{"id":"https://openalex.org/W2313610473","doi":"https://doi.org/10.1615/forumimmundisther.2016015242","title":"Experimental Approaches for Eliminating Latent HIV","display_name":"Experimental Approaches for Eliminating Latent HIV","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2313610473","doi":"https://doi.org/10.1615/forumimmundisther.2016015242","mag":"2313610473","pmid":"https://pubmed.ncbi.nlm.nih.gov/28191361","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5302864"},"language":"en","primary_location":{"id":"doi:10.1615/forumimmundisther.2016015242","doi":"https://doi.org/10.1615/forumimmundisther.2016015242","is_oa":false,"landing_page_url":"https://doi.org/10.1615/forumimmundisther.2016015242","pdf_url":null,"source":{"id":"https://openalex.org/S20825486","display_name":"Forum on Immunopathological Diseases and Therapeutics","issn_l":"2151-8017","issn":["2151-8017","2151-8025"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310315730","host_organization_name":"Begell House","host_organization_lineage":["https://openalex.org/P4310315730"],"host_organization_lineage_names":["Begell House"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Forum on Immunopathological Diseases and Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5302864","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085918660","display_name":"Matthew D. Marsden","orcid":"https://orcid.org/0000-0002-4857-8712","observed_orcids":["https://orcid.org/0000-0002-4857-8712"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew D. Marsden","raw_affiliation_strings":["Department of Medicine, Division of Hematology and Oncology, University of California, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Hematology and Oncology, University of California, Los Angeles, CA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072471885","display_name":"Jerome A. Zack","orcid":"https://orcid.org/0000-0001-5486-8495","observed_orcids":["https://orcid.org/0000-0001-5486-8495"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerome A. Zack","raw_affiliation_strings":["Department of Medicine, Division of Hematology and Oncology, University of California, Los Angeles, CA; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA","Department of Medicine, Division of Hematology and Oncology, University of California, Los Angeles, CA","Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Hematology and Oncology, University of California, Los Angeles, CA; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Medicine, Division of Hematology and Oncology, University of California, Los Angeles, CA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":null,"apc_paid":null,"fwci":1.1869,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.77701186,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"6","issue":"1-2","first_page":"91","last_page":"99"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-cure","display_name":"HIV cure","score":0.6869999766349792},{"id":"https://openalex.org/keywords/latent-hiv-reservoir","display_name":"latent HIV reservoir","score":0.8450000286102295},{"id":"https://openalex.org/keywords/hiv-provirus","display_name":"HIV provirus","score":0.4490000009536743},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.7570000290870667},{"id":"https://openalex.org/keywords/hematopoietic-stem-cell-transplantation","display_name":"hematopoietic stem cell transplantation","score":0.9049999713897705},{"id":"https://openalex.org/keywords/crispr-cas9-genome-editing","display_name":"CRISPR/Cas9 genome editing","score":0.746999979019165},{"id":"https://openalex.org/keywords/shock-and-kill","display_name":"shock and kill","score":0.8569999933242798},{"id":"https://openalex.org/keywords/viral-reactivation","display_name":"viral reactivation","score":0.6710000038146973},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.7799999713897705}],"concepts":[{"id":"https://openalex.org/C2910737674","wikidata":"https://www.wikidata.org/wiki/Q4115619","display_name":"Latent Virus","level":3,"score":0.667533814907074},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.6415903568267822},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.5692676901817322},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5405096411705017},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4772748351097107},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.4716493487358093},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.47018352150917053},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.4661627411842346},{"id":"https://openalex.org/C2778852064","wikidata":"https://www.wikidata.org/wiki/Q4115619","display_name":"Virus latency","level":4,"score":0.46534690260887146},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4541177749633789},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.41948258876800537},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.38252297043800354},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3626707196235657},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.30197465419769287}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1615/forumimmundisther.2016015242","doi":"https://doi.org/10.1615/forumimmundisther.2016015242","is_oa":false,"landing_page_url":"https://doi.org/10.1615/forumimmundisther.2016015242","pdf_url":null,"source":{"id":"https://openalex.org/S20825486","display_name":"Forum on Immunopathological Diseases and Therapeutics","issn_l":"2151-8017","issn":["2151-8017","2151-8025"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310315730","host_organization_name":"Begell