{"id":"https://openalex.org/W2313699666","doi":"https://doi.org/10.1055/s-2004-833121","title":"Multimodale Bildgebung verbessert die pr\u00e4chirurgische Diagnostik (3 T MRT, 3 T DTI, automatisierte quantitative Analysemethoden, 306-channel MEG und EEG) von Patienten mit fokalen Epilepsien - eine prospektive Studie mit 70 Patienten","display_name":"Multimodale Bildgebung verbessert die pr\u00e4chirurgische Diagnostik (3 T MRT, 3 T DTI, automatisierte quantitative Analysemethoden, 306-channel MEG und EEG) von Patienten mit fokalen Epilepsien - eine prospektive Studie mit 70 Patienten","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W2313699666","doi":"https://doi.org/10.1055/s-2004-833121","mag":"2313699666"},"language":"de","primary_location":{"id":"doi:10.1055/s-2004-833121","doi":"https://doi.org/10.1055/s-2004-833121","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2004-833121","pdf_url":null,"source":{"id":"https://openalex.org/S48308836","display_name":"Aktuelle Neurologie","issn_l":"0302-4350","issn":["0302-4350","1438-9428"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aktuelle Neurologie","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015701509","display_name":"Susanne Knake","orcid":"https://orcid.org/0000-0002-6298-0513","observed_orcids":["https://orcid.org/0000-0002-6298-0513"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Knake","raw_affiliation_strings":["(Marburg; Boston, USA)","(Marburg","Boston, USA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(Marburg; Boston, USA)","institution_ids":[]},{"raw_affiliation_string":"(Marburg","institution_ids":[]},{"raw_affiliation_string":"Boston, USA)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069652684","display_name":"Patricia Ellen Grant","orcid":"https://orcid.org/0000-0003-1005-4013","observed_orcids":["https://orcid.org/0000-0003-1005-4013"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"PE Grant","raw_affiliation_strings":["(Marburg; Boston, USA)","(Marburg","Boston, USA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(Marburg; Boston, USA)","institution_ids":[]},{"raw_affiliation_string":"(Marburg","institution_ids":[]},{"raw_affiliation_string":"Boston, USA)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020315656","display_name":"Steven M. Stufflebeam","orcid":"https://orcid.org/0000-0002-7011-5212","observed_orcids":["https://orcid.org/0000-0002-7011-5212"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Stufflebeam","raw_affiliation_strings":["(Marburg; Boston, USA)","(Marburg","Boston, USA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(Marburg; Boston, USA)","institution_ids":[]},{"raw_affiliation_string":"(Marburg","institution_ids":[]},{"raw_affiliation_string":"Boston, USA)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101417476","display_name":"Hideaki Shiraishi","orcid":"https://orcid.org/0000-0003-4199-0728","observed_orcids":["https://orcid.org/0000-0003-4199-0728"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Shiraishi","raw_affiliation_strings":["(Marburg; Boston, USA)","(Marburg","Boston, USA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(Marburg; Boston, USA)","institution_ids":[]},{"raw_affiliation_string":"(Marburg","institution_ids":[]},{"raw_affiliation_string":"Boston, USA)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005761034","display_name":"Lawrence L. Wald","orcid":"https://orcid.org/0000-0001-8278-6307","observed_orcids":["https://orcid.org/0000-0001-8278-6307"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Wald","raw_affiliation_strings":["(Marburg; Boston, USA)","(Marburg","Boston, USA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(Marburg; Boston, USA)","institution_ids":[]},{"raw_affiliation_string":"(Marburg","institution_ids":[]},{"raw_affiliation_string":"Boston, USA)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074086023","display_name":"David H. Salat","orcid":"https://orcid.org/0000-0002-2246-9657","observed_orcids":["https://orcid.org/0000-0002-2246-9657"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Salat","raw_affiliation_strings":["(Marburg; Boston, USA)","(Marburg","Boston, USA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(Marburg; Boston, USA)","institution_ids":[]},{"raw_affiliation_string":"(Marburg","institution_ids":[]},{"raw_affiliation_string":"Boston, USA)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027685710","display_name":"David S. Tuch","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Tuch","raw_affiliation_strings":["(Marburg; Boston, USA)","(Marburg","Boston, USA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(Marburg; Boston, USA)","institution_ids":[]},{"raw_affiliation_string":"(Marburg","institution_ids":[]},{"raw_affiliation_string":"Boston, USA)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103544311","display_name":"HM