{"id":"https://openalex.org/W2313401482","doi":"https://doi.org/10.1097/md.0000000000000269","title":"The Relationship Between Skeletal-Related Events and Bone Scan Index for the Treatment of Bone Metastasis With Breast Cancer Patients","display_name":"The Relationship Between Skeletal-Related Events and Bone Scan Index for the Treatment of Bone Metastasis With Breast Cancer Patients","publication_year":2014,"publication_date":"2014-12-01","ids":{"openalex":"https://openalex.org/W2313401482","doi":"https://doi.org/10.1097/md.0000000000000269","mag":"2313401482","pmid":"https://pubmed.ncbi.nlm.nih.gov/25526456","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4603075"},"language":"en","primary_location":{"id":"doi:10.1097/md.0000000000000269","doi":"https://doi.org/10.1097/md.0000000000000269","is_oa":true,"landing_page_url":"https://doi.org/10.1097/md.0000000000000269","pdf_url":null,"source":{"id":"https://openalex.org/S28966261","display_name":"Medicine","issn_l":"0025-7974","issn":["0025-7974","1536-5964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1097/md.0000000000000269","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018426062","display_name":"Toshiaki Iwase","orcid":"https://orcid.org/0000-0002-5302-2292","observed_orcids":["https://orcid.org/0000-0002-5302-2292"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]},{"id":"https://openalex.org/I4210115246","display_name":"Chiba Cancer Center","ror":"https://ror.org/02120t614","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210115246"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Toshiaki Iwase","raw_affiliation_strings":["From the Division of Breast Surgery (TI, NY); Division of Nuclear Medicine (HI, TT), Chiba Cancer Center, Japan; and Department of General Surgery (TI, TN, MM), Chiba Graduate School of Medicine, Japan","Abbreviations: aBSI = automated bone scan index, ANN = artificial neural network, ER = estrogen receptor, HER2 = human epidermal growth factor 2, PgR = progesterone receptor, SRE = skeletal related events","Accepted October 20, 2014","Department of General Surgery (TI, TN, MM), Chiba Graduate School of Medicine, Japan","Division of Nuclear Medicine (HI, TT), Chiba Cancer Center, Japan","From the Division of Breast Surgery (TI, NY)","Naohito Yamamoto received research funding from Pfizer, Bayer, Parexel, and Eli Lilly. Those funders had no control over the interpretation, or publication of this work. This study was presented on the 9th European breast cancer conference, 19\u201321 March 2014 at Glasgow, Scotland","Received September 5, 2014","Received in revised form October 9, 2014","The authors have no conflicts of interest to disclose","This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Breast Surgery (TI, NY); Division of Nuclear Medicine (HI, TT), Chiba Cancer Center, Japan; and Department of General Surgery (TI, TN, MM), Chiba Graduate School of Medicine, Japan","institution_ids":["https://openalex.org/I4210115246"]},{"raw_affiliation_string":"Abbreviations: aBSI = automated bone scan index, ANN = artificial neural network, ER = estrogen receptor, HER2 = human epidermal growth factor 2, PgR = progesterone receptor, SRE = skeletal related events","institution_ids":[]},{"raw_affiliation_string":"Accepted October 20, 2014","institution_ids":[]},{"raw_affiliation_string":"Department of General Surgery (TI, TN, MM), Chiba Graduate School of Medicine, Japan","institution_ids":["https://openalex.org/I159385669"]},{"raw_affiliation_string":"Division of Nuclear Medicine (HI, TT), Chiba Cancer Center, Japan","institution_ids":["https://openalex.org/I4210115246"]},{"raw_affiliation_string":"From the Division of Breast Surgery (TI, NY)","institution_ids":[]},{"raw_affiliation_string":"Naohito Yamamoto received research funding from Pfizer, Bayer, Parexel, and Eli Lilly. Those funders had no control over the interpretation, or publication of this work. This study was presented on the 9th European breast cancer conference, 19\u201321 March 2014 at Glasgow, Scotland","institution_ids":[]},{"raw_affiliation_string":"Received September 5, 2014","institution_ids":[]},{"raw_affiliation_string":"Received in revised form October 9, 2014","institution_ids":[]},{"raw_affiliation_string":"The authors have no conflicts of interest to disclose","institution_ids":[]},{"raw_affiliation_string":"This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113826098","display_name":"Naohito Yamamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]},{"id":"https://openalex.org/I4210115246","display_name":"Chiba Cancer Center","ror":"https://ror.org/02120t614","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210115246"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naohito Yamamoto","raw_affiliation_strings":["Division of Nuclear Medicine (HI, TT), Chiba Cancer Center, Japan","From the Division of Breast Surgery (TI, NY)","and Department of General Surgery (TI, TN, MM), Chiba Graduate School of Medicine, Japan","Abbreviations: aBSI = automated bone scan index, ANN = artificial neural network, ER = estrogen receptor, HER2 = human epidermal growth factor 2, PgR = progesterone receptor, SRE = skeletal related events","Accepted October 20, 2014","Department of General Surgery (TI, TN, MM), Chiba Graduate School of Medicine, Japan","Naohito Yamamoto received research funding from Pfizer, Bayer, Parexel, and Eli Lilly. Those funders had no control over the interpretation, or publication of this work. This study was presented on the 9th European breast cancer conference, 19\u201321 March 2014 at Glasgow, Scotland","Received September 5, 2014","Received in revised form October 9, 2014","The authors have no conflicts of interest to disclose","This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nuclear Medicine (HI, TT), Chiba Cancer Center, Japan","institution_ids":["https://openalex.org/I4210115246"]},{"raw_affiliation_string":"From the Division of Breast Surgery (TI, NY)","institution_ids":[]},{"raw_affiliation_string":"and Department of General Surgery (TI, TN, MM), Chiba Graduate School of Medicine, Japan","institution_ids":["https://openalex.org/I159385669"]},{"raw_affiliation_string":"Abbreviations: aBSI = automated bone scan index, ANN = artificial neural network, ER = estrogen receptor, HER2 = human epidermal growth factor 2, PgR = progesterone receptor, SRE = skeletal related events","institution_ids":[]},{"raw_affiliation_string":"Accepted October 20, 2014","institution_ids":[]},{"raw_affiliation_string":"Department of General Surgery (TI, TN, MM), Chiba Graduate School of Medicine, Japan","institution_ids":["https://openalex.org/I159385669"]},{"raw_affiliation_string":"Naohito Yamamoto received research funding from Pfizer, Bayer, Parexel, and Eli Lilly. Those funders had no control over the interpretation, or publication of this work. This study was presented on the 9th European breast cancer conference, 19\u201321 March 2014 at Glasgow, Scotland","institution_ids":[]},{"raw_affiliation_string":"Received September 5, 2014","institution_ids":[]},{"raw_affiliation_string":"Received in revised form October 9, 2014","institution_ids":[]},{"raw_affiliation_string":"The authors have no conflicts of interest to disclose","institution_ids":[]},{"raw_affiliation_string":"This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083327578","display_name":"Hironori Ichihara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]},{"id":"https://openalex.org/I4210115246","display_name":"Chiba Cancer Center","ror":"https://ror.org/02120t614","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210115246"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hironori Ichihara","raw_affiliation_strings":["Division of Nuclear Medicine (HI, TT), Chiba Cancer Center, Japan","From the Division of Breast Surgery (TI, NY)","and Department of General Surgery (TI, TN, MM), Chiba Graduate School of Medicine, Japan","Abbreviations: aBSI = automated bone scan index, ANN = artificial neural network, ER = estrogen receptor, HER2 = human epidermal growth factor 2, PgR = progesterone receptor, SRE = skeletal related events","Accepted October 20, 2014","Department of General Surgery (TI, TN, MM), Chiba Graduate School of Medicine, Japan","Naohito Yamamoto received research funding from Pfizer, Bayer, Parexel, and Eli Lilly. Those funders had no control over the interpretation, or publication of this work. This study was presented on the 9th European breast cancer conference, 19\u201321 March 2014 at Glasgow, Scotland","Received September 5, 2014","Received in revised form October 9, 2014","The authors have no conflicts of interest to disclose","This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nuclear Medicine (HI, TT), Chiba Cancer Center, Japan","institution_ids":["https://openalex.org/I4210115246"]},{"raw_affiliation_string":"From the Division of Breast Surgery (TI, NY)","institution_ids":[]},{"raw_affiliation_string":"and