{"id":"https://openalex.org/W2314733893","doi":"https://doi.org/10.1128/iai.00142-16","title":"Role of Host Type IA Phosphoinositide 3-Kinase Pathway Components in Invasin-Mediated Internalization of Yersinia enterocolitica","display_name":"Role of Host Type IA Phosphoinositide 3-Kinase Pathway Components in Invasin-Mediated Internalization of Yersinia enterocolitica","publication_year":2016,"publication_date":"2016-04-12","ids":{"openalex":"https://openalex.org/W2314733893","doi":"https://doi.org/10.1128/iai.00142-16","mag":"2314733893","pmid":"https://pubmed.ncbi.nlm.nih.gov/27068087","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4907137"},"language":"en","primary_location":{"id":"doi:10.1128/iai.00142-16","doi":"https://doi.org/10.1128/iai.00142-16","is_oa":true,"landing_page_url":"https://doi.org/10.1128/iai.00142-16","pdf_url":"https://iai.asm.org/content/iai/84/6/1826.full.pdf","source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://iai.asm.org/content/iai/84/6/1826.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066791617","display_name":"Georgina C. Dowd","orcid":"https://orcid.org/0000-0003-1063-0834","observed_orcids":["https://orcid.org/0000-0003-1063-0834"]},"institutions":[{"id":"https://openalex.org/I80281795","display_name":"University of Otago","ror":"https://ror.org/01jmxt844","country_code":"NZ","type":"education","lineage":["https://openalex.org/I80281795"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Georgina C. Dowd","raw_affiliation_strings":["Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand","institution_ids":["https://openalex.org/I80281795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079826815","display_name":"Manmeet Bhalla","orcid":"https://orcid.org/0000-0001-9382-6538","observed_orcids":["https://orcid.org/0000-0001-9382-6538"]},"institutions":[{"id":"https://openalex.org/I80281795","display_name":"University of Otago","ror":"https://ror.org/01jmxt844","country_code":"NZ","type":"education","lineage":["https://openalex.org/I80281795"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Manmeet Bhalla","raw_affiliation_strings":["Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand","institution_ids":["https://openalex.org/I80281795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022808546","display_name":"Bernard Kean","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I80281795","display_name":"University of Otago","ror":"https://ror.org/01jmxt844","country_code":"NZ","type":"education","lineage":["https://openalex.org/I80281795"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Bernard Kean","raw_affiliation_strings":["Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand","institution_ids":["https://openalex.org/I80281795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041379523","display_name":"Rowan R Thomas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I80281795","display_name":"University of Otago","ror":"https://ror.org/01jmxt844","country_code":"NZ","type":"education","lineage":["https://openalex.org/I80281795"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Rowan Thomas","raw_affiliation_strings":["Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand","institution_ids":["https://openalex.org/I80281795"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002962194","display_name":"Keith Ireton","orcid":"https://orcid.org/0000-0002-9188-1995","observed_orcids":["https://orcid.org/0000-0002-9188-1995"]},"institutions":[{"id":"https://openalex.org/I80281795","display_name":"University of Otago","ror":"https://ror.org/01jmxt844","country_code":"NZ","type":"education","lineage":["https://openalex.org/I80281795"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Keith Ireton","raw_affiliation_strings":["Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand","institution_ids":["https://openalex.org/I80281795"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I80281795"],"apc_list":null,"apc_paid":null,"fwci":2.6849,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.89618558,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"84","issue":"6","first_page":"1826","last_page":"1841"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12232","display_name":"Yersinia bacterium, plague, ectoparasites research","score":0.7250999808311462,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12232","display_name":"Yersinia