Hamer","orcid":"https://orcid.org/0000-0003-1709-8617","observed_orcids":["https://orcid.org/0000-0003-1709-8617"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"HM Hamer","raw_affiliation_strings":["(Marburg; Boston, USA)","(Marburg","Boston, USA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(Marburg; Boston, USA)","institution_ids":[]},{"raw_affiliation_string":"(Marburg","institution_ids":[]},{"raw_affiliation_string":"Boston, USA)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028930979","display_name":"Felix Rosenow","orcid":"https://orcid.org/0000-0002-3989-7471","observed_orcids":["https://orcid.org/0000-0002-3989-7471"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Rosenow","raw_affiliation_strings":["(Marburg; Boston, USA)","(Marburg","Boston, USA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(Marburg; Boston, USA)","institution_ids":[]},{"raw_affiliation_string":"(Marburg","institution_ids":[]},{"raw_affiliation_string":"Boston, USA)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110210411","display_name":"WH Oertel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"WH Oertel","raw_affiliation_strings":["(Marburg; Boston, USA)","(Marburg","Boston, USA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(Marburg; Boston, USA)","institution_ids":[]},{"raw_affiliation_string":"(Marburg","institution_ids":[]},{"raw_affiliation_string":"Boston, USA)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022799533","display_name":"Bruce R. Fischl","orcid":"https://orcid.org/0000-0002-2413-1115","observed_orcids":["https://orcid.org/0000-0002-2413-1115"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Fischl","raw_affiliation_strings":["(Marburg; Boston, USA)","(Marburg","Boston, USA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(Marburg; Boston, USA)","institution_ids":[]},{"raw_affiliation_string":"(Marburg","institution_ids":[]},{"raw_affiliation_string":"Boston, USA)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087626511","display_name":"Anders Martin Dale","orcid":"https://orcid.org/0000-0002-6126-2966","observed_orcids":["https://orcid.org/0000-0002-6126-2966"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"AM Dale","raw_affiliation_strings":["(Marburg; Boston, USA)","(Marburg","Boston, USA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(Marburg; Boston, USA)","institution_ids":[]},{"raw_affiliation_string":"(Marburg","institution_ids":[]},{"raw_affiliation_string":"Boston, USA)","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083626013","display_name":"Eric Halgren","orcid":"https://orcid.org/0000-0001-5926-6872","observed_orcids":["https://orcid.org/0000-0001-5926-6872"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Halgren","raw_affiliation_strings":["(Marburg; Boston, USA)","(Marburg","Boston, USA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(Marburg; Boston, USA)","institution_ids":[]},{"raw_affiliation_string":"(Marburg","institution_ids":[]},{"raw_affiliation_string":"Boston, USA)","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.2516701,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"S 1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10429","display_name":"EEG and Brain-Computer Interfaces","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/focal-epilepsy","display_name":"focal epilepsy","score":0.8370000123977661},{"id":"https://openalex.org/keywords/drug-resistant-epilepsy","display_name":"drug-resistant epilepsy","score":0.9459999799728394},{"id":"https://openalex.org/keywords/preoperative-assessment","display_name":"preoperative assessment","score":0.8080000281333923},{"id":"https://openalex.org/keywords/multimodal-neuroimaging","display_name":"multimodal neuroimaging","score":0.9509999752044678},{"id":"https://openalex.org/keywords/3t-mri","display_name":"3T MRI","score":0.6050000190734863},{"id":"https://openalex.org/keywords/diffusion-tensor-imaging","display_name":"diffusion tensor imaging","score":0.8629999756813049},{"id":"https://openalex.org/keywords/fractional-anisotropy","display_name":"fractional anisotropy","score":0.9430000185966492},{"id":"https://openalex.org/keywords/cortical-dysplasia","display_name":"cortical dysplasia","score":0.6959999799728394},{"id":"https://openalex.org/keywords/electroencephalography","display_name":"EEG","score":0.6620000004768372},{"id":"https://openalex.org/keywords/equivalent-current-dipole","display_name":"equivalent current dipole","score":0.9089999794960022},{"id":"https://openalex.org/keywords/spike-propagation","display_name":"spike propagation","score":0.6869999766349792},{"id":"https://openalex.org/keywords/cortical-thickness","display_name":"cortical thickness","score":0.8119999766349792},{"id":"https://openalex.org/keywords/subcortical-structures","display_name":"subcortical