Department of General Surgery (TI, TN, MM), Chiba Graduate School of Medicine, Japan","institution_ids":["https://openalex.org/I159385669"]},{"raw_affiliation_string":"Abbreviations: aBSI = automated bone scan index, ANN = artificial neural network, ER = estrogen receptor, HER2 = human epidermal growth factor 2, PgR = progesterone receptor, SRE = skeletal related events","institution_ids":[]},{"raw_affiliation_string":"Accepted October 20, 2014","institution_ids":[]},{"raw_affiliation_string":"Department of General Surgery (TI, TN, MM), Chiba Graduate School of Medicine, Japan","institution_ids":["https://openalex.org/I159385669"]},{"raw_affiliation_string":"Naohito Yamamoto received research funding from Pfizer, Bayer, Parexel, and Eli Lilly. Those funders had no control over the interpretation, or publication of this work. This study was presented on the 9th European breast cancer conference, 19\u201321 March 2014 at Glasgow, Scotland","institution_ids":[]},{"raw_affiliation_string":"Received September 5, 2014","institution_ids":[]},{"raw_affiliation_string":"Received in revised form October 9, 2014","institution_ids":[]},{"raw_affiliation_string":"The authors have no conflicts of interest to disclose","institution_ids":[]},{"raw_affiliation_string":"This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108228080","display_name":"Takashi Togawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]},{"id":"https://openalex.org/I4210115246","display_name":"Chiba Cancer Center","ror":"https://ror.org/02120t614","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210115246"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Togawa","raw_affiliation_strings":["Division of Nuclear Medicine (HI, TT), Chiba Cancer Center, Japan","From the Division of Breast Surgery (TI, NY)","and Department of General Surgery (TI, TN, MM), Chiba Graduate School of Medicine, Japan","Abbreviations: aBSI = automated bone scan index, ANN = artificial neural network, ER = estrogen receptor, HER2 = human epidermal growth factor 2, PgR = progesterone receptor, SRE = skeletal related events","Accepted October 20, 2014","Department of General Surgery (TI, TN, MM), Chiba Graduate School of Medicine, Japan","Naohito Yamamoto received research funding from Pfizer, Bayer, Parexel, and Eli Lilly. Those funders had no control over the interpretation, or publication of this work. This study was presented on the 9th European breast cancer conference, 19\u201321 March 2014 at Glasgow, Scotland","Received September 5, 2014","Received in revised form October 9, 2014","The authors have no conflicts of interest to disclose","This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nuclear Medicine (HI, TT), Chiba Cancer Center, Japan","institution_ids":["https://openalex.org/I4210115246"]},{"raw_affiliation_string":"From the Division of Breast Surgery (TI, NY)","institution_ids":[]},{"raw_affiliation_string":"and Department of General Surgery (TI, TN, MM), Chiba Graduate School of Medicine, Japan","institution_ids":["https://openalex.org/I159385669"]},{"raw_affiliation_string":"Abbreviations: aBSI = automated bone scan index, ANN = artificial neural network, ER = estrogen receptor, HER2 = human epidermal growth factor 2, PgR = progesterone receptor, SRE = skeletal related events","institution_ids":[]},{"raw_affiliation_string":"Accepted October 20, 2014","institution_ids":[]},{"raw_affiliation_string":"Department of General Surgery (TI, TN, MM), Chiba Graduate School of Medicine, Japan","institution_ids":["https://openalex.org/I159385669"]},{"raw_affiliation_string":"Naohito Yamamoto received research funding from Pfizer, Bayer, Parexel, and Eli Lilly. Those funders had no control over the interpretation, or publication of this work. This study was presented on the 9th European breast cancer conference, 19\u201321 March 2014 at Glasgow, Scotland","institution_ids":[]},{"raw_affiliation_string":"Received September 5, 2014","institution_ids":[]},{"raw_affiliation_string":"Received in revised form October 9, 2014","institution_ids":[]},{"raw_affiliation_string":"The authors have no conflicts of interest to disclose","institution_ids":[]},{"raw_affiliation_string":"This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065280788","display_name":"Takeshi Nagashima","orcid":"https://orcid.org/0000-0002-7261-9908","observed_orcids":["https://orcid.org/0000-0002-7261-9908"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]},{"id":"https://openalex.org/I4210115246","display_name":"Chiba