bacterium, plague, ectoparasites research","score":0.7250999808311462,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.08510000258684158,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.05460000038146973,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/yersinia-enterocolitica","display_name":"Yersinia enterocolitica","score":0.9990000128746033},{"id":"https://openalex.org/keywords/listeria-monocytogenes","display_name":"Listeria monocytogenes","score":0.9879999756813049},{"id":"https://openalex.org/keywords/internalin-b","display_name":"InlB","score":0.753000020980835},{"id":"https://openalex.org/keywords/host-pathogen-interaction","display_name":"host-pathogen interaction","score":0.7049999833106995},{"id":"https://openalex.org/keywords/actin-cytoskeleton-reorganization","display_name":"actin cytoskeleton remodeling","score":0.9549999833106995},{"id":"https://openalex.org/keywords/dock180","display_name":"DOCK180","score":0.8799999952316284},{"id":"https://openalex.org/keywords/focal-adhesion-kinase","display_name":"focal adhesion kinase","score":1.0},{"id":"https://openalex.org/keywords/pld2","display_name":"phospholipase D2","score":0.8999999761581421},{"id":"https://openalex.org/keywords/mtor","display_name":"mTOR","score":0.953000009059906},{"id":"https://openalex.org/keywords/rnai-screen","display_name":"RNAi screen","score":0.652999997138977},{"id":"https://openalex.org/keywords/bacterial-entry-into-host-cells","display_name":"bacterial entry into host cells","score":0.7379999756813049}],"concepts":[{"id":"https://openalex.org/C139770010","wikidata":"https://www.wikidata.org/wiki/Q1339807","display_name":"Internalization","level":3,"score":0.9317501783370972},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7515811920166016},{"id":"https://openalex.org/C2776234502","wikidata":"https://www.wikidata.org/wiki/Q135177","display_name":"Yersinia enterocolitica","level":3,"score":0.6938577890396118},{"id":"https://openalex.org/C2993400109","wikidata":"https://www.wikidata.org/wiki/Q329638","display_name":"Actin cytoskeleton","level":4,"score":0.6580680012702942},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.5981718897819519},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.546369194984436},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.49691441655158997},{"id":"https://openalex.org/C2777353990","wikidata":"https://www.wikidata.org/wiki/Q139928","display_name":"Yersinia pseudotuberculosis","level":4,"score":0.49173668026924133},{"id":"https://openalex.org/C2781217973","wikidata":"https://www.wikidata.org/wiki/Q1644417","display_name":"Shigella flexneri","level":4,"score":0.4893586039543152},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4566257894039154},{"id":"https://openalex.org/C2781350384","wikidata":"https://www.wikidata.org/wiki/Q292015","display_name":"Listeria monocytogenes","level":3,"score":0.454860657453537},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.41958779096603394},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.37871623039245605},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.37745752930641174},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.1380373239517212},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.12491205334663391},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11239320039749146},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.09754970669746399},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.09598714113235474},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.07695797085762024},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06457668542861938}],"mesh":[{"descriptor_ui":"D000081082","descriptor_name":"Phosphoinositide-3 Kinase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008089","descriptor_name":"Listeria monocytogenes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008089","descriptor_name":"Listeria monocytogenes","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D008089","descriptor_name":"Listeria monocytogenes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008841","descriptor_name":"Actin Cytoskeleton","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008841","descriptor_name":"Actin Cytoskeleton","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D008841","descriptor_name":"Actin