{"id":"https://openalex.org/W2315316307","doi":"https://doi.org/10.1158/1538-7445.am2012-1364","title":"Abstract 1364: Osteoprotegerin production by breast cancer cells: Regulation by NF-kappaB and role in metastasis","display_name":"Abstract 1364: Osteoprotegerin production by breast cancer cells: Regulation by NF-kappaB and role in metastasis","publication_year":2012,"publication_date":"2012-04-01","ids":{"openalex":"https://openalex.org/W2315316307","doi":"https://doi.org/10.1158/1538-7445.am2012-1364","mag":"2315316307"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2012-1364","doi":"https://doi.org/10.1158/1538-7445.am2012-1364","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2012-1364","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068555154","display_name":"Michael Weichhaus","orcid":"https://orcid.org/0000-0003-3743-8893","observed_orcids":["https://orcid.org/0000-0003-3743-8893"]},"institutions":[{"id":"https://openalex.org/I35722693","display_name":"University of Hawaii at Hilo","ror":"https://ror.org/02mp2av58","country_code":"US","type":"education","lineage":["https://openalex.org/I35722693"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Weichhaus","raw_affiliation_strings":["1Univ. of Hawaii at Hilo, Hilo, HI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Univ. of Hawaii at Hilo, Hilo, HI","institution_ids":["https://openalex.org/I35722693"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056102735","display_name":"Prabu Segaran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I35722693","display_name":"University of Hawaii at Hilo","ror":"https://ror.org/02mp2av58","country_code":"US","type":"education","lineage":["https://openalex.org/I35722693"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Prabu Segaran","raw_affiliation_strings":["1Univ. of Hawaii at Hilo, Hilo, HI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Univ. of Hawaii at Hilo, Hilo, HI","institution_ids":["https://openalex.org/I35722693"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035090143","display_name":"Dirk Geerts","orcid":"https://orcid.org/0000-0002-6386-8187","observed_orcids":["https://orcid.org/0000-0002-6386-8187"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Dirk Geerts","raw_affiliation_strings":["2Erasmus University Medical Center, Rotterdam, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Erasmus University Medical Center, Rotterdam, Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012678680","display_name":"Linda Connelly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I35722693","display_name":"University of Hawaii at Hilo","ror":"https://ror.org/02mp2av58","country_code":"US","type":"education","lineage":["https://openalex.org/I35722693"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda Connelly","raw_affiliation_strings":["1Univ. of Hawaii at Hilo, Hilo, HI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Univ. of Hawaii at Hilo, Hilo, HI","institution_ids":["https://openalex.org/I35722693"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"72","issue":"8_Supplement","first_page":"1364","last_page":"1364"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.3075999915599823,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.3075999915599823,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.2786000072956085,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.14100000262260437,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteoprotegerin","display_name":"osteoprotegerin","score":0.9900000095367432},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9580000042915344},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.968999981880188},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.765999972820282},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8349999785423279},{"id":"https://openalex.org/keywords/thymoquinone","display_name":"thymoquinone","score":1.0},{"id":"https://openalex.org/keywords/breast-cancer-subtypes","display_name":"breast cancer subtypes","score":0.6990000009536743},{"id":"https://openalex.org/keywords/basal-like-breast-cancer","display_name":"basal-like breast cancer","score":0.8100000023841858},{"id":"https://openalex.org/keywords/her2-positive-breast-cancer","display_name":"HER2-positive breast cancer","score":0.9869999885559082},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.640999972820282},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.7749999761581421},{"id":"https://openalex.org/keywords/sirna-knockdown","display_name":"siRNA knockdown","score":0.5910000205039978},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.8550000190734863},{"id":"https://openalex.org/keywords/mda-mb-435","display_name":"MDA-MB-435","score":0.9959999918937683}],"concepts":[{"id":"https://openalex.org/C2780426850","wikidata":"https://www.wikidata.org/wiki/Q3357478","display_name":"Osteoprotegerin","level":4,"score":0.810608983039856},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.6643259525299072},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.5756884217262268},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5703350901603699},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5613815188407898},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5182468891143799},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.5110117197036743},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4870067238807678},{"id":"https://openalex.org/C2777783956","wikidata":"https://www.wikidata.org/wiki/Q848085","display_name":"Bone