{"id":"https://openalex.org/W2314036203","doi":"https://doi.org/10.15380/2277-5706.jcsr.13.070","title":"Deoxyribonucleic acid (DNA) methylation and its impact in generation of cancer","display_name":"Deoxyribonucleic acid (DNA) methylation and its impact in generation of cancer","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2314036203","doi":"https://doi.org/10.15380/2277-5706.jcsr.13.070","mag":"2314036203"},"language":"en","primary_location":{"id":"doi:10.15380/2277-5706.jcsr.13.070","doi":"https://doi.org/10.15380/2277-5706.jcsr.13.070","is_oa":true,"landing_page_url":"https://doi.org/10.15380/2277-5706.jcsr.13.070","pdf_url":null,"source":{"id":"https://openalex.org/S2764498497","display_name":"The Journal of Clinical and Scientific Research","issn_l":"2277-5706","issn":["2277-5706","2277-8357"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical and Scientific Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.15380/2277-5706.jcsr.13.070","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046041605","display_name":"Jithine Jayakumar Rajeswari","orcid":"https://orcid.org/0000-0002-7421-391X","observed_orcids":["https://orcid.org/0000-0002-7421-391X"]},"institutions":[{"id":"https://openalex.org/I177001074","display_name":"Acharya Nagarjuna University","ror":"https://ror.org/02mfapa96","country_code":"IN","type":"education","lineage":["https://openalex.org/I177001074"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"J Rajeswari","raw_affiliation_strings":["Acharya Nagarjuna University, Guntur"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acharya Nagarjuna University, Guntur","institution_ids":["https://openalex.org/I177001074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083484116","display_name":"G. P. Chakravarthi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177001074","display_name":"Acharya Nagarjuna University","ror":"https://ror.org/02mfapa96","country_code":"IN","type":"education","lineage":["https://openalex.org/I177001074"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"GP Chakravarthi","raw_affiliation_strings":["Acharya Nagarjuna University, Guntur"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acharya Nagarjuna University, Guntur","institution_ids":["https://openalex.org/I177001074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I177001074"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"3","issue":"3","first_page":"181","last_page":"181"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11928","display_name":"Genetic Syndromes and Imprinting","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":1.0},{"id":"https://openalex.org/keywords/epigenetics","display_name":"epigenetics","score":0.7599999904632568},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.6549999713897705},{"id":"https://openalex.org/keywords/cpg-dinucleotides","display_name":"CpG","score":0.8600000143051147},{"id":"https://openalex.org/keywords/promoter-hypermethylation","display_name":"promoter hypermethylation","score":0.8740000128746033},{"id":"https://openalex.org/keywords/global-hypomethylation","display_name":"global hypomethylation","score":0.8159999847412109},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.9850000143051147},{"id":"https://openalex.org/keywords/dna-methylation-inhibitors","display_name":"DNA methylation inhibitors","score":0.746999979019165},{"id":"https://openalex.org/keywords/epigenetic-therapy","display_name":"epigenetic therapy","score":0.8650000095367432},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.578000009059906}],"concepts":[{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.8062047958374023},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6777673363685608},{"id":"https://openalex.org/C114691636","wikidata":"https://www.wikidata.org/wiki/Q5031434","display_name":"Cancer epigenetics","level":5,"score":0.6164351105690002},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.6086646914482117},{"id":"https://openalex.org/C37080517","wikidata":"https://www.wikidata.org/wiki/Q18353747","display_name":"Epigenetics of physical exercise","level":5,"score":0.5590396523475647},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5249635577201843},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5137554407119751},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.498349666595459},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.48474904894828796},{"id":"https://openalex.org/C163002167","wikidata":"https://www.wikidata.org/wiki/Q7277124","display_name":"RNA-Directed DNA Methylation","level":5,"score":0.47718966007232666},{"id":"https://openalex.org/C136953436","wikidata":"https://www.wikidata.org/wiki/Q6000286","display_name":"Illumina Methylation Assay","level":5,"score":0.4729727804660797},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4456920921802521},{"id":"https://openalex.org/C2776023528","wikidata":"https://www.wikidata.org/wiki/Q178425","display_name":"Cytosine","level":3,"score":0.43597516417503357},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4106462001800537},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34683874249458313},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3334158957004547},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1533273160457611}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.15380/2277-5706.jcsr.13.070","doi":"https://doi.org/10.15380/2277-5706.jcsr.13.070","is_oa":true,"landing_page_url":"https://doi.org/10.15380/2277-5706.jcsr.13.070","pdf_url":null,"source":{"id":"https://openalex.org/S2764498497","display_name":"The