{"id":"https://openalex.org/W2314819291","doi":"https://doi.org/10.1021/ie3035114","title":"Design of Dynamic Experiments: A Data-Driven Methodology for the Optimization of Time-Varying Processes","display_name":"Design of Dynamic Experiments: A Data-Driven Methodology for the Optimization of Time-Varying Processes","publication_year":2013,"publication_date":"2013-05-03","ids":{"openalex":"https://openalex.org/W2314819291","doi":"https://doi.org/10.1021/ie3035114","mag":"2314819291"},"language":"en","primary_location":{"id":"doi:10.1021/ie3035114","doi":"https://doi.org/10.1021/ie3035114","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ie3035114","pdf_url":null,"source":{"id":"https://openalex.org/S202680183","display_name":"Industrial & Engineering Chemistry Research","issn_l":"0888-5885","issn":["0888-5885","1520-5045"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Industrial &amp; Engineering Chemistry Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065898070","display_name":"Christos Georgakis","orcid":"https://orcid.org/0000-0001-9895-8564","observed_orcids":["https://orcid.org/0000-0001-9895-8564"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christos Georgakis","raw_affiliation_strings":["Department of Chemical and Biological Engineering and Systems Research Institute for Chemical and Biological Processes, Tufts University, Medford, Massachusetts 02155, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biological Engineering and Systems Research Institute for Chemical and Biological Processes, Tufts University, Medford, Massachusetts 02155, United States","institution_ids":["https://openalex.org/I121934306"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5065898070"],"corresponding_institution_ids":["https://openalex.org/I121934306"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":2.9816,"has_fulltext":false,"cited_by_count":77,"citation_normalized_percentile":{"value":0.91228366,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"52","issue":"35","first_page":"12369","last_page":"12382"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11798","display_name":"Optimal Experimental Design Methods","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1803","display_name":"Management Science and Operations Research"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11798","display_name":"Optimal Experimental Design Methods","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1803","display_name":"Management Science and Operations Research"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11053","display_name":"Process Optimization and Integration","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11236","display_name":"Control Systems and Identification","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/process-optimization","display_name":"process optimization","score":0.6299999952316284},{"id":"https://openalex.org/keywords/batch-processes","display_name":"batch processes","score":0.8169999718666077},{"id":"https://openalex.org/keywords/fed-batch-process","display_name":"fed-batch operation","score":0.9580000042915344},{"id":"https://openalex.org/keywords/non-isothermal-reactor","display_name":"non-isothermal reactor","score":0.890999972820282},{"id":"https://openalex.org/keywords/penicillin-fermentation","display_name":"penicillin fermentation","score":0.9909999966621399},{"id":"https://openalex.org/keywords/model-free-optimization","display_name":"model-free optimization","score":0.7160000205039978},{"id":"https://openalex.org/keywords/data-driven-methodology","display_name":"data-driven methodology","score":0.4309999942779541}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6696826219558716},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.6212406754493713},{"id":"https://openalex.org/C34559072","wikidata":"https://www.wikidata.org/wiki/Q2334061","display_name":"Design of experiments","level":2,"score":0.47711852192878723},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.46225446462631226},{"id":"https://openalex.org/C136197465","wikidata":"https://www.wikidata.org/wiki/Q1729295","display_name":"Variety (cybernetics)","level":2,"score":0.4593518078327179},{"id":"https://openalex.org/C172658912","wikidata":"https://www.wikidata.org/wiki/Q661613","display_name":"Batch processing","level":2,"score":0.44775646924972534},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.42484793066978455},{"id":"https://openalex.org/C19768560","wikidata":"https://www.wikidata.org/wiki/Q320727","display_name":"Dependency (UML)","level":2,"score":0.42074254155158997},{"id":"https://openalex.org/C21880701","wikidata":"https://www.wikidata.org/wiki/Q2144042","display_name":"Process engineering","level":1,"score":0.4153371751308441},{"id":"https://openalex.org/C13736549","wikidata":"https://www.wikidata.org/wiki/Q4489420","display_name":"Industrial engineering","level":1,"score":0.3664380609989166},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.15983831882476807},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.11988392472267151},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.1070702075958252},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/ie3035114","doi":"https://doi.org/10.1021/ie3035114","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ie3035114","pdf_url":null,"source":{"id":"https://openalex.org/S202680183","display_name":"Industrial & Engineering Chemistry Research","issn_l":"0888-5885","issn":["0888-5885","1520-5045"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Industrial &amp; Engineering Chemistry Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W566632165","https://openalex.org/W1968312012","https://openalex.org/W1974852879","https://openalex.org/W1976753084","https://openalex.org/W1998664883","https://openalex.org/W2002763634","https://openalex.org/W2014074856","https://openalex.org/W2015256861","https://openalex.org/W2029346132","https://openalex.org/W2033708979","https://openalex.org/W2039477419","https://openalex.org/W2040033809","https://openalex.org/W2056903613","https://openalex.org/W2079255132","https://openalex.org/W2087937190","https://openalex.org/W2100933114","https://openalex.org/W2799326321"],"related_works":["https://openalex.org/W2079255132","https://openalex.org/W3040975771","https://openalex.org/W2801607297","https://openalex.org/W23529327","https://openalex.org/W6903691999","https://openalex.org/W2300929650","https://openalex.org/W2581001771","https://openalex.org/W7204643392","https://openalex.org/W2074200820","https://openalex.org/W3197202130"],"abstract_inverted_index":{"A":[0],"new":[1,113],"methodology":[2],"for":[3],"the":[4,16,29,38,42,82,91,116,138,142,161,164,176,182,190,199],"design":[5],"of":[6,18,21,31,41,56,84,97,118,130,141,163,172,181],"experiments":[7,124,173],"is":[8,76],"presented":[9],"that":[10,58,125,201],"provides":[11],"a":[12,19,32,85,127,155,169,207],"way":[13],"to":[14,80,175],"optimize":[15],"operation":[17],"variety":[20],"batch":[22,151],"and":[23,93,154,178],"semibatch":[24,156],"or":[25,34,46,70,105,146],"fed-batch":[26],"processes":[27,57],"without":[28],"use":[30],"knowledge-driven":[33,86,208],"fundamental":[35],"model":[36,209],"describing":[37],"inner":[39],"workings":[40],"process,":[43],"when":[44],"one":[45],"more":[47],"time-varying":[48],"decision":[49,103,144],"variables":[50,145],"must":[51],"be":[52],"selected.":[53],"The":[54,88,112,184],"types":[55],"can":[59],"benefit":[60],"from":[61,198],"this":[62],"approach":[63,89,193],"include":[64],"those":[65],"producing":[66],"specialty":[67],"chemical,":[68],"pharmaceutical,":[69],"food":[71],"products":[72],"whose":[73],"production":[74],"rate":[75],"not":[77],"high":[78],"enough":[79],"justify":[81],"development":[83],"model.":[87],"generalizes":[90],"classical":[92],"widely":[94],"used":[95],"Design":[96,117],"Experiments":[98,120],"(DoE),":[99],"which":[100,107],"considers":[101],"only":[102,195],"variables,":[104],"factors,":[106],"are":[108,194],"constant":[109],"with":[110],"time.":[111],"approach,":[114],"called":[115,133],"Dynamic":[119],"(DoDE),":[121],"systematically":[122],"designs":[123],"explore":[126],"considerable":[128],"number":[129,171],"dynamic":[131,134],"signatures,":[132],"subfactors":[135],"(DSFs),":[136],"in":[137],"time":[139],"dependency":[140],"unknown":[143],"factors.":[147],"Two":[148],"example":[149],"processes\u2014a":[150],"nonisothermal":[152],"reactor":[153],"penicillin":[157],"fermentation":[158],"process\u2014amply":[159],"demonstrate":[160],"utility":[162],"method.":[165],"In":[166],"both":[167],"cases,":[168],"small":[170],"lead":[174],"quick":[177],"accurate":[179],"optimization":[180],"process.":[183],"calculated":[185],"optimal":[186],"operating":[187],"conditions":[188],"through":[189],"proposed":[191],"DoDE":[192],"slightly":[196],"different":[197],"optimum":[200],"would":[202],"have":[203],"been":[204],"obtained":[205],"if":[206],"were":[210],"available.":[211]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}
