{"id":"https://openalex.org/W2313511484","doi":null,"title":"Activation of Inward Rectifier Potassium Channels in High Salt Impairment of Hydrogen Sulfide-Induced Aortic Relaxation in Rats","display_name":"Activation of Inward Rectifier Potassium Channels in High Salt Impairment of Hydrogen Sulfide-Induced Aortic Relaxation in Rats","publication_year":2015,"publication_date":"2015-12-10","ids":{"openalex":"https://openalex.org/W2313511484","mag":"2313511484"},"language":"en","primary_location":{"id":"mag:2313511484","doi":null,"is_oa":false,"landing_page_url":"http://phypha.ir/ppj/article-1-1137-en.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Physiology and Pharmacology","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056086230","display_name":"Abbas Burhan Salihi","orcid":"https://orcid.org/0000-0002-1342-2849","observed_orcids":["https://orcid.org/0000-0002-1342-2849"]},"institutions":[{"id":"https://openalex.org/I46208956","display_name":"Salahaddin University-Erbil","ror":"https://ror.org/02124dd11","country_code":"IQ","type":"education","lineage":["https://openalex.org/I46208956"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Abbas Salihi","raw_affiliation_strings":["Biology Department, College of Science, Salahaddin University, Erbil, Kurdistan Region, Iraq"],"raw_orcid":"https://orcid.org/0000-0002-1342-2849","affiliations":[{"raw_affiliation_string":"Biology Department, College of Science, Salahaddin University, Erbil, Kurdistan Region, Iraq","institution_ids":["https://openalex.org/I46208956"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057577914","display_name":"Salahaddin University-Erbil","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Salahaddin University-Erbil","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2312,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.57392107,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"19","issue":"4","first_page":"263","last_page":"273"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.4189000129699707,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.4189000129699707,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11481","display_name":"Sulfur Compounds in Biology","score":0.41260001063346863,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.09440000355243683,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydrogen-sulfide","display_name":"hydrogen sulfide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/high-salt-diet","display_name":"high-salt diet","score":0.7990000247955322},{"id":"https://openalex.org/keywords/aortic-relaxation","display_name":"aortic relaxation","score":0.7450000047683716},{"id":"https://openalex.org/keywords/inwardly-rectifying-potassium-channels","display_name":"inwardly rectifying potassium channels","score":0.8849999904632568},{"id":"https://openalex.org/keywords/potassium-channels","display_name":"potassium channels","score":0.47200000286102295},{"id":"https://openalex.org/keywords/sodium-disulfide","display_name":"sodium disulfide","score":0.8080000281333923},{"id":"https://openalex.org/keywords/vascular-tone","display_name":"vascular tone","score":0.5989999771118164},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.8320000171661377},{"id":"https://openalex.org/keywords/voltage-gated-potassium-channels","display_name":"voltage-gated potassium channels","score":0.6729999780654907},{"id":"https://openalex.org/keywords/atp-sensitive-potassium-channels","display_name":"ATP-sensitive potassium channels","score":0.5400000214576721},{"id":"https://openalex.org/keywords/phenylephrine-induced-contraction","display_name":"phenylephrine-induced contraction","score":0.5929999947547913},{"id":"https://openalex.org/keywords/salt-induced-hypertension","display_name":"salt-induced hypertension","score":0.41600000858306885}],"concepts":[{"id":"https://openalex.org/C2777952589","wikidata":"https://www.wikidata.org/wiki/Q421910","display_name":"Phenylephrine","level":3,"score":0.6798986792564392},{"id":"https://openalex.org/C94924445","wikidata":"https://www.wikidata.org/wiki/Q841456","display_name":"Inward-rectifier potassium ion channel","level":4,"score":0.6265178918838501},{"id":"https://openalex.org/C83743174","wikidata":"https://www.wikidata.org/wiki/Q423778","display_name":"Potassium channel","level":2,"score":0.5708150267601013},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.547491729259491},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4985771179199219},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.4685830771923065},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.4529010057449341},{"id":"https://openalex.org/C517785266","wikidata":"https://www.wikidata.org/wiki/Q703","display_name":"Potassium","level":2,"score":0.4330650269985199},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.43121904134750366},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4290938675403595},{"id":"https://openalex.org/C2776029896","wikidata":"https://www.wikidata.org/wiki/Q3935810","display_name":"Relaxation (psychology)","level":2,"score":0.41681334376335144},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4150792062282562},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38211488723754883},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3573843836784363},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.247992604970932},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.2315385341644287},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09987026453018188},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.09726360440254211},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2313511484","doi":null,"is_oa":false,"landing_page_url":"http://phypha.ir/ppj/article-1-1137-en.