Journal of Clinical and Scientific Research","issn_l":"2277-5706","issn":["2277-5706","2277-8357"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical and Scientific Research","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:3118a4ede3ff42ed8216b276605678ec","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3118a4ede3ff42ed8216b276605678ec","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Clinical and Scientific Research, Vol 3, Iss 3, Pp 181-187 (2014)","raw_type":"article"},{"id":"mag:2189101461","doi":null,"is_oa":false,"landing_page_url":"https://svimstpt.ap.nic.in/jcsr/jul-sep14_files/ra314.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.15380/2277-5706.jcsr.13.070","doi":"https://doi.org/10.15380/2277-5706.jcsr.13.070","is_oa":true,"landing_page_url":"https://doi.org/10.15380/2277-5706.jcsr.13.070","pdf_url":null,"source":{"id":"https://openalex.org/S2764498497","display_name":"The Journal of Clinical and Scientific Research","issn_l":"2277-5706","issn":["2277-5706","2277-8357"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical and Scientific Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W1482289695","https://openalex.org/W1522855936","https://openalex.org/W1528728961","https://openalex.org/W1531766774","https://openalex.org/W1554775680","https://openalex.org/W1556996865","https://openalex.org/W1558122435","https://openalex.org/W1607145333","https://openalex.org/W1652583010","https://openalex.org/W1732253485","https://openalex.org/W1821797507","https://openalex.org/W1910957402","https://openalex.org/W1973759523","https://openalex.org/W1978419388","https://openalex.org/W1984004239","https://openalex.org/W1995585583","https://openalex.org/W1997986614","https://openalex.org/W2009121506","https://openalex.org/W2015888582","https://openalex.org/W2025797510","https://openalex.org/W2039687299","https://openalex.org/W2048640680","https://openalex.org/W2054823635","https://openalex.org/W2055171335","https://openalex.org/W2057089696","https://openalex.org/W2058112748","https://openalex.org/W2058203909","https://openalex.org/W2060446375","https://openalex.org/W2061578142","https://openalex.org/W2066022960","https://openalex.org/W2070484728","https://openalex.org/W2071298219","https://openalex.org/W2072337838","https://openalex.org/W2076619054","https://openalex.org/W2080620002","https://openalex.org/W2084118479","https://openalex.org/W2096330673","https://openalex.org/W2099189400","https://openalex.org/W2103007980","https://openalex.org/W2107972234","https://openalex.org/W2112481194","https://openalex.org/W2121417064","https://openalex.org/W2130808015","https://openalex.org/W2142711018","https://openalex.org/W2144806790","https://openalex.org/W2147003974","https://openalex.org/W2148882352","https://openalex.org/W2149858761","https://openalex.org/W2158526038","https://openalex.org/W2160195772","https://openalex.org/W2175849508","https://openalex.org/W2182746672","https://openalex.org/W2335568766","https://openalex.org/W2914618148","https://openalex.org/W4210997484","https://openalex.org/W4237365353","https://openalex.org/W6631800413","https://openalex.org/W6633317617","https://openalex.org/W6683500250"],"related_works":["https://openalex.org/W2189101461","https://openalex.org/W7100097110","https://openalex.org/W2053823503","https://openalex.org/W2147003974","https://openalex.org/W2319765741","https://openalex.org/W2000879435","https://openalex.org/W1831033366","https://openalex.org/W2603566939","https://openalex.org/W2132894713","https://openalex.org/W2289569940"],"abstract_inverted_index":{"The":[0],"arrangement":[1],"of":[2,19,60,68,79,84,95],"genes":[3,72],"in":[4,50,76,92],"the":[5,29,34,65,69,93],"chromosome":[6],"is":[7],"dependent":[8],"on":[9],"histone":[10],"modifications,":[11],"deoxyribonucleic":[12],"acid":[13],"(DNA)":[14],"binding":[15],"proteins":[16],"and":[17,39,53,62],"methylation":[18,26,86],"cytosines":[20],"within":[21],"51\u2013cytosine-phosphate-Guanine\u201331":[22],"(CpG)":[23],"dinucleotides.":[24],"DNA":[25,85],"can":[27],"modify":[28],"gene":[30,35,44],"activity":[31],"without":[32],"changing":[33],"sequence.":[36],"Aberrant":[37],"hypomethylation":[38,56],"hypermethylations,":[40],"causal":[41],"or":[42,82],"heritable":[43],"expressions":[45],"play":[46],"an":[47],"important":[48],"role":[49],"tumour":[51,70],"initiation":[52],"progression.":[54],"Global":[55],"at":[57,64],"some":[58],"part":[59],"genome":[61],"hypermethylation":[63],"promoter":[66],"regions":[67],"suppressor":[71],"could":[73],"generate":[74],"mutations":[75],"several":[77],"types":[78],"cancers.":[80],"Reversal":[81],"inhibition":[83],"mechanism":[87],"provides":[88],"a":[89,115],"promising":[90],"improvement":[91],"treatment":[94,105],"cancer":[96],"along":[97,106],"with":[98,107],"chemotherapy.":[99],"A":[100],"combined":[101],"approach":[102],"utilising":[103],"epigenetic":[104],"standard":[108],"chemotherapy":[109],"appears":[110],"to":[111],"hold":[112],"promise":[113],"as":[114],"future":[116],"therapy.":[117]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}