{"id":"https://openalex.org/W2315200026","doi":"https://doi.org/10.1016/j.juro.2016.02.1081","title":"PD35-09 DIFFERENTIAL ACTIONS OF ER\u03b1 AND ER\u03b2 VIA NON-GENOMIC SIGNALING IN HUMAN PROSTATE STEM-PROGENITOR CELLS","display_name":"PD35-09 DIFFERENTIAL ACTIONS OF ER\u03b1 AND ER\u03b2 VIA NON-GENOMIC SIGNALING IN HUMAN PROSTATE STEM-PROGENITOR CELLS","publication_year":2016,"publication_date":"2016-03-28","ids":{"openalex":"https://openalex.org/W2315200026","doi":"https://doi.org/10.1016/j.juro.2016.02.1081","mag":"2315200026"},"language":"en","primary_location":{"id":"doi:10.1016/j.juro.2016.02.1081","doi":"https://doi.org/10.1016/j.juro.2016.02.1081","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.juro.2016.02.1081","pdf_url":"https://www.auajournals.org/doi/pdf/10.1016/j.juro.2016.02.1081","source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.auajournals.org/doi/pdf/10.1016/j.juro.2016.02.1081","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110500274","display_name":"Shyama Majumdar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shyama Majumdar","raw_affiliation_strings":["Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chicago, IL","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015082103","display_name":"Neha R. Malhotra","orcid":"https://orcid.org/0000-0002-0494-3896","observed_orcids":["https://orcid.org/0000-0002-0494-3896"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Neha Malhotra","raw_affiliation_strings":["Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chicago, IL","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Susan Kasper","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Susan Kasper","raw_affiliation_strings":["Cincinnati, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cincinnati, OH","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029096524","display_name":"Lishi Xie","orcid":"https://orcid.org/0000-0003-2376-6685","observed_orcids":["https://orcid.org/0000-0003-2376-6685"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lishi Xie","raw_affiliation_strings":["Chicago, IL","xuejiang guo, changjun yin, jiahao sha, Nanjing, China, People's Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chicago, IL","institution_ids":[]},{"raw_affiliation_string":"xuejiang guo, changjun yin, jiahao sha, Nanjing, China, People's Republic","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049617125","display_name":"Timothy D. Gauntner","orcid":"https://orcid.org/0000-0002-4745-2130","observed_orcids":["https://orcid.org/0000-0002-4745-2130"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Timothy Gauntner","raw_affiliation_strings":["Chicago, IL","xuejiang guo, changjun yin, jiahao sha, Nanjing, China, People's Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chicago, IL","institution_ids":[]},{"raw_affiliation_string":"xuejiang guo, changjun yin, jiahao sha, Nanjing, China, People's Republic","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029667495","display_name":"Wen\u2010Yang Hu","orcid":"https://orcid.org/0000-0001-7811-2078","observed_orcids":["https://orcid.org/0000-0001-7811-2078"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wen-yang Hu","raw_affiliation_strings":["Chicago, IL","xuejiang guo, changjun yin, jiahao sha, Nanjing, China, People's Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chicago, IL","institution_ids":[]},{"raw_affiliation_string":"xuejiang guo, changjun yin, jiahao sha, Nanjing, China, People's Republic","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049719845","display_name":"Gail S. Prins","orcid":"https://orcid.org/0000-0002-9044-4734","observed_orcids":["https://orcid.org/0000-0002-9044-4734"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gail Prins","raw_affiliation_strings":["Chicago, IL","xuejiang guo, changjun yin, jiahao sha, Nanjing, China, People's Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chicago, IL","institution_ids":[]},{"raw_affiliation_string":"xuejiang guo, changjun yin, jiahao sha, Nanjing, China, People's Republic","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0219668,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"195","issue":"4S","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.5776000022888184,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.5776000022888184,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.41920000314712524,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estrogen-receptor-alpha","display_name":"estrogen receptor alpha","score":0.9649999737739563},{"id":"https://openalex.org/keywords/estrogen-receptor-beta","display_name":"estrogen receptor beta","score":1.0},{"id":"https://openalex.org/keywords/nongenomic-estrogen-signaling","display_name":"non-genomic estrogen signaling","score":0.9810000061988831},{"id":"https://openalex.org/keywords/membrane-initiated-signaling","display_name":"membrane-initiated signaling","score":0.7200000286102295},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.8640000224113464},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.7950000166893005},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.9240000247955322},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.7450000047683716},{"id":"https://openalex.org/keywords/erk1-2","display_name":"ERK1/2","score":0.8539999723434448},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.6759999990463257},{"id":"https://openalex.org/keywords/prostate-development","display_name":"prostate