Cancer Center","ror":"https://ror.org/02120t614","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210115246"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takeshi Nagashima","raw_affiliation_strings":["Division of Nuclear Medicine (HI, TT), Chiba Cancer Center, Japan","From the Division of Breast Surgery (TI, NY)","and Department of General Surgery (TI, TN, MM), Chiba Graduate School of Medicine, Japan","Abbreviations: aBSI = automated bone scan index, ANN = artificial neural network, ER = estrogen receptor, HER2 = human epidermal growth factor 2, PgR = progesterone receptor, SRE = skeletal related events","Accepted October 20, 2014","Department of General Surgery (TI, TN, MM), Chiba Graduate School of Medicine, Japan","Naohito Yamamoto received research funding from Pfizer, Bayer, Parexel, and Eli Lilly. Those funders had no control over the interpretation, or publication of this work. This study was presented on the 9th European breast cancer conference, 19\u201321 March 2014 at Glasgow, Scotland","Received September 5, 2014","Received in revised form October 9, 2014","The authors have no conflicts of interest to disclose","This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nuclear Medicine (HI, TT), Chiba Cancer Center, Japan","institution_ids":["https://openalex.org/I4210115246"]},{"raw_affiliation_string":"From the Division of Breast Surgery (TI, NY)","institution_ids":[]},{"raw_affiliation_string":"and Department of General Surgery (TI, TN, MM), Chiba Graduate School of Medicine, Japan","institution_ids":["https://openalex.org/I159385669"]},{"raw_affiliation_string":"Abbreviations: aBSI = automated bone scan index, ANN = artificial neural network, ER = estrogen receptor, HER2 = human epidermal growth factor 2, PgR = progesterone receptor, SRE = skeletal related events","institution_ids":[]},{"raw_affiliation_string":"Accepted October 20, 2014","institution_ids":[]},{"raw_affiliation_string":"Department of General Surgery (TI, TN, MM), Chiba Graduate School of Medicine, Japan","institution_ids":["https://openalex.org/I159385669"]},{"raw_affiliation_string":"Naohito Yamamoto received research funding from Pfizer, Bayer, Parexel, and Eli Lilly. Those funders had no control over the interpretation, or publication of this work. This study was presented on the 9th European breast cancer conference, 19\u201321 March 2014 at Glasgow, Scotland","institution_ids":[]},{"raw_affiliation_string":"Received September 5, 2014","institution_ids":[]},{"raw_affiliation_string":"Received in revised form October 9, 2014","institution_ids":[]},{"raw_affiliation_string":"The authors have no conflicts of interest to disclose","institution_ids":[]},{"raw_affiliation_string":"This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112156986","display_name":"Masaru Miyazaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]},{"id":"https://openalex.org/I4210115246","display_name":"Chiba Cancer Center","ror":"https://ror.org/02120t614","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210115246"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaru Miyazaki","raw_affiliation_strings":["Division of Nuclear Medicine (HI, TT), Chiba Cancer Center, Japan","From the Division of Breast Surgery (TI, NY)","and Department of General Surgery (TI, TN, MM), Chiba Graduate School of Medicine, Japan","Abbreviations: aBSI = automated bone scan index, ANN = artificial neural network, ER = estrogen receptor, HER2 = human epidermal growth factor 2, PgR = progesterone receptor, SRE = skeletal related events","Accepted October 20, 2014","Department of General Surgery (TI, TN, MM), Chiba Graduate School of Medicine, Japan","Naohito Yamamoto received research funding from Pfizer, Bayer, Parexel, and Eli Lilly. Those funders had no control over the interpretation, or publication of this work. This study was presented on the 9th European breast cancer conference, 19\u201321 March 2014 at Glasgow, Scotland","Received September 5, 2014","Received in revised form October 9, 2014","The authors have no conflicts of interest to disclose","This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nuclear Medicine (HI, TT), Chiba Cancer Center, Japan","institution_ids":["https://openalex.org/I4210115246"]},{"raw_affiliation_string":"From the Division of Breast Surgery (TI, NY)","institution_ids":[]},{"raw_affiliation_string":"and Department of General Surgery (TI, TN, MM), Chiba Graduate School of Medicine, Japan","institution_ids":["https://openalex.org/I159385669"]},{"raw_affiliation_string":"Abbreviations: aBSI = automated bone scan index, ANN = artificial neural network, ER = estrogen receptor, HER2 = human epidermal growth factor 2, PgR = progesterone receptor, SRE = skeletal related events","institution_ids":[]},{"raw_affiliation_string":"Accepted October 20, 2014","institution_ids":[]},{"raw_affiliation_string":"Department of General Surgery (TI, TN, MM), Chiba Graduate School of Medicine, Japan","institution_ids":["https://openalex.org/I159385669"]},{"raw_affiliation_string":"Naohito Yamamoto received research funding from Pfizer, Bayer, Parexel, and Eli Lilly. Those funders had no control over the interpretation, or publication of this work. This study was presented on the 9th European breast cancer conference, 19\u201321 March 2014 at Glasgow, Scotland","institution_ids":[]},{"raw_affiliation_string":"Received September 5, 2014","institution_ids":[]},{"raw_affiliation_string":"Received in revised form October 9, 2014","institution_ids":[]},{"raw_affiliation_string":"The authors have no conflicts of interest to disclose","institution_ids":[]},{"raw_affiliation_string":"This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5018426062"],"corresponding_institution_ids":["https://openalex.org/I159385669","https://openalex.org/I4210115246"],"apc_list":{"value":1950,"currency":"USD","value_usd":1950},"apc_paid":{"value":1950,"currency":"USD","value_usd":1950},"fwci":1.146,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.77247105,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"93","issue":"28","first_page":"e269","last_page":"e269"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12108","display_name":"Management of metastatic bone disease","score":0.010300000198185444,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.6700000166893005},{"id":"https://openalex.org/keywords/bone-metastases","display_name":"bone metastasis","score":0.996999979019165},{"id":"https://openalex.org/keywords/skeletal-related-events","display_name":"skeletal-related events","score":0.9769999980926514},{"id":"https://openalex.org/keywords/neural-network","display_name":"artificial neural networks","score":0.9779999852180481},{"id":"https://openalex.org/keywords/imaging-biomarkers","display_name":"imaging biomarkers","score":0.7829999923706055},{"id":"https://openalex.org/keywords/event-free-survival","display_name":"event-free survival","score":0.734000027179718},{"id":"https://openalex.org/keywords/alkaline-phosphatase","display_name":"alkaline phosphatase","score":0.9520000219345093},{"id":"https://openalex.org/keywords/bone-turnover-markers","display_name":"bone turnover markers","score":0.621999979019165},{"id":"https://openalex.org/keywords/radiologist-interpretation","display_name":"radiologist interpretation","score":0.5099999904632568}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8658880591392517},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7568827867507935},{"id":"https://openalex.org/C2777783956","wikidata":"https://www.wikidata.org/wiki/Q848085","display_name":"Bone metastasis","level":4,"score":0.5877247452735901},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.5255509614944458},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5048040151596069},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.42522504925727844},{"id":"https://openalex.org/C66339696","wikidata":"https://www.wikidata.org/wiki/Q6089397","display_name":"Log-rank test","level":3,"score":0.4230990409851074},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4163805842399597},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.35923153162002563},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.306277334690094},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.08846685290336609}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1097/md.0000000000000269","doi":"https://doi.org/10.1097/md.0000000000000269","is_oa":true,"landing_page_url":"https://doi.org/10.1097/md.0000000000000269","pdf_url":null,"source":{"id":"https://openalex.org/S28966261","display_name":"Medicine","issn_l":"0025-7974","issn":["0025-7974","1536-5964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4603075","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4603075/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4603075/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine (Baltimore)","raw_type":"Text"},{"id":"pmid:25526456","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25526456","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.780.5559","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.780.5559","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/5a/1c/medi-93-e269.PMC4603075.