{"id":"https://openalex.org/W2315096014","doi":"https://doi.org/10.1158/1538-7445.am2013-4990","title":"Abstract 4990: Complement promotes growth of ovarian cancer.","display_name":"Abstract 4990: Complement promotes growth of ovarian cancer.","publication_year":2013,"publication_date":"2013-04-01","ids":{"openalex":"https://openalex.org/W2315096014","doi":"https://doi.org/10.1158/1538-7445.am2013-4990","mag":"2315096014"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2013-4990","doi":"https://doi.org/10.1158/1538-7445.am2013-4990","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2013-4990","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019650612","display_name":"Min Soon Cho","orcid":"https://orcid.org/0000-0002-9992-8356","observed_orcids":["https://orcid.org/0000-0002-9992-8356"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Min Soon Cho","raw_affiliation_strings":["MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103388295","display_name":"Hernan G. Vasquez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hernan G. Vasquez","raw_affiliation_strings":["MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043280625","display_name":"Hee Dong Han","orcid":"https://orcid.org/0000-0002-3300-5575","observed_orcids":["https://orcid.org/0000-0002-3300-5575"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hee Dong Han","raw_affiliation_strings":["MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043392987","display_name":"Sunila Pradeep","orcid":"https://orcid.org/0000-0003-2441-7727","observed_orcids":["https://orcid.org/0000-0003-2441-7727"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sunila Pradeep","raw_affiliation_strings":["MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052973096","display_name":"Rajesha Rupaimoole","orcid":"https://orcid.org/0000-0002-4795-7921","observed_orcids":["https://orcid.org/0000-0002-4795-7921"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rajesh Rupaimoole","raw_affiliation_strings":["MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105369415","display_name":"Behrouz Zand","orcid":"https://orcid.org/0000-0002-8327-3535","observed_orcids":["https://orcid.org/0000-0002-8327-3535"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Behrouz Zand","raw_affiliation_strings":["MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015003674","display_name":"Michael H. Kroll","orcid":"https://orcid.org/0000-0001-6817-5761","observed_orcids":["https://orcid.org/0000-0001-6817-5761"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Kroll","raw_affiliation_strings":["MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100640276","display_name":"Anil K. Sood","orcid":"https://orcid.org/0000-0002-5415-9901","observed_orcids":["https://orcid.org/0000-0002-5415-9901"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anil K. Sood","raw_affiliation_strings":["MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006820634","display_name":"Vahid Afshar\u2010Kharghan","orcid":"https://orcid.org/0000-0003-2911-1284","observed_orcids":["https://orcid.org/0000-0003-2911-1284"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vahid Afshar-Kharghan","raw_affiliation_strings":["MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"73","issue":"8_Supplement","first_page":"4990","last_page":"4990"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.9434000253677368,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.9434000253677368,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.04859999939799309,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/complement-system","display_name":"complement system","score":0.9760000109672546},{"id":"https://openalex.org/keywords/complement-c3","display_name":"complement C3","score":0.847000002861023},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.9940000176429749},{"id":"https://openalex.org/keywords/tumor-cell-proliferation","display_name":"tumor cell proliferation","score":0.6129999756813049},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.7919999957084656},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.8230000138282776},{"id":"https://openalex.org/keywords/orthotopic-murine-model","display_name":"orthotopic murine model","score":0.7540000081062317},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.8180000185966492},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8130000233650208},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.5929999947547913},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.6710000038146973},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9940000176429749},{"id":"https://openalex.org/keywords/intercellular-communication","display_name":"intercellular communication","score":0.7250000238418579},{"id":"https://openalex.org/keywords/organ-regeneration","display_name":"organ regeneration","score":0.8220000267028809}],"concepts":[{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.8118309378623962},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.6543571949005127},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5812389850616455},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5695320963859558},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5342732071876526},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5101204514503479},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.5010464191436768},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.44373413920402527},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4339819550514221},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.4207492768764496},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3255959749221802},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2996012568473816},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2861109972000122},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.17375773191452026},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1312824785709381},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2013-4990","doi":"https://doi.org/10.1158/1538-7445.am2013-4990","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2013-4990","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2739217321","https://openalex.org/W3185617580","https://openalex.org/W2112529812","https://openalex.org/W2062911784","https://openalex.org/W2800806639","https://openalex.org/W2980624791","https://openalex.org/W2037833540","https://openalex.org/W7096832097","https://openalex.org/W1999644056","https://openalex.org/W2805552948"],"abstract_inverted_index":{"Abstract":[0],"Objective:":[1],"The":[2],"complement":[3,34,243,260],"system":[4,35,261],"is":[5],"a":[6,208,217,228,239,263],"component":[7],"of":[8,77,101,119,126,140,160,180,269,300,306,311],"innate":[9],"immunity":[10],"against":[11],"invading":[12],"pathogens,":[13],"but":[14],"also":[15],"mediates":[16],"the":[17,33,75,102,259,267,307,312],"cell-cell":[18],"communication":[19],"in":[20,39,53,59,81,84,90,113,143,147,151,163,169,173,182,187,191,199,213,244],"organ":[21],"regeneration,":[22],"angiogenesis,":[23],"epithelial-mesenchymal":[24],"transition":[25],"(EMT)":[26],"and":[27,58,83,95,111,137,201,253],"cell":[28,56,93,108],"migration.":[29],"We":[30],"studied":[31],"whether":[32],"affect":[36],"tumor":[37,60,96,141,158,251],"growth":[38,125,252,299],"ovarian":[40,54,65,91,106,120,204,301],"cancer.":[41,66,302],"Materials":[42],"&":[43],"Methods:":[44],"Complement":[45,297],"C3":[46,78,87,103,122,164,183,210,230,249],"mRNA":[47,211,231],"level":[48,212,232],"was":[49,71,88,132],"quantified":[50],"using":[51],"qRT-PCR":[52],"cancer":[55,92,107,205,245],"lines":[57,94],"specimens":[61],"from":[62,98],"patients":[63,206],"with":[64,197,207,220,227],"Small":[67],"interfering":[68],"RNA":[69],"(siRNA)":[70],"used":[72],"to":[73,149,225],"investigate":[74],"consequences":[76],"gene":[79,104],"silencing":[80],"vitro":[82,200],"vivo.":[85],"Results:":[86],"expressed":[89],"tissues":[97],"patients.":[99],"Silencing":[100],"decreased":[105],"proliferation,":[109],"migration":[110],"invasion":[112],"vitro.":[114],"In":[115],"orthotopic":[116],"murine":[117],"models":[118],"cancer,":[121],"siRNA":[123,153,165,184],"reduced":[124],"implanted":[127],"tumors":[128,215],"by":[129,134],"60%":[130],"as":[131,262],"evident":[133],"lower":[135,229],"number":[136,179],"smaller":[138],"size":[139],"nodules":[142],"C3-siRNA":[144],"treated":[145,154],"mice":[146,156],"comparison":[148],"those":[150,226],"scrambled":[152,170,188],"control":[155],"(average":[157],"weight":[159],"0.19":[161],"g":[162,168],"vs.":[166,185],"0.61":[167],"siRNA,":[171,189],"n=8":[172,190],"each":[174,192],"group,":[175,193],"p=0.017;":[176],"average":[177],"nodule":[178],"4.4":[181],"11.4":[186],"p=0.05;":[194],"t-test).":[195],"Consistent":[196],"our":[198],"animal":[202],"studies,":[203],"higher":[209],"their":[214],"had":[216],"worse":[218],"prognosis":[219],"overall":[221],"survival":[222],"rates":[223],"compared":[224],"(n=75,":[233],"p=0.03).":[234],"Conclusion:":[235],"Our":[236,255],"studies":[237,256],"revealed":[238],"novel":[240],"role":[241],"for":[242,266,315],"biology.":[246],"Cancer":[247,316,326],"cell-derived":[248],"promotes":[250,298],"progression.":[254],"might":[257],"identify":[258],"new":[264,270],"target":[265],"development":[268],"anti-tumor":[271],"reagents.":[272],"Citation":[273],"Format:":[274],"Min":[275],"Soon":[276],"Cho,":[277],"Hernan":[278],"G.":[279],"Vasquez,":[280],"Hee":[281],"Dong":[282],"Han,":[283],"Sunila":[284],"Pradeep,":[285],"Rajesh":[286],"Rupaimoole,":[287],"Behrouz":[288],"Zand,":[289],"Michael":[290],"Kroll,":[291],"Anil":[292],"K.":[293],"Sood,":[294],"Vahid":[295],"Afshar-Kharghan.":[296],"[abstract].":[303],"In:":[304],"Proceedings":[305],"104th":[308],"Annual":[309],"Meeting":[310],"American":[313],"Association":[314],"Research;":[317],"2013":[318],"Apr":[319],"6-10;":[320],"Washington,":[321],"DC.":[322],"Philadelphia":[323],"(PA):":[324],"AACR;":[325],"Res":[327],"2013;73(8":[328],"Suppl):Abstract":[329],"nr":[330],"4990.":[331],"doi:10.1158/1538-7445.AM2013-4990":[332]},"counts_by_year":[],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2016-06-24T00:00:00"}