House","host_organization_lineage":["https://openalex.org/P4310315730"],"host_organization_lineage_names":["Begell House"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Forum on Immunopathological Diseases and Therapeutics","raw_type":"journal-article"},{"id":"pmid:28191361","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28191361","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Forum on immunopathological diseases and therapeutics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5302864","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5302864","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"For Immunopathol Dis Therap","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5302864","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5302864","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"For Immunopathol Dis Therap","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1196829039","display_name":"Centers of Excellence for Influenza Research and Surveillance","funder_award_id":"n01ai70010-17-0-1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3121688723","display_name":null,"funder_award_id":"N01 AI070010","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4974770859","display_name":"Targeting HIV Reservoirs in vitro and in vivo","funder_award_id":"R01AI070010","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7811902380","display_name":"UCLA Center for AIDS Research (CFAR)","funder_award_id":"P30AI028697","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8999746926","display_name":"Martin Delaney Collaboratory to Eradicate HIV-1 Infection","funder_award_id":"U19AI096113","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W1491954563","https://openalex.org/W1497870368","https://openalex.org/W1963802821","https://openalex.org/W1964761653","https://openalex.org/W1966452674","https://openalex.org/W1974496433","https://openalex.org/W1975258429","https://openalex.org/W1990750190","https://openalex.org/W1991259997","https://openalex.org/W1992324754","https://openalex.org/W1995324146","https://openalex.org/W1995457108","https://openalex.org/W1995527299","https://openalex.org/W2011208161","https://openalex.org/W2019508559","https://openalex.org/W2019623291","https://openalex.org/W2030844138","https://openalex.org/W2035813371","https://openalex.org/W2044170979","https://openalex.org/W2047300635","https://openalex.org/W2055796578","https://openalex.org/W2060829964","https://openalex.org/W2063458746","https://openalex.org/W2063628696","https://openalex.org/W2064140898","https://openalex.org/W2066848476","https://openalex.org/W2067747048","https://openalex.org/W2070290307","https://openalex.org/W2075106941","https://openalex.org/W2081224837","https://openalex.org/W2081550246","https://openalex.org/W2085384576","https://openalex.org/W2090238266","https://openalex.org/W2090646713","https://openalex.org/W2104958625","https://openalex.org/W2105028368","https://openalex.org/W2106074514","https://openalex.org/W2113081839","https://openalex.org/W2115580899","https://openalex.org/W2124058652","https://openalex.org/W2124114936","https://openalex.org/W2125593632","https://openalex.org/W2130560337","https://openalex.org/W2130651313","https://openalex.org/W2135135539","https://openalex.org/W2137255891","https://openalex.org/W2139250164","https://openalex.org/W2160076049","https://openalex.org/W2163921097","https://openalex.org/W2167867167","https://openalex.org/W2312477362","https://openalex.org/W2334860476","https://openalex.org/W4290750977"],"related_works":["https://openalex.org/W2946439345","https://openalex.org/W2782696110","https://openalex.org/W2402508510","https://openalex.org/W2529202871","https://openalex.org/W3199664635","https://openalex.org/W2961032267","https://openalex.org/W2588293872","https://openalex.org/W2993302639","https://openalex.org/W4389785622","https://openalex.org/W2316371451"],"abstract_inverted_index":{"T":[0],"cells":[1,36,46,104],"represent":[2],"a":[3,13],"major":[4],"reservoir":[5],"of":[6,60,80],"HIV":[7,16,65,106,117,124],"that":[8,20,57,99],"persists":[9],"during":[10],"ART.":[11],"Therefore,":[12],"cure":[14,125],"for":[15,32,114],"must":[17],"include":[18,37],"methods":[19,29],"either":[21],"permanently":[22],"inactivate":[23],"or":[24,62,96],"eliminate":[25],"latent":[26,81,116],"virus.":[27],"Experimental":[28],"under":[30],"investigation":[31],"eliminating":[33,115],"latently":[34],"infected":[35,45],"transplantation/gene":[38],"therapy":[39],"approaches":[40,75,113],"intended":[41],"to":[42,77,86],"deplete":[43],"the":[44,84],"and":[47,53,73,102],"replace":[48],"them":[49],"with":[50,119],"HIV-resistant":[51],"ones,":[52],"DNA":[54],"editing":[55],"strategies":[56],"are":[58],"capable":[59],"damaging":[61],"excising":[63],"non-expressing":[64],"proviruses.":[66],"Alternatively,":[67],"\"activation-elimination,\"":[68],"also":[69],"known":[70],"as":[71],"\"shock":[72],"kill,\"":[74],"aim":[76],"induce":[78],"expression":[79],"virus,":[82],"allowing":[83],"virus":[85],"be":[87],"eliminated":[88],"by":[89],"viral":[90],"cytopathic":[91],"effects,":[92],"immune":[93],"effector":[94],"mechanisms,":[95],"additional":[97],"cells/antibodies":[98],"specifically":[100],"target":[101],"kill":[103],"expressing":[105],"proteins.":[107],"Here,":[108],"we":[109],"describe":[110],"these":[111],"experimental":[112],"along":[118],"other":[120],"recent":[121],"advances":[122],"in":[123],"research.":[126]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":2}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}