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1097/md.0000000000000269","doi":"https://doi.org/10.1097/md.0000000000000269","is_oa":true,"landing_page_url":"https://doi.org/10.1097/md.0000000000000269","pdf_url":null,"source":{"id":"https://openalex.org/S28966261","display_name":"Medicine","issn_l":"0025-7974","issn":["0025-7974","1536-5964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"},{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2313401482.pdf","grobid_xml":"https://content.openalex.org/works/W2313401482.grobid-xml"},"referenced_works_count":13,"referenced_works":["https://openalex.org/W1705165894","https://openalex.org/W1974415729","https://openalex.org/W1996023821","https://openalex.org/W2044057692","https://openalex.org/W2077463952","https://openalex.org/W2096827177","https://openalex.org/W2115205376","https://openalex.org/W2143037181","https://openalex.org/W2156604663","https://openalex.org/W2159044597","https://openalex.org/W2160319249","https://openalex.org/W2165011173","https://openalex.org/W2286543792"],"related_works":["https://openalex.org/W7096984624","https://openalex.org/W2474904856","https://openalex.org/W4210873844","https://openalex.org/W3013059805","https://openalex.org/W2957285621","https://openalex.org/W2800010484","https://openalex.org/W2169028823","https://openalex.org/W4376140955","https://openalex.org/W2617715906","https://openalex.org/W2591479215"],"abstract_inverted_index":{"The":[0,161],"aim":[1],"of":[2,74,128,169,184,211,231,240],"the":[3,9,12,47,72,88,131,167,182,209,229],"present":[4,48],"study":[5],"was":[6,34,44,146,203],"to":[7,57],"investigate":[8],"relationships":[10,89],"between":[11,90,130,193],"automated":[13],"bone":[14,27,54,196,235],"scan":[15,173],"index":[16],"(aBSI)":[17],"and":[18,70,82,87,93,109,138,175,195,224],"skeletal-related":[19],"events":[20],"(SRE)":[21],"in":[22,125,135,140,149,181,228],"breast":[23,58],"cancer":[24,59],"patients":[25,51,233],"with":[26,53,206,234],"metastasis.":[28],"A":[29,137],"computer-aided":[30],"software":[31],"(BONENAVI\u2122)":[32],"that":[33],"developed":[35],"using":[36],"an":[37],"Artificial":[38,78],"Neural":[39,42,79],"Network":[40,80],"(Artificial":[41],"Network)":[43],"used":[45],"for":[46],"analysis.":[49],"Forty-five":[50],"diagnosed":[52],"metastasis":[55,236],"due":[56],"from":[60],"April":[61],"2005":[62],"through":[63],"March":[64],"2013":[65],"were":[66,85,95,163,179,191],"retrospectively":[67],"analyzed.":[68,96],"Before":[69],"after":[71,104],"time":[73,210],"initial":[75,105,212],"treatment,":[76],"aBSI,":[77],"score,":[81],"hotspot":[83],"number":[84,183],"calculated,":[86],"these":[91],"scores":[92],"SRE":[94,129,185],"Twenty":[97],"cases":[98,111],"showed":[99,112],"decreased":[100],"(improved)":[101],"aBSI":[102,115,194,207,218],"values":[103,116],"treatment":[106,213],"(Group":[107,117],"A),":[108],"25":[110],"unchanged/increased":[113],"(worsened)":[114],"B).":[118],"Chi-square":[119],"analysis":[120],"revealed":[121],"a":[122,222],"significant":[123,177],"difference":[124],"incident":[126],"numbers":[127],"two":[132],"groups--one":[133],"case":[134],"Group":[136,141,150],"12":[139],"B":[142,151],"(P<0.001).":[143],"Event-free":[144],"survival":[145],"significantly":[147,204],"shorter":[148],"(hazard":[152],"ratio:":[153],"8.31,":[154],"95%":[155],"CI:":[156],"1.33-12.14,":[157],"log-rank":[158],"test;":[159],"P<0.05).":[160,215],"groups":[162],"also":[164],"divided":[165],"by":[166],"results":[168],"2":[170],"radiologists'":[171],"visual":[172],"interpretations,":[174],"no":[176],"differences":[178],"shown":[180],"(P=0.82,":[186],"P=0.10).":[187],"When":[188],"correlation":[189],"analyses":[190],"performed":[192],"metabolic":[197],"or":[198],"tumor":[199],"markers,":[200],"alkaline":[201],"phosphatase":[202],"correlated":[205],"at":[208,237],"(R=0.69,":[214],"In":[216],"conclusion,":[217],"is":[219],"proposed":[220],"as":[221],"useful":[223],"objective":[225],"imaging":[226],"biomarker":[227],"detection":[230],"breast-cancer":[232],"high":[238],"risk":[239],"SRE.":[241]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}
