalex.org/W2010892052","https://openalex.org/W2018532002","https://openalex.org/W2028659031","https://openalex.org/W2041760911","https://openalex.org/W2043128309","https://openalex.org/W2045615786","https://openalex.org/W2046910335","https://openalex.org/W2058927229","https://openalex.org/W2060182573","https://openalex.org/W2061401525","https://openalex.org/W2062081863","https://openalex.org/W2062404237","https://openalex.org/W2081928620","https://openalex.org/W2096834315","https://openalex.org/W2097961294","https://openalex.org/W2109658199","https://openalex.org/W2117784014","https://openalex.org/W2145709015","https://openalex.org/W2146001934","https://openalex.org/W2248388752","https://openalex.org/W2309411620","https://openalex.org/W2331533543","https://openalex.org/W2464379983","https://openalex.org/W4230932862","https://openalex.org/W4319705337"],"related_works":["https://openalex.org/W2408825075","https://openalex.org/W2013606562","https://openalex.org/W2063374664","https://openalex.org/W2301410228","https://openalex.org/W2416776788","https://openalex.org/W2429608769","https://openalex.org/W2409187575","https://openalex.org/W2235391078","https://openalex.org/W2429540088","https://openalex.org/W2418459757"],"abstract_inverted_index":{"STUDY":[0],"DESIGN:":[1],"Immunohistologic":[2,142,244],"analysis":[3,143,245],"was":[4,114,147,196,216,220,231,261],"performed":[5,21,148],"on":[6,64,149],"surgically":[7],"removed":[8],"samples":[9,154,165],"of":[10,18,37,46,51,60,86,92,103,128,159,178,184,194,249,255,308,340,349],"herniated":[11,52,80,93,111,129,151,162,256,282,312,324,350],"nucleus":[12,39,53,65,81,94,112,130,152,163,203,257,266,283,313,325,351],"pulposus":[13,66,82,95,113,153,164,204,267,284,314,326],"to":[14,28,56,155],"examine":[15,57],"the":[16,44,58,87,126,157,174,192,223,227,237,247,252,264,276,346,354],"expression":[17,158],"stromelysin-1.":[19,160,180],"We":[20],"in":[22,25,48,79,84,110,125,168,173,229,251,271,297,310,323,337],"vitro":[23],"and":[24,55,89,191,212,226,328,357],"vivo":[26],"experiments":[27],"determine":[29],"whether":[30],"recombinant":[31,62],"human":[32,281,341],"(rh)":[33],"stromelysin-1":[34,47,122,132,219,250,260,296,329,342],"is":[35,123,318],"capable":[36],"degrading":[38,108],"pulposus.":[40,258],"OBJECTIVE:":[41],"To":[42],"analyze":[43],"production":[45,102,248],"various":[49],"types":[50,91],"pulposus,":[54,131,352],"effects":[59],"this":[61],"protein":[63],"tissues.":[67],"SUMMARY":[68],"OF":[69],"BACKGROUND":[70],"DATA:":[71],"The":[72,117],"authors":[73,118],"previously":[74],"demonstrated":[75,246],"a":[76,105,138,169,319,332],"progressive":[77],"decrease":[78,358],"size":[83,230,272],"some":[85],"transligamentous":[88],"sequestration":[90],"using":[96,144,240],"magnetic":[97],"resonance":[98],"imaging.":[99],"An":[100],"increased":[101],"stromelysin-1,":[104],"cartilage":[106],"proteoglycan":[107,195,309],"enzyme,":[109],"reported":[115],"recently.":[116],"speculated":[119],"that":[120],"if":[121],"involved":[124],"degradation":[127],"itself":[133],"may":[134,330,343],"be":[135,331],"used":[136],"as":[137],"chemonucleolytic":[139],"agent.":[140],"METHODS:":[141],"streptoavidin-biotin":[145],"method":[146],"20":[150],"investigate":[156],"Five":[161],"were":[166,189,206],"incubated":[167],"tissue":[170],"culture":[171,300],"medium":[172],"presence":[175],"or":[176],"absence":[177],"rh":[179],"After":[181],"24":[182],"hours":[183],"incubation,":[185],"their":[186],"weight":[187,291],"changes":[188],"measured,":[190],"loss":[193,292],"assessed":[197],"by":[198,233],"Safranin":[199,302],"O":[200,303],"staining.":[201],"Rat":[202],"tissues":[205,254],"obtained":[207,286],"from":[208,236],"coccygeal":[209],"intervertebral":[210],"discs,":[211],"autologous":[213],"subcutaneous":[214],"transplantation":[215],"performed.":[217],"Rh":[218],"injected":[221,262],"into":[222,263],"grafted":[224],"materials,":[225],"reduction":[228],"followed":[232],"two-dimensional":[234],"measurements":[235],"skin":[238],"surface,":[239],"engineer's":[241],"calipers.":[242],"RESULTS:":[243],"granulation":[253],"When":[259],"murine":[265],"tissues,":[268],"they":[269],"reduced":[270],"more":[273],"rapidly":[274],"than":[275],"control":[277],"group.":[278],"In":[279],"addition,":[280],"materials":[285],"at":[287],"surgery":[288],"showed":[289],"significant":[290],"when":[293],"treated":[294],"with":[295],"an":[298],"organ":[299],"system.":[301],"staining":[304],"revealed":[305],"extensive":[306],"depletion":[307],"these":[311],"samples.":[315],"CONCLUSIONS:":[316],"Stromelysin-1":[317],"possible":[320],"key":[321],"enzyme":[322],"resorption,":[327],"good":[333],"candidate":[334],"for":[335],"use":[336],"chemonucleolysis.":[338,361],"Administration":[339],"physiologically":[344],"facilitate":[345],"resorption":[347],"process":[348],"increase":[353],"healing":[355],"rate":[356],"complications":[359],"after":[360]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
