{"id":"https://openalex.org/W2313757396","doi":"https://doi.org/10.1016/j.ijid.2012.05.061","title":"Co-infection with Mycobacterium tuberculosis impairs HIV-specific CD8+ and CD4+ T cell functionality","display_name":"Co-infection with Mycobacterium tuberculosis impairs HIV-specific CD8+ and CD4+ T cell functionality","publication_year":2012,"publication_date":"2012-06-01","ids":{"openalex":"https://openalex.org/W2313757396","doi":"https://doi.org/10.1016/j.ijid.2012.05.061","mag":"2313757396"},"language":"en","primary_location":{"id":"doi:10.1016/j.ijid.2012.05.061","doi":"https://doi.org/10.1016/j.ijid.2012.05.061","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ijid.2012.05.061","pdf_url":null,"source":{"id":"https://openalex.org/S35071406","display_name":"International Journal of Infectious Diseases","issn_l":"1201-9712","issn":["1201-9712","1878-3511"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.ijid.2012.05.061","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059261770","display_name":"Senica Chetty","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["ZA"],"is_corresponding":true,"raw_author_name":"S. Chetty","raw_affiliation_strings":["University of KwaZulu-Natal, Durban, KZN, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of KwaZulu-Natal, Durban, KZN, South Africa","institution_ids":["https://openalex.org/I95023434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084318417","display_name":"Filippos Porichis","orcid":"https://orcid.org/0000-0002-6345-9316","observed_orcids":["https://orcid.org/0000-0002-6345-9316"]},"institutions":[{"id":"https://openalex.org/I2802422659","display_name":"Ragon Institute of MGH, MIT and Harvard","ror":"https://ror.org/053r20n13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I2802422659","https://openalex.org/I4210087915","https://openalex.org/I48633490","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F. Porichis","raw_affiliation_strings":["The Ragon Institute of MGH,MIT and Harvard, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ragon Institute of MGH,MIT and Harvard, Boston, MA, USA","institution_ids":["https://openalex.org/I2802422659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011051247","display_name":"Patrick Govender","orcid":"https://orcid.org/0000-0002-9131-590X","observed_orcids":["https://orcid.org/0000-0002-9131-590X"]},"institutions":[{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"P. Govender","raw_affiliation_strings":["University of KwaZulu-Natal, Durban, KZN, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of KwaZulu-Natal, Durban, KZN, South Africa","institution_ids":["https://openalex.org/I95023434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007398409","display_name":"Jennifer Zupkosky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802422659","display_name":"Ragon Institute of MGH, MIT and Harvard","ror":"https://ror.org/053r20n13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I2802422659","https://openalex.org/I4210087915","https://openalex.org/I48633490","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Zupkosky","raw_affiliation_strings":["The Ragon Institute of MGH,MIT and Harvard, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ragon Institute of MGH,MIT and Harvard, Boston, MA, USA","institution_ids":["https://openalex.org/I2802422659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081455404","display_name":"Manormoney Pillay","orcid":"https://orcid.org/0000-0002-0253-479X","observed_orcids":["https://orcid.org/0000-0002-0253-479X"]},"institutions":[{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"M. Pillay","raw_affiliation_strings":["University of KwaZulu-Natal, Durban, KZN, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of KwaZulu-Natal, Durban, KZN, South Africa","institution_ids":["https://openalex.org/I95023434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016518899","display_name":"Bruce D. Walker","orcid":"https://orcid.org/0000-0001-6122-9245","observed_orcids":["https://orcid.org/0000-0001-6122-9245","https://orcid.org/0000-0002-8506-6740"]},"institutions":[{"id":"https://openalex.org/I2802422659","display_name":"Ragon Institute of MGH, MIT and Harvard","ror":"https://ror.org/053r20n13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I2802422659","https://openalex.org/I4210087915","https://openalex.org/I48633490","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. Walker","raw_affiliation_strings":["The Ragon Institute of MGH,MIT and Harvard, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ragon Institute of MGH,MIT and Harvard, Boston, MA, USA","institution_ids":["https://openalex.org/I2802422659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040954811","display_name":"Thumbi Ndung\u2019u","orcid":"https://orcid.org/0000-0003-2962-3992","observed_orcids":["https://orcid.org/0000-0003-2962-3992"]},"institutions":[{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"T. Ndung\u2019u","raw_affiliation_strings":["University of KwaZulu-Natal, Durban, KZN, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of KwaZulu-Natal, Durban, KZN, South Africa","institution_ids":["https://openalex.org/I95023434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078444774","display_name":"DE Kaufmann","orcid":"https://orcid.org/0000-0003-4467-136X","observed_orcids":["https://orcid.org/0000-0003-4467-136X"]},"institutions":[{"id":"https://openalex.org/I2802422659","display_name":"Ragon Institute of MGH, MIT and