structures","score":0.7940000295639038},{"id":"https://openalex.org/keywords/epilepsy-surgery-outcomes","display_name":"epilepsy surgery outcomes","score":0.5360000133514404}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9104673862457275},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.3909012973308563}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1055/s-2004-833121","doi":"https://doi.org/10.1055/s-2004-833121","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2004-833121","pdf_url":null,"source":{"id":"https://openalex.org/S48308836","display_name":"Aktuelle Neurologie","issn_l":"0302-4350","issn":["0302-4350","1438-9428"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aktuelle Neurologie","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2625561419","https://openalex.org/W6931598968","https://openalex.org/W159935296","https://openalex.org/W4377820335","https://openalex.org/W2326058840","https://openalex.org/W6925121535","https://openalex.org/W6983573499","https://openalex.org/W2793949318","https://openalex.org/W2020479015","https://openalex.org/W7055855018"],"abstract_inverted_index":{"Fragestellung:":[0],"Verbessert":[1],"die":[2,7,109,125,147,161,250],"kombinierte":[3],"Anwendung":[4],"neuer":[5],"Bildgebungsverfahren":[6],"pr\u00e4chirurgische":[8],"Diagnostik":[9,29,148,242],"bei":[10,169],"Patienten":[11,18],"mit":[12,20,113,171,177,245,261],"therapieresistenten":[13],"fokalen":[14,22,246],"Epilepsien?":[15],"Methoden:":[16],"70":[17],"(Pat)":[19],"therapierefrakt\u00e4ren":[21],"Epilepsien":[23,247],"wurden":[24,44,57,65,78,106,122,141],"im":[25],"Rahmen":[26],"der":[27,70,87,136,151,180,185,193,202,213,240,259],"pr\u00e4chirurgischen":[28,241],"mittels":[30,39,45,58,85],"eines":[31,46],"standardiserten":[32],"Protokolls":[33],"untersucht:":[34],"1.":[35],"Hochaufl\u00f6sende":[36,50],"3T":[37,51],"Bildgebung":[38,53,145,163,233],"8-Kanal-Oberfl\u00e4chenspule":[40],"(SC-Imaging).":[41],"Die":[42,256],"Bilder":[43],"Korrekturalgorithmus":[47],"normalisiert.":[48],"2.":[49],"Diffusions-Tensor":[52],"(DTI):":[54],"Pat/eine":[55],"Kontrollgruppe":[56],"DTI":[59,166],"untersucht.":[60],"Fractional":[61],"Anisotropie":[62],"(FA)":[63],"maps":[64],"zur":[66,200],"Erfassung":[67],"mikrostruktureller":[68],"Ver\u00e4nderungen":[69,179,212,220],"weissen":[71,181],"Substanz":[72],"berechnet.":[73],"3.":[74],"306-Kanal":[75],"Ganzkopf-MEG/60-Kanal":[76],"EEG":[77],"simultan":[79],"abgeleitet,":[80],"iktale/interiktale":[81],"epilepsietypische":[82],"Aktivit\u00e4t":[83],"wurde":[84],"Berechnung":[86],"\u201eequivalent":[88],"current":[89],"dipoles":[90],"(ECD)\u201cunter":[91],"Verwendung":[92],"des":[93,206,221],"\u201eboundary":[94],"head":[95],"element":[96],"model\u201c":[97],"dargestellt.":[98],"\u201eDynamic":[99],"statistic":[100],"parametric":[101],"maps\u201c":[102],"(dSPM,":[103],"Dale":[104],"2000)":[105],"berechnet,":[107],"um":[108,124],"Propagation":[110],"von":[111,216,243],"Spikes":[112],"hoher":[114],"zeitlich-r\u00e4umlicher":[115],"Aufl\u00f6sung":[116],"darzustellen.":[117],"4.":[118],"Quantitative":[119],"semiautomatisierte":[120],"MRT-Analysetechniken":[121],"angewandt,":[123],"kortikale":[126],"Dicke":[127,204,215],"und":[128,205,219,234,248],"das":[129],"Volumen":[130],"subkortikaler":[131],"Strukturen":[132,209,224],"zu":[133],"ermitteln.":[134],"Einfluss":[135],"Ergebnisse":[137,260],"auf":[138],"Outcome/klinisches":[139],"Management":[140],"erfasst.":[142],"Ergebnisse:":[143],"Multimodale":[144],"verbesserte":[146,160],"in":[149,164,192,239],"52%":[150],"Pat.":[152,170,244],"Alle":[153],"Methoden":[154],"alleine":[155],"lieferten":[156],"wichtige":[157,237],"Informationen:":[158],"SC-Imaging":[159],"strukturelle":[162],"37,5%.":[165],"zeigte":[167],"insbesondere":[168],"kortikalen":[172,214],"Dysplasien":[173,218],"eine":[174],"ausgedehntere":[175,211],"Pathologie":[176],"mikrostrukturellen":[178],"Substanz.":[182],"Durch":[183],"Darstellung":[184,201],"Spike-Propagation":[186],"lieferte":[187],"dSPM":[188],"einen":[189],"wertvollen":[190],"Beitrag":[191],"praechirurgischen":[194],"Evaluation":[195],"(Abb.":[196],"1).":[197],"Automatisierte":[198],"Verfahren":[199],"cortikalen":[203,217],"Volumens":[207,222],"subcortikaler":[208,223],"fanden":[210],"als":[225],"durch":[226],"visuelle":[227],"Inspektion":[228],"angenommen.":[229],"Schlussfolgerung:":[230],"Kombinierte":[231],"multimodale":[232],"Analyse":[235],"liefern":[236],"Informationen":[238],"k\u00f6nnen":[249],"Selektion":[251],"geeigneter":[252],"Kandidaten":[253],"deutlich":[254],"verbessern.":[255],"weitere":[257],"Korrelation":[258],"postchirurgischem":[262],"Outcome/Histopathologie":[263],"ist":[264],"erforderlich.":[265]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}