{"id":"https://openalex.org/W2314926355","doi":"https://doi.org/10.3181/00379727-143-37452","title":"Growth Hormone Modulation of Liver Drug Metabolic Enzyme Activity in the Rat II. Specificity of the Hormone Effect","display_name":"Growth Hormone Modulation of Liver Drug Metabolic Enzyme Activity in the Rat II. Specificity of the Hormone Effect","publication_year":1973,"publication_date":"1973-09-01","ids":{"openalex":"https://openalex.org/W2314926355","doi":"https://doi.org/10.3181/00379727-143-37452","mag":"2314926355","pmid":"https://pubmed.ncbi.nlm.nih.gov/4743717"},"language":"en","primary_location":{"id":"doi:10.3181/00379727-143-37452","doi":"https://doi.org/10.3181/00379727-143-37452","is_oa":false,"landing_page_url":"https://doi.org/10.3181/00379727-143-37452","pdf_url":null,"source":{"id":"https://openalex.org/S67514239","display_name":"Experimental Biology and Medicine","issn_l":"0071-3384","issn":["0071-3384","1535-3699","1535-3702"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Biology and Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037982412","display_name":"John T. Wilson","orcid":"https://orcid.org/0000-0002-9144-2634","observed_orcids":["https://orcid.org/0000-0002-9144-2634"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J. T. Wilson","raw_affiliation_strings":["Division of Pediatric Clinical Pharmacology, Departments of Pediatrics and Pharmacology, Vanderbilt University, Medical School, Nashville, Tennessee 37232"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Clinical Pharmacology, Departments of Pediatrics and Pharmacology, Vanderbilt University, Medical School, Nashville, Tennessee 37232","institution_ids":["https://openalex.org/I200719446"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5037982412"],"corresponding_institution_ids":["https://openalex.org/I200719446"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":null,"fwci":1.4486,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.82467842,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"143","issue":"4","first_page":"978","last_page":"985"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.5220000147819519,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.5220000147819519,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.45649999380111694,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/growth-hormone","display_name":"growth hormone","score":1.0},{"id":"https://openalex.org/keywords/liver-drug-metabolism","display_name":"liver drug metabolism","score":0.902999997138977},{"id":"https://openalex.org/keywords/cytochrome-p450","display_name":"cytochrome P450","score":0.9369999766349792},{"id":"https://openalex.org/keywords/prolactin","display_name":"prolactin","score":0.8180000185966492},{"id":"https://openalex.org/keywords/human-placental-lactogen","display_name":"human placental lactogen","score":0.9819999933242798},{"id":"https://openalex.org/keywords/hexobarbital-metabolism","display_name":"hexobarbital metabolism","score":0.8379999995231628},{"id":"https://openalex.org/keywords/p-nitrobenzoic-acid","display_name":"p-nitrobenzoic acid","score":0.843999981880188},{"id":"https://openalex.org/keywords/aminopyrine","display_name":"aminopyrine","score":0.9020000100135803},{"id":"https://openalex.org/keywords/microsomal-enzyme-induction","display_name":"microsomal enzyme induction","score":0.6819999814033508},{"id":"https://openalex.org/keywords/hormone-specificity","display_name":"hormone specificity","score":0.6710000038146973}],"concepts":[{"id":"https://openalex.org/C2777466164","wikidata":"https://www.wikidata.org/wiki/Q421183","display_name":"Hexobarbital","level":4,"score":0.8788415193557739},{"id":"https://openalex.org/C2780753045","wikidata":"https://www.wikidata.org/wiki/Q554881","display_name":"Ethylmorphine","level":4,"score":0.8197677135467529},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6789082884788513},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6730575561523438},{"id":"https://openalex.org/C2779064019","wikidata":"https://www.wikidata.org/wiki/Q66590068","display_name":"Prolactin","level":3,"score":0.5767678022384644},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.5629552006721497},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5561076998710632},{"id":"https://openalex.org/C89311334","wikidata":"https://www.wikidata.org/wiki/Q1124842","display_name":"Drug