development","score":0.4519999921321869},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.5320000052452087}],"concepts":[{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.7566913366317749},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.6411904692649841},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6058179140090942},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5170381665229797},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5122222304344177},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.5044752359390259},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.4623836874961853},{"id":"https://openalex.org/C15729860","wikidata":"https://www.wikidata.org/wiki/Q2329919","display_name":"Progenitor","level":4,"score":0.45241615176200867},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2801380157470703},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26166725158691406},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25958842039108276},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.23338526487350464},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0679156482219696}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.juro.2016.02.1081","doi":"https://doi.org/10.1016/j.juro.2016.02.1081","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.juro.2016.02.1081","pdf_url":"https://www.auajournals.org/doi/pdf/10.1016/j.juro.2016.02.1081","source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.juro.2016.02.1081","doi":"https://doi.org/10.1016/j.juro.2016.02.1081","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.juro.2016.02.1081","pdf_url":"https://www.auajournals.org/doi/pdf/10.1016/j.juro.2016.02.1081","source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2315200026.pdf","grobid_xml":"https://content.openalex.org/works/W2315200026.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2969861992","https://openalex.org/W2373415794","https://openalex.org/W2151262466","https://openalex.org/W2390694881","https://openalex.org/W7097518746","https://openalex.org/W2327909430","https://openalex.org/W2084445689","https://openalex.org/W2947444821","https://openalex.org/W2324974238","https://openalex.org/W2003832876"],"abstract_inverted_index":{"INTRODUCTION":[0],"AND":[1],"OBJECTIVES:":[2],"Estrogens":[3],"have":[4,30],"been":[5],"implicated":[6],"in":[7,38,56,256,278,289,327],"prostate":[8,26,60,67,92,114,136,337,359],"development":[9],"and":[10,18,50,91,97,125,201,217,239,247,343],"cancer;":[11],"however,":[12],"specific":[13,46],"roles":[14,47],"of":[15,71,123,177,182,194,234,260,264,283,292,297,317],"estrogen":[16,19,39],"receptor-a":[17],"receptor-b":[20],"are":[21,36,254],"not":[22,267],"well":[23,364],"established.Using":[24],"human":[25,113,135,336],"stem-progenitor":[27,57,61,338,360],"cells":[28,62,186,198,285,339],"we":[29],"previously":[31,82],"shown":[32],"that":[33,270,301,320,335,357],"non-genomic":[34],"pathways":[35],"involved":[37,255],"actions.Our":[40],"present":[41,332],"study":[42],"sought":[43],"to":[44,104,146,152,160,174,227,329,353],"elucidate":[45],"for":[48,188],"ERa":[49,87,124,189,205,287,309,342],"ERb":[51,89,148,191,207,271],"via":[52,315],"membrane":[53,251,324,348],"initiated":[54],"signaling":[55,318,349],"cells.METHODS:":[58],"Human":[59],"were":[63,84,150,212,219],"enriched":[64],"from":[65],"primary":[66],"epithelial":[68],"cell":[69,94,107,116,139,361],"culture":[70],"young,":[72],"diseasefree":[73],"donors":[74],"using":[75,86],"a":[76,131,158],"3D":[77],"prostasphere":[78],"(PS)":[79],"model":[80],"as":[81,199,203,363,365],"described.Cells":[83],"labeled":[85,187],"or":[88,190,206],"antibodies":[90],"stem":[93,115],"markers":[95],"CD49f":[96],"TROP2":[98],"followed":[99],"by":[100],"triple":[101],"channel":[102],"FACS":[103,180],"quantify":[105,175],"ERa+/ERb+":[106],"numbers.To":[108],"explore":[109],"ERa,":[110],"the":[111,275,323],"benign":[112],"line":[117,140],"WPE-stem,":[118],"with":[119,130],"extremely":[120],"low":[121],"levels":[122,296],"ERb,":[126,344],"was":[127,144,172],"stably":[128],"transfected":[129],"lentiviral-ERa":[132],"expression":[133],"vector.The":[134],"cancer":[137],"stem-like":[138],"HuSLC":[141],"(ERb++,":[142],"ERa-)":[143],"used":[145,173],"interrogate":[147],"actions.Cells":[149],"exposed":[151,226],"10":[153,228],"nM":[154,229],"estradiol":[155],"(E2)":[156],"over":[157,242],"15":[159],"60":[161,243],"minute":[162],"time":[163],"course":[164],"+/-ICI":[165],"182,870":[166],"(ICI),":[167],"an":[168],"ERa/b":[169],"antagonist.Western":[170],"Blotting":[171],"phosphorylation":[176,233,263,291,299],"target":[178],"proteins.RESULTS:":[179],"analysis":[181],"day":[183,195],"7":[184,196],"PS":[185,197,209],"revealed":[192],"66%":[193],"ERa+":[200],"40%":[202],"ERb+.Among":[204],"positive":[208],"cells,":[210],"4%":[211],"Trop2+/CD49f":[213,220],"high":[214],"(stem-like":[215],"cells)":[216],"10-12%":[218],"medium":[221],"(early":[222],"stage":[223],"progenitor":[224],"cells).PS":[225],"E2":[230,281],"showed":[231,262],"sequential":[232],"Src,":[235],"Erk1/2,":[236],"p38,":[237],"Akt":[238,246,293,302],"NFkB":[240],"(p65)":[241],"minutes.ICI":[244],"attenuated":[245],"Erk1/2":[248,265,298],"phosphorylation,":[249],"confirming":[250],"bound":[252],"ERs":[253,311],"downstream":[257,355],"signaling.E2":[258],"treatment":[259,282],"HuSLCs":[261],"but":[266,294],"Akt,":[268],"indicating":[269],"signals":[272],"exclusively":[273],"through":[274],"MAPK":[276],"pathway":[277],"these":[279],"cells.Conversely,":[280],"WPE-stem":[284],"overexpressing":[286],"resulted":[288],"robust":[290],"lower":[295],"suggesting":[300],"activation":[303,316],"may":[304,351],"be":[305],"more":[306],"reliant":[307],"on":[308],"signaling.CONCLUSIONS:":[310],"trigger":[312],"cellular":[313],"responses":[314],"cascades":[319],"originate":[321],"at":[322],"(non-genomic":[325],"signaling)":[326],"addition":[328],"nuclear":[330],"signaling.The":[331],"findings":[333],"reveal":[334],"express":[340],"both":[341],"which":[345],"differentially":[346],"activate":[347],"cascades.This":[350],"lead":[352],"unique":[354],"actions":[356],"influence":[358],"proliferation":[362],"lineage":[366],"commitment":[367],"decisions.":[368]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}
