{"id":"https://openalex.org/W2313974235","doi":"https://doi.org/10.1177/000348940010900304","title":"Distribution and Location of Immunoreactive Atrial Natriuretic Peptides in Middle Ear Mucosa of Guinea Pig","display_name":"Distribution and Location of Immunoreactive Atrial Natriuretic Peptides in Middle Ear Mucosa of Guinea Pig","publication_year":2000,"publication_date":"2000-03-01","ids":{"openalex":"https://openalex.org/W2313974235","doi":"https://doi.org/10.1177/000348940010900304","mag":"2313974235","pmid":"https://pubmed.ncbi.nlm.nih.gov/10737307"},"language":"en","primary_location":{"id":"doi:10.1177/000348940010900304","doi":"https://doi.org/10.1177/000348940010900304","is_oa":false,"landing_page_url":"https://doi.org/10.1177/000348940010900304","pdf_url":null,"source":{"id":"https://openalex.org/S174332447","display_name":"Annals of Otology Rhinology & Laryngology","issn_l":"0003-4894","issn":["0003-4894","1943-572X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Otology, Rhinology & Laryngology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114375978","display_name":"Hexin Chen","orcid":"https://orcid.org/0000-0001-9300-0859","observed_orcids":["https://orcid.org/0000-0001-9300-0859"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Hexin Chen","raw_affiliation_strings":["Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangzhou, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5114375978"],"corresponding_institution_ids":[],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.21278912,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"109","issue":"3","first_page":"258","last_page":"261"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10861","display_name":"Ear Surgery and Otitis Media","score":0.42289999127388,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10861","display_name":"Ear Surgery and Otitis Media","score":0.42289999127388,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.2969000041484833,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.06679999828338623,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atrial-natriuretic-peptide","display_name":"atrial natriuretic peptide","score":1.0},{"id":"https://openalex.org/keywords/middle-ear-mucosa","display_name":"middle ear mucosa","score":0.9900000095367432},{"id":"https://openalex.org/keywords/anp-secretion","display_name":"ANP secretion","score":0.671999990940094},{"id":"https://openalex.org/keywords/capillary-endothelium","display_name":"capillary endothelium","score":0.7229999899864197},{"id":"https://openalex.org/keywords/guinea-pig","display_name":"guinea pig","score":0.7129999995231628},{"id":"https://openalex.org/keywords/immunoelectron-microscopy","display_name":"immunoelectron microscopy","score":0.6129999756813049},{"id":"https://openalex.org/keywords/immunocytochemistry","display_name":"immunocytochemistry","score":0.8579999804496765}],"concepts":[{"id":"https://openalex.org/C35866371","wikidata":"https://www.wikidata.org/wiki/Q6005502","display_name":"Immunocytochemistry","level":2,"score":0.7775160074234009},{"id":"https://openalex.org/C2778069365","wikidata":"https://www.wikidata.org/wiki/Q78185357","display_name":"Atrial natriuretic peptide","level":2,"score":0.688573956489563},{"id":"https://openalex.org/C2778815084","wikidata":"https://www.wikidata.org/wiki/Q79803","display_name":"Guinea pig","level":2,"score":0.6537363529205322},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5527422428131104},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46691134572029114},{"id":"https://openalex.org/C93877712","wikidata":"https://www.wikidata.org/wiki/Q132560","display_name":"Electron microscope","level":2,"score":0.4385085701942444},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.37527039647102356},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.36787527799606323},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.36446183919906616},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3302910327911377},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.32012081146240234},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15167823433876038},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.09476298093795776},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.08459627628326416}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004432","descriptor_name":"Ear, Middle","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004432","descriptor_name":"Ear, Middle","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009092","descriptor_name":"Mucous Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009092","descriptor_name":"Mucous Membrane","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D009320","descriptor_name":"Atrial Natriuretic Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1177/000348940010900304","doi":"https://doi.org/10.1177/000348940010900304","is_oa":false,"landing_page_url":"https://doi.org/10.1177/000348940010900304","pdf_url":null,"source":{"id":"https://openalex.org/S174332447","display_name":"Annals of Otology Rhinology & Laryngology","issn_l":"0003-4894","issn":["0003-4894","1943-572X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Otology, Rhinology & Laryngology","raw_type":"journal-article"},{"id":"pmid:10737307","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10737307","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Annals of otology, rhinology, and laryngology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W155013205","https://openalex.org/W1969348779","https://openalex.org/W2037065013","https://openalex.org/W2057969526","https://openalex.org/W2076856388","https://openalex.org/W2397147490","https://openalex.org/W2460727173"],"related_works":["https://openalex.org/W2066789300","https://openalex.org/W2105528465","https://openalex.org/W2051298926","https://openalex.org/W3145325763","https://openalex.org/W2011138809","https://openalex.org/W2401061416","https://openalex.org/W3114787322","https://openalex.org/W1977160389","https://openalex.org/W2039800312","https://openalex.org/W2398367084"],"abstract_inverted_index":{"The":[0,51,84],"distribution":[1],"and":[2,25,39],"location":[3],"of":[4,15,31,48,61,77,86,96,108],"atrial":[5],"natriuretic":[6],"peptides":[7],"(ANP)":[8],"in":[9,45,57,82,111],"the":[10,46,49,58,62,69,91,94,102,106,112],"middle":[11],"ear":[12],"mucosa":[13],"(MEM)":[14],"guinea":[16],"pigs":[17],"were":[18],"studied":[19],"with":[20],"immunocytochemistry":[21],"(avidin-biotin-peroxidase":[22],"complex":[23],"method)":[24],"immuno-electron":[26,67],"microscopy.":[27],"A":[28],"great":[29],"quantity":[30],"ANP-immunoreactive":[32],"(ANP-IR)":[33],"cells,":[34,42],"including":[35],"oval":[36],"small":[37],"cells":[38],"irregular":[40],"large":[41],"was":[43,55,72],"observed":[44,56],"tissue":[47],"MEM.":[50,113],"strong":[52],"ANP-IR":[53,70],"product":[54,71],"inner":[59],"membrane":[60],"partial":[63],"capillary":[64],"walls.":[65],"Under":[66],"microscopy,":[68],"found":[73],"to":[74,79],"be":[75],"spheres":[76],"250":[78],"350":[80],"nm":[81],"diameter.":[83],"results":[85],"this":[87],"study":[88,107],"suggest":[89],"that":[90],"MEM":[92],"has":[93],"function":[95,110],"secreting":[97],"ANP.":[98],"This":[99],"paper":[100],"provides":[101],"morphological":[103],"basis":[104],"for":[105],"ANP's":[109]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}