metabolism","level":3,"score":0.5388512015342712},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4149835705757141},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3717155456542969},{"id":"https://openalex.org/C87644729","wikidata":"https://www.wikidata.org/wiki/Q547502","display_name":"Microsome","level":3,"score":0.36921316385269165},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28349268436431885},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2747997045516968},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11074304580688477}],"mesh":[{"descriptor_ui":"D000418","descriptor_name":"Albumins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000814","descriptor_name":"Aniline Compounds","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001565","descriptor_name":"Benzoates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005916","descriptor_name":"Globulins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006591","descriptor_name":"Hexobarbital","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008862","descriptor_name":"Microsomes, Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009020","descriptor_name":"Morphine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009578","descriptor_name":"Nitrobenzenes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010928","descriptor_name":"Placental Lactogen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011388","descriptor_name":"Prolactin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013006","descriptor_name":"Growth Hormone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3181/00379727-143-37452","doi":"https://doi.org/10.3181/00379727-143-37452","is_oa":false,"landing_page_url":"https://doi.org/10.3181/00379727-143-37452","pdf_url":null,"source":{"id":"https://openalex.org/S67514239","display_name":"Experimental Biology and Medicine","issn_l":"0071-3384","issn":["0071-3384","1535-3699","1535-3702"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Biology and Medicine","raw_type":"journal-article"},{"id":"pmid:4743717","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4743717","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1544027667","https://openalex.org/W2080673761","https://openalex.org/W1900302189","https://openalex.org/W2100915119","https://openalex.org/W381953176","https://openalex.org/W2088378533","https://openalex.org/W2005307272","https://openalex.org/W2470881423","https://openalex.org/W2419552449","https://openalex.org/W191796792"],"abstract_inverted_index":{"The":[0,65,137],"specificity":[1],"of":[2,20,62,68,81,91,102,112,119,125,132,139,141,147,153,192,201],"growth":[3],"hormone":[4],"(GH)":[5],"on":[6,143,151],"liver":[7,66,193],"drug":[8,148,194],"metabolic":[9,114],"enzyme":[10],"activity":[11,111],"was":[12,121,127,134],"examined":[13],"by":[14,40],"(a)":[15],"injecting":[16],"rats":[17],"with":[18,43,163,168],"one":[19,117],"three":[21],"hormones":[22],"[GH,":[23],"prolactin,":[24],"or":[25,47,49,167],"human":[26,63],"chorionic":[27],"somatomammotropin":[28],"(HCS)]":[29],"known":[30],"to":[31,57],"have":[32],"similar":[33,54],"structural":[34],"and":[35,38,72,76,79,104,130,150,180],"biological":[36],"characteristics,":[37],"(b)":[39],"treating":[41],"animals":[42],"nonhormonal":[44,165],"polypeptides":[45,166],"(albumin":[46],"globulin)":[48],"an":[50],"amino":[51,59,170],"acid":[52,60,74,171],"mixture":[53],"in":[55,203],"composition":[56],"the":[58,77,94,100,123,144,154,164,169,178,187,204],"content":[61],"GH.":[64,92],"metabolism":[67,124,149,195],"hexobarbital,":[69],"ethylmorphine,":[70],"aniline":[71],"p-nitrobenzoic":[73],"(PNBA)":[75],"rate":[78,146],"extent":[80],"cytochrome":[82,156],"P-450":[83,157],"reduction":[84],"showed":[85],"a":[86,197],"dose-dependent":[87],"decrease":[88,110],"following":[89],"injection":[90],"Boiling":[93],"GH":[95,142,202],"reduced":[96],"its":[97],"effectiveness.":[98],"With":[99],"exception":[101],"ethylmorphine":[103],"PNBA":[105],"metabolism,":[106],"prolactin":[107],"did":[108],"not":[109,160],"this":[113,185],"system.":[115],"When":[116],"dose":[118,179],"HCS":[120],"studied,":[122],"hexobarbital":[126],"slightly":[128,135],"decreased":[129,188],"that":[131],"aminopyrine":[133],"increased.":[136],"spectrum":[138],"effects":[140],"overall":[145],"components":[152],"microsomal":[155],"system":[158],"could":[159],"be":[161],"reproduced":[162],"mixture.":[172],"It":[173],"is":[174,196],"concluded":[175],"that,":[176],"within":[177],"time":[181],"periods":[182],"used":[183],"for":[184],"study,":[186],"steady":[189],"state":[190],"level":[191],"relatively":[198],"specific":[199],"action":[200],"rat.":[205]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}