Cytoskeleton","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010739","descriptor_name":"Phospholipase D","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010739","descriptor_name":"Phospholipase D","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015008","descriptor_name":"Yersinia enterocolitica","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015008","descriptor_name":"Yersinia enterocolitica","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D015008","descriptor_name":"Yersinia enterocolitica","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018829","descriptor_name":"Adhesins, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018829","descriptor_name":"Adhesins, Bacterial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020744","descriptor_name":"rac GTP-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020744","descriptor_name":"rac GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051417","descriptor_name":"Focal Adhesion Kinase 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051417","descriptor_name":"Focal Adhesion Kinase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058543","descriptor_name":"Class Ia Phosphatidylinositol 3-Kinase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D058543","descriptor_name":"Class Ia Phosphatidylinositol 3-Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1128/iai.00142-16","doi":"https://doi.org/10.1128/iai.00142-16","is_oa":true,"landing_page_url":"https://doi.org/10.1128/iai.00142-16","pdf_url":"https://iai.asm.org/content/iai/84/6/1826.full.pdf","source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4907137","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4907137","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infect Immun","raw_type":"Text"},{"id":"pmid:27068087","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27068087","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and immunity","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1128/iai.00142-16","doi":"https://doi.org/10.1128/iai.00142-16","is_oa":true,"landing_page_url":"https://doi.org/10.1128/iai.00142-16","pdf_url":"https://iai.asm.org/content/iai/84/6/1826.full.pdf","source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310371","display_name":"University of Otago","ror":"https://ror.org/01jmxt844"},{"id":"https://openalex.org/F4320325804","display_name":"Lottery Health Research","ror":"https://ror.org/01614jm39"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2314733893.pdf"},"referenced_works_count":96,"referenced_works":["https://openalex.org/W25410375","https://openalex.org/W1428132730","https://openalex.org/W1522122447","https://openalex.org/W1538471627","https://openalex.org/W1911421974","https://openalex.org/W1930235823","https://openalex.org/W1963988270","https://openalex.org/W1964252660","https://openalex.org/W1964562548","https://openalex.org/W1964865474","https://openalex.org/W1964940884","https://openalex.org/W1964954110","https://openalex.org/W1965303438","https://openalex.org/W1967976750","https://openalex.org/W1969063564","https://openalex.org/W1969540615","https://openalex.org/W1972431062","https://openalex.org/W1972452213","https://openalex.org/W1974406469","https://openalex.org/W1975473523","https://openalex.org/W1976642928","https://openalex.org/W1980943505","https://openalex.org/W1984422003","https://openalex.org/W1984821034","https://openalex.org/W1988243126","https://openalex.org/W1990130046","https://openalex.org/W1991340429","https://openalex.org/W1992732876","https://openalex.org/W1993159760","https://openalex.org/W1994668150","https://openalex.org/W1995785411","https://openalex.org/W1997103512","https://openalex.org/W1999828450","https://openalex.org/W2002047195","https://openalex.org/W2002822654","https://openalex.org/W2004934164","https://openalex.org/W2007889492","https://openalex.org/W2009826571","https://openalex.org/W2009886463","https://openalex.org/W2011337290","https://openalex.org/W2018060049","https://openalex.org/W2019031014","https://openalex.org/W2019284054","https://openalex.org/W2021168925","https://openalex.org/W2023035638","https://openalex.org/W2033883874","https://openalex.org/W2034584476","https://openalex.org/W2037771970","https://openalex.org/W2039185825","https://openalex.org/W2042181517","https://openalex.org/W2043312574","https://openalex.org/W2044025320