metastasis","level":4,"score":0.46876686811447144},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4017584025859833},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35763809084892273},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3486802279949188},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.31044894456863403},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.11250323057174683},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2012-1364","doi":"https://doi.org/10.1158/1538-7445.am2012-1364","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2012-1364","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2058896471","https://openalex.org/W2030599500","https://openalex.org/W2326790348","https://openalex.org/W2398408006","https://openalex.org/W2362106712","https://openalex.org/W1931719913","https://openalex.org/W2160527120","https://openalex.org/W2592135907","https://openalex.org/W2334562803","https://openalex.org/W1599072092"],"abstract_inverted_index":{"Abstract":[0],"Human":[1,147,178],"breast":[2,48,79,148,231,265,276,287,321],"cancer":[3,22,49,80,149,232,266,277,288,322],"cells":[4,50,81,150,190,211,246,323],"and":[5,51,77,115,228,304,364],"tissues":[6,278],"express":[7],"the":[8,17,35,62,134,141,154,167,184,215,243,249,348,373,395,400],"protein":[9],"osteoprotegerin":[10],"(OPG).":[11],"While":[12],"many":[13],"studies":[14,30,338],"have":[15],"investigated":[16,71],"role":[18],"of":[19,26,143,242,394,399],"OPG":[20,45,57,73,106,118,144,196,204,244,261,272,293,318,341,351,356,371],"in":[21,66,75,183,240,268,274,300,320,336,362,372],"as":[23],"a":[24,162,237,328,378],"mediator":[25],"bone":[27,36],"remodeling,":[28],"few":[29],"consider":[31],"its":[32,52,353],"impact":[33],"outside":[34],"microenvironment.":[37],"Further":[38],"investigation":[39],"is":[40,171,324],"therefore":[41],"required":[42],"into":[43],"endogenous":[44],"expression":[46,74,107,198,262,273,295,319],"by":[47,61,84,110,173,286,326],"effects":[53],"on":[54,145],"tumor":[55,163,270,308,375],"progression.":[56],"can":[58],"be":[59],"regulated":[60,83,325],"transcription":[63,329],"factor":[64,330],"NF-kappaB":[65,103],"several":[67],"cell":[68,233],"types.":[69],"We":[70,132,187,235,251,344],"whether":[72,260],"MDA-MB-231":[76,189],"MDA-MB-435":[78],"was":[82,108,223,279],"NF-kappaB.":[85],"Cells":[86],"were":[87,120,151,212],"treated":[88,210],"for":[89,177,230,382,403],"24":[90],"hours":[91,202],"with":[92,124,128,191,264,282,297,332,359],"10ng/ml":[93],"TNF-alpha":[94,125],"or":[95,101,206],"10\u00b5M":[96],"thymoquinone":[97],"(TQ),":[98],"to":[99,139,166,200,248,258],"stimulate":[100],"inhibit":[102],"activity":[104],"respectively.":[105],"measured":[109],"real":[111,174],"time":[112,175],"RT-PCR":[113],"(mRNA)":[114],"ELISA":[116],"(protein).":[117],"levels":[119,357],"increased":[121],"after":[122],"treatment":[123,127,368],"while":[126],"TQ":[129],"decreased":[130],"expression.":[131],"used":[133],"chick":[135,155,168,185,221],"embryo":[136],"metastasis":[137,241],"model":[138],"determine":[140,259],"effect":[142],"metastasis.":[146,234,343],"inoculated":[152,213],"onto":[153,214],"chorioallantoic":[156],"membrane":[157],"(CAM)":[158],"where":[159],"they":[160],"form":[161],"that":[164,291,317,340],"metastasizes":[165],"tissue.":[169,186],"Metastasis":[170],"quantified":[172],"PCR":[176],"Alu":[179],"repeat":[180],"DNA":[181],"sequences":[182],"transfected":[188],"OPG-specific":[192],"siRNA":[193],"which":[194],"reduced":[195],"mRNA":[197,254,294],"up":[199],"72":[201],"post-transfection.":[203],"knockdown":[205,245],"control":[207],"(non-targeting":[208],"siRNA)":[209],"CAM":[216],"at":[217,225],"embryonic":[218],"day":[219,226],"9;":[220],"tissue":[222],"harvested":[224],"16":[227],"analyzed":[229],"found":[236],"significant":[238],"reduction":[239],"compared":[247],"control.":[250],"performed":[252],"genome-wide":[253],"microarray":[255],"data":[256,315],"analysis":[257],"correlates":[263],"progression":[267],"human":[269],"samples.":[271],"1809":[275],"not":[280],"correlated":[281,296],"prognosis.":[283],"However,":[284],"analyses":[285],"subtypes":[289,309],"showed":[290],"high":[292],"poorer":[298,360],"prognosis":[299,361],"basal":[301,363],"(p=0.0028,":[302],"n=383)":[303],"also":[305],"HER2":[306,365],"positive":[307,366],"(p=0.021,":[310],"n=408).":[311],"In":[312],"summary,":[313],"our":[314],"suggest":[316,339],"NF-kappaB,":[327],"associated":[331],"pro-tumor":[333],"effects.":[334,354],"Our":[335],"vivo":[337],"promotes":[342],"are":[345],"currently":[346],"determining":[347],"mechanism":[349],"whereby":[350],"exerts":[352],"Since":[355],"correlate":[358],"tumors,":[367],"strategies":[369],"targeting":[370],"primary":[374],"may":[376],"represent":[377],"potential":[379],"therapeutic":[380],"strategy":[381],"these":[383],"disease":[384],"subytpes.":[385],"Citation":[386],"Format:":[387],"{Authors}.":[388],"{Abstract":[389],"title}":[390],"[abstract].":[391],"In:":[392],"Proceedings":[393],"103rd":[396],"Annual":[397],"Meeting":[398],"American":[401],"Association":[402],"Cancer":[404,415],"Research;":[405],"2012":[406],"Mar":[407],"31-Apr":[408],"4;":[409],"Chicago,":[410],"IL.":[411],"Philadelphia":[412],"(PA):":[413],"AACR;":[414],"Res":[416],"2012;72(8":[417],"Suppl):Abstract":[418],"nr":[419],"1364.":[420],"doi:1538-7445.AM2012-1364":[421]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-06-24T00:00:00"}