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Physiology and Pharmacology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W1987282","https://openalex.org/W1487516961","https://openalex.org/W1553992654","https://openalex.org/W1639251217","https://openalex.org/W1753089048","https://openalex.org/W1965642395","https://openalex.org/W1970947429","https://openalex.org/W1974361621","https://openalex.org/W1975072795","https://openalex.org/W1982507137","https://openalex.org/W1991982384","https://openalex.org/W1994124212","https://openalex.org/W1998953654","https://openalex.org/W2003272398","https://openalex.org/W2013152983","https://openalex.org/W2013457351","https://openalex.org/W2015407072","https://openalex.org/W2019375282","https://openalex.org/W2025192472","https://openalex.org/W2025791617","https://openalex.org/W2028843294","https://openalex.org/W2033031318","https://openalex.org/W2034208532","https://openalex.org/W2050899420","https://openalex.org/W2054064167","https://openalex.org/W2060974177","https://openalex.org/W2061049180","https://openalex.org/W2069915524","https://openalex.org/W2071309984","https://openalex.org/W2073236176","https://openalex.org/W2074812993","https://openalex.org/W2083086394","https://openalex.org/W2085113848","https://openalex.org/W2094928959","https://openalex.org/W2095278806","https://openalex.org/W2098478078","https://openalex.org/W2101762356","https://openalex.org/W2102447197","https://openalex.org/W2105640139","https://openalex.org/W2107380897","https://openalex.org/W2110674977","https://openalex.org/W2113220448","https://openalex.org/W2117611302","https://openalex.org/W2121153005","https://openalex.org/W2122119818","https://openalex.org/W2122874855","https://openalex.org/W2125766324","https://openalex.org/W2131577505","https://openalex.org/W2139593461","https://openalex.org/W2139637725","https://openalex.org/W2143575334","https://openalex.org/W2144317724","https://openalex.org/W2147804877","https://openalex.org/W2156615759","https://openalex.org/W2160414655","https://openalex.org/W2166444429","https://openalex.org/W2332389779","https://openalex.org/W2472790191","https://openalex.org/W3173348828"],"related_works":["https://openalex.org/W2174931527","https://openalex.org/W2025378333","https://openalex.org/W4200552377","https://openalex.org/W4402379181","https://openalex.org/W2030241661","https://openalex.org/W3126324923","https://openalex.org/W2010291333","https://openalex.org/W2389658594","https://openalex.org/W132184680","https://openalex.org/W2580225780"],"abstract_inverted_index":{"Introduction:":[0],"Hydrogen":[1],"sulfide":[2],"(H2S)":[3],"plays":[4],"a":[5,119,146],"key":[6],"role":[7,43],"in":[8,50,57,104,118,136,186,222],"the":[9,23,42,51,247,255],"regulation":[10],"of":[11,16,25,44,54,68,107,125,154,157,204,207,249,257,262],"vascular":[12,29],"tone":[13],"and":[14,62,245,260],"protection":[15],"blood":[17],"vessels":[18],"against":[19],"endothelial":[20],"dysfunction.":[21],"Since":[22],"mechanism":[24,248],"salt":[26,114],"impairing":[27],"H2S-induced":[28],"relaxation":[30,93,133,185,241,250],"is":[31,251],"not":[32],"fully":[33],"clear,":[34],"therefore":[35],"this":[36],"study":[37],"was":[38,102,134],"designed":[39],"to":[40,95],"investigate":[41],"potassium":[45],"(K":[46],"+":[47,142,164,179,216],")":[48],"channels":[49,166,181,199,218,226,259],"vasodilatory":[52],"effects":[53,193],"exogenous":[55],"H2S":[56,100],"rat":[58],"aortic":[59,66,105,155,205,240],"rings.":[60,131],"Materials":[61],"Methods:":[63],"Isolated":[64],"thoracic":[65],"rings":[67,106,137,156,195,206],"adult":[69],"male":[70],"albino":[71],"rats":[72,108,160,210],"fed":[73,112],"8%":[74],"NaCl":[75,127],"diet":[76],"for":[77,82],"six":[78],"weeks":[79],"were":[80,110],"used":[81],"isometric":[83],"tension":[84],"recording":[85],"using":[86],"PowerLab":[87],"tissue":[88],"bath":[89],"system.":[90],"Results:":[91],"The":[92],"response":[94],"sodium":[96],"disulfide":[97],"(Na2S,":[98],"an":[99],"donor)":[101],"reduced":[103],"that":[109,236,246],"either":[111,172],"high":[113,140],"(HS)":[115],"or":[116,123,169,175,221],"incubated":[117],"medium":[120],"containing":[121],"1,3":[122],"5mM/L":[124],"extra":[126],"compared":[128],"with":[129,161,171,197,211,224],"control":[130],"Na2S-induced":[132,184,230],"lower":[135],"precontracted":[138],"by":[139,243,254],"K":[141,163,178,215],"than":[143],"phenylephrine":[144],"(PE,":[145],"selective":[147],"\u03b11adrenergic":[148],"receptor":[149],"agonist).":[150],"In":[151,201],"addition,":[152],"incubation":[153,203],"HS":[158,208,237],"loaded":[159,209],"inward-rectifier":[162],"(KIR)":[165],"blocker":[167,219,227],"individually":[168,220],"simultaneously":[170],"ATP-dependent":[173],"(KATP)":[174],"voltage-":[176],"sensitive":[177],"(KV)":[180],"blockers":[182],"inhibited":[183],"PE-precontracted":[187],"rings;":[188],"however":[189],"it":[190],"had":[191],"no":[192],"on":[194],"pretreated":[196],"KATP":[198],"blocker.":[200],"contrast,":[202],"Ca":[212],"+2":[213],"activated":[214],"(KCa)":[217],"combination":[223],"KIR":[225,258],"significantly":[228],"enhanced":[229],"relaxation.":[231],"Conclusion:":[232],"These":[233],"results":[234],"revealed":[235],"partially":[238],"impairs":[239],"caused":[242],"H2S,":[244],"mainly":[252],"mediated":[253],"stimulation":[256],"inhibition":[261],"KCa":[263],"channels.":[264]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}