Harvard","ror":"https://ror.org/053r20n13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I2802422659","https://openalex.org/I4210087915","https://openalex.org/I48633490","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Kaufmann","raw_affiliation_strings":["The Ragon Institute of MGH,MIT and Harvard, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ragon Institute of MGH,MIT and Harvard, Boston, MA, USA","institution_ids":["https://openalex.org/I2802422659"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024073579","display_name":"Victoria O Kasprowicz","orcid":"https://orcid.org/0000-0001-8518-0458","observed_orcids":["https://orcid.org/0000-0001-8518-0458"]},"institutions":[{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"V. Kasprowicz","raw_affiliation_strings":["University of KwaZulu-Natal, Durban, KZN, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of KwaZulu-Natal, Durban, KZN, South Africa","institution_ids":["https://openalex.org/I95023434"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5059261770"],"corresponding_institution_ids":["https://openalex.org/I95023434"],"apc_list":{"value":2900,"currency":"USD","value_usd":2900},"apc_paid":{"value":2900,"currency":"USD","value_usd":2900},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.23707957,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":null,"first_page":"e23","last_page":"e23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.513700008392334,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.513700008392334,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.44290000200271606,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":0.03150000050663948,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tuberculosis-hiv-co-infection","display_name":"tuberculosis-HIV coinfection","score":0.7940000295639038},{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hiv-specific-t-cells","display_name":"HIV-specific T cells","score":0.9210000038146973},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9860000014305115},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":1.0},{"id":"https://openalex.org/keywords/t-cell-function","display_name":"T cell function","score":0.777999997138977},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.871999979019165},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.6129999756813049}],"concepts":[{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.7414963841438293},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.7037391662597656},{"id":"https://openalex.org/C2779053233","wikidata":"https://www.wikidata.org/wiki/Q731235","display_name":"ELISPOT","level":4,"score":0.7028040289878845},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6889341473579407},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.6740261316299438},{"id":"https://openalex.org/C2776301714","wikidata":"https://www.wikidata.org/wiki/Q259346","display_name":"Sputum","level":3,"score":0.5894410610198975},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5146394968032837},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.4360637962818146},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.43501460552215576},{"id":"https://openalex.org/C2779806340","wikidata":"https://www.wikidata.org/wiki/Q4254929","display_name":"Latent tuberculosis","level":4,"score":0.41813924908638},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4133613109588623},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.317399799823761},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.05874451994895935}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.ijid.2012.05.061","doi":"https://doi.org/10.1016/j.ijid.2012.05.061","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ijid.2012.05.061","pdf_url":null,"source":{"id":"https://openalex.org/S35071406","display_name":"International Journal of Infectious Diseases","issn_l":"1201-9712","issn":["1201-9712","1878-3511"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Infectious Diseases","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.ijid.2012.05.061","doi":"https://doi.org/10.1016/j.ijid.2012.05.061","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ijid.2012.05.061","pdf_url":null,"source":{"id":"https://openalex.org/S35071406","display_name":"International Journal of Infectious Diseases","issn_l":"1201-9712","issn":["1201-9712","1878-3511"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Infectious Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2904701318","https://openalex.org/W4392865292","https://openalex.org/W1972401985","https://openalex.org/W2740017267","https://openalex.org/W1486000687","https://openalex.org/W2097204706","https://openalex.org/W2342527492","https://openalex.org/W2029751486","https://openalex.org/W2563731287","https://openalex.org/W4391914909"],"abstract_inverted_index":{"Background:":[0],"The":[1,39],"ability":[2],"of":[3,17,36,41,49],"antigen-specific":[4],"T":[5,54],"cells":[6],"to":[7,32,45],"simultaneously":[8],"produce":[9],"multiple":[10],"cytokines":[11],"has":[12],"been":[13],"associated":[14],"with":[15,24],"control":[16],"HIV":[18,25],"and":[19,26],"tuberculosis":[20,28],"(TB).":[21],"Dual":[22],"infection":[23,51],"Mycobacterium":[27],"(MTB)":[29],"is":[30],"thought":[31],"increase":[33],"disease":[34],"progression":[35],"both":[37],"diseases.":[38],"aim":[40],"this":[42],"study":[43],"was":[44],"assess":[46],"the":[47],"impact":[48],"MTB":[50],"on":[52],"HIV-specific":[53],"cell":[55],"functionality.":[56]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}