","https://openalex.org/W2044895919","https://openalex.org/W2046826693","https://openalex.org/W2047401805","https://openalex.org/W2048825955","https://openalex.org/W2049699990","https://openalex.org/W2059013355","https://openalex.org/W2060589715","https://openalex.org/W2069121608","https://openalex.org/W2070264872","https://openalex.org/W2075763483","https://openalex.org/W2076197679","https://openalex.org/W2076202013","https://openalex.org/W2078223360","https://openalex.org/W2081143487","https://openalex.org/W2081646428","https://openalex.org/W2082000147","https://openalex.org/W2086178673","https://openalex.org/W2087919267","https://openalex.org/W2096944866","https://openalex.org/W2098482477","https://openalex.org/W2098964008","https://openalex.org/W2099061568","https://openalex.org/W2100265489","https://openalex.org/W2102228176","https://openalex.org/W2103162157","https://openalex.org/W2106793145","https://openalex.org/W2111238561","https://openalex.org/W2112425640","https://openalex.org/W2114918609","https://openalex.org/W2114967795","https://openalex.org/W2123179262","https://openalex.org/W2124593509","https://openalex.org/W2125073987","https://openalex.org/W2125106648","https://openalex.org/W2126920695","https://openalex.org/W2127063807","https://openalex.org/W2127249665","https://openalex.org/W2131152565","https://openalex.org/W2148443839","https://openalex.org/W2148707237","https://openalex.org/W2164443997","https://openalex.org/W2167962815","https://openalex.org/W2168721537","https://openalex.org/W2171716204"],"related_works":["https://openalex.org/W637957721","https://openalex.org/W1994852714","https://openalex.org/W2042181517","https://openalex.org/W2033883874","https://openalex.org/W2112425640","https://openalex.org/W2089626761","https://openalex.org/W2081646428","https://openalex.org/W2170938180","https://openalex.org/W1995785411","https://openalex.org/W2785722598"],"abstract_inverted_index":{"Many":[0],"bacterial":[1],"pathogens":[2,36],"subvert":[3],"mammalian":[4],"type":[5,31,55],"IA":[6,32,56],"phosphoinositide":[7],"3-kinase":[8],"(PI3K)":[9],"in":[10,60],"order":[11],"to":[12,50,142],"induce":[13],"their":[14],"internalization":[15,22,170,202],"into":[16],"host":[17,182],"cells.":[18],"How":[19],"PI3K":[20,33,57,115,198],"promotes":[21],"is":[23,29],"not":[24],"well":[25],"understood.":[26],"Also":[27],"unclear":[28],"whether":[30],"affects":[34],"different":[35],"through":[37],"similar":[38,87],"or":[39,81],"distinct":[40],"mechanisms.":[41],"Here,":[42],"we":[43],"performed":[44,92],"an":[45,66],"RNA":[46],"interference":[47],"(RNAi)-based":[48],"screen":[49,89,103],"identify":[51,180],"components":[52,200],"of":[53,63,84,101,113,123,144,157,164,175,197,203],"the":[54,94,102,114,158,165,189],"pathway":[58,116,199],"involved":[59],"invasin-mediated":[61,120],"entry":[62,174],"Yersinia":[64],"enterocolitica,":[65],"enteropathogen":[67],"that":[68,108,184,194],"causes":[69],"enteritis":[70],"and":[71,136,151,192,207],"lymphadenitis.":[72],"The":[73,99],"69":[74],"genes":[75],"targeted":[76],"encode":[77],"known":[78],"upstream":[79],"regulators":[80],"downstream":[82],"effectors":[83],"PI3K.":[85],"A":[86],"RNAi":[88],"was":[90],"previously":[91],"with":[93,104],"food-borne":[95],"bacterium":[96],"Listeria":[97],"monocytogenes":[98,177],"results":[100,179],"Y.":[105,205],"enterocolitica":[106,206],"indicate":[107,193],"at":[109],"least":[110],"nine":[111],"members":[112],"are":[117],"needed":[118],"for":[119,155],"entry.":[121,145,162],"Several":[122],"these":[124],"proteins,":[125],"including":[126],"centaurin-\u03b11,":[127,148],"Dock180,":[128],"focal":[129],"adhesion":[130],"kinase":[131],"(FAK),":[132],"Grp1,":[133],"LL5\u03b1,":[134],"LL5\u03b2,":[135],"PLD2":[137],"(phospholipase":[138],"D2),":[139],"were":[140,153],"recruited":[141],"sites":[143],"In":[146],"addition,":[147],"FAK,":[149],"PLD2,":[150],"mTOR":[152],"required":[154],"remodeling":[156],"actin":[159,190],"cytoskeleton":[160,191],"during":[161],"Six":[163],"human":[166],"proteins":[167,183],"affecting":[168],"invasin-dependent":[169],"also":[171],"promote":[172,201],"InlB-mediated":[173],"L.":[176,208],"Our":[178],"several":[181],"mediate":[185],"invasin-induced":[186],"effects":[187],"on":[188],"a":[195],"subset":[196],"both":[204],"monocytogenes.":[209]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}