{"id":"https://openalex.org/W2313480486","doi":"https://doi.org/10.1097/cco.0b013e3283477a94","title":"Phase 1 clinical trials for sarcomas: the cutting edge","display_name":"Phase 1 clinical trials for sarcomas: the cutting edge","publication_year":2011,"publication_date":"2011-04-26","ids":{"openalex":"https://openalex.org/W2313480486","doi":"https://doi.org/10.1097/cco.0b013e3283477a94","mag":"2313480486","pmid":"https://pubmed.ncbi.nlm.nih.gov/21519259"},"language":"en","primary_location":{"id":"doi:10.1097/cco.0b013e3283477a94","doi":"https://doi.org/10.1097/cco.0b013e3283477a94","is_oa":false,"landing_page_url":"https://doi.org/10.1097/cco.0b013e3283477a94","pdf_url":null,"source":{"id":"https://openalex.org/S179395531","display_name":"Current Opinion in Oncology","issn_l":"1040-8746","issn":["1040-8746","1080-8140","1531-703X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Oncology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043675371","display_name":"Vivek Subbiah","orcid":"https://orcid.org/0000-0002-6064-6837","observed_orcids":["https://orcid.org/0000-0002-6064-6837"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Vivek Subbiah","raw_affiliation_strings":["Department of Investigational Cancer Therapeutics (A Phase I Program), University of Texas, MD Anderson Cancer Center, Houston, Texas 77030, USA. vsubbiah@mdanderson.org","Department of Investigational Cancer Therapeutics (A Phase I Program), USA","Department of Pediatrics, University of Texas, MD Anderson Cancer Center, Houston, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Investigational Cancer Therapeutics (A Phase I Program), University of Texas, MD Anderson Cancer Center, Houston, Texas 77030, USA. vsubbiah@mdanderson.org","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Investigational Cancer Therapeutics (A Phase I Program), USA","institution_ids":[]},{"raw_affiliation_string":"Department of Pediatrics, University of Texas, MD Anderson Cancer Center, Houston, Texas, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053481267","display_name":"Razelle Kurzrock","orcid":"https://orcid.org/0000-0003-4110-1214","observed_orcids":["https://orcid.org/0000-0003-4110-1214"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Razelle Kurzrock","raw_affiliation_strings":["Department of Investigational Cancer Therapeutics (A Phase I Program), USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Investigational Cancer Therapeutics (A Phase I Program), USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5043675371"],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":null,"apc_paid":null,"fwci":0.8865,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.65834768,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"23","issue":"4","first_page":"352","last_page":"360"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sarcoma","display_name":"sarcoma","score":0.9800000190734863},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.9020000100135803},{"id":"https://openalex.org/keywords/ewing-sarcoma","display_name":"Ewing sarcoma","score":0.984000027179718},{"id":"https://openalex.org/keywords/chondrosarcoma","display_name":"chondrosarcoma","score":0.9390000104904175},{"id":"https://openalex.org/keywords/crizotinib","display_name":"crizotinib","score":0.871999979019165},{"id":"https://openalex.org/keywords/alveolar-soft-part-sarcoma","display_name":"alveolar soft part sarcoma","score":0.9959999918937683},{"id":"https://openalex.org/keywords/osteosarcoma","display_name":"osteosarcoma","score":0.9810000061988831},{"id":"https://openalex.org/keywords/trabectedin","display_name":"trabectedin","score":0.9860000014305115},{"id":"https://openalex.org/keywords/soft-tissue-sarcoma","display_name":"soft tissue sarcoma","score":0.9210000038146973},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.6700000166893005},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.8080000281333923},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.48399999737739563},{"id":"https://openalex.org/keywords/advanced-sarcoma","display_name":"advanced sarcoma","score":0.5529999732971191}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8594713807106018},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.689841091632843},{"id":"https://openalex.org/C117643217","wikidata":"https://www.wikidata.org/wiki/Q17824987","display_name":"Anaplastic lymphoma kinase","level":4,"score":0.5816760063171387},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5479776859283447},{"id":"https://openalex.org/C2779422266","wikidata":"https://www.wikidata.org/wiki/Q5186964","display_name":"Crizotinib","level":4,"score":0.5289309620857239},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.5109209418296814},{"id":"https://openalex.org/C2778629024","wikidata":"https://www.wikidata.org/wiki/Q720020","display_name":"Soft tissue sarcoma","level":3,"score":0.5038413405418396},{"id":"https://openalex.org/C2781064419","wikidata":"https://www.wikidata.org/wiki/Q795057","display_name":"Cabozantinib","level":3,"score":0.4940031170845032},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.46921980381011963},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4678072929382324},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43189117312431335},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.39638257026672363},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3229806423187256},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.15370801091194153},{"id":"https://openalex.org/C2776232967","wikidata":"https://www.wikidata.org/wiki/Q6743514","display_name":"Malignant pleural effusion","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012509","descriptor_name":"Sarcoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D017321","descriptor_name":"Clinical Trials, Phase I as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/cco.0b013e3283477a94","doi":"https://doi.org/10.1097/cco.0b013e3283477a94","is_oa":false,"landing_page_url":"https://doi.org/10.1097/cco.0b013e3283477a94","pdf_url":null,"source":{"id":"https://openalex.org/S179395531","display_name":"Current Opinion in Oncology","issn_l":"1040-8746","issn":["1040-8746","1080-8140","1531-703X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Oncology","raw_type":"journal-article"},{"id":"pmid:21519259","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21519259","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in oncology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1901027039","display_name":null,"funder_award_id":"CA 016672","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000878657","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA016672","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332521","display_name":"University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1972829319","https://openalex.org/W1975918136","https://openalex.org/W1985429138","https://openalex.org/W2001264986","https://openalex.org/W2004598454","https://openalex.org/W2010938751","https://openalex.org/W2012887758","https://openalex.org/W2016334273","https://openalex.org/W2020583412","https://openalex.org/W2027266396","https://openalex.org/W2057660831","https://openalex.org/W2058616187","https://openalex.org/W2060722365","https://openalex.org/W2063365274","https://openalex.org/W2066159416","https://openalex.org/W2102335858","https://openalex.org/W2104878828","https://openalex.org/W2110830431","https://openalex.org/W2112996193","https://openalex.org/W2127933711","https://openalex.org/W2128560398","https://openalex.org/W2133221875","https://openalex.org/W2133403258","https://openalex.org/W2136522433","https://openalex.org/W2138579656","https://openalex.org/W2152274262","https://openalex.org/W2156136395","https://openalex.org/W2156946872","https://openalex.org/W2156969792","https://openalex.org/W2158734599","https://openalex.org/W2159152276","https://openalex.org/W2160996281","https://openalex.org/W2167112360","https://openalex.org/W2167156722","https://openalex.org/W2169823832","https://openalex.org/W2170927895","https://openalex.org/W2172208023","https://openalex.org/W2284960363","https://openalex.org/W2484691022"],"related_works":["https://openalex.org/W2962041394","https://openalex.org/W2099868678","https://openalex.org/W2137852376","https://openalex.org/W2135870323","https://openalex.org/W150885687","https://openalex.org/W1965860757","https://openalex.org/W4240756401","https://openalex.org/W2999660159","https://openalex.org/W2538831707","https://openalex.org/W3040872370"],"abstract_inverted_index":{"PURPOSE":[0],"OF":[1],"REVIEW:":[2],"Few":[3],"standard":[4],"second-line":[5],"treatment":[6,151],"options":[7],"exist":[8],"for":[9,84,94,100,109,120,180],"advanced":[10,139],"sarcoma":[11,35,45,147],"patients.":[12],"Some":[13],"of":[14,126,159,191,205],"these":[15],"patients":[16],"are":[17,176],"offered":[18],"early-phase":[19],"clinical":[20,208],"trials":[21,33],"involving":[22,34],"targeted":[23,52,118,153,181],"or":[24,193],"nontargeted":[25],"agents.":[26],"This":[27],"review":[28],"outlines":[29],"recent":[30],"phase":[31,53,160],"1":[32,54,161],"patients,":[36],"explores":[37],"current":[38],"challenges":[39],"and":[40,114,169],"highlights":[41],"future":[42],"opportunities":[43],"in":[44,59,74,128,138,156,202],"developmental":[46],"therapeutics.":[47],"RECENT":[48],"FINDINGS:":[49],"New":[50],"molecularly":[51],"studies":[55],"have":[56,69,165],"demonstrated":[57],"efficacy":[58,137],"sarcomas.":[60],"For":[61],"instance,":[62],"insulin-like":[63],"growth":[64],"factor-1":[65],"receptor":[66],"(IGF1R)":[67],"antibodies":[68],"produced":[70],"single":[71],"agent":[72],"activity":[73],"Ewing's":[75],"sarcoma.":[76,142],"Other":[77],"promising":[78,178],"novel":[79],"agents":[80,132],"include":[81],"an":[82],"agonist":[83],"the":[85,157,188],"apoptosis":[86],"ligand":[87,92],"2/tumor":[88],"necrosis":[89],"factor-related":[90],"apoptosis-inducing":[91],"(Apo2L/TRAIL)":[93],"chondrosarcoma,":[95],"small":[96],"molecule":[97],"inhibitor":[98],"crizotinib":[99],"anaplastic":[101],"lymphoma":[102],"kinase":[103],"(ALK)-rearranged":[104],"inflammatory":[105],"myofibroblastic":[106],"tumor,":[107],"cedarinib":[108],"alveolar":[110],"soft":[111,140],"part":[112],"sarcoma,":[113],"rexin-G,":[115],"a":[116,166],"tumor":[117],"retrovector":[119],"osteosarcoma.":[121],"In":[122],"addition,":[123],"different":[124],"combinations":[125],"chemotherapy":[127],"combination":[129],"with":[130,145,152,197],"newer":[131],"such":[133],"as":[134],"trabectedin":[135],"exhibited":[136],"tissue":[141],"SUMMARY:":[143],"Patients":[144],"refractory":[146],"demonstrate":[148],"benefit":[149],"from":[150],"drugs":[154],"even":[155],"setting":[158],"trials.":[162],"Sarcomas":[163],"that":[164,171],"defined":[167],"translocation":[168],"those":[170],"express":[172],"specific":[173,198],"activated":[174],"kinases":[175],"particularly":[177],"tumors":[179],"therapy.":[182],"The":[183],"primary":[184],"challenge":[185],"is":[186],"identifying":[187],"biomarkers":[189],"predictive":[190],"response":[192],"resistance,":[194],"matching":[195],"them":[196],"patient":[199],"histology,":[200],"resulting":[201],"successful":[203],"translation":[204],"biology":[206],"into":